Supplementary material for the paper

Pathway Analysis of MicroRNAs in Mouse Heart Development

Ganqiang Liu, Min Ding, Haiyun Wang and Jinyan Huang

School of Life Science and Technology, Tongji University, Shanghai 200092, China

E-mail: 6guns@tongji.edu.cn, 0326_dingmin@tongji.edu.cn, wanghaiyun@tongji.edu.cn, ekeen@tongji.edu.cn

These authors contributed equally to this work.

Qing Jing

Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, China

E-mail: qjing@sibs.ac.cn

Bairong Shen*

Center for Systems Biology, Postbox 206, Soochow University, Suzhou 215006, Jiangsu, China

E-mail: bairong.shen(at)suda.edu.cn

*corresponding author

 

KEGG ID

KEGG Pathway name

Targets Genes Count

P value

mmu05200

Pathways in cancer

185

3.90E-40

mmu04010

MAPK signaling pathway

134

2.05E-26

mmu04020

Calcium signaling pathway

105

1.07E-23

mmu04310

Wnt signaling pathway

92

2.36E-22

mmu04510

Focal adhesion

100

5.91E-20

mmu04916

Melanogenesis

70

1.43E-19

mmu04810

Regulation of actin cytoskeleton

99

3.03E-18

mmu04080

Neuroactive ligand-receptor interaction

101

4.74E-18

mmu04912

GnRH signaling pathway

60

1.64E-15

mmu05210

Colorectal cancer

57

2.44E-15

mmu04360

Axon guidance

69

6.20E-15

mmu04540

Gap junction

55

4.51E-14

mmu04012

ErbB signaling pathway

53

1.37E-13

mmu05220

Chronic myeloid leukemia

49

6.31E-13

mmu04370

VEGF signaling pathway

47

9.34E-13

mmu05218

Melanoma

46

1.96E-12

mmu04670

Leukocyte transendothelial migration

56

4.77E-12

mmu05217

Basal cell carcinoma

38

1.13E-11

mmu05223

Non-small cell lung cancer

39

1.20E-11

mmu04350

TGF-beta signaling pathway

47

1.48E-11

mmu04660

T cell receptor signaling pathway

56

2.52E-11

mmu05211

Renal cell carcinoma

43

2.54E-11

mmu04060

Cytokine-cytokine receptor interaction

85

2.68E-11

mmu05212

Pancreatic cancer

44

3.42E-11

mmu05214

Glioma

42

3.72E-11

mmu05221

Acute myeloid leukemia

38

5.57E-11

mmu04720

Long-term potentiation

42

7.43E-11

mmu04910

Insulin signaling pathway

60

1.14E-10

mmu05215

Prostate cancer

46

6.11E-10

mmu04664

Fc epsilon RI signaling pathway

41

7.70E-10

mmu05010

Alzheimer's disease

70

9.29E-10

mmu04630

Jak-STAT signaling pathway

58

1.22E-09

mmu04730

Long-term depression

41

1.91E-09

mmu04340

Hedgehog signaling pathway

33

2.32E-09

mmu05213

Endometrial cancer

33

3.34E-09

mmu05219

Bladder cancer

30

4.88E-09

mmu00010

Glycolysis / Gluconeogenesis

37

9.43E-09

mmu05014

Amyotrophic lateral sclerosis (ALS)

35

1.13E-08

mmu04260

Cardiac muscle contraction

36

1.41E-08

mmu04650

Natural killer cell mediated cytotoxicity

49

1.53E-08

mmu04520

Adherens junction

38

2.64E-08

mmu04210

Apoptosis

40

6.22E-08

mmu05222

Small cell lung cancer

40

7.23E-08

mmu04514

Cell adhesion molecules (CAMs)

52

7.67E-08

mmu04662

B cell receptor signaling pathway

37

1.92E-07

mmu04920

Adipocytokine signaling pathway

33

1.98E-07

mmu04530

Tight junction

47

5.26E-07

mmu05216

Thyroid cancer

21

6.29E-07

mmu04512

ECM-receptor interaction

35

7.92E-07

mmu00020

Citrate cycle (TCA cycle)

21

9.34E-07

mmu04930

Type II diabetes mellitus

24

1.69E-06

mmu04115

p53 signaling pathway

30

8.84E-06

mmu04110

Cell cycle

41

1.22E-05

mmu04640

Hematopoietic cell lineage

32

1.56E-05

mmu04940

Type I diabetes mellitus

24

2.20E-05

mmu05330

Allograft rejection

22

2.26E-05

mmu00910

Nitrogen metabolism

15

2.82E-05

mmu03320

PPAR signaling pathway

29

3.17E-05

mmu00071

Fatty acid metabolism

21

3.41E-05

mmu05332

Graft-versus-host disease

21

9.62E-05

mmu04620

Toll-like receptor signaling pathway

30

0.00011249

mmu04742

Taste transduction

15

0.000120242

mmu04070

Phosphatidylinositol signaling system

28

0.000177035

mmu00565

Ether lipid metabolism

16

0.000201434

mmu00564

Glycerophospholipid metabolism

24

0.000235036

mmu05320

Autoimmune thyroid disease

20

0.000363349

mmu04330

Notch signaling pathway

20

0.000505174

mmu00604

Glycosphingolipid biosynthesis - ganglioseries

10

0.000909808

mmu00190

Oxidative phosphorylation

35

0.00098451

mmu00230

Purine metabolism

39

0.001008179

mmu00720

Reductive carboxylate cycle (CO2 fixation)

8

0.001324979

mmu05012

Parkinson's disease

35

0.002146142

mmu00590

Arachidonic acid metabolism

21

0.002364705

mmu02010

ABC transporters - General

16

0.002567929

mmu04612

Antigen processing and presentation

23

0.002881522

mmu04150

mTOR signaling pathway

18

0.004279906

mmu00561

Glycerolipid metabolism

15

0.004526397

mmu05016

Huntington's disease

44

0.004772538

mmu00562

Inositol phosphate metabolism

17

0.004938574

mmu00051

Fructose and mannose metabolism

13

0.006593472

mmu04950

Maturity onset diabetes of the young

10

0.007392064

mmu00603

Glycosphingolipid biosynthesis - globoseries

7

0.00911286

mmu00052

Galactose metabolism

10

0.009351515