首  页 | 中心概况 | 中心成员 | 通知公告 | 科研工作 | 合作交流 | 中心教学 | 招生信息 | 活动 | 国际交流 | 联系我们 |
 中文/English
  您的位置:首页->详细信息
龙漫远

龙漫远

美国芝加哥大学终身教授,并受聘于北京大学为长江讲座教授,系统生物学研究中心兼职教授

邮  箱:mlong at uchicago.edu

 

龙漫远教授主要从事生物信息学领域的研究,在基因组演化研究方面有很深的造诣,特别是在新基因的起源、性基因的演化等研究领域取得了多项突破性成果,在Science,Nature,Nature Genetics,Nature Rev Genet,PNAS,PLoS,Cell,Plant Cell等发表论文20多篇文章,在重要专业杂志和书刊Mol Biol Evol,J Mol Evol,Genetics,Curr Opin Genet Develop,Genome Resea rch上发表文章30多篇,主编了荷兰出版的《当代遗传与进化重要问题》第十卷“新基因功能的起源与进化”。研究成果被美国和欧洲主要进化遗传领域教科书写成重要内容。美国和欧洲许多报刊或新闻网站以多种文字报道了这些发现。

他目前兼任北京大学“长江学者”讲座教授、国务院国家自然科学奖和国家自然科学基金会重点课题的特邀评审员、美国国家科学基金会和美国健康研究院课题评审组成员等多个学术职务,还担任Faculty of 1000, Journal of Molecular Evolution,Biology Direct,Journal of Experimental Zoology等专业杂志的编辑委员以及Nature,Science,PNAS 和若干专业杂志的特邀评审员。

经历

1983-1985 四川农业大学,,硕士,植物遗传育种专业, 师从高之仁教授,荣廷昭教授和明道绪教授

1987-1992 加利福尼亚大学戴维斯分校,博士,遗传学系;师从Charles Langley and John Gillespie教授

1993-1997 哈佛大学,博士后,分子细胞及进化生物学系;师从Walter Gilbert and Richard Lewontin教授

PUBLICATIONS

1. Ming, D. and M. Long 1985. Mathematical principle and application of canonical correlation to quantitative genetic analysis. J. of Sichuan Agri. Univ. 3: 250-255.

2. Long, M. 1985. A new method to measure the kernel volume of maize (Zea mays, L.). J. of Sichuan Agri. Univ. 3: 415-420.

3. Long, M. 1986. On the application of fuzzy clustering to genetic analysis. J. of Sichuan Agri. Univ. 4: 239-247.

4. Long, M. 1987. Study on the relationship between genetic distances and specific combining ability of yields in maize (Zea mays, L.). Genetic Research in China. 5 (ed by Genetics Society of China) (Hunnan Press of Science and Technology, Changsha).

5. Long, M. 1987. The methods for measuring genetic distance and the relationship between yield heterosis/specific combining ability and genetic distance in maize (Zea mays, L.). Acta Agronomica Sinica 13: 193-200.

6. Long, M. 1988. Computational search of a special orthogonal experiment design scheme. J. of Sichuan Agri. Univ. 6: 100-103.

7. Long, M. 1993. Estimating genetic variation in restriction fragment length polymorphism of nucleic acids. Hereditas (Beijing) 15: 44-48.

8. Long, M. 1986. History of science: G. W. Yule – A founder of polygene hypothesis of quantitative genetics who should not have been forgot. J of Sichuan Agri, Univ. Volume 4.

9. Williamson, V. W., M. Long, G. Theodoris 1991. Isolation of Caenorhabditis elegans mutants lacking alcohol dehydrogenase activity. Biochem. Genet. 29: 313-323.

10. Long, M., J. H. Gillespie 1991. Codon usage divergence of homologous vertebrate genes and codon usage clock. J. Mol. Evol. 32: 6-15.

11. Long, M., C. H. Langley 1993. Natural selection and the origin of jingwei, a chimeric processed functional gene in Drosophila. Science 260: 91-95.

12.Gilbert, W., M. Long, C. Rosenberg, M. Glylias 1995. Tests of the exon theory of genes. In: Tracing Biological Evolution in Protein and Gene Structures. Ed. M. Go and P. Schimmel. Elsevier Science B. V., Amsterdam.

13. Long, M, S. J. de Souza, W. Gilbert 1995. Evolution of intron/exon structure of eukaryotic genes. Curr. Opin. Genet. Dev. 5: 774-778.

14. Long, M., C. Rosenberg, W. Gilbert 1995. Intron phase correlations and the evolution of intron/exon structure of genes. Proc. Natl. Acad. Sci. USA 92: 12495-12499.

15. De Souza, S. J., M. Long, L. Schoenbach, W. Gilbert 1996. Intron positions correlate with module boundaries in ancient proteins. Proc. Natl. Acad. Sci. USA 93: 14632-14636.

16. Long, M., S. J. De Souza, C. Rosenberg, W. Gilbert 1996. Exon shuffling and origin of plant mitochondrial targeting targeting in cytochrome c1 precursor. Proc. Natl. Acad. Sci. USA 93: 7727-7731.

17. DeSouza, S. J., M. Long, and W. Gilbert 1996. Introns and gene evolution. Genes toCells 1: 493-505.

18. Richter, B., M. Long, R. C. Lewontin, E. Nitasaka 1997. Nucleotide polymorphism and evolution of the decapentaplegic gene in Drosophila. Genetics 145: 311-323.

19. Long, M., S.J. De Souza, W. Gilbert 1997. Delta-interacting protein A and the origin of hepatitis delta antigen. Science 276: 824-825.

20. Gilbert, W., S.J. De Souza, M. Long 1997. Origin of genes. Proc. Natl. Acad. Sci. USA 94: 7698-7703.

21. Long, M., S.J. De Souza, W. Gilbert 1997. The yeast splice site revisited: A new exon consensus from genomic analysis. Cell 91: 739-740.

22. De Souza S.J., M. Long, L. Schoenbach, S.W. Roy, W. Gilbert 1997. The correlation between introns and the three-dimensional structure of proteins. Gene 205: 141-144.

23. Long, M., S.J. de Souza, W. Gilbert 1998. Relationship between "proto-splice sites" and intron phases: Evidence from Dicodon Analysis. Proc. Natl. Acad. Sci. USA 95: 219-223.

24. De Souza, S. J., M. Long, R. J. Klein, S. Roy, S. Lin, W. Gilbert 1998. Towards a
resolution of the introns early/late debate. Only phase zero introns are correlated with the structure of ancient proteins. Proc. Natl. Acad. Sci. USA 95: 5094-5099.

25. Long, M. and S. J. de Souza 1998. Intron-exon structures: from molecular to population biology. Adv. Genome Biol: Genes and Genomes 5A: 143-178.

26. Long, M., W. Wang, and J. Zhang 1999. Origin of New Genes and source for N-terminal domain of the chimerical gene, jingwei, in Drosophila. Gene 238: 135-142.

27. Long, M. and M. Deutsch 1999. Association of intron phases with conservation at splice site sequences and evolution of spliceosomal introns. Mol. Biol. Evol. 16: 1528-1534.

28. Deutsch, M. and M. Long 1999. Intron-exon structures of model organisms. Nucl. Acid Res. 27: 3219-3228.

29. Cáceres, M., J. M. Ranz, Barbadilla, M. Long, and A. Ruiz 1999, Generation of a widespread Drosophila inversion by a transposable element. Science 285: 415-418.

30. Sakharkar,M., M. Long, T. W. Tan, S. J. De Souza 2000. ExInt-an Exon/Intron database. Nucl. Acid Res. 28: 191-192.

31. Long, M. 2000. Protein coding segments: evolution of exon-intron gene structure.Encyclopaedia of Life Science, Macmillan Reference Ltd, London.

32. Wang, W., J. Zhang, C. Alvarez, A. Llopart, and M. Long 2000. The origin of the jingwei Gene and the complex modular structure of its parental gene, yellow emperor, in D. Mol. Biol. Evol. 17:1294-1301.

33. Sakharkar, M. K., P. Kangueane, T. W. Woon, T. W. Tan, P. R. Kolatkar, M. Long, and S. J. De Souza 2000. IE-Kb: intron exon knowledge base. Bioinformatics 16: 1151-1152.

34. Long, M. 2000. A new function evolved from gene fusion. Genome Res. 10: 1655-1657.

35. Long, M. and C. Rosenberg 2000. Testing the "proto-splice sites" model of intron origin: Evidence from analysis of intron-phase correlations. Mol. Biol. Evol. 17: 1789-1796.

36. Long, M. 2001. Book review : "Adaptive evolution of genes and genomes" by Austin Hughes, Oxford University Press, New York. Persp. Biol. Med. 44, 460-464.

37. Létitia J., M. Long, J. Young, P. Péry, F. Tomley 2001. AP genes from apicomplexan parasites: Evidence for evolution of the gene structure. Trends Paras. 17: 491-498.

38. Long, M., K. Thornton 2001. Gene duplication and evolution. Science 293:1551.

39. Long, M. 2001. Evolution of novel genes. Curr Opin Genet Dev 11:673-680.

40. Long, M. and R. Cerff. 2002. Introns: Movement. Encyclopaedia of the Human Genome, Macmillan Reference Ltd, London.

41. Long, M. 2002. Pseudoexons. Encyclopaedia of the Human Genome, Macmillan Reference Ltd, London.

42. Wang, W., K. Thornton, A. Berry, and M. Long. 2002. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science 295:134-137.

43. Wang, W., F. G. Brunet, E. Nevo, M. Long 2002. Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA.. 99: 4448-4453.

44. Betrán E., M. Long 2002. Expansion of genome coding regions by acquisition of new genes. Genetica 115: 65-80.

45. Betrán, E., W. Wang, L. Jin, M. Long 2002. Evolution of the phophoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene. Mol. Biol. Evol.. 19: 654-663.

46. Thornton, K., M. Long 2002. Rapid divergence of gene duplicates on the Drosophila X chromosome. Mol. Biol. Evol. 19: 918-925.

47. Betrán, E., K. Thornton, and M. Long 2002. Retroposed new genes out of the X in Drosophila Genome Res. 12: 1854-1859.

48. Llopart, A., J. M. Comeron, F. G. Brunet, D. Lachaise, M. Long 2002. Intron presence / absence polymorphism in Drosophila driven by positive Darwinian selection. Proc. Natl. Acad. Sci. USA 99: 8121-8126.

49. Sakharkar M, F. Passetti F, J. E. de Souza, M. Long, S. J. de Souza 2002. ExInt: an Exon Intron Database. Nucl. Acid. Res. 30:191-194.

50. Betran, E., M. Long 2003. Dntf-2r, a young Drosophila retroposed gene with specific male expression under positive Darwinian selection. Genetics 164: 977-988

51. Long, M., M. Deutsch, W. Wang, E. Betrán, F. Brunet, J. Zhang 2003. Origin of new genes: Results from experimental and computational analysis. Genetica 118: 171-182.

52. Long, M., 2003. Preface, Origin and evolution of new gene functions. Contemporary Issues
In Genetics and Evoluton 10: 97.

53. Long, M. 2003. Fusion genes. Encyclopaedia of the Human Genome, Macmillan Reference Ltd, London.Nature Publishing Group. Macmillan Publishers Ltd, Nature Publishing Group.

54. Long, M., E. Betrán, K. Thornton, and W. Wang. 2003. The origin of new genes: glimpses from the young and old. Nature Reviews Genetics 4: 865-875.

55. Wang, W, K. Thornton, J. J. Emerson, and M. Long 2004. Nucleotide Variation and Recombination Along the Fourth Chromosome in Drosophila Simulans Genetics 166: 1783-1794.

56. Emerson J.J., H. Kaesmann, E. Betrán and M. Long 2004. Extensive gene traffic on the human X chromosome. Science 303: 537-540.

57. Wang, W., H. Yu and M. Long 2004. Duplication-degeneration as a mechanism of gene fission and the origin of Drosophila new genes. Nature Genetics 36: 523 – 527.

58. Zhang, J., A. M. Dean, F. Brunet and M. Long 2004. Evolving functional diversity in new genes of Drosophila. Proc Natl Acad Sci USA. 101: 16246 -16250

59. Betrán, E., J.J. Emerson, H. Kaessmann, and M. Long 2004. Sex chromosomes and male functions: where do new genes go? Cell Cycle 3: 873-875.

63. International Chick Genome Sequencing Consortium, 2004. Sequencing and comparative analysis of the chicken genome. Nature 432: 432:695-716.

61. Thornton K, Long M. 2005. Excess of Amino Acid Substitutions Relative to Polymorphism between X-linked Duplications in Drosophila melanogaster. Mol Biol Evol.22: 273-284.

62. Zhang J, Long M, and Li L, 2005. Translational effects of differential codon usage among
intragenic domains of the young Drosophila gene. Biochim Biophys Acta 1728:135-142.

63. Arguello JR, Chen Y, Yang S, Wang W, and Long M, 2006. An X-linked Testes Chimeric Gene by Illegitimate Recombination in Drosophila. PLoS Genetics 2: 0745-0754. e77.

64. Wang W, Zheng H, Fan C, Li J, Shi J, Cai Z, et al, 2006. High rate of chimeric gene origination by retroposition in plant genomes. Plant Cell 18: 1791-1802.

65. Dai H, Yoshimatsu TF, Long M, 2006. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Gene (Special Volume for “6th Anton Dohrn Workshop: Genome Evolution). Gene 385: 96-102.

66. Arguello JR, Fan C, Wang W and Long M (2006). Origination of Chimeric Genes through DNA-level Recombination. Genome Dynamics: Evolution of Gene Functions. Volume 3, Karger publishers. (Accepted).

67. Fan C and Long M, 2007. A New Retroposed Gene in Drosophila Heterochromatin Detected by Microarray-Based Comparative Genomic Hybridization. J Mol Evol 64:272-283.

68. Shiao MS, Khil PP, Smirnova NA, Camerini-Otero RD, Shiroishi T, Yu HT, Long M. 2007. Natural Selection Targeting on Expression Novelties in X-related Retrogenes in Rodents. Mol Biol Evol 24: 2242-2253.

69. Havlioglu N, Wang J, Kuo D, Fushimi K, Vibranovski MD, Kan Z, Gish W, Fedorov A, Long M and Wu JY. 2007. Genomic Signal for Alternative Splicing of a Large Number of Gene Families in the Human Genome. PLoS One 2(11): e1246.

70. Elde. NC, Long M, and Turkwitz AP. 2007. A role for convergent evolution in the secretory life of cells. Trends in Cell Biology 17:157-164.

71. Fan C, Vibranovski M, Chen Y and Long M, 2007. A Microarray-based genomic hybridization method for identification of new genes in plants: case analyses of Arabidopsis and Rice Journal of Integrative Plant Biology. 49: 915-926.

72. Arguello JR, Fan C, Wang W, and Long M, 2007. Origination of Chimeric Genes through DNA-level Recombination. Genome Dynamics 3: 131-146.

73. Long M., 2007. Journal Club: Mystery Genes. Nature 449: 511.

74. Drosophila 12 Genomes Consortium, 2007. Evolution of genes and genomes on the Drosophila phylogeny. Nature 450: 203-218.

75. Vibranovski M, Nobara, M, Long M, 2007. Birth and Evolution of Human Exons. Encyclopedia of Life Sciences. A0020777. John Wiley & Sons, Ltd. www.els.net

76. Fan C, Emerson JJ, and Long M, 2007. The Origin of New Genes. In: Evolutionary Genomics and Proteomics Ed. By Mark Pagel and Andrew Pomiankowski. Sinauer Associates.

77. Yang S., Arguello R, Li X, Ding Y, Zhou Q, Chen Y, Zhang Y, Zhao R, Brunet F, Peng L, Long M, Wang W., 2008. Repetitive Elements-mediated Recombination as a Mechanism for New Gene Origination in Drosophila PLoS Genetics 4(1): e3. 0001-0010.

78. Shiao MS, Liao BY, Long M, Yu HT, 2008. The adaptive evolution of insulin two-gene system in rodents. Genetics (Accepted).

79. Fan C and Long M, 2008. A Newly Tandem Duplicated Gene Cluster under Darwinian Positively Selection Evolved a Specific Expression Pattern in Reproductive Organs in Drosophila. Submitted.

dating tips,dating advice,dating tips and advice,dating tips advice,dating advice tip dating tips,dating advice,dating tips and advice,dating tips advice,dating advice tip dating tips,dating advice,dating tips and advice,dating tips advice,dating advice tip dating tips,dating advice,dating tips and advice,dating tips advice,dating advice tips
      【打印】 【关闭】  
地址:苏州市十梓街1号173号 邮编:215006
版权所有:苏州大学系统生物学研究中心
制作维护:维程信息 后台管理
沪ICP备09014983号