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李丽明

个人主页:http://fsmweb.northwestern.edu/faculty/FacultyProfile.cfm?xid=12338

美国西北大学分子药理学和生物化学系副教授,主要研究方向是利用酵母和其他模式生物去研究朊病毒如何获得感染力以及最终的致病机理。李教授的多篇文章发表在Science, Nature Genetics等重要专业杂志上。

求学经历

加利福尼亚大学戴维斯分校,1992年,博士

加利福尼亚大学戴维斯分校,1993年,博士后

发表文献

1   Crow ET, Li L. Newly identified prions in budding yeast, and their possible functions. Semin Cell Dev Biol. 2011 Mar 10.

2   Hines JK, Li X, Du Z, Higurashi T, Li L, Craig EA. [SWI], the Prion Formed by  the Chromatin Remodeling Factor Swi1, Is Highly Sensitive to Alterations in Hsp70 Chaperone System Activity. PLoS Genet. 2011 Feb;7(2):e1001309.

3   Du Z, Crow ET, Kang HS, Li L. Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function. Mol Cell Biol. 2010 Oct;30(19):4644-55.

4   Li L, Napper S, Cashman NR. Immunotherapy for prion diseases: opportunities and obstacles. Immunotherapy. 2010 Mar;2(2):269-82.

5   Hedlin PD, Cashman NR, Li L, Gupta J, Babiuk LA, Potter AA, Griebel P, Napper  S. Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses. Vaccine. 2010 Jan 22;28(4):981-8.

6   Li L, Guest W, Huang A, Plotkin SS, Cashman NR. Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding. Protein Eng Des Sel.2009 Aug;22(8):523-9.

7   Crow E, Du Z, Li L. New insights into prion biology from the novel [SWI+]system. Prion. 2008 Oct;2(4):141-4. PMCID: PMC2658763.

8   Herbst A, McIlwain S, Schmidt JJ, Aiken JM, Page CD, Li L. Prion disease diagnosis by proteomic profiling. J Proteome Res. 2009 Feb;8(2):1030-6.

9   Wang X, Sun W, Zhu X, Wu X, Li L, Zhu S, Du T, Liu Y, Niu N, Wang Y, Liu Y. M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population. Eur J Neurol. 2008 Aug;15(8):827-30.

10  Park KW, Li L. Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans. Biochem Biophys Res Commun. 2008 Aug 8;372(4):697-702.

11  Zhou RY, Li XL, Li LH, Wang HY, Lü JG. Polymorphism of the PRNP gene in the main breeds of indigenous Chinese goats. Arch Virol. 2008;153(5):979-82.

12  Du Z, Park KW, Yu H, Fan Q, Li L. Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Nat Genet. 2008 Apr;40(4):460-5.

13  Fan Q, Park KW, Du Z, Morano KA, Li L. The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion. Genetics. 2007 Nov;177(3):1583-93.

14  Li L, Coulthart MB, Balachandran A, Chakrabartty A, Cashman NR. Species barriers for chronic wasting disease by in vitro conversion of prion protein.Biochem Biophys Res Commun. 2007 Dec 28;364(4):796-800.

15  Li LB, Xu K, Bonini NM. Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila. J Biol Chem. 2007 Dec 28;282(52):37694-701.

16  Lan Z, Wang Z, Li L, Li J, Liu Y. Establishment of a TaqMan-based real-time PCR and its application to sheep PRNP genotyping. Anim Genet. 2007 Aug;38(4):427.

17  Park KW, Hahn JS, Fan Q, Thiele DJ, Li L. De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor. Genetics. 2006 May;173(1):35-47.

18  La Spada AR, Fu YH, Sopher BL, Libby RT, Wang X, Li LY, Einum DD, Huang J, Possin DE, Smith AC, Martinez RA, Koszdin KL, Treuting PM, Ware CB, Hurley JB,Ptácek LJ, Chen S. Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron. 2001 Sep 27;31(6):913-27.

19  Lindquist S, Krobitsch S, Li L, Sondheimer N. Investigating protein conformation-based inheritance and disease in yeast. Philos Trans R Soc Lond B Biol Sci. 2001 Feb 28;356(1406):169-76.

20  Li L, Lindquist S. Creating a protein-based element of inheritance. Science. 2000 Jan 28;287(5453):661-4.

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