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苏州市生物医学数据公共服务平台:生物大数据系列讲座(47)(2017-09-01)(新)

Intra-sample cellular heterogeneity: statistical challenges and algorithms

演讲人:Andrew E Teschendorff 教授
University College London

演讲人简介:https://iris.ucl.ac.uk/iris/browse/profile?upi=ATESC93#tabsProfilePub

研究方向:Personalised Medicine
• Zheng, S. C., Beck, S., Jaffe, A. E., Koestler, D. C., Hansen, K. D., Houseman, A. E., . . . Teschendorff, A. E. (2017). Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses. NATURE METHODS, 14 (3), 216-217.
• Pan, S., Lai, H., Shen, Y., Breeze, C., Beck, S., Hong, T., . . . Teschendorff, A. E. (2017). DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve. Cardiovascular research. doi:10.1093/cvr/cvx050
• Teschendorff, A. E., & Enver, T. (2017). Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome. NATURE COMMUNICATIONS, 8, ARTN 15599. doi:10.1038/ncomms15599
• Yang, Z., Wong, A., Kuh, D., Paul, D. S., Rakyan, V. K., Leslie, R. D., . . . Teschendorff, A. E. (2016). Correlation of an epigenetic mitotic clock with cancer risk. GENOME BIOLOGY, 17, ARTN 205. doi:10.1186/s13059-016-1064-3
• Yang, Z., Wu, L., Wang, A., Tang, W., Zhao, Y., Zhao, H., & Teschendorff, A. E. (2016). dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers. Nucleic Acids Res, 45 (D1), D812-D818. doi:10.1093/nar/gkw1079
• Teschendorff, A. E., Gao, Y., Jones, A., Ruebner, M., Beckmann, M. W., Wachter, D. L., . . . Widschwendter, M. (2016). DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer. NATURE COMMUNICATIONS, 7, ARTN 10478. doi:10.1038/ncomms10478
• Gao, Y., & Teschendorff, A. E. (2016). Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains. Nucleic Acids Res, 45 (2), 583-596. doi:10.1093/nar/gkw1100
• Paul, D. S., Teschendorff, A. E., Dang, M. A., Lowe, R., Hawa, M. I., Ecker, S., . . . Leslie, R. D. (2016). Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nat Commun, 7, 13555. doi:10.1038/ncomms13555
• Levine, M. E., Lu, A. T., Chen, B. H., Hernandez, D. G., Singleton, A. B., Ferrucci, L., . . . Horvath, S. (2016). Menopause accelerates biological aging. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113 (33), 9327-9332. doi:10.1073/pnas.1604558113
• Teschendorff, A. E., Zheng, S. C., Feber, A., Yang, Z., Beck, S., & Widschwendter, M. (2016). The multi-omic landscape of transcription factor inactivation in cancer. GENOME MEDICINE, 8, ARTN 89. doi:10.1186/s13073-016-0342-8

主持人:沈百荣教授(苏州大学系统生物学研究中心);

时间: 2017年9月1日下午4:00;
地点: 苏州大学本部纯水楼402

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