"117" "CID_1" "21151960" "cANRIL(circular ANRIL)" "circular RNA" "Atherosclerotic vascular disease" "NA" "Diagnosis" "NO" "Chapel Hill, USA, North America" "NA" "NA" "NA" "NA" "cell lines, primary peripheral blood T-lymphocytes" "qRT-PCR, Loop PCR, Sequence capture, next-generation sequencing" "NA" "Burd, CE et al. PLoS Genet. 2010" "NA" "NA" "Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk" "cANRIL is a stable, naturally occurring, circular RNA species produced in most INK4/ARF expressing cells, and its expression correlates with rs10757278 genotype which related to atherosclerosis." "392" "CID_10" "27531932" "cTTN5" "circular RNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/6" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "414" "CID_11" "29910675" "hsa_circRNA_002086" "circular RNA" "Congenital ventricular septal defect " "up" "Diagnosis" "NO" "Nanjing, China, Asia" "6" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change: 55.98" "Liu, H et al. Int J Med Sci. 2018" "mean(SD)" "NA" "Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect" "These circRNA are significantly differentially in myocardial tissue in congenital ventricular septal defect patients, might involve in the regulation of mycardial developmwnt." "415" "CID_12" "29910675" "hsa_circRNA_007878" "circular RNA" "Congenital ventricular septal defect " "down" "Diagnosis" "NO" "Nanjing, China, Asia" "6" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change: 56.33" "Liu, H et al. Int J Med Sci. 2018" "mean(SD)" "NA" "Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect" "These circRNA are significantly differentially in myocardial tissue in congenital ventricular septal defect patients, might involve in the regulation of mycardial developmwnt." "416" "CID_13" "29910675" "hsa_circRNA_100709" "circular RNA" "Congenital ventricular septal defect " "down" "Diagnosis" "NO" "Nanjing, China, Asia" "6" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change: 312.08" "Liu, H et al. Int J Med Sci. 2018" "mean(SD)" "NA" "Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect" "These circRNA are significantly differentially in myocardial tissue in congenital ventricular septal defect patients, might involve in the regulation of mycardial developmwnt." "417" "CID_14" "29910675" "hsa_circRNA_101965" "circular RNA" "Congenital ventricular septal defect " "down" "Diagnosis" "NO" "Nanjing, China, Asia" "6" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "NA " "Liu, H et al. Int J Med Sci. 2018" "mean(SD)" "NA" "Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect" "These circRNA are significantly differentially in myocardial tissue in congenital ventricular septal defect patients, might involve in the regulation of mycardial developmwnt." "418" "CID_15" "29910675" "hsa_circRNA_402565" "circular RNA" "Congenital ventricular septal defect " "down" "Diagnosis" "NO" "Nanjing, China, Asia" "6" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change: 53.33" "Liu, H et al. Int J Med Sci. 2018" "mean(SD)" "NA" "Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect" "These circRNA are significantly differentially in myocardial tissue in congenital ventricular septal defect patients, might involve in the regulation of mycardial developmwnt." "471" "CID_16" "28045102" "A combination of hsa_circ_0124644 and hsa_circ_0098964 " "circular RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Zhengzhou, China, Asia" "12/30/137" "6/17/73" "6/13/54" "62.4(5.6)/59.3(7.1)/61.4(7.3)" "blood" "Microarray, qPCR" "AUC=0.811, 95%CI: 0.756-0.865. P<0.001, Sensitivity: 0.825, Specificity: 0.730;" "Zhao, Z et al. Sci Rep. 2017" "mean(SD)" "Microarray cohort/Validation 1/Validation 2" "Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease" "A combination of hsa_circ_0124644 and hsa_circ_0098964 can be served as a diagnostic biomarker for coronary artery disease." "472" "CID_17" "28045102" "Hsa_circ_0124644" "circular RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Zhengzhou, China, Asia" "12/30/137" "6/17/73" "6/13/54" "62.4(5.6)/59.3(7.1)/61.4(7.3)" "blood" "Microarray, qPCR" "Validation 1: AUC=0.872, 95%CI: 0.785-0.960. P<0.001, Sensitivity: 0.867, Specificity: 0.767; Validation 2: AUC=0.769, 95%CI: 0.710-0.827. P<0.001, Sensitivity: 0.861, Specificity: 0.626; " "Zhao, Z et al. Sci Rep. 2017" "mean(SD)" "Microarray cohort/Validation 1/Validation 2" "Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease" "Hsa_circ_0124644 can be served as a diagnostic biomarker for coronary artery disease." "473" "CID_18" "28777011" "hsa-circRNA11783-2" "circular RNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Zhengzhou, China, Asia" "6/20/81" "3/11/45" "3/9/36" "61.7(7.9)/48.6(2.9)/50.8(6.0)" "blood" "Microarray, quantitative real-time polymerase chain reaction" "NA" "Li, X et al. Diab Vasc Dis Res. 2017" "mean(SD)" "First cohort/Second cohort/Third cohort" "Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus" "Hsa-circRNA11783-2 exhibited the strongest correlation with coronary artery disease." "474" "CID_19" "28777011" "hsa-circRNA11806-28" "circular RNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Zhengzhou, China, Asia" "6/20" "3/11" "3/7" "61.7(7.9)/48.6(2.9)" "blood" "Microarray, quantitative real-time polymerase chain reaction" "NA" "Li, X et al. Diab Vasc Dis Res. 2017" "mean(SD)" "First cohort/Second cohort" "Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus" "Hsa-circRNA11806-28 exhibited the correlation with coronary artery disease." "118" "CID_2" "27539542" "cANRIL(circular antisense non-coding RNA in the INK4 locus)" "circular RNA" "Atherosclerosis" "down" "Treatment" "YES" "Munich, Germany, Europe" "218" "NA" "NA" "NA" "cell lines, tissue" "PCR, qPCR, Genome-wide expression profiling, Westernblotting, northern blotting, In situ hybridization and immunohistochemical stainings" "Patients with high circANRIL expression developed less CAD (P=0.047; odds ratio=0.8; linear regression) and highest circANRIL/linANRIL ratios were found in patients free of CAD (P=5.9 × 10?5; odds ratio=0.75)" "Holdt, LM et al. Nat Commun. 2016 " "mean(SEM)" "NA" "Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans" "This study suggest circANRIL as a potential therapeutic target for the treatment of atherosclerosis because it can promote antiatherogenic cel function." "475" "CID_20" "28777011" "hsa-circRNA6510-1" "circular RNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Zhengzhou, China, Asia" "6/20" "3/11" "3/7" "61.7(7.9)/48.6(2.9)" "blood" "Microarray, quantitative real-time polymerase chain reaction" "NA" "Li, X et al. Diab Vasc Dis Res. 2017" "mean(SD)" "First cohort/Second cohort" "Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus" "Hsa-circRNA6510-1 exhibited correlation with coronary artery disease." "1117" "CID_21" "27609688" "MICRA(myocardial infarction-associated circular RNA)" "circular RNA" "Myocardial infarction" "down" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe;Leipzig, Gemany, Europe" "409/233" "294/170" "115/63" "62/60" "blood" "qPCR" "In the test cohort,with an integrated discrimination improvement (IDI) of 0.07 (95% CI: 0.02 to 0.12),in the validation cohort, MICRA predicted LV dysfunction with an odds ratio of 0.53 (95% CI: 0.29 to 0.97) and provided an IDI of 0.02 (95% CI: -0.01 to " "Vausort, M et al. J Am Coll Cardiol. 2016" "NA" "Test cohort/Validation cohort" "Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction" "Patients with low levels of MICRA were at high risk of left ventricular dysfunction after myocardial infarction,the circRNA may be useful in outcome prediction at an early stage after myocardial infarction witnin few hours." "1118" "CID_22" "29159270" "MICRA(myocardial infarction-associated circular RNA)" "circular RNA" "Myocardial infarction" "NA" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe;Leipzig, Gemany, Europe" "472" "356" "116" "60.9(30-91)" "blood" "qRT-PCR" "NA" "Salgado-Somoza, A et al. Int J Cardiol Heart Vasc. 2017" "NA" "NA" "The circular RNA MICRA for risk stratification after myocardial infarction" "The circRNA MICRA improves risk classification after myocardial infarction, supporting the value of this novel biomarker in future prognosis." "1148" "CID_23" "26873092" "circ-Foxo3" "circular RNA" "Cardiac senescence" "up" "Treatment" "NO" "Toronto, Canada, North America " "NA" "NA" "NA" "NA" "tissue" "RT-PCR, real-time PCR, Situ hybridization" "NA" "Du, WW et al. Eur Heart J. 2017" "NA" "NA" "Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses" "The level of circ-Foxo3 was highly expressed in the tissues of aged patients, silencing circ-Foxo3 decreased cell senescence and apoptosis." "1149" "CID_24" "26377962" "cZNF292" "circular RNA" "Angiogenesis" "up(in hypoxia)" "Treatment" "NO" "Frankfurt, Germany, Europe" "NA" "NA" "NA" "NA" "human umbilical venous endothelial cells" "RT-PCR" "NA" "Boeckel, JN et al. Cric Res. 2015" "mean(SD)" "NA" "Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA" "The circRNA cZNF292 exhibits a proangiogenic function, not the sponge of microRNA." "1150" "CID_25" "28082450" "circSlc8a1-1" "circular RNA" "Heart develpoment" "NA" "NA" "NO" "Singapore, Singapore, Asia" "12" "NA" "NA" "NA" "tissue" "PCR, qPCR, RT-PCR, Situ hybridization" "NA" "Tan, WL et al. Cardiovasc Res. 2017" "NA" "NA" "A landscape of circular RNA expression in the human heart" "The cardic-expressed circRNA is abundant in heart, but lack of differential expression in huamn diseased hearts." "1151" "CID_26" "28082450" "circTTN" "circular RNA" "Heart develpoment" "NA" "NA" "NO" "Singapore, Singapore, Asia" "12" "NA" "NA" "NA" "tissue" "PCR, qPCR, RT-PCR, Situ hybridization" "NA" "Tan, WL et al. Cardiovasc Res. 2017" "NA" "NA" "A landscape of circular RNA expression in the human heart" "The cardic-expressed circRNA is abundant in heart, but lack of differential expression in huamn diseased hearts." "1276" "CID_27" "29114076" "circDLGAP4" "circular RNA" "Acute ischemic stroke" "down" "Diagnosis, Treatment" "YES" "Nanjing, China, Asia" "26" "13" "13" "65.4(2.03)" "plasma" "Real-time PCR, Northern Blots, Fluorescence in situ hybridization (FISH)" "NA" "Bai, Y et al. J Neurosci. 2018" "mean(SEM)" "NA" "Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity" "The plasma circDLGAP4 is a promising biomarker for diagnosing acute ischemic stroke and evaluateing the degree of damage, and a therapeutic target in acute cerebrovascular protection." "1277" "CID_28" "28779016" "Ratio of circR-284/miR-221" "circular RNA" "Stroke" "up" "Prognosis" "YES" "New Orleans, USA, North America" "112" "75" "37" "69.2(6.7)" "serum" "RT-PCR, Droplet Digital PCR" "Validation Study: AUC=0.98, 95%CI: 0.96-1.00, Sensitivity: 0.93, Specificity: 0.97;" "Bazan, HA et al. Circ Cardiovasc Genet. 2017" "mean(SEM)" "NA" "Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels" "The cir-284:miR-221 ratio has greater potential as a diagnostic test for an acute ischemic cerebrovascular event after carotid plaque rupture." "119" "CID_3" "28779016" "Ratio of circR-284/miR-221" "circular RNA" "Atherosclerosis" "up" "Diagnosis" "YES" "New Orleans, USA, North America" "41" "30" "11" "68.4(1.9)" "serum" "RT-PCR, Droplet Digital PCR" "Discovery Study: AUC=0.82, 95%CI: 0.69-0.96, Sensitivity: 0.76, Specificity: 0.88;" "Bazan, HA et al. Circ Cardiovasc Genet. 2017" "mean(SEM)" "NA" "Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels" "The circ-284:miR-221 has potential an a diagnostic test for carotid plaque rupture leading to acute ischemic event." "386" "CID_4" "27531932" "cCAMK2D" "circular RNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/6" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "387" "CID_5" "27531932" "cCAMK2D" "circular RNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/7" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "388" "CID_6" "29523209" "circSLC8A1" "circular RNA" "Dilated cardiomyopathy" "up" "Diagnosis" "NO" "Suzhou, China, Asia" "NA" "NA" "NA" "NA" "tissue, human induced pluripotent stem cells, hiPSC-derived cardiomyocytes" "RNA sequencing, RT-PCR, quantitative real-time PCR" "NA" "Lei, W et al. Stem Cell Res Ther. 2018" "mean(SD)" "NA" "Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes" "The expression of circSLC8A1 in dilated cardiomyopathy is increased, related to pathological status of heart diseases." "389" "CID_7" "27531932" "cTTN1" "circular RNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/6" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "390" "CID_8" "27531932" "cTTN2" "circular RNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/6" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "391" "CID_9" "27531932" "cTTN4" "circular RNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "2/6" "1/NA" "1/NA" "51.5/NA" "tissue" "qRT-PCR, RT-PCR" "NA" "Khan, MA et al. Circ RES. 2016" "mean(SEM)" "Test cohort/Validation cohort" "RBM20 Regulates Circular RNA Production From the Titin Gene" "Loss of RBM20 may induce disease also by loss of circRNAs." "65" "LID_1" "24875884" "HIF1A-AS1(HIF 1 alpha-antisense RNA 1)" "long non-coding RNA" "Thoracic aortic aneurysms" "up" "Diagnosis" "NO" "Shanghai, China, Asia" "20" "NA" "NA" "NA" "tissue" "qRT-PCR" "expression levels of HIF1A-AS1 were upregulated by 3.26-fold compared with control by BRG1 overexpression." "Wang, S et al. Eur J Cardiothorac Surg. 2015" "NA" "NA" "BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro" "BRG1 is overexpressed in the thoracic aortic aneurysms,and it promote apoptosis and inhibit proliferation of vascular smooth muscle cells through HIF1A-AS1." "244" "LID_10" "26339410" "ENST00000425309" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.00059, P value=0.005" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "1275" "LID_100" "29258823" "RMST" "long non-coding RNA" "Ischemic stroke" "up" "Treatment" "NO" "Nanjing, China, Asia" "10" "NA" "NA" "NA" "plasma" "qRT-PCR" "NA" "Hou, XX et al. Biochem Biophys Res Commun. 2018" "mean(SEM)" "NA" "Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke" "Long non-coding RNA RMST silencing is involved in the pathogenesis of ischemic stroke, suggesting a promising approach of RMST inhibition in treating ischemic stroke." "245" "LID_11" "26339410" "ENST00000575612" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.0019, P value=0.024" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "246" "LID_12" "26908457" "NONHSAT040387" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Shanghai, China, Asia" "NA" "NA" "NA" "55(5)" "blood" "Microarray, qPCR" "Fold change=6.94, P value=0.01" "Xu, Y et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults" "The expression of the lncRNA is upregulated in atrial fibrillation patients." "247" "LID_13" "26908457" "NONHSAT098586" "long non-coding RNA" "Atrial fibrillation" "down" "Treatment" "YES" "Shanghai, China, Asia" "NA" "NA" "NA" "55(5)" "blood" "Microarray, qPCR" "Fold change=6.94, P value=0.01" "Xu, Y et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults" "The expression of the lncRNA is downregulated in atrial fibrillation patients." "248" "LID_14" "26339410" "NR_033661" "long non-coding RNA" "Atrial fibrillation" "down" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.011, P value=0.004" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "249" "LID_15" "26339410" "TCONS_00006371" "long non-coding RNA" "Atrial fibrillation" "down" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.00021, P value=0.038" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "250" "LID_16" "26339410" "uc001eqh.1" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.00026, P value=0.00035" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "251" "LID_17" "26339410" "X85157" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.0048, P value=0.00026" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "252" "LID_18" "26339410" "Z74666" "long non-coding RNA" "Atrial fibrillation" "down" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.029, P value=0.0014" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "372" "LID_19" "26141701" "ENST00000442794.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "102" "LID_2" "27789555" "H19" "long non-coding RNA" "Calcific aortic valve disease" "up" "Diagnosis" "NO" "Saguenay, Canada, North America" "9/106" "9/61" "0/45" "65(1)/67(1)" "tissue" "RNA sequencing, qPCR" "NA" "Hadji, F et al. Circulation. 2016" "mean(SEM)" "RNA sequencing/qPCR" "Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1" "LncRNA H19 promotes mineralization by silencing NOTCH1 in calcific aortic valve disease" "373" "LID_20" "26141701" "ENST00000453100.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "374" "LID_21" "26141701" "ENST00000504833.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "375" "LID_22" "26141701" "ENST00000508961.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "376" "LID_23" "26141701" "ENST00000563521.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "377" "LID_24" "26141701" "ENST00000568819.1" "long non-coding RNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "378" "LID_25" "26141701" "HIT000075931" "long non-coding RNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "379" "LID_26" "30355944" "KCNQ1OT1" "long non-coding RNA" "Dilated cardiomyopathy" "up" "Treatment" "YES" "Harbin, China, Asia" "8" "NA" "NA" "NA" "serum" "qRT-PCR" "NA" "Yang, F et al. Cell Physiol Biochem. 2018" "NA" "NA" "LncRNA KCNQ1OT1 Mediates Pyroptosis in Diabetic Cardiomyopathy" "Silencing Kcnq1ot1 inhibits pyroptosis by influencing miR-214-3p and caspase-1 expression in diabetic cardiomyopathy." "380" "LID_27" "24786300" "novlnc6" "long non-coding RNA" "Cardiomyopathy" "down" "Diagnosis" "YES" "Lausanne, Switzerland, Europe" "12" "9" "3" "56(4)" "tissue" "qRT-PCR" "NA" "Ounzain, S et al. Eur Heart J. 2015" "mean(SEM)" "NA" "Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs" "Novlnc6 was significantly down-regulated in dilated cardiomyopathy." "381" "LID_28" "29365080" "RP11-544D21.2" "long non-coding RNA" "Dilated cardiomyopathy" "up" "Treatment" "NO" "Wuhan, China, Asia" "14" "13" "1" "48" "tissue, human cardiac myocytes, human cardiac fibroblasts, human cardiac microvascular endothelial cells" "Microarray, RNA-sequencing, qRT-PCR" "NA" "Li, H et al. Cardiovasc Res. 2018" "NA" "NA" "Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy" "This lncRNA significantly regulated dilated cardiomyopathy-associated genes in cardiomyocytes, and also effected tube formation and cell migration in endothelial cells, may provide new therapeutic target in dilated cardiomyopathy patients." "382" "LID_29" "26141701" "TCONS_00013406" "long non-coding RNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "111" "LID_3" "29035780" "ANRIL(Cyclin-dependent kinase inhibitor 2B antisense RNA 1)" "long non-coding RNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Sivas, Turkey, Asia" "20" "17" "3" "62(40-84)" "tissue" "qPCR" "NA" "Arslan, S et al. Atherosclerosis. 2017" "NA" "NA" "Long non-coding RNAs in the atherosclerotic plaque" "The lncRNA were upregulated in atherosclerotic arteries compared to non-atherosclerotic." "383" "LID_30" "26141701" "uc.279+" "long non-coding RNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis, Prognosis, Treatment" "NO" "Chengdu, China, Asia" "7" "4" "3" "48" "tissue" "Microarray, real-time PCR" "NA" "Yang, W et al. BMC Cardiovasc Disord. 2015" "mean age" "NA" "Microarray profiling of long non-coding RNA (lncRNA) associated with hypertrophic cardiomyopathy" "LncRNAs are involved in the pathogenesis of hypertrophic cardiomyopathy through the modulation of multiple pathogenetic pathways." "384" "LID_31" "27422984" "uc004cov.4" "long non-coding RNA" "Hypertrophic obstructive cardiomyopathy" "up" "Diagnosis" "YES" "Hannover, Germany, Europe" "57" "29" "28" "56.86" "serum" "quantitative real-time PCR" "AUC=0.6638, p=0.0197" "Kitow, J et al. Am J Physiol Heart Circ Physiol. 2016" "mean(SEM)" "NA" "Mitochondrial long noncoding RNAs as blood based biomarkers for cardiac remodeling in patients with hypertrophic cardiomyopathy" "The lncRNA can identify hypertrophic obstructive cardiomyopathy and could be useful biomarker in the future. " "385" "LID_32" "27422984" "uc022bqu.1" "long non-coding RNA" "Hypertrophic obstructive cardiomyopathy" "up" "Diagnosis" "YES" "Hannover, Germany, Europe" "57" "29" "28" "56.86" "serum" "quantitative real-time PCR" "AUC=0.6820, p=0.0083" "Kitow, J et al. Am J Physiol Heart Circ Physiol. 2016" "mean(SEM)" "NA" "Mitochondrial long noncoding RNAs as blood based biomarkers for cardiac remodeling in patients with hypertrophic cardiomyopathy" "The lncRNA can identify hypertrophic obstructive cardiomyopathy and could be useful biomarker in the future. " "408" "LID_33" "27035723" "AA584040" "long non-coding RNA" "Fetal congenital heart defects in pregnant women" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "62" "0" "62" "26.45(5.52)" "plasma" "Microarray, RT-PCR" "AUC=0.755; Sensitivity: 0.677; Specificity:0.661." "Gu, M et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating LncRNAs as Novel, Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects" "The lncRNA differentially expressed in the plasma of pregnant women and may be used as novel biomarkers for diagnosis of congenital heart defects." "409" "LID_34" "27035723" "AA709223" "long non-coding RNA" "Fetal congenital heart defects in pregnant women" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "62" "0" "62" "26.45(5.52)" "plasma" "Microarray, RT-PCR" "AUC=0.882; Sensitivity: 0.790; Specificity:0.774." "Gu, M et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating LncRNAs as Novel, Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects" "The lncRNA differentially expressed in the plasma of pregnant women and may be used as novel biomarkers for diagnosis of congenital heart defects." "410" "LID_35" "27035723" "BX478947" "long non-coding RNA" "Fetal congenital heart defects in pregnant women" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "62" "0" "62" "26.45(5.52)" "plasma" "Microarray, RT-PCR" "AUC=0.886; Sensitivity: 0.839; Specificity:0.823." "Gu, M et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating LncRNAs as Novel, Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects" "The lncRNA differentially expressed in the plasma of pregnant women and may be used as novel biomarkers for diagnosis of congenital heart defects." "411" "LID_36" "27035723" "ENST00000422826" "long non-coding RNA" "Fetal congenital heart defects in pregnant women" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "62" "0" "62" "26.45(5.52)" "plasma" "Microarray, RT-PCR" "AUC=0.817; Sensitivity: 0.710; Specificity:0.710." "Gu, M et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating LncRNAs as Novel, Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects" "The lncRNA differentially expressed in the plasma of pregnant women and may be used as novel biomarkers for diagnosis of congenital heart defects." "412" "LID_37" "27035723" "ENST00000436681" "long non-coding RNA" "Fetal congenital heart defects in pregnant women" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "62" "0" "62" "26.45(5.52)" "plasma" "Microarray, RT-PCR" "AUC=0.892; Sensitivity: 0.839; Specificity:0.823." "Gu, M et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating LncRNAs as Novel, Non-Invasive Biomarkers for Prenatal Detection of Fetal Congenital Heart Defects" "The lncRNA differentially expressed in the plasma of pregnant women and may be used as novel biomarkers for diagnosis of congenital heart defects." "413" "LID_38" "29559566" "MALAT1(metastasis-associated lung adenocarcinoma transcript 1) polymorphism rs619586 A>G" "long non-coding RNA" "Congenital heart disease" "up(MALAT1)" "Diagnosis" "YES" "Kunshan, China, Asia" "713" "361" "352" "41.9(26.9)" "blood" "Luciferase assay" "AG/GG genotypes of rs619586 were associated with significantly lower risk of CHD subtype VSD against AA genotype (adjusted P=0.011, OR = 0.72, 95% CI = 0.54-0.92). " "Li, Q et al. Biosci Rep. 2018" "NA" "NA" "The MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese" "G allele of rs619586 decreased MALAT1 expression in vivo, higher expression of MALAT1 in plasma was found in congenital heart disease, result in lower risk of congenital heart disease, so MALAT1 polymorphism rs619586 A>G could be a pivotal novel and effe" "460" "LID_39" "26857419" "IL21R-AS1" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Chongqing, China, Asia" "161/50/50" "104/30/28" "57/20/22" "65.58(10.98)/64.28(9.85)/65.97(9.78)" "plasma, peripheral blood mononuclear cells" "quantitative RT-PCR, Microarray" "Independent set: AUC=0.825" "Cai, Y et al. Cardiovasc Res. 2016 " "mean(SD)" "Training set/Test set/Independent set" "Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease" "IL21R-AS1 is deregulated in coronary artery disease patients." "112" "LID_4" "29196750" "lnc-KDM5D-4" "long non-coding RNA" "Atherosclerosis" "exist" "Treatment" "YES" "Ballarat, Australia, Oceania" "7" "5" "2" "18-50" "HepG2 cell, tissue, blood" "NA" "NA" "Molina, E et al. Sci Rep. 2017" "mean(SEM)" "NA" "A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes" "Lnc-KDM5D-4 in key processes related to fatty liver and cellular inflammation associated with atherosclerosis and coronary artery disease in men." "461" "LID_40" "28790415" "LIPCAR(long noncoding RNA uc022bqs.1)" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "300" "188" "112" "64.21(10.77)" "plasma" "qRT-PCR" "AUC=0.722 (95% CI=0.669-0.782), Sensitivity: 72.2%, Specificity:62.3%" "Zhang, Z et al. Sci Rep. 2017" "NA" "NA" "Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population" "Increased plasma levels of H19 is associated with increased risk of coronary artery disease and may be considered as novel biomarkers for coronary artery disease." "462" "LID_41" "29196750" "lnc-KDM5D-4" "long non-coding RNA" "Coronary artery disease" "exist" "Treatment" "YES" "Ballarat, Australia, Oceania" "7" "5" "2" "18-50" "HepG2 cell, tissue, blood " "real-time PCR" "NA" "Molina, E et al. Sci Rep. 2017" "mean(SEM)" "NA" "A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes" "Lnc-KDM5D-4 in key processes related to fatty liver and cellular inflammation associated with atherosclerosis and coronary artery disease in men." "463" "LID_42" "26871769" "LncPPARdelta(long noncoding RNA NONHSAT112178)" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Chongqing, China, Asia" "20/161/50" "15/95/39" "5/66/11" "NA/65.51(9.86)/64.38(11.12)" "blood" "Microarray, RT-qPCR" "Microarray: AUC=0.875, 95%CI:0.783-0.852; Training set: AUC=0.712, 95%CI:0.653-0.771; Testing set: AUC=0.769, 95%CI:0.677-0.861" "Cai, Y et al. Medicine (Baltimore). 2016 " "mean(SD)" "Microarray set/Training set/Testing set" "Circulating ""LncPPARdelta"" From Monocytes as a Novel Biomarker for Coronary Artery Diseases" "LncRNA lncPPARdelta regulate the expression of protein-coding genes, and it's direct target gens ADRP and ANGPTL4, as a biomarker for coronary artery diseases." "464" "LID_43" "23315372" "ANRIL(Cyclin-dependent kinase inhibitor 2B antisense RNA 1)" "long non-coding RNA" "Coronary artery disease" "NA" "Diagnosis" "NO" "Framingham, USA, North America" "281" "158" "123" "60(8)" "blood" "PCR " "NA" "Johnson, AD et al. Circulation. 2013" "mean(SD)" "NA" "Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study" "Complex regulatory variation affecting ANRIL and CDKN2B gene expression may contribute to increased risk for clinically apparent and subclinical coronary artery disease." "465" "LID_44" "26857419" "BAT5" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Chongqing, China, Asia" "161/50/50" "104/30/28" "57/20/22" "65.58(10.98)/64.28(9.85)/65.97(9.78)" "plasma, peripheral blood mononuclear cells" "quantitative RT-PCR, Microarray" "Independent set: AUC=0.818" "Cai, Y et al. Cardiovasc Res. 2016 " "mean(SD)" "Training set/Test set/Independent set" "Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease" "BAT5 is deregulated in coronary artery disease patients." "466" "LID_45" "23315372" "CDKN2B" "long non-coding RNA" "Coronary artery disease" "NA" "Diagnosis" "NO" "Framingham, USA, North America" "281" "158" "123" "60(8)" "blood" "PCR " "NA" "Johnson, AD et al. Circulation. 2013" "mean(SD)" "NA" "Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study" "Complex regulatory variation affecting ANRIL and CDKN2B gene expression may contribute to increased risk for clinically apparent and subclinical coronary artery disease." "467" "LID_46" "26201019" "CoroMarker(AC100865.1) " "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Chongqing, China, Asia" "20/161/50" "15/95/39" "5/66/11" "NA/65.51(9.86)/64.38(11.12)" "plasma" "Microarray, qPCR" "Microarray: AUC=0.8975; Training set: AUC=0.796, 95%CI:0.749-0.843; Testing set: AUC=0.811, 95%CI:0.710-0.912" "Yang, Y et al. Clin Sci (Lond). 2015" "mean(SD)" "Microarray set/Training set/Testing set" "Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease" "CoroMarker was stable in plasma as a novel biomarker for diagnosis of coronary artery disease." "468" "LID_47" "26857419" "CoroMarker(OTTHUMT00000387022)" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Chongqing, China, Asia" "161/50/50" "104/30/28" "57/20/22" "65.58(10.98)/64.28(9.85)/65.97(9.78)" "plasma, peripheral blood mononuclear cells" "quantitative RT-PCR, Microarray" "AUC=0.920 95% confidence interval (CI)=0.892-0.947" "Cai, Y et al. Cardiovasc Res. 2016 " "mean(SD)" "Training set/Test set/Independent set" "Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease" "CoroMarker is a novel and specific biomarker of coronary artery disease." "469" "LID_48" "29267258" "GAS5" "long non-coding RNA" "Coronary artery disease" "down" "Diagnosis" "YES" "Tianmen, China, Asia" "30" "18" "12" "29-76" "plasma" "Quantitative real-time PCR" "AUC=0.9783 (p<0.0001)" "Yin, Q et al. Med Sci Monit. 2017" "Age range" "NA" "Plasma Long Non-Coding RNA (lncRNA) GAS5 is a New Biomarker for Coronary Artery Disease" "The decrease in the expression level of GAS5 was found to be a promising biomarker for coronary artery disease." "470" "LID_49" "28790415" "H19" "long non-coding RNA" "Coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "300" "188" "112" "64.21(10.77)" "plasma" "qRT-PCR" "AUC=0.631 (95% CI=0.551-0.788), Sensitivity: 53.6%, Specificity:73%" "Zhang, Z et al. Sci Rep. 2017" "NA" "NA" "Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population" "Increased plasma levels of H19 is associated with increased risk of coronary artery disease and may be considered as novel biomarkers for coronary artery disease." "113" "LID_5" "29035780" "MALAT1(Metastasis-associated lung adenocarcinoma transcript 1)" "long non-coding RNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Sivas, Turkey, Asia" "20" "17" "3" "62(40-84)" "tissue" "qPCR" "NA" "Arslan, S et al. Atherosclerosis. 2017" "NA" "NA" "Long non-coding RNAs in the atherosclerotic plaque" "The lncRNA were downregulated in atherosclerotic arteries compared to non-atherosclerotic." "774" "LID_50" "27317124" "CDKN2B-AS1/ANRIL" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "775" "LID_51" "27317124" "EGOT" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "776" "LID_52" "30031611" "EGOT(eosinophil granule ontogeny transcript)" "long non-coding RNA" "Heart failure" "down" "Treatment" "NO" "Guangzhou, China, Asia" "NA" "NA" "NA" "NA" "H9c2 cells" "Quantitative PCR" "NA" "Zhang, C et al. Biochem Biophys Res Commun. 2018" "NA" "NA" "Recombinant human brain natriuretic peptide regulates PI3K/AKT/mTOR pathway through lncRNA EGOT to attenuate hypoxia-induced injury in H9c2 cardiomyocytes" "Administration of rhBNP alleviated hypoxia-induced injury in H9c2 cells and elevated expression of EGOT, provide a new strategy for the treatment of heart failure induced by hypoxia" "777" "LID_53" "27317124" "H19" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "778" "LID_54" "27317124" "HOTAIR(HOX antisense intergenic RNA)" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "779" "LID_55" "28611075" "HypERlnc(ENSG00000262454)" "long non-coding RNA" "Heart failure" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "19" "NA" "NA" "NA" "human primary pericytes cells, lung tissue, heart tissue" "RT-qPCR, Luciferase reporter array" "NA" "Bischoff, FC et al. Circ Res. 2017" "NA" "NA" "Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes" "HypERlnc is deregulated in human heart failure and correlates with pericyte marker expression in human lung disease." "780" "LID_56" "24663402" "LIPCAR(long noncoding RNA uc022bqs.1)" "long non-coding RNA" "Chronic heart failure" "up" "Prognosis" "YES" "Hannover, Germany, Europe" "246" "200" "46" "57(14)" "plasma" "Microarray" "NA" "Kumarswamy, R et al. Circ Res. 2014" "NA" "NA" "Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure" "LIPCAR is a novel biomrker of future death in patients with heart failure or acute myocardial infarction." "781" "LID_57" "27317124" "LOC285194/TUSC7" "long non-coding RNA" "Ischemic heart failure" "down" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "782" "LID_58" "26323562" "LSINCT5" "long non-coding RNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Shanghai, China, Asia" "NA" "NA" "NA" "NA" "human myocardial cells" "RT-qPCR, PCR array" "NA" "Zhang, X et al. Mol Med Rep. 2015" "NA" "NA" "Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide/long non-coding RNA LSINCT5/caspase-1/interleukin 1β signaling pathway" "High expression levels of BNP promote the apoptosis of myocardial cells through the lncRNA LSINCT5 mediator, which activates the caspase?1/IL?1β signaling pathway in heart failure patients." "783" "LID_59" "28296001" "MHRT(Myosin heavy-chain-associated RNA transcripts)" "long non-coding RNA" "Heart failure" "up" "Diagnosis" "YES" "Harbin, China, Asia" "72" "47" "25" "59.31(11.19)" "plasma" "real-time RT-PCR" "AUC=0.702 (95% CI=0.612-0.791); odds ratios (OR) were 1.701 (95% CI: 1.225-2.363)" "Xuan, L et al. J Cell Mol Med. 2017" "mean(SD)" "NA" "Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure" "Elevation of circulating MHRT predicts heart failure and may be considered as novel diagnosis biomarkers of heart failure." "114" "LID_6" "29035780" "MIAT(Myocardial infarction-associated transcript)" "long non-coding RNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Sivas, Turkey, Asia" "20" "17" "3" "62(40-84)" "tissue" "qPCR" "NA" "Arslan, S et al. Atherosclerosis. 2017" "NA" "NA" "Long non-coding RNAs in the atherosclerotic plaque" "The lncRNA were upregulated in atherosclerotic arteries compared to non-atherosclerotic." "784" "LID_60" "28296001" "NRON(Non-coding repressor of NFAT)" "long non-coding RNA" "Heart failure" "up" "Diagnosis" "YES" "Harbin, China, Asia" "72" "47" "25" "59.31(11.19)" "plasma" "real-time RT-PCR" "AUC=0.865 (95% CI=0.805-0.926); odds ratios (OR) were 4.505 (95% CI: 2.393-8.478)" "Xuan, L et al. J Cell Mol Med. 2017" "mean(SD)" "NA" "Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure" "Elevation of circulating NRON predicts heart failure and may be considered as novel diagnosis biomarkers of heart failure." "785" "LID_61" "27317124" "RMRP" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "786" "LID_62" "27317124" "RNY5" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "787" "LID_63" "27317124" "SOX2-OT" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "788" "LID_64" "27317124" "SRA1" "long non-coding RNA" "Ischemic heart failure" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "18" "17" "1" "65(0.6)" "tissue, peripheral blood mononuclear cells" "RT-qPCR, In situ hybridization" "NA" "Greco, S et al. J Transl Med. 2016" "mean(SEM)" "NA" "Long noncoding RNA dysregulation in ischemic heart failure" "The deregulation of the lncRNA in the peripheral blood suggests a potential as disease biomarkers." "789" "LID_65" "29126880" "TRDN-AS" "long non-coding RNA" "Heart failure" "up" "Treatment" "NO" "Luxembourg, Luxembourg, Europe" "43" "NA" "NA" "NA" "cardiac biopsies" "qRT-PCR" "NA" "Zhang, L et al. Biochim Biophys Acta. 2018" "mean(SD)" "NA" "A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin" "The long non-coding RNA regulate the balance between cardiac and skeletal muscle triadin, may apply to the treatment of heart failure." "790" "LID_66" "28490726" "UCA1(urothelial carcinoma-associated 1)" "long non-coding RNA" "Chronic heart failure" "up" "Diagnosis, Prognosis" "YES" "Beijing, China, Asia" "67" "37" "30" "68.13(1.228)" "plasma" "qRT-PCR" "AUC=0.89, Sensitivity: 100%, Specificity:76.12%" "Yu, X et al. Med Sci Monit. 2017" "mean(SD)" "NA" "Plasma Long Noncoding RNA Urothelial Carcinoma Associated 1 Predicts Poor Prognosis in Chronic Heart Failure Patients" "Plasma UCA1 might be an excellent indicator to diagnose chronic heart failure and it might predict poor outcomes of chronic heart failure." "829" "LID_67" "29917257" "CARMEN(Cardiac mesoderm enhancer-associated non-coding RNA)" "long non-coding RNA" "Hypertensive" "up" "Treatment" "YES" "Crete, Greece, Europe" "80" "NA" "NA" "NA" "blood" "qPCR" "31.24(4.40) versus 10.05(2.69), p=0.010, positive correlation (r=0.458, p<0.001) with LVMI." "Kontaraki, JE et al. Clin Exp Pharmacol Physiol. 2018" "NA" "NA" "The long non coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy" "The lncRNA show distinct expression profiles in hypertensive patients and possibly candidate therapeutic tragets in hypertensive heart disease." "830" "LID_68" "29917257" "FENDRR(Foxf1 adjacent non-coding developmental regulatory RNA)" "long non-coding RNA" "Hypertensive" "up" "Treatment" "YES" "Crete, Greece, Europe" "80" "NA" "NA" "NA" "blood" "qPCR" "37.34(5.83) versus 10.52(3.44), p=0.013, negative correlations of MHRT (r=-0.380, p=0.001) with LVMI. " "Kontaraki, JE et al. Clin Exp Pharmacol Physiol. 2018" "NA" "NA" "The long non coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy" "The lncRNA show distinct expression profiles in hypertensive patients and possibly candidate therapeutic tragets in hypertensive heart disease." "831" "LID_69" "28611075" "HypERlnc(ENSG00000262454)" "long non-coding RNA" "Idiopathic pulmonary arterial hypertension" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "17" "NA" "NA" "NA" "human primary pericytes cells, lung tissue, heart tissue" "RT-qPCR, Luciferase reporter array" "NA" "Bischoff, FC et al. Circ Res. 2017" "NA" "NA" "Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes" "HypERlnc expression significantly correlated with pericyte markers in human lungs derived from patients diagnosed with idiopathic pulmonary arterial hypertension." "115" "LID_7" "29136944" "MIAT(Myocardial infarction-associated transcript)" "long non-coding RNA" "Atherosclerosis" "up" "Treatment" "YES" "Kaifeng, China, Asia" "20" "12" "8" "50-70" "serum" "Luciferase activity assays, RNA immunoprecipitation (RIP) assays, CCK-8 assays, " "P<0.05" "Zhong, X et al. Biomed Pharmacother. 2018" "mean(SD)" "NA" "MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models" "MIAT promote atherosclerosis(AS) progression by modulating miR-181b, it may be employed as potential therapeutic target for AS." "832" "LID_70" "29917257" "MHRT(Myosin heavy-chain-associated RNA transcripts)" "long non-coding RNA" "Hypertensive" "up" "Treatment" "YES" "Crete, Greece, Europe" "80" "NA" "NA" "NA" "blood" "qPCR" "72.62(11.07) versus 6.83(1.99), p=0.001, negative correlations of MHRT (r=-0.323, p=0.003) with LVMI." "Kontaraki, JE et al. Clin Exp Pharmacol Physiol. 2018" "NA" "NA" "The long non coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy" "The lncRNA show distinct expression profiles in hypertensive patients and possibly candidate therapeutic tragets in hypertensive heart disease." "1094" "LID_71" "27634901" "A combination of ENSG00000246526, ENSG00000232451, ENSG00000258086, ENSG00000249835, ENSG00000276107, ENSG00000279980, ENSG00000270075, ENSG00000228262, ENSG00000236266 " "long non-coding RNA" "Myocardial infarction" "up" "Diagnosis" "YES" "Harbin, China, Asia" "80" "NA" "NA" "NA" "circulating endothelial cells, blood" "Microarray" "Discovery cohort: AUC=0.985; Sensitivity: 0.9388; Specificity:0.98; Validation cohort: AUC=0.771; Sensitivity: 0.7097; Specificity:0.6191." "Sun, C et al. Oncotarget. 2016" "NA" "NA" "Identification of long non-coding RNAs biomarkers for early diagnosis of myocardial infarction from the dysregulated coding-non-coding co-expression network" "The 9LncSigacute myocardial infarction can identify myocardial infarction from healthy patients with a high diagnosis of myocardial infarction." "1095" "LID_72" "29179461" "A combination of LOC145474, LOC100129518, BRE-AS1, MIR22HG, MIR3945HG, ATP2B1-AS1, CATIP-AS1 and LINC00528, WDR86-AS1, A2M-AS1 and LINC00612" "long non-coding RNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Harbin, China, Asia" "49/31/21" "NA/18/16" "NA/13/5" "NA/53(38-65)/59" "blood, circulating endothelial cells" "Microarray" "Discovery cohort: AUC=0.955, Sensitivity: 0.714, Specificity:0.909, DOR=25; Validation cohort: AUC=0.92;, Sensitivity: 0.786, Specificity:0.893, DOR=30.6; Further cohort: AUC=0.701, Sensitivity: 0.903, Specificity: 0.429, DOR=7" "Li, L et al. Oncotarget. 2017" "NA" "NA" "Differential expression profiles of long non-coding RNAs as potential biomarkers for the early diagnosis of acute myocardial infarction" "This study indicates the combination of 11 long non-coding RNA has potential role of early diagnosis of acute myocardial infarction." "1096" "LID_73" "29531832" "A combination of RP11-363E7.4, CTA-29F11.1, RP5-894A10.6" "long non-coding RNA" "Myocardial infarction" "NA" "Prognosis" "YES" "Harbin, China, Asia" "31" "18" "13" "53(38-65)" "blood" "Microarray" "AUC=0.891, Accuracy=0.889" "Zhang, G et al. Cell Death Discov. 2018" "NA" "NA" "Characterization of dysregulated lncRNA-mRNA network based on ceRNA hypothesis to reveal the occurrence and recurrence of myocardial infarction" "The study provided a global view for ceRNA crosstalks between mRNAs and lncRNAs in mycardial infarction occurrence and recurrence and identify oanel biomarkers for mycardial infarction. " "1097" "LID_74" "29531832" "A combination of RP1-239B22.5, AC135048.13, RP11-4O1.2, RP11-285F7.2" "long non-coding RNA" "Myocardial infarction" "NA" "Diagnosis" "YES" "Harbin, China, Asia" "31/49" "18/NA" "13/NA" "53(38-65)/NA" "blood" "Microarray" "Train set: AUC=0.891, Accuracy=0.885; Test set: AUC=0.768, Accuracy=0.813" "Zhang, G et al. Cell Death Discov. 2018" "NA" "train set/test set" "Characterization of dysregulated lncRNA-mRNA network based on ceRNA hypothesis to reveal the occurrence and recurrence of myocardial infarction" "The study provided a global view for ceRNA crosstalks between mRNAs and lncRNAs in mycardial infarction occurrence and recurrence and identify oanel biomarkers for mycardial infarction. " "1098" "LID_75" "26928231" "A combination of ZFAS1 and CDR1AS " "long non-coding RNA" "Acute myocardial infarction " "NA" "Diagnosis" "YES" "Harbin, China, Asia" "103" "75" "28" "60.71(11.05 " "blood" "real-time RT-PCR" "Between AMI and non-AMI；AUC=0.691(95% CI?=?0.622-0.760)； Between AMI and HV：AUC=0.752(95% CI= (0.684-0.820)" "Zhang, Y et al. Sci Rep. 2016" "mean(SD)" "NA" "Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction" "Combination of two long non-coding RNA can increase power of sensitivity and specificity of prediction." "1099" "LID_76" "25035150" "aHIF(hypoxia inducible factor 1A antisense RNA 2)" "long non-coding RNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "140/274" "102/199" "38/75" "62(30-89)/61(35-89)" "blood" "qPCR" "Prognostic AUC=0.52" "Vausort, M et al. Circ Res. 2014" "NA" "NSTEMI/STEMI" "Long noncoding RNAs in patients with acute myocardial infarction" "Level of lncRNA in acute mycardial infarcyion are different regulated and can have prognostic value." "1100" "LID_77" "25035150" "ANRIL(Cyclin-dependent kinase inhibitor 2B antisense RNA 1)" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "140/274" "102/199" "38/75" "62(30-89)/61(35-89)" "blood" "qPCR" "Prognostic AUC=0.67" "Vausort, M et al. Circ Res. 2014" "NA" "NSTEMI/STEMI" "Long noncoding RNAs in patients with acute myocardial infarction" "Level of lncRNA in acute mycardial infarcyion are different regulated and can have prognostic value." "1101" "LID_78" "29372117" "APPAT(atherosclerotic plaque pathogenesis associated transcript)" "long non-coding RNA" "Myocardial infarction" "down" "Diagnosis" "YES" "Changsha, China, Asia" "47" "26" "21" "63(8.25" "tissue, plasma, vascular smooth muscle cell" "RNA sequencing, qPCR, immunofluorescence and fluorescence in situ hybridization (IF-FISH)" "AUC=0.9302; Sensitivity: 0.7872; Specificity:0.9302." "Meng, F et al. PeerJ. 2018" "mean(SD)" "NA" "Expression status and clinical significance of lncRNA APPAT in the progression of atherosclerosis" "The deregulation of APPAT on mycardial infarction patients play function and have indicating ability on the progression of atherosclerosis." "1102" "LID_79" "26928231" "CDR1AS(Cdr1 antisense)" "long non-coding RNA" "Acute myocardial infarction " "up" "Diagnosis" "YES" "Harbin, China, Asia" "103" "75" "28" "60.71(11.05) " "blood" "real-time RT-PCR" "Between AMI and non-AMI；AUC=0.671(95% CI=0.600-0.742)； Between AMI and HV：AUC=0.657(95% CI=0.581-0.734)" "Zhang, Y et al. Sci Rep. 2016" "mean(SD)" "NA" "Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction" "The long non-coding RNA show different expression in acute myocardial infarction patients, it is a novel biomarkers for acute myocardial infarction." "116" "LID_8" "27253412" "RNCR3" "long non-coding RNA" "Atherosclerosis" "up" "Treatment" "NO" "Nanjing, China, Asia" "NA" "NA" "NA" "NA" "endothelial cell, vascular smooth muscle cell, plasma" "qRT-PCR, situ hybridization" "NA" "Shan, K et al. Cell Death Dis. 2016" "NA" "NA" "Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction" "RNCA3 is upregulated in huamn aortic atherosclerosis lesions, knockdown can reduce proliferation and migration." "1103" "LID_80" "28418905" "ENST00000416860.2" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis" "NO" "Urumqi, China, Asia" "55" "29" "26" "52.6(10.9)" "blood" "Microarray, qRT-PCR" "Fold Change: 1.52-fold" "Zhai, K et al. Oncotarget. 2017" "mean(SD)" "NA" "Expression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients" "This study indicated that lncRNAs were significantly expressed in the peripheral blood of acute myocardial infarction, these can have potential role in the development of acute myocardial infarction." "1104" "LID_81" "28418905" "ENST00000421157.1" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis" "NO" "Urumqi, China, Asia" "55" "29" "26" "52.6(10.9)" "blood" "Microarray, qRT-PCR" "Fold Change: 5.29-fold" "Zhai, K et al. Oncotarget. 2017" "mean(SD)" "NA" "Expression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients" "This study indicated that lncRNAs were significantly expressed in the peripheral blood of acute myocardial infarction, these can have potential role in the development of acute myocardial infarction." "1105" "LID_82" "30223352" "H19" "long non-coding RNA" "Acute myocardial infarction" "NA" "Treatment" "NO" "Changsha, China, Asia" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Yu, BY et al. Int J Cardiol. 2018 " "NA" "NA" "LncRNA H19 regulates cardiomyocyte apoptosis and acute myocardial infarction by targeting miR-29b" "lncRNA H19 may protect cardiomyocytes against acute myocardial infarction via anti-apoptosis by targeting miR-29b." "1106" "LID_83" "29258067" "HOTAIR(HOX antisense intergenic RNA)" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Zhengzhou, China, Asia" "50" "31" "19" "61.2(11.3)" "blood" "Quantitative real-time PCR, Luciferase Assay" "NA" "Gao, L et al. Cell Physiol Biochem. 2017 " "mean(SD)" "NA" "Circulating Long Noncoding RNA HOTAIR is an Essential Mediator of Acute Myocardial Infarction" "The results demonstrated that in acute myocardial infarction patients the expression levels of HOTAIR were significantly decreased in the early phase following the occurrence of acute myocardial infarction, it can be biomarker for diagnosis. " "1107" "LID_84" "25035150" "KCNQ1OT1" "long non-coding RNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "140/274" "102/199" "38/75" "62(30-89)/61(35-89)" "blood" "qPCR" "Prognostic AUC=0.68" "Vausort, M et al. Circ Res. 2014" "NA" "NSTEMI/STEMI" "Long noncoding RNAs in patients with acute myocardial infarction" "Level of lncRNA in acute mycardial infarcyion are different regulated and can have prognostic value." "1108" "LID_85" "28780351" "KCNQ1OT1" "long non-coding RNA" "Acute myocardial infarction" "up" "Treatment" "YES" "Xian, China, Asia" "NA" "NA" "NA" "NA" "H9c2 cells" "qRT-PCR" "NA" "Li, X et al. Biochem Biophys Res Commun. 2017" "NA" "NA" "Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia/reperfusion injury following acute myocardial infarction" "Suppression of KCNQ1OT1 reduce inflammation and cell apoptosis by regulating AdipoR1." "1109" "LID_86" "24663402" "LIPCAR(long noncoding RNA uc022bqs.1)" "long non-coding RNA" "Acute myocardial infarction" "down and up" "Diagnosis, Prognosis" "YES" "Hannover, Germany, Europe" "246" "200" "46" "57(14" "plasma" "Microarray" "NA" "Kumarswamy, R et al. Circ Res. 2014" "NA" "NA" "Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure" "LIPCAR is a novel biomrker of future death in patients with heart failure or acute myocardial infarction." "1110" "LID_87" "25035150" "MALAT1(Metastasis-associated lung adenocarcinoma transcript 1)" "long non-coding RNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "140/274" "102/199" "38/75" "62(30-89)/61(35-89)" "blood" "qPCR" "Prognostic AUC=0.64" "Vausort, M et al. Circ Res. 2014" "NA" "NSTEMI/STEMI" "Long noncoding RNAs in patients with acute myocardial infarction" "Level of lncRNA in acute mycardial infarcyion are different regulated and can have prognostic value." "1111" "LID_88" "26759697" "MHRT(Myosin Heavy Chain Associated RNA Transcripts)" "long non-coding RNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Weihai, China, Asia" "47" "NA" "NA" "NA" "plasma" "qRT-PCR" "NA" "Zhang, J et al. Biomol Ther (Seoul). 2016" "NA" "NA" "Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis" "The lncRNA may be a biomarker for diagnosis in acute maocardial infarction patients and knochdown of it lead to significant more apoptotic cells." "1112" "LID_89" "25035150" "MIAT(Myocardial infarction-associated transcript)" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "140/274" "102/199" "38/75" "62(30-89)/61(35-89)" "blood" "qPCR" "Prognostic AUC=0.64" "Vausort, M et al. Circ Res. 2014" "NA" "NSTEMI/STEMI" "Long noncoding RNAs in patients with acute myocardial infarction" "Level of lncRNA in acute mycardial infarcyion are different regulated and can have prognostic value." "243" "LID_9" "26339410" "BC064139" "long non-coding RNA" "Atrial fibrillation" "up" "Treatment" "YES" "Taizhou, China, Asia" "3" "NA" "NA" "NA" "tissue" "Microarray, qRT-PCR" "Fold change=0.00065, P value=0.026" "Ruan, Z et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "Long non-coding RNA expression profile in atrial fibrillation" "LncRNAs expression in atrial tissues of atrial fibrillation patients may further provide potential therapeutic targets for prophylaxis and treatment of atrial fibrillation. " "1113" "LID_90" "28418905" "TCONS_00025701" "long non-coding RNA" "Acute myocardial infarction" "down" "Diagnosis" "NO" "Urumqi, China, Asia" "55" "29" "26" "52.6(10.9)" "blood" "Microarray, qRT-PCR" "Fold Change: 8.16-fold" "Zhai, K et al. Oncotarget. 2017" "mean(SD)" "NA" "Expression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients" "This study indicated that lncRNAs were significantly expressed in the peripheral blood of acute myocardial infarction, these can have potential role in the development of acute myocardial infarction." "1114" "LID_91" "26949706" "UCA1(urothelial carcinoma-associated 1)" "long non-coding RNA" "Acute myocardial infarction" "down and up" "Diagnosis, Prognosis" "YES" "Changchun, China, Asia" "49" "30" "19" "61.02(11.83)" "plasma" "qRT-PCR" "AUC=0.757" "Yan, Y et al. Biomed Res Int. 2016" "mean(SD)" "NA" "Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction" "The level of plasma UCA1 is decreased at the early state of acute myocardial infarction patients and increased at day 3 after acute myocardial infarction, can be used as a novel biomarker for the diagnosis or prognosis of acute myocardial infarction." "1115" "LID_92" "29226319" "XIST(X-inactive specific transcript RNA)" "long non-coding RNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Guizhou, China, Asia" "49" "NA" "NA" "NA" "circulating endothelial cells(blood)" "Microarray, qRT-PCR, Dual luciferase reporter assay, MTT assay, Western blot" "NA" "Zhou, T et al. J Cell Physiol. 2017" "mean(SD)" "NA" "LncRNA XIST regulates myocardial infarction by targeting miR-130a-3p" "High-expressed XIST promoted myocardial cell apoptosis, and also inhibited myocardial cell proliferation, XIST regulate mycardial infarction by downregulating miR-130a-3p." "1116" "LID_93" "26928231" "ZFAS1(Zinc finger antisense 1)" "long non-coding RNA" "Acute myocardial infarction " "down" "Diagnosis" "YES" "Harbin, China, Asia" "103" "75" "28" "60.71(11.05) " "blood" "real-time RT-PCR" "Between AMI and non-AMI；AUC=0.664(95% CI=0.594-0.733)； Between AMI and HV：AUC=0.732(95% CI: 0.662-0.803)" "Zhang, Y et al. Sci Rep. 2016" "mean(SD)" "NA" "Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction" "The long non-coding RNA show different expression in acute myocardial infarction patients, it is a novel biomarkers for acute myocardial infarction." "1133" "LID_94" "26038570" "H19" "long non-coding RNA" "Myocardial injury" "up" "Treatment" "NO" "Qingdao, China, Asia" "NA" "NA" "NA" "NA" "H9c2 cells" "qRT-PCR, Luciferase assay" "NA" "Wang, JX et al. Circ Res. 2015" "NA" "NA" "MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD" "Long noncoding RNA H19 directly binds to miR-103/107 and regulates FADD expression and necrosis." "1134" "LID_95" "28780351" "KCNQ1OT1" "long non-coding RNA" "Myocardial injury" "up" "Treatment" "YES" "Xian, China, Asia" "NA" "NA" "NA" "NA" "H9c2 cells" "qRT-PCR" "NA" "Li, X et al. Biochem Biophys Res Commun. 2017" "NA" "NA" "Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia/reperfusion injury following acute myocardial infarction" "Suppression of KCNQ1OT1 reduce inflammation and cell apoptosis by regulating AdipoR1." "1146" "LID_96" "25761653" "HIF1A-AS1(HIF 1 alpha-antisense RNA 1)" "long non-coding RNA" "Cardiovascular disease" "up" "Treatment" "YES" "Kunming, China Asia" "NA" "NA" "NA" "NA" "human vascular endothelial cells" "PCR array, Quantitative real-time PCR" "NA" "Wang, J et al. Mol Cell Biochem. 2015" "NA" "NA" "Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic aLID via suppression of the long non-coding RNA HIF1A-AS1 in vitro" "Clopidogrel reduces apoptosis and promotes proliferation of PA-treated human umbilical vein endothelial cells via suppression of the long non-coding RNA HIF1A-AS1 in vitro" "1147" "LID_97" "30355909" "SNHG1" "long non-coding RNA" "Cardiomyocyte apoptosis" "down" "Treatment" "NO" "Xian, China, Asia" "NA" "NA" "NA" "NA" "human cardiomyocytes" "qRT-PCR, Luciferase assay" "NA" "Zhang, N et al. Cell Physiol Biochem. 2018" "NA" "NA" "The Long Non-Coding RNA SNHG1 Attenuates Cell Apoptosis by Regulating miR-195 and BCL2-Like Protein 2 in Human Cardiomyocytes" "Overexpression of SNHG1 may play an anti-apoptotic role in human cardiomyocytes apoptosis." "1273" "LID_98" "29284304" "LOC105372881" "long non-coding RNA" "Ischemic stroke" "up" "Diagnosis" "NO" "Shantou, China, Asia" "3" "1" "2" "63" "blood" "RNA sequencing, Microarray" "log2FC:1.53455" "He, W et al. Hum Gene Ther. 2018" "NA" "NA" "Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke" "This study is the first to identify blood lncRNAs in human ischemic stroke using RNA sequencing, and may be the foundation for understanding the potential role of lncRNAs in ischemic stroke." "1274" "LID_99" "29284304" "LOC101929707" "long non-coding RNA" "Ischemic stroke" "down" "Diagnosis" "NO" "Shantou, China, Asia" "3" "1" "2" "63" "blood" "RNA sequencing, Microarray" "log2FC:-2.08237" "He, W et al. Hum Gene Ther. 2018" "NA" "NA" "Altered Long Non-Coding RNA Transcriptomic Profiles in Ischemic Stroke" "This study is the first to identify blood lncRNAs in human ischemic stroke using RNA sequencing, and may be the foundation for understanding the potential role of lncRNAs in ischemic stroke." "0" "MID_1" "25519160" "hsa-miR-100-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Tokushima, Japan, Asia" "32" "21" "11" "69(7)" "tissue, plasma" "qPCR" "Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=-0.41, P<0.05)" "Soeki, T et al. Circ J. 2015" "mean(SD)" "NA" "Plasma microRNA-100 is associated with coronary plaque vulnerability" "Plasma miR-100 was higher in the coronary sinus than in the aorta." "10" "MID_10" "21642241" "hsa-miR-1-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Kyoto, Japan, Asia" "29" "23" "6" "69.7(2.4)" "serum" "qRT-PCR" "AUC=0.777" "Kuwabara, Y et al. Circ Cardiovasc Genet. 2011" "mean(SEM)" "NA" "Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage" "Circulating miR-1 levels in serum can be used as a biomarker for the diagnosis of acute coronary syndrome." "101" "MID_100" "26045772" "hsa-miR-98-5p" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "NO" "Changsha, China, Asia" "NA" "NA" "NA" "NA" "human Aortic Smooth Muscle Cells" "real-time PCR, Luciferase reporter assay" "NA" "Wang, Q et al. Int J Clin Exp Pathol. 2015" "NA" "NA" "A crosstalk triggered by hypoxia and maintained by MCP-1/miR-98/IL-6/p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation" "Hypoxia triggers the regulatory loop of MCP-1/miR-98/IL-6, and the signal loop maintains the molecular crosstalk and leads to hSMCs apoptosis." "1090" "MID_1000" "24900964" "hsa-miR-486-3p/hsa-miR-26a-5p ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.8205" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "1091" "MID_1001" "28011706" "A combination of hsa-miR-26b-5p, hsa-miR-320a, hsa-miR-660-5p" "microRNA" "ST-segment elevation myocardial infarction" "up" "Diagnosis" "NO" "Zurich, Switzerland, Europe" "10/63" "2/12" "8/51" "67.3(13.5)/71.54(13.34)" "plasma" "Real-time qPCR" "AUC=0.718(95 CI%:0.68-0.75)" "Jakob, P et al. Eur Heart J. 2017" "mean(SD)" "derivation cohort/validation cohort" "Profiling and validation of circulating microRNAs for cardiovascular events in patients presenting with ST-segment elevation myocardial infarction" "These MiRNA are associated with adverse cardiovascular events in patients presenting with ST elevation myocardial infarction, and it is involved in pathways regulating cardiomyocyte apoptosis, adverse cardiac remodelling, and active platelet production." "1092" "MID_1002" "27192016" "A combination of miR-106a-5p, miR-424-5p, let-7g-5p, miR-144-3p and miR-660-5p" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "NO" "Trondheim, Norway, Europe" "56/50" "46/28" "10/22" "60.2(8.4)/61.5(7.2)" "serum" "real-time PCR" "AUC=0.72 (95% CI:[0.61-0.82])" "Bye, A et al. J Mol Cell Cardiol. 2016" "mean(SD)" "derivation cohort/validation cohort" "Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study" "The panel of 5 miRs can enhance acute myocardial infarction risk prediction in healthy individuals." "1093" "MID_1003" "29304813" "pre-miR-27a rs895819 AG AA" "microRNA" "Myocardial infarction" "NA" "Diagnosis" "NO" "Dongguan, China, Asia" "287" "222" "65" "61.82(11.98)" "blood" "polymerase chain reaction-ligase detection reaction(PCR-LDR)" "NA" "Cai, MY et al. Lipids Health Dis. 2018" "mean(SD)" "NA" "The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population" "Pre-miR-27a rs895819 polymorphism is associated with myocardial infarction susceptibility." "1119" "MID_1004" "23630629" "hsa-miR-1-3p" "microRNA" "Myocardial injury in open-heart surgeries with cardiopulmonary bypass." "up" "Diagnosis" "YES" "Luzhou, China, Asia" "20" "12" "8" "46.76(15.08)" "blood, urine" "qRT-PCR" "T1, before CPB(cardiopulmonary bypass) (pre-CPB) 0 fold ; T2, 60 min after CPB (post-CPB) highest fold, serun more than urine; and T3, 24 hours after CPB (post-CPB) decreased.." "Zhou, X et al. PLoS One. 2013" "mean(SD)" "NA" "Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass" "Serum miR-1 levels are significantly increased in patients after the open-heart surgeries and CBP,The results suggest that serum and urine miR-1 may be a novel sensitive biomarker for myocardial injury in open-heart surgeries with CPB." "1120" "MID_1005" "26038570" "hsa-miR-103a-3p" "microRNA" "Myocardial necrosis" "up" "Treatment" "NO" "Qingdao, China, Asia" "NA" "NA" "NA" "NA" "fetal cardiomyocyte-derived H9c2 cell line" "qPCR, Luciferase assays" "NA" "Wang, JX et al. Circ Res. 2015" "NA" "NA" "MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD" "H19 inhibited myocardial necrosis by downregulating miR-103." "1121" "MID_1006" "26038570" "hsa-miR-107" "microRNA" "Myocardial necrosis" "up" "Treatment" "NO" "Qingdao, China, Asia" "NA" "NA" "NA" "NA" "fetal cardiomyocyte-derived H9c2 cell line" "qPCR, Luciferase assays" "NA" "Wang, JX et al. Circ Res. 2015" "NA" "NA" "MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD" "H19 inhibited myocardial necrosis by downregulating miR-107." "1122" "MID_1007" "23816326" "hsa-miR-133a" "microRNA" "Early myocardial injury after heart transplantation" "from high to low levels early after operation" "Prognosis" "YES" "Beijing, China, Asia" "7" "7" "0" "46.71(12.31)" "serum" "qRT-PCR" "The Sensitivity and specificity of miRNAs were: miR-133a (85.7%,100%)" "Wang, E et al. J Cardiothorac Surg. 2013" "mean(SD)" "NA" "Circulating miRNAs reflect early myocardial injury and recovery after heart transplantation" "Circulating miRNAs are suggested to be a good predictive parameter for graft dysfunction and recent prognosis of patients after operation." "1123" "MID_1008" "23816326" "hsa-miR-133b" "microRNA" "Early myocardial injury after heart transplantation" "from high to low levels early after operation" "Prognosis" "YES" "Beijing, China, Asia" "7" "7" "0" "46.71(12.31)" "serum" "qRT-PCR" "The Sensitivity and specificity of miRNAs were: miR-133b(90%,100%)" "Wang, E et al. J Cardiothorac Surg. 2013" "mean(SD)" "NA" "Circulating miRNAs reflect early myocardial injury and recovery after heart transplantation" "Circulating miRNAs are suggested to be a good predictive parameter for graft dysfunction and recent prognosis of patients after operation." "1124" "MID_1009" "26175501" "hsa-miR-139-5p" "microRNA" "Myocardial ischemic" "down" "Diagnosis" "NO" "Boston, USA, North America" "9" "6" "3" "74(65-82)" "tissue" "Reverse-transcription PCR and real-time quantitative PCR." "NA" "Saddic, LA et al. Physiol Genomics. 2015" "median age(range)" "NA" "Integrated microRNA and mRNA responses to acute human left ventricular ischemia" "MiR-139-5p was downregulated in patients' left ventricular tissue undergoing cardiac surgery with cardiopulmonary bypass and cardioplegic arrest." "103" "MID_101" "27624142" "hsa-miR-10b-5p" "microRNA" "Aortic stenosis" "down" "Diagnosis, Prognosis" "NO" "Malaga, Spain, Europe" "16/12" "2/6" "14/6" "72(2)/71(2)" "tissue" "TaqMan low density array, real time- reverse transcription PCR" "NA" "Gallego, I et al. Clin Sci (Lond). 2016" "mean(SEM)" "lower levels of cardiomyocyte apoptosis (CMAI<=0.08%)/higher levels of apoptosis (CMAI >0.08%)" "Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients" "Down-regulation of miR-10b and increases Apaf-1 protein expression is associated with the severity of cardiomyocyte apoptosis in aortic stenosis patients and heart failure development." "1125" "MID_1010" "29328381" "hsa-miR-150-5p" "microRNA" "myocardial injury" "down" "Treatment" "YES" "Binzhou, China, Asia" "NA" "NA" "NA" "NA" "cardiomyocytes" "RT-qPCR" "NA" "Ma, JL et al. Mol Med Rep. 2018" "NA" "NA" "Overexpressing microRNA-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting glucose-regulated protein-94" "MiR-150 may serve a protective role in cardiomyocyte hypoxia injury." "1126" "MID_1011" "20550618" "hsa-miR-155-5p" "microRNA" "myocardial injury" "up(treat)" "Treatment" "YES" "Jinan, China, Asia" "NA" "NA" "NA" "NA" "tissue" "Quantitative RT-PCR" "Using quantitative PCR, we observed a 4-fold increase of miR-155 when CMPCs were exposed to hydrogen-peroxide stimulation. " "Liu, J et al. J Cell Mol Med. 2011" "mean(SEM)" "NA" "MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1" "Overexpressing miR-155 in cardiomyocyte progenitor cells can attenuate necrotic cell death, and can be a potential novel therapeutic strategy." "1127" "MID_1012" "23816326" "hsa-miR-208a" "microRNA" "Early myocardial injury after heart transplantation" "from high to low levels early after operation" "Prognosis" "YES" "Beijing, China, Asia" "7" "7" "0" "46.71(12.31)" "serum" "qRT-PCR" "The Sensitivity and specificity of miRNAs were: miR-208b (100%,100%)" "Wang, E et al. J Cardiothorac Surg. 2013" "mean(SD)" "NA" "Circulating miRNAs reflect early myocardial injury and recovery after heart transplantation" "Circulating miRNAs are suggested to be a good predictive parameter for graft dysfunction and recent prognosis of patients after operation." "1128" "MID_1013" "29532851" "hsa-miR-30e-5p" "microRNA" "Myocardial injury" "down" "Treatment" "NO" "Xi'an, China, Asia" "24" "24" "0" "47-63" "blood" "RT-qPCR" "NA" "Zheng, J et al. Int J Mol Med. 2018" "age range" "NA" "MicroRNA-30e protects the heart against ischemia and reperfusion injury through autophagy and the Notch1/Hes1/Akt signaling pathway" "MiRNA-30e serves a significant role in suppressing MI/R-induced apoptosis and oxidative stress via autophagy and the Notch1/Hes1/Akt signaling pathway." "1129" "MID_1014" "26175501" "hsa-miR-339-5p" "microRNA" "Myocardial ischemic" "up" "Diagnosis" "NO" "Boston, USA, North America" "9" "6" "3" "74(65-82)" "tissue" "Reverse-transcription PCR and real-time quantitative PCR." "NA" "Saddic, LA et al. Physiol Genomics. 2015" "median age(range)" "NA" "Integrated microRNA and mRNA responses to acute human left ventricular ischemia" "MiR-339-5p was upregulated in patients' left ventricular tissue undergoing cardiac surgery with cardiopulmonary bypass and cardioplegic arrest." "1130" "MID_1015" "27082497" "hsa-miR-429" "microRNA" "Myocardial ischemic" "up" "Treatment" "YES" "Xi'an, China, Asia" "NA" "NA" "NA" "NA" "cardiomyocytes" "TUNEL assay, Dual-luciferase reporter assay, Reverse transcription-quantitative PCR (RT-qPCR)" "NA" "Xu, H et al. Int J Mol Med. 2016" "NA" "NA" "Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression" "Downregulation of miR-429 by increasing Notch1 expression contributes to the survival of human cardiomyocytes, and inhibits apoptosis under hypoxic conditions." "1131" "MID_1016" "26175501" "hsa-miR-483-3p" "microRNA" "Myocardial ischemic" "up" "Diagnosis" "NO" "Boston, USA, North America" "9" "6" "3" "74(65-82)" "tissue" "Reverse-transcription PCR and real-time quantitative PCR." "NA" "Saddic, LA et al. Physiol Genomics. 2015" "median age(range)" "NA" "Integrated microRNA and mRNA responses to acute human left ventricular ischemia" "MiR-483-3p was upregulated in patients' left ventricular tissue undergoing cardiac surgery with cardiopulmonary bypass and cardioplegic arrest." "1132" "MID_1017" "27119510" "hsa-miR-93-5p" "microRNA" "I/R-induced cardiomyocyte injury" "down" "Treatment" "NO" "Shanghai, China, Asia" "NA" "NA" "NA" "NA" "H9c2 cells" "Real-time quantitative PCR" "NA" "Ke, ZP et al. Oncotarget. 2016" "NA" "NA" "MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN" "MiR-93 can decrease cardiomyocyte apoptosis induced by I/R via inhibiting PTEN and increasing nuclear AKT, it may be a potential drug target for treating cardiomyocyte I/R injury." "1135" "MID_1018" "23247724" "hsa-miR-1246" "microRNA" "Diastolic dysfunction" "up" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 32392- to 48179-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-1246 is highly upregulated in diastolic dysfunction patients." "1136" "MID_1019" "20185794" "hsa-miR-1254" "microRNA" "Non-HF forms of dyspnea" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "HF patients/non-HF forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is slightly elevated in non-heart failure forms of dyspnea compared with heart failure and healthy patients, so these miRNAs can distinguish non-heart failure forms of dyspnea from heart failure." "104" "MID_102" "26203686" "hsa-miR-125b-5p" "microRNA" "Calcific aortic valve disease" "up" "Diagnosis, Treatment" "YES" "Oulu, Finland, Asia" "3/28" "NA" "NA" "NA" "aortic valves" "miRNA array, quantitative RT-PCR" "NA" "Ohukainen, P et al. Ann Med. 2015" "mean(SEM)" "Discovery /Validation cohort" "MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease" "MiR-125b may offer novel therapeutic and diagnostic strategies in calcific aortic valve disease by targeting CCL4." "1137" "MID_1020" "20185794" "hsa-miR-129-5p" "microRNA" "Non-HF forms of dyspnea" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "HF patients/non-HF forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is slightly elevated in non-heart failure forms of dyspnea compared with heart failure and healthy patients, so these miRNAs can distinguish non-heart failure forms of dyspnea from heart failure." "1138" "MID_1021" "27505319" "hsa-miR-148b-3p" "microRNA" "Mitral regurgitation" "down" "Prognosis" "YES" "Taiwan, China, Asia" "32" "17" "15" "56(12)" "tissue" "real-time RT-PCR" "AUC=0.904(95% confidence interval, 0.758-1.00, p=0.002)" "Chen, MC et al. Int J Cardiol. 2016" "mean(SD)" "NA" "Circulating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitation" "Circulating miR-148b-3p might serve as biomarker for future development of heart failure in asymptomatic mitral regurgitation patients." "1139" "MID_1022" "20185794" "hsa-miR-18b-3p" "microRNA" "Non-HF forms of dyspnea" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "HF patients/non-HF forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is slightly elevated in non-heart failure forms of dyspnea compared with heart failure and healthy patients, so these miRNAs can distinguish non-heart failure forms of dyspnea from heart failure." "1140" "MID_1023" "24972764" "hsa-miR-196a2 SNP rs11614913" "microRNA" "Risk of cardiovascular disease in type 2 diabetes" "NA" "Diagnosis" "NO" "Lublin, Poland, Europe" "534" "262" "272" "65(16)" "blood" "PCR PCR-RFLP and restriction analysis" "The odds ratio for the T allele in the CVD+?subgroup of patients was 1.76 (1.35–2.30), p<0.0001 vs. CVD? subgroup, the highest risk of development of CVD was observed in the additive model for TT homozygotes (OR 3.33, 95% CI 2.05–5.42, p<0.0001)." "Buraczynska, M et al. J Diabetes Complications. 2014" "mean(SD)" "NA" "Polymorphism in microRNA-196a2 contributes to the risk of cardiovascular disease in type 2 diabetes patients" "In conclusion, the results of this study suggest that miRNA-196a2 T/C polymorphism (rs11614913) is associated with an increased risk of cardiovascular disease in type 2 diabetes patients. " "1141" "MID_1024" "20080987" "hsa-miR-223-3p" "microRNA" "Type 2 diabetes with left ventricular dysfunction" "up" "Diagnosis" "NO" "London, UK, Europe" "NA" "NA" "NA" "NA" "tissue" "qRT-PCR" "NA" "Lu, H et al. Cardiovasc Res. 2010" "mean(SEM)" "NA" "MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism" "MiR-223 are upregualted in patients with type 2 diabetes with left wentricular dysfunction, and miRNA-target genes can be upregulated in terminally differentiated cardiomyocytes." "1142" "MID_1025" "23247724" "hsa-miR-454-3p" "microRNA" "Diastolic dysfunction" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 41,400- to 60,370-fold (p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-454 is highly downregulated in diastolic dysfunction patients." "1143" "MID_1026" "23247724" "hsa-miR-500a-3p ; hsa-miR-500a-5p" "microRNA" "Diastolic dysfunction" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 10,271 to 14,836(p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-500 is highly downregulated in diastolic dysfunction patients." "1144" "MID_1027" "20185794" "hsa-miR-622" "microRNA" "Non-HF forms of dyspnea" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "HF patients/non-HF forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is slightly elevated in non-heart failure forms of dyspnea compared with heart failure and healthy patients, so these miRNAs can distinguish non-heart failure forms of dyspnea from heart failure." "1145" "MID_1028" "20185794" "HS_202.1" "microRNA" "Non-HF forms of dyspnea" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "HF patients/non-HF forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is slightly elevated in non-heart failure forms of dyspnea compared with heart failure and healthy patients, so these miRNAs can distinguish non-heart failure forms of dyspnea from heart failure." "1152" "MID_1029" "24129592" "hsa-let-7e" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.71; P=0.02; 95%CI: 0.55-0.88;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 2" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "105" "MID_103" "26304936" "hsa-miR-22-3p" "microRNA" "Aortic Stenosis" "up" "Diagnosis" "NO" "Dunedin, New Zealand, Oceania" "94" "47" "47" "78.8(7.5)" "blood" "Microarray, qPCR" "NA" "Coffey, S et al. J Am Heart Assoc. 2015" "mean(SD)" "NA" "Circulating microRNA Profiling Needs Further Refinement Before Clinical Use in Patients With Aortic Stenosis" "MiR-21-5p was increased in aortic stenosis patients without coronary artery disease." "1153" "MID_1030" "24129592" "hsa-miR-126-3p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.88; P<0.001; 95%CI: 0.77-0.98;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 9" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1154" "MID_1031" "24129592" "hsa-miR-1274A" "microRNA" "Peripheral arterial disease" "up" "Diagnosis, Treatment" "NO" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "Flod change=3.45; P=0.08" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 14" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA was dyregulated in peripheral arterial disease patients." "1155" "MID_1032" "24129592" "hsa-miR-15b-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.92; P<0.001; 95%CI: 0.82-1.00;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 2" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1156" "MID_1033" "24129592" "hsa-miR-16-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.93; P<0.001; 95%CI: 0.86-1.00;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 3" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1157" "MID_1034" "24129592" "hsa-miR-195-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.89; P<0.001; 95%CI: 0.79-1.00;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 10" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1158" "MID_1035" "24129592" "hsa-miR-20b-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.69; P=0.04; 95%CI: 0.52-0.86;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 4" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1159" "MID_1036" "24129592" "hsa-miR-25-3p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.75; P=0.01; 95%CI: 0.59-0.91;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 5" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1160" "MID_1037" "24129592" "hsa-miR-26b-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.77; P<0.001; 95%CI: 0.62-0.93;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 6" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1161" "MID_1038" "24129592" "hsa-miR-27b-3p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.87; P<0.001; 95%CI: 0.75-0.99;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 7" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1162" "MID_1039" "24129592" "hsa-miR-28-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.86; P<0.001; 95%CI: 0.75-0.97;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 8" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "106" "MID_104" "25625292" "hsa-miR-133" "microRNA" "Arrhythmia" "down" "Diagnosis" "YES" "Guangzhou, China, Asia" "24" "15" "9" "6.6(3.9)" "blood" "Reverse transcription (RT) and fluorescent quantitative PCR (qPCR)" "AUC=0.533, P=0.73, 95%CI: 0.534-0.711" "Sun, L et al. Mol Med Rep. 2015" "mean(SD)" "NA" "Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia" "MiR-133 levels were significantly increased in the ventricular tachycardia group." "1163" "MID_1040" "24129592" "hsa-miR-335-5p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.76; P<0.001; 95%CI: 0.61-0.91;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 11" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1164" "MID_1041" "24129592" "hsa-miR-363-3p" "microRNA" "Peripheral arterial disease" "down" "Diagnosis, Treatment" "YES" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "AUC=0.93; P<0.001; 95%CI: 0.85-1.00;" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 12" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA have the potential for diagnosis and therapeutic targets in peripheral arterial diseases." "1165" "MID_1042" "27132035" "hsa-miR-425-5p" "microRNA" "Peripheral arterial disease" "down" "Treatment" "NO" "Guangzhou, China, Asia" "NA" "NA" "NA" "NA" "human umbilical vein endothelial cells" "qRT-PCR, Luciferase reporter assay" "NA" "Gao, Y et al. Toxicol Lett. 2016" "NA" "NA" "Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3" "Overexpression of miR-425-5p by NaAsO2 treatment reversed the NaAsO2-induced antangiogenesis." "1166" "MID_1043" "24129592" "hsa-miR-720" "microRNA" "Peripheral arterial disease" "up" "Diagnosis, Treatment" "NO" "Leicester, United Kingdom, Europe" "5/10/10" "NA/NA/NA" "NA/NA/NA" "NA/NA/NA" "blood" "qRT-PCR" "Flod change=6.05; P=0.04" "Stather, PW et al. Circ Cardiovasc Genet. 2013" "NA" "Initial sample set/Validation sample set 1/Validation sample set 13" "Differential microRNA expression profiles in peripheral arterial disease" "The miRNA was dyregulated in peripheral arterial disease patients." "1167" "MID_1044" "26022377" "hsa-miR-101-3p" "microRNA" "Rheumatic heart disease" "down" "Diagnosis, Treatment" "YES" "Qingdao, China, Asia" "11" "4" "7" "40.82(9.94)" "tissue, serum" "RT-qPCR, Dual luciferase assay, Western blotting" "NA" "Dong, H et al. Med Sci Monit. 2015" "mean(SD)" "NA" "Down-Regulation of miR-101 Contributes to Rheumatic Heart Disease Through Up-Regulating TLR2" "This work also found an association between down-regulated miR-101 and rheumatic heart disease, which sheds light on the mechanism of RHD pathogenesis and may create an opportunity to approach the diagnosis and treatment of RHD." "1168" "MID_1045" "26539505" "hsa-miR-1183" "microRNA" "Rheumatic heart disease" "up" "Diagnosis" "YES" "Ningbo, China, Asia" "10/10" "3/4" "7/6" "54.2(5.73)/59.2(6.27)" "blood" "qRT-PCR, Microarray Analysis" "Chip results suggested that miR-1299 and miR-1183 expressed in RHD were significantly upregulated (>10-fold)" "Li, N et al. Biomed Res Int. 2015" "mean(SD)" "high pulmonary artery pressure group in RHD patients/low pulmonary artery pressure group in RHD patients" "Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease: miR-1183 and miR-1299 as Potential Diagnostic Biomarkers" "MiR-1183 and miR-1299 appear to play distinct roles in rheumatic heart disease pathogenesis accompanied by secondary pulmonary hypertension(PAH) and could be used as potential biological markers for disease development." "1169" "MID_1046" "26539505" "hsa-miR-1299" "microRNA" "Rheumatic heart disease" "up" "Diagnosis" "YES" "Ningbo, China, Asia" "10/10" "3/4" "7/6" "54.2(5.73)/59.2(6.27)" "blood" "qRT-PCR, MicroRNA Microarray Analysis" "Chip results suggested that miR-1299 and miR-1183 expressed in RHD were significantly upregulated (>10-fold)" "Li, N et al. Biomed Res Int. 2015" "mean(SD)" "high pulmonary artery pressure group in RHD patients/low pulmonary artery pressure group in RHD patients" "Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease: miR-1183 and miR-1299 as Potential Diagnostic Biomarkers" "MiR-1183 and miR-1299 appear to play distinct roles in rheumatic heart disease pathogenesis accompanied by secondary pulmonary hypertension(PAH) and could be used as potential biological markers for disease development." "1170" "MID_1047" "24237608" "hsa-let-7b-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "38/42/40/38/39" "19/20/21/20/20" "19/22/19/18/19" "62.45(6)/64(6)/64(2.2)/64.97(6)/64.77(6.7)" "plasma" "qRT-PCR" "AUC of 0.93 (95% CI=0.879-0.980), 0.92(95%CI =0.866-0.98), 0.92(95%CI =0.858-0.98) and 0.91(95%CI= 0.849-0.97),sensitivity of 92%, 90%, 92% and 89%, and a specificity of 84%, 84%, 86% and 80% at 24h, 1w, 4w and 24w." "Long, G et al. BMC Neurol. 2013" "mean(SD)" "24h/1 week/4 week/24 week/48 week" "Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans" "The study suggest that let-7b might be useful biomarkers for ischemic stroke in humans." "1171" "MID_1048" "25127724" "hsa-let-7c" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "cerebrospinal fluid" "Real-Time qPCR" "Fold Change=1.45, P=0.01" "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs that have previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "1172" "MID_1049" "26415639" "hsa-let-7e-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Hangzhou, China, Asia" "72/68/63" "41/38/34" "31/30/29" "72.4(9.2)/73.7(10.2)/69.5(6.6)" "serum, cerebral spinal fluid" "RT-PCR" "AUC=0.86 (95%CI=0.754-0.968), the specificity value was 73.4% and sensitivity level was 82.8%." "Peng, G et al. Transl Stroke Res. 2015" "mean(SD)" "acute stage/subacute stage/recover stage" "MicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke" "The study report that a specific miRNA of let-7e, with high diagnostic accuracy in acute ischemic stroke." "107" "MID_105" "23497314" "hsa-miR-133a-2 variant 79T>C" "microRNA" "Arrhythmia" "NA" "NA" "NO" "Darlinghurst, Austraila, Oceania" "120" "NA" "NA" "NA" "blood" "PCR" "NA" "Ohanian, M et al. BMC Genet. 2013 " "NA" "NA" "A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance" "MIR133A2 variant that alters strand abundance during miRNA processing and results in accumulation of miR-133a-5p." "1173" "MID_1050" "27776139" "hsa-let-7e-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Shenzhen" "44/302" "26/182" "18/120" "57.32(11.35)/57.50(10.40)" "blood" "qRT-PCR" "Higher levels of let-7e-5p were associated with increased occurrence of ischemic stroke (adjusted OR, 1.89; 95% CI, 1.61-2.21, p<0.001). The addition of let-7e-5p to traditional risk factors led to an improvement in the area under the curve, which increas" "Huang, S et al. PLoS One. 2016" "mean(SD)" "NA" "Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke" "In summary, our study suggests the potential diagnistic value of blood let-7e-5p as a biomarker for ischemic stroke." "1174" "MID_1051" "27784773" "hsa-let-7i-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "106" "55" "51" "61.9(12.5)" "blood" "quantitative reverse transcription PCR, microarray" "Fold change=?1.70, p=0.00001, a modest inverse correlation between let-7i and NIH Stroke Scale score at admission (r=-0.32, p=0.02), infarct volume (r=-0.21, p=0.04), and plasma MMP9 (r=-0.46, p=0.01)." "Jickling，GC et al. Neurology. 2016" "NA" "NA" "Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke" "Let-7i regulates the immune response in relation to severity of stroke." "1175" "MID_1052" "24911610" "hsa-let-7i-5p" "microRNA" "Ischemic Stroke " "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "let-7i (FC=-2.07, FDR p-value 0.023)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1176" "MID_1053" "25410304" "hsa-miR-106-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "31" "22" "68(1.5)" "serum" "qRT-PCR, MicroRNA Microarray Analysis" "NA" "Li, P et al. Cell Mol Neurobiol. 2015" "mean(SEM)" "NA" "Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke" "Serum miR-106-5p may serve as potential diagnostic biomarkers for ischemic stroke. " "1177" "MID_1054" "25287657" "hsa-miR-106b-5p" "microRNA" "Acute stroke" "up" "Diagnosis" "YES" "Suzhou, China, Asia" "60/76" "35/40" "25/36" "50(13)" "plasma" "Real-time reverse transcription polymerase chain reaction (RT-PCR) assays" "ROC curves: hsa-miR-106b-5P MRI(-),0.999 (95% confidence interval [CI], .997-1.000; P=0.000); hsa-miR-106b-5P MRI(+), 0.962 (95% CI, 0.930-0.993; P=0.000). " "Wang, W et al. J Stroke Cerebrovasc Dis. 2014" "mean(SD)" "MRI(+)/MRI(?) If the patient suffered from acute stroke that was detected with diffusion-weighted imaging, the patient was defined as an MRI(+) patient. Otherwise, it was defined as an MRI(?) patient." "Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans" "Regarding a lack of biomarkers in acute stroke thus far, the availability of miRNAs such as hsa-miR-106b-5P, hsa-miR-4306, hsa-miR-320e, and hsa-miR-320d might facilitate the diagnosis and clinical management of acute stroke." "1178" "MID_1055" "29353353" "hsa-miR-106b-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "NO" "Tabriz, Iran, Asia" "30" "11" "19" "67.3(8.9)" "peripheral blood mononuclear cells" "Real-time PCR" "NA" "Dolati, S et al. Neurol Sci. 2018" "mean(SD)" "NA" "Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke" "MiR-106b was upregulated in ischemic stroke patients." "1179" "MID_1056" "27181533" "hsa-miR-107" "microRNA" "Ischemia stroke" "down" "Diagnosis" "YES" "Changsha, China, Asia" "114" "78" "36" "61(11.3)" "plasma" "qRT-PCR, Biochemical and clinical assays" "With an area under curve (AUC) of 0.971; cut-off point: 2.03; sensitivity: 0.938; specificity: 0.922; 95%CI: 0.929-0.991;" "Yang, Z B et al. Intern Med. 2016" "mean(SD)" "NA" "The Diagnostic Value of Circulating Brain-specific MicroRNAs for Ischemic Stroke" "The study suggest that circulating miR-107 might be used as potential novel non-invasive biomarkers for the diagnosis of ischemia stroke." "1180" "MID_1057" "27151415" "hsa-miR-122-5p" "microRNA" "Ischemia stroke" "down" "Treatment" "YES" "Shantou, China, Asia" "5" "2" "3" "50-83" "peripheral blood" "Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment, qRT-PCR" "NA" "He, W et al. J Stroke Cerebrovasc Dis. 2016" "NA" "microarray expression profile data were downloaded from the Gene Expression Omnibus database" "Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke." "MiR-145 and miR-122 represent new biomarkers and underlying targets for the prevention and treatment of ischemic stroke." "1181" "MID_1058" "24911610" "hsa-miR-122-5p" "microRNA" "Ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-122 (FC=-2.29, FDR p-value 0.047)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1182" "MID_1059" "25257664" "hsa-miR-124-3p" "microRNA" "Acute ischemic stroke" "down" "Treatment" "YES" "Wuhan, China, Asia" "31" "21" "10" "66.32(12.56)" "serum, plasma" "real-time polymerase chain reaction and serum levels of metalloproteinase-9, high-sensitivity C-reactive protein (hs-CRP) levels" "Area under the ROC curve for prediction of infarction by serum miR-124 was 0.76 (95% confidence interval 0.6109-0.9164, p=0.011). " "Liu, Y et al. J Clin Neurosci. 2015" "mean(SD)" "NA" "Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke" "In conclusion, serum miR-124, miR-9 and miR-219 were suppressed in acute ischemic stroke thus facilitating neuroinflammation and brain injury, syST-elevation myocardial infarctionc administration of these miRNAa in the acute period of stroke might be a pr" "108" "MID_106" "25625292" "hsa-miR-1-3p" "microRNA" "Arrhythmia" "down" "Diagnosis" "YES" "Guangzhou, China, Asia" "24" "15" "9" "6.6(3.9)" "blood" "Reverse transcription (RT) and fluorescent quantitative PCR (qPCR)" "AUC=0.773, P=0.004, 95%CI: 0.630-0.917" "Sun, L et al. Mol Med Rep. 2015" "mean(SD)" "NA" "Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia" "MiR-1 levels were decreased in the arrhythmia group compared with those in the healthy controls." "1183" "MID_1060" "26968104" "hsa-miR-124-3p" "microRNA" "Acute stroke" "up(dead)" "Prognosis" "YES" "Hongkong, China, Asia" "84" "43" "41" "72" "plasma" "RT reaction, RT-qPCR" "Within 24h of symptom onset: AUC=0.75(0.65-0.84), sensitivity and specificity 75% and 73,2%.Within 6h from time of symptom onset: AUC=0.87 (95%CI: 0.72-0.96)." "Rainer, TH. et al. Clin Biochem. 2016" "NA" "NA" "Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke" "Plasma miR-24-3p are markers which could be useful for the early prediction of mortality and post-stroke modified Rankin Score." "1184" "MID_1061" "24650689" "hsa-miR-124-3p" "microRNA" "Hemorrhagic stroke" "up" "Diagnosis" "YES" "Hongkong, China, Asia" "93" "47" "46" "72" "plasma" "real-time PCR" "Median plasma 124-3p concentrations taken within 24h of symptom onset were higher in HS patients than that in IS patients (3.8×10(5) vs 2.0×10(5) copies/ml plasma, p=0.0109).The odds ratio (OR) for discriminating HS and IS with miR-124-3p was 5.37 respec" "Leung, L Y et al. Clin Chim Acta. 2014" "mean(SEM)" "NA" "Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke" "Both miR-124-3p and miR-16 are diagnostic markers to discriminate hemorrhage stroke and ischemic stroke, miR-124-3p is a better marker in the diagnosis of hemorrhagic stroke, especially in early symptoms onset(≤6h)." "1185" "MID_1062" "26968104" "hsa-miR-124-3p" "microRNA" "Acute stroke" "up(died compared to survived)" "Prognosis" "YES" "Hongkong, China, Asia" "84" "43" "41" "43-92" "plasma" "reserve transcription quantitative real-time polymerase chain reaction(RT-qPCR)" "3-month mortality in patients presenting within 6 h: AUC=0.87 (95%CI: 0.72-0.96), Sensitivity:88.9%, Specificity:77.8%" "Rainer, TH et al. Clin Biochem. 2016" "NA" "NA" "Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke" "Plasma miR-124-3p is molecular markers which could be useful for the early prediction of 3-month mortality." "1186" "MID_1063" "25410304" "hsa-miR-1246" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "31" "22" "68(1.5)" "serum" "qRT-PCR, MicroRNA Microarray Analysis" "NA" "Li, P et al. Cell Mol Neurobiol. 2015" "mean(SEM)" "NA" "Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke" "MiR-1246 may serve as potential diagnostic biomarkers for ischemic stroke." "1187" "MID_1064" "24237608" "hsa-miR-126-3p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "38/42/40/38/39" "19/20/21/20/20" "19/22/19/18/19" "62.45(6)/64(6)/64(2.2)/64.97(6)/64.77(6.7)" "plasma" "qRT-PCR" "AUC were 0.92(95% CI=0.871-0.978), 0.94(95% CI=0.895-0.985), 0.93(95% CI=0.878-0.982) and 0.92(95% CI=0.864- 0.977).the sensitivity of miR-126-score for the diagnosis of stroke was 92%, 90%, 92% and 92%, the specificity was 84%, 86%, 84% and 82% at 24 h, " "Long, G et al. BMC Neurol. 2013" "mean(SD)" "24h/1 week/4 week/24 week/48 week" "Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans" "These study suggest that miR-126 might be useful biomarkers for ischemic stroke in humans." "1188" "MID_1065" "28875333" "hsa-miR-126-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.654(95% CI:0.580-0.728)" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1189" "MID_1066" "30030634" "hsa-miR-126-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Cangzhou, China, Asia" "148" "92" "56" "61.5(9.2)" "plasma" "RT-qPCR" "AUC=0.665 (95%CI 0.602-0.728)" "Jin, F et al. Neurol Sci. 2018" "mean(SD)" "NA" "Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients" "MiR-126 levels correlate with lower disease risk, decreased disease severity in acute ischemic stroke patients." "1190" "MID_1067" "27181533" "hsa-miR-128b" "microRNA" "Ischemia stroke" "down" "Diagnosis" "YES" "Changsha, China, Asia" "114" "78" "36" "61(11.3) " "plasma" "qRT-PCR, Biochemical and clinical assays" "With an area under curve (AUC) of 0.881; cut-off point: 1.57; sensitivity: 0.728; specificity: 0.92; 95%CI: 0.853-0.953;" "Li, C et al.Eur J Med Res. 2015" "mean(SD)" "NA" "The Diagnostic Value of Circulating Brain-specific MicroRNAs for Ischemic Stroke" "The study suggest that circulating miR-128b might be used as potential novel non-invasive biomarkers for the diagnosis of ischemia stroke." "1191" "MID_1068" "28875333" "hsa-miR-130a-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.642(95% CI:0.568-0.175)" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1192" "MID_1069" "30030634" "hsa-miR-130a-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Cangzhou, China, Asia" "148" "92" "56" "61.5(9.2)" "plasma" "RT-qPCR" "AUC=0.619 (95%CI 0.556-0.683)" "Jin, F et al. Neurol Sci. 2018" "mean(SD)" "NA" "Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients" "MiR-130a levels correlate with lower disease risk, decreased disease severity in acute ischemic stroke patients." "109" "MID_107" "17401374" "hsa-miR-1-3p" "microRNA" "Arrhythmia" "up" "Treatment" "YES" "Harbin, China, Asia" "6/7" "NA/NA" "NA/NA" "NA/NA" "tissue" "qRT-PCR" "NA" "Yang, B et al. Nat Med. 2007" "NA" "rejected hearts of healthy persons during heart transplantation/seven explanted hearts of CAD individuals" "The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2" "Knockdown of endogenous miR-1 can inhibit ischemic arrhythmias, which might represent a new approach for antiarrhythmic therapy." "1193" "MID_1070" "26806865" "hsa-miR-132-3p" "microRNA" "Stroke" "up" "Diagnosis" "YES" "Fuzhou, China, Asia" "39" "20" "19" "66.2(8.8)" "serum" "qRT-PCR" "AUC=0.961(p<0.0001), cut off was -0.696898108 with 94.9% sensitivity, 86.7% specificity and 89.5% accuracy." "Huang, S et al. Neurosci Lett. 2016" "mean(SD)" "NA" "Serum miR-132 is a risk marker of post-stroke cognitive impairment" "In conclusion, detection of serum miR-132 might serve as a diagnostic risk marker for post-stroke cognitive impairment." "1194" "MID_1071" "25127724" "hsa-miR-140-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "plasma" "Real-Time qPCR" "Fold Change=1.38, P=0.02" "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs tha thave previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "1195" "MID_1072" "26175178" "hsa-miR-144-3p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "NO" "Changsha, China, Asia" "56" "NA" "NA" "53.3(9.94)" "platelet, plasam" "qPCR, RT-PCR, RT-qPCR, Weatern Blot" "Correlation analysis: Platelet miR-144 and Platelet activation rate r=0.846, P<0.001;" "Yang, S et al. Cardiovasc Toxicol. 2016" "mean(SEM)" "NA" "Biomarkers Associated with Ischemic Stroke in Diabetes Mellitus Patients" "The miR-144 levels in plasma and platelets, but not in leukocytes, were significantly higher in type 2 diabetes mellitus patients with ischemic stroke (P<0.001), is a risk factor for ischemic stroke in type 2 diabetes mellitus patients." "1196" "MID_1073" "27151415" "hsa-miR-145-5p" "microRNA" "Ischemia stroke" "up" "Treatment" "YES" "Shantou, China, Asia" "5" "2" "3" "50-83" "blood" "Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment、qRT-PCR" "NA" "He, W et al. J Stroke Cerebrovasc Dis. 2016" "NA" "microarray expression profile data were downloaded from the Gene Expression Omnibus database" "Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke." "MiR-145 and miR-122 represent new biomarkers and underlying targets for the prevention and treatment of ischemic stroke." "1197" "MID_1074" "26096228" "hsa-miR-145-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Liaocheng, China, Asia" "146" "112" "34" "67.29(14.16)" "blood" "quantitative real time-PCR" "The combination of hs-CRP and miR-145 won the highest sensitivity/specificity (AUC=0.896, 95% confidence interval 0.804-0.951, p<0.001), which was 12.5% higher than that of plasma hs-CRP alone." "Jia, L H et al. Cell Biochem Funct. 2015" "mean(SD)" "NA" "Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients" "Conclusively, our preliminary findings indicate that serum miR-145 upregulated in acute ischemic stroke might be a new biomarker for acute ischemia stroke evaluation." "1198" "MID_1075" "27708363" "hsa-miR-145-5p rs4705342 T>C " "microRNA" "Ischemic stroke" "NA" "Treatment" "NO" "Baise, China, Asia" "445" "308" "137" "60.1(11.0)" "blood" "quantitative real-time PCR" "NA" "Wei, YS et al. Sci Rep. 2016" "mean(SD)" "NA" "An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke" "Rs4705342 T>C was associated with a reduced risk of ischemic stroke." "1199" "MID_1076" "24908639" "hsa-miR-146a-5p" "microRNA" "Diabetes mellitus with ischemic stroke" "down" "Diagnosis" "YES" "Changsha, China, Asia" "2007/6/6" "NA" "NA" "47.14(9.155)/49.33(5.645)/51.33(9.933)" "platelet, plasam" "Reverse transcription and real-time quantitative PCR" "MiR-146a in patients with diabetes mellitus and ischemic stroke (p=0.007)" "Duan, X et al. J Diabetes Complications. 2014" "mean(SEM)" "DM (n=7) IS (n=6) ISwDM (n=6)" "Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke" "Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients, can be used as a biomarker for diabetes mellitus with or without ischemic stroke in Chinese patients." "1200" "MID_1077" "26044809" "hsa-miR-146a-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis, Treatment" "YES" "Nanning, China, Asia" "30/30" "16/15" "14/15" "62.57(11.53)/60.13(9.82)" "blood" "miRNA microarray, qRT-PCR" "When we compared ISS to healthy subjects, miR-146a had the highest area under the curve (AUC; 81.1%), moreover, when we compared ISA to ISS, the miR-146a was a better discriminator to distinguish ISS (AUC=97.0%)" "Li, SH et al. Curr Neurovasc Res. 2015" "mean(SD)" "acute ishemic stroke/subacute ishemic stroke" "Differential Regulation of microRNAs in Patients with Ischemic Stroke" "MiR-146a was a better discriminator of ischemic stroke in the subacute phase(ISS) from ischemic stroke in the acute phase(ISA) and healthy subjects." "1201" "MID_1078" "28202285" "hsa-miR-146a-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "NO" "Nanning, China, Asia" "30" "16" "14" "62.57(11.53)" "blood" "Microarray, Reverse transcription and quantitative real-time PCR" "AUC=0.91" "Li, SH et al. Neurochem Int. 2017" "mean(SD)" "NA" "Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis" "MiR-146a expression was significantly downregulated in acute ischemic stroke, and Fbxl10 was identified as a target of miR-146a." "1202" "MID_1079" "23202363" "hsa-miR-146a-5p G allele, hsa-149-5p T allele, hsa-miR-196a2 C allele, hsa-miR-499a-5p G allele" "microRNA" "Stroke" "NA" "Diagnosis" "NO" "Seoul, Korea, Asia" "678" "336" "342" "64.16(11.90)" "plasma" "PCR-restriction fragment length polymorphism (RFLP), real-time PCR " "OR, 2.480, 95% CI, 1.207-5.096" "Jeon, YJ et al. Arterioscler Thromb Vasc Biol. 2013" "mean(SD)" "NA" "Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk" "In conclusion, the G allele of the miR-146a polymorphism was associated with an increased risk of ischemic stroke in the Korean population." "110" "MID_108" "28796037" "hsa-miR-3144-5p" "microRNA" "Arrhythmia" "up" "Diagnosis" "NO" "Wuhan, China, Asia" "NA" "NA" "NA" "human cardiac myocytes" "Real-time PCR assay, Dual-luciferase reporter plasmid assay" "NA" "Ruan, L et al. Medicine (Baltimore). 2017" "NA" "NA" "Functional prediction of miR-3144-5p in human cardiac myocytes based on transcriptome sequencing and bioinformatics" "MiR-3144-5p overexpression plays a role in human cardiac myocytes by regulating the expression of these genes and transcription factor." "1203" "MID_1080" "23202363" "hsa-miR-146a-5p polymorphism G allele" "microRNA" "Stroke" "NA" "Diagnosis" "NO" "Seoul, Korea, Asia" "678" "336" "342" "64.16(11.90)" "plasma" "PCR-restriction fragment length polymorphism (RFLP), real-time PCR " "Genetype analyse: CC versus GG: AOR, 1.583, 95% CI, 1.104 – 2.270; CC+CG versus GG:AOR, 1.444, 95% CI, 1.047 – 1.991; C allele versus G allele:AOR, 1.244, 95% CI, 1.051 – 1.472; Subtype analyse: CC versus GG: AOR(adjusted odds ratio), 1.588, 95% CI, 1.002" "Jeon, YJ et al. Arterioscler Thromb Vasc Biol. 2013" "mean(SD)" "NA" "Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk" "In conclusion, the G allele of the miR-146a polymorphism was associated with an increased risk of ischemic stroke in the Korean population." "1204" "MID_1081" "28397233" "hsa-miR-146a-5p rs2910164 " "microRNA" "Ischemic stroke" "NA" "Diagnosis" "NO" "Dongyang, China, Asia" "510" "321" "189" "61.0(10.2)" "blood" "PCR" "Codominant (CG vs. CC: P=0.002, OR=1.878, 95%CI=1.269-2.789), dominant (P=0.012, OR=1.325, 95%CI=1.110-1.580), recessive (P=0.008, OR=1.630, 95%CI=1.130-2.342) and allele (P=0.002, OR=1.449, 95%CI=1.210-1.731) genetic models." "Zhu, H et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017" "NA" "NA" "Analysis of association of genetic polymorphisms of microRNAs with ischemic stroke" "Hsa-miR-146a rs2910164 is significantly associated with ischemic stroke in those with smoking and hypertension in Dongyang region." "1205" "MID_1082" "27164084" "hsa-miR-146a-5p SNP rs2910164" "microRNA" "Ischemic Stroke " "NA" "Prognosis" "YES" "Beijing, Tianjin Yanzhou, Xi’an, Wuhan Xiehe, Wuhan Tongji, and Chongqing" "1139" "718" "421" "61.30(9.40)" "plasma" "meta-analysis" "The prospective study showed that rs2910164 led to a 1.56-fold increased risk of stroke recurrence (hazard ratio (HR) = 1.56; 95% CI = 1.10-2.20; p = 0.013) and a 2.13-fold increased risk of death caused by cardiovascular disease or stroke (Csdeath) (HR =" "Qu, J Y et al. Int J Mol Sci. 2016" "NA" "Genotype C/C 355 G/C 618 G/G 166" "Association of the MicroRNA-146a SNP rs2910164 with Ischemic Stroke Incidence and Prognosis in a Chinese Population" "Rs2910164 increased the risk of stroke recurrence and Csdeath in a Chinese population but did not predict stroke incidence in Asian populations, suggesting that it has the potential to be a target for therapeutic interventions that aim to reduce inflammat" "1206" "MID_1083" "25658319" "hsa-miR-146a-5p SNP rs2910164" "microRNA" "Ischemia stroke" "NA" "Diagnosis" "NO" "Shenzhen, China, Asia" "531" "327" "204" "63" "blood" "TaqMan assay" "Results suggest that subjectswith rs2910164GG genotype had a higher ischemic stroke risk compared with subjects carrying CC genotype (OR=2.00, 95% CI, 1.29-3.12, p=0.002; Padd=0.004)." "Huang, SL et al. PLoS One. 2015" "NA" "NA" "Association of the genetic polymorphisms in pre-microRNAs with risk of ischemic stroke in a Chinese population" "The study suggested that the miR-146a/rs2910164 C/G polymorphism might beassociated with ischemic stroke risk in a Chinesepopulation." "1207" "MID_1084" "24952884" "hsa-miR-146a-5p SNP rs2910164" "microRNA" "Ischemia stroke" "NA" "Diagnosis" "NO" "Shenyang， China, Asia" "368" "253" "115" "61.62(0.986)" "blood" "polymerase chain reaction-ligation detection reaction" "In subgroup meta-analysis, rs2910164 in miR-146a and large-artery atherosclerosis, rather than small-vessel disease, showed the significant association under the dominant model (CC vs CG+GG, OR 1.694; 95% CI 1.199-2.395 p=0.003)." "Zhu, R et al. Neurochem Res. 2015" "mean(SD)" "NA" "MiR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population" "The CC genotype and C allele of rs2910164 within miR-146a are associated with an increased incidence of large-artery atherosclerotic stroke in the northern Chinese Han population." "1208" "MID_1085" "29402769" "hsa-miR-146b-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Nanning, China, Asia" "128" "109" "19" "68.42(17.26)" "serum" "quantitative real time PCR" "AUC=0.776 (95% confidence interval 0.628-0.813, p<0.001)" "Chen, Z et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke" "Upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for acute ischemic stroke evaluation." "1209" "MID_1086" "29402769" "hsa-miR-146b-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Nanning, China, Asia" "128" "109" "19" "68.42(17.26)" "blood" "Real-time PCR" "AUC=0.776, 95%CI: 0.628-0.813, p<0.001" "Chen, Z et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke" "Upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for evaluation." "1210" "MID_1087" "24911610" "hsa-miR-148a-3p" "microRNA" "Ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-148a (FC=-2.05, FDR p-value 0.009)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1211" "MID_1088" "25867405" "hsa-miR-149-5p SNP rs2292832" "microRNA" "Ischemia stroke" "NA" "Diagnosis" "NO" "Zhenjiang, China, Asia" "382" "205" "177" "65.7(11.5)" "plasma" "polymerase chain reaction (PCR)-based direct DNA sequencing" "IS patients had a lower frequency of GG genotype distribution of the hsa-mir-149 polymorphism (11.5 vs 16.0%) and a higher frequency of TT (46.6 vs 39.0%). The risk of IS was significantly lower among subjects carrying the GG genotype than in subjects car" "Chen, QY et al. Genet Mol Res. 2015" "mean(SD)" "NA" "Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population" "The study suggest that the miR-149 single nucleotide polymorphism rs71428439 influences plasma levels of homocysteine and is associated with IS risk in the Jiangsu Han population." "1212" "MID_1089" "27246008" "hsa-miR-150-5p SNP rs73056059" "microRNA" "Ischemia stroke" "NA" "Diagnosis" "YES" "Seongnam, Republic of Korea, Asia" "596" "254" "342" "63.67(10.42)" "blood" "PCR-RFLP analysis" "The miR?150 polymorphisms were significantly associated with ischemic stroke subgroups, such as left anterior descending artery(LAD) disease [GGvs.AA: adjusted odds ratio(AOR), 1.922; 95% confidence interval(CI), 1.003-3.681] and cardioembolism (GGvs.AA: " "Choi, G H et al. Int J Moi Med. 2016" "mean(SD)" "NA" "Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke." "The study suggest that miR-150 polymorphisms may contribute to ischemic stroke and may serve as biomarkers for the diagnosis of ischemic stroke." "120" "MID_109" "29197872" "A combination of hsa-miR-29b-3p and IL-6" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Ghangzhou, China, Asia" "85" "41" "44" "50.48(5.78)" "plasma" "S-Poly (T) RT-qPCR" "AUC=0.901, sensitivity=95.2%, specificity=85.1%" "Huang, YQ et al. Cell Physiol Biochem. 2017" "mean(SD)" "NA" "The Association of Circulating MiR-29b and Interleukin-6 with Subclinical Atherosclerosis" "Upregulation of circulating miR-29b and IL-6 may serve as new biomarkers for subclinical or clinical atherosclerosis." "1213" "MID_1090" "25127724" "hsa-miR-151a-3p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "plasma" "Real-Time qPCR" "Fold change (FC)=1.79, P= 0.003" "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs tha thave previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "1214" "MID_1091" "27181533" "hsa-miR-153" "microRNA" "Ischemia stroke" "down" "Diagnosis" "YES" "Changsha, China, Asia" "114" "78" "36" "61(11.3)" "plasma" "qRT-PCR, Biochemical and clinical assays" "With an area under curve (AUC) of 0.738; cut-off point: 1.1; sensitivity: 0.912; specificity: 0.74; 95%CI: 0.837-0.950;" "Li, C et al.Eur J Med Res. 2015" "mean(SD)" "NA" "The Diagnostic Value of Circulating Brain-specific MicroRNAs for Ischemic Stroke" "The study suggest that circulating miR-153 might be used as potential novel non-invasive biomarkers for the diagnosis of ischemia stroke." "1215" "MID_1092" "26968104" "hsa-miR-16-5p" "microRNA" "Acute stroke" "down(dead)" "Prognosis" "YES" "Hongkong, China, Asia" "84" "43" "41" "72" "plasma" "RT reaction、RT-qPCR" "Within 24h of symptom onset: AUC=0.69(0.58-0.79), the sensitivity and specificity were 75% and 68.6%." "Rainer, TH et al. Clin Biochem. 2016" "NA" "NA" "Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke" "Plasma miR-16 are markers which could be useful for the early prediction of mortality and post-stroke modified Rankin Score." "1216" "MID_1093" "24650689" "hsa-miR-16-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Hongkong, China, Asia" "93" "47" "25" "72" "plasma" "real-time PCR" "Median miR-16 concentration in IS patients were higher than that in HS patients (1.6×10(9) vs 1.3×10(9) copies/ml plasma, p=0.0399).The odds ratio (OR) for discriminating HS and IS with miR-16 was 9.75 respectively, The areas under the curve for plasma mi" "Leung, L Y et al. Clin Chim Acta. 2014" "mean(SEM)" "NA" "Comparison of miR-124-3p and miR-16 for early diagnosis of hemorrhagic and ischemic stroke" "Both miR-124-3p and miR-16 are diagnostic markers to discriminate hemorrhage stroke and ischemic stroke, miR-16 is a better marker in the diagnosis of IS in late symptom onset (>6-24h)." "1217" "MID_1094" "26968104" "hsa-miR-16-5p" "microRNA" "Acute stroke" "down(died compared to survived)" "Prognosis" "YES" "Hongkong, China, Asia" "84" "43" "41" "43-92" "plasma" "reserve transcription quantitative real-time polymerase chain reaction(RT-qPCR)" "3-month mortality in patients presenting more than 6 h but within 24 h: AUC=0.79(95%CI: 0.65-0.90), Sensitivity:100%, Specificity:75%" "Rainer, TH et al. Clin Biochem. 2016" "NA" "NA" "Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke" "Plasma miR-16 is molecular markers which could be useful for the early prediction of 3-month mortality." "1218" "MID_1095" "25697638" "hsa-miR-17-5p" "microRNA" "Acute ischemic stroke" "up" "Prognosis" "YES" "Seoul, South Korea, Asia" "8/75" "5/50" "3/25" "61.5(22.7)/66.7(12.9)" "plasma, plaque" "qRT-PCR" "The area under the ROC of miRNA-17 was 0.642 (37.4 % sensitivity and 89.2 % specificity at a cutoff of 0.1265, p=0.013)" "Kim, JM et al. Transl Stroke Res. 2015" "mean(SD)" "with recurrence/without recurrence" "Atherosclerosis-Related Circulating MicroRNAs as a Predictor of Stroke Recurrence" "This study shows that the miR-17 level was elevated in acute ischemic stroke and associated with future stroke recurrence." "1219" "MID_1096" "28251236" "hsa-miR-181a-5p" "microRNA" "Ischemic stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "227" "160" "67" "60.1(11.3)" "serum" "qRT-PCR" "AUC=0.684(95% CI: 0.608-0.760, p<0.001)" "Wu, J et al. Thromb Haemost. 2017" "mean(SD)" "NA" "Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients" "The increased serum miRNAs manifested predictive and discriminative potentials as novel biomarker for ischaemic stroke." "1220" "MID_1097" "26044809" "hsa-miR-185-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis, Treatment" "YES" "Nanning, China, Asia" "30/30" "16/15" "14/15" "62.57(11.53)/60.13(9.82)" "blood" "miRNA microarray, qRT-PCR" "The miR-185 had the highest area under the curve (AUC; 91.7%) when ISA were compared to healthy control." "Li, SH et al. Curr Neurovasc Res. 2015" "mean(SD)" "acute ishemic stroke/subacute ishemic stroke" "Differential Regulation of microRNAs in Patients with Ischemic Stroke" "MiR-185 is more useful to distinguish ischemic stroke in the acute phase(ISA) from healthy subjects." "1221" "MID_1098" "28875333" "hsa-miR-185-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.601(95% CI:0.525-0.676)" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1222" "MID_1099" "25127724" "hsa-miR-18b-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "plasma, cerebrospinal fluid" "Real-Time qPCR" "Fold Change=0.83, P=0.03" "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs tha thave previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "11" "MID_11" "27357355" "hsa-miR-140-3p" "microRNA" "Acute coronary syndrome" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "430" "349" "81" "63(55-68)" "serum" "RT-qPCR" "AUC=0.756" "Karakas, M et al. Eur Heart J. 2017" "NA" "acute coronary syndrome" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "121" "MID_110" "22917031" "hsa-let-7c" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Changsha, China, Asia" "NA" "NA" "NA" "NA" "human umbilical cord vein endothelial cells" "qRT-PCR, Luciferase Assays" "NA" "Qin, B et al. BMB Rep. 2012" "NA" "NA" "MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis" "Let-7c contributes to endothelial apoptosis through suppression of Bcl-xl." "1223" "MID_1100" "24911610" "hsa-miR-19a-3p" "microRNA" "Ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-19a (FC=-1.66, FDR p-value 0.030)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1224" "MID_1101" "28199366" "hsa-miR-19a-3p" "microRNA" "Cardioembolic stroke" "NA" "Diagnosis" "YES" "Kuala Lumpur, Malaysia, Asia" "13/26" "8/16" "5/10" "67.50(16.13)/62.84(11.61)" "human umbilical vein endothelial cells(HUVECs)" "Luciferase assay, qPCR" "AUC=0.918" "Tan, JR et al. PLoS One. 2017" "mean(SD)" "Cardioembolic stroke/Non-cardioembolic stroke" "MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke" "The miRNA is more accurate in the diagnosis of cardioembolic stroke patients, could distinguish cardioembolic stroke from non-cardioembolic stroke." "1225" "MID_1102" "28199366" "hsa-miR-20a-5p" "microRNA" "Cardioembolic stroke" "NA" "Diagnosis" "YES" "Kuala Lumpur, Malaysia, Asia" "13/26" "8/16" "5/10" "67.50(16.13)/62.84(11.61)" "human umbilical vein endothelial cells(HUVECs)" "Luciferase assay, qPCR" "AUC=0.953" "Tan, JR et al. PLoS One. 2017" "mean(SD)" "Cardioembolic stroke/Non-cardioembolic stroke" "MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke" "The miRNA is more accurate in the diagnosis of cardioembolic stroke patients, could distinguish cardioembolic stroke from non-cardioembolic stroke." "1226" "MID_1103" "23154383" "hsa-miR-210" "microRNA" "Acute ischemic stroke" "up(good outcomes)" "Prognosis" "YES" "Shanghai, China, Asia" "40/65" "26/47" "14/18" "66(54-74)/68(57-78)" "plasma" "real-time PCR" "The prediction sensitivity of miR-210 for stroke outcome was 82.5%" "Zeng, L et al. Eur Neurol. 2013" "NA" "Good outcomes/Poor outcomes" "Cocktail blood biomarkers: prediction of clinical outcomes in patients with acute ischemic stroke." "The miR-210 a high sensitivity for predicting stroke recovery, it serves as a potential cocktail blood biomarker. It provides a novel approach for stroke prognosis." "1227" "MID_1104" "20378606" "hsa-miR-211-5p" "microRNA" "Stroke" "NA" "Treatment" "NO" "Beijing, China, Asia" "438/1791" "209/1139" "229/652" "60.4(8.2)/60.4(9.5)" "plasma" "Luciferase assay" "In the two studies combined, the TT genotype was significantly lower in patients with stroke than in the controls [13.5 versus 19.5%, P = 1.2 × 10 ?8 (crude OR = 0.64, 95% CI 0.35–0.75)]" "Chen, J et al. Hum Mol Genet. 2010" "mean(SD)" "First study/Second study" "A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211" "The TT genotype (rs2507800) in the 3'-UTR of angiopoietin-1 lower in stroke patients and might reduce the risk of stroke by interfering with miR-211 binding." "1228" "MID_1105" "27288814" "hsa-miR-21-5p" "microRNA" "Stroke with stroke-associated infection " "up" "Diagnosis, Treatment" "YES" "Guangzhou, China, Asia" "32" "20" "12" "62.156(11.981)" "plasma" "PCR" "The area under the ROC curve (AUC) for miRNA-21 was 0.667(95%CI, 0.525 to 0.798, p=0.028)." "Lin, SP et al. J Neurol Sci. 2016" "mean(SD)" "NA" "Increased expression of microRNA-21 in peripheral blood mediates the down-regulation of IFN-gamma and increases the prevalence of stroke-associated infection" "MiRNA-21 upregulated in plasma in acute stroke can be considered new biological predictors for stroke-associated infection and new therapeutic targets." "1229" "MID_1106" "28251236" "hsa-miR-21-5p" "microRNA" "Ischemic stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "227" "160" "67" "60.1(11.3)" "serum" "qRT-PCR" "AUC=0.734 (95% CI: 0.667-0.801, p<0.001)" "Wu, J et al. Thromb Haemost. 2017" "mean(SD)" "NA" "Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients" "The increased serum miRNAs manifested predictive and discriminative potentials as novel biomarker for ischaemic stroke." "1230" "MID_1107" "28875333" "hsa-miR-218-5p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.624(95% CI:0.549-0.699)" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1231" "MID_1108" "25257664" "hsa-miR-219a-5p" "microRNA" "Acute ischemic stroke" "NA" "Treatment" "YES" "Wuhan, China, Asia" "31" "21" "10" "66.32(12.56)" "serum, plasma" "real-time polymerase chain reaction and serum levels of metalloproteinase-9, high-sensitivity C-reactive protein (hs-CRP) levels" "A negative correlation was found between MMP-9 and serum miR-219 levels based on the data of patients within 24?hours after stroke and controls (r=-0.434, p=0.024)." "Liu, Y et al. J Clin Neurosci. 2015" "mean(SD)" "NA" "Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke" "In conclusion, serum miR-124, miR-9 and miR-219 were suppressed in acute ischemic stroke thus facilitating neuroinflammation and brain injury, ST-elevation myocardial infarctionc administration of these miRNAa in the acute period of stroke might be a prom" "1232" "MID_1109" "26096228" "hsa-miR-221-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "NO" "Liaocheng, China, Asia" "146" "112" "34" "67.29(14.16)" "blood" "quantitative real time-PCR" "NA" "Jia, LH et al. Cell Biochem Funct. 2015" "mean(SD)" "NA" "Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients" "MiR-23a and miR-221 were significantly down-regulated in the serum of acute ischemic stroke patients." "122" "MID_111" "28535009" "hsa-let-7g-5p" "microRNA" "Atherosclerosis" "NA" "Treatment" "YES" "Beijing, China, Asia" "NA" "NA" "NA" "NA" "human aortic smooth muscle cells" "Luciferase reporter assay, qPCR" "NA" "Liu, M et al. Int J Mol Med. 2017" "mean(SD)" "NA" "MicroRNA let-7g alleviates atherosclerosis via the targeting of LOX-1 in vitro and in vivo" "MiR-let-7g markedly inhibited LOX-1 expression in human aortic smooth muscle cells by directly binding to the 3' untranslated region of LOX-1, it may be a therapeutic target for treating atherosclerosis." "1233" "MID_1110" "25127724" "hsa-miR-221-3p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "cerebrospinal fluid" "Real-Time qPCR" "Fold Change=1.70, P=0.02" "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs tha thave previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "1234" "MID_1111" "28111007" "hsa-miR-221-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Tianjin, China, Asia" "78" "55" "23" "60(10.47)" "serum" "real-time PCR" "AUC=0.8106 (P<0.001; 95% CI:0.7252-0.8960)" "Wang, Y et al. J Stroke Cerebrovasc Dis. 2017" "mean(SD)" "NA" "The Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke" "MiRNA-221-3p might be used as potential noninvasive biomarkers for the diagnosis of ischemic stroke." "1235" "MID_1112" "28875333" "hsa-miR-222-3p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.584 (95% CI:0.508-0.661)" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1236" "MID_1113" "24708646" "hsa-miR-223-3p" "microRNA" "Acute ischemic stroke((less than 72?hours)" "up" "Diagnosis, Treatment" "YES" "Shanghai, China, Asia" "79" "58" "21" "65.1(10.0)" "blood" "Reverse transcription and Real-time PCR" "The results of logistic regression suggested that the level of blood miR-223 was a stroke risk factor (p=0.011, adjusted odd ratio=1.002, 95% CI: 1.000-1.004)." "Wang, Y et al. BMC Neurol. 2014" "mean(SD)" "NA" "Increase of circulating miR-223 and insulin-like growth factor-1 is associated with the pathogenesis of acute ischemic stroke in patients" "The study reported circulating miR-223 based markers for acute ischemic stroke occurrence, subtypes and infarct volume and believe that miR-223 has great potential as a novel therapeutic target for ischemic stroke." "1237" "MID_1114" "24908639" "hsa-miR-223-3p" "microRNA" "Diabetes mellitus with ischemic stroke" "down" "Diagnosis" "YES" "Changsha, China, Asia" "2007/6/6" "NA" "NA" "47.14(9.155)/49.33(5.645)/51.33(9.933)" "platelet, plasam" "Reverse transcription and real-time quantitative PCR" "The expressions of platelet miR-223 in patients with diabetes mellitus and ischemic stroke (p=0.047); The expressions of plasma miR-223 in patients with diabetes mellitus and ischemic stroke (p=0.020)" "Duan, X et al. J Diabetes Complications. 2014" "mean(SEM)" "DM (n=7) IS (n=6) ISwDM (n=6)" "Detection of platelet microRNA expression in patients with diabetes mellitus with or without ischemic stroke" "Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients, can be used as a biomarker for diabetes mellitus with or without ischemic stroke in Chinese patients." "1238" "MID_1115" "26175178" "hsa-miR-223-3p" "microRNA" "Ischemia stroke" "down" "Diagnosis" "NO" "Changsha, China, Asia" "56" "NA" "NA" "53.3(9.94)" "platelet, plasam" "qPCR, RT-PCR, RT-qPCR, Weatern Blot" "Correlation analysis: Platelet miR-223 and Platelet activation rate r =-0.888, P<0.001;" "Yang, S et al. Cardiovasc Toxicol. 2016" "mean(SEM)" "NA" "Biomarkers Associated with Ischemic Stroke in Diabetes Mellitus Patients" "MiR-223 levels in plasma and platelets, but not in leukocytes, were significantly lower in type 2 diabetes mellitus patients with ischemic stroke (P<0.001), is a risk factor for ischemic stroke in type 2 diabetes mellitus patients." "1239" "MID_1116" "26096228" "hsa-miR-23a-3p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "NO" "Liaocheng, China, Asia" "146" "112" "34" "67.29(14.16)" "blood" "quantitative real time-PCR" "NA" "Jia, LH et al. Cell Biochem Funct. 2015" "mean(SD)" "NA" "Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients" "MiR-23a and miR-221 were significantly down-regulated in the serum of AIS patients." "1240" "MID_1117" "28251236" "hsa-miR-23b-3p" "microRNA" "Ischemic stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "227" "160" "67" "60.1(11.3)" "serum" "qRT-PCR" "AUC=0.851(95% CI: 0.802-0.899, p<0.001)" "Wu, J et al. Thromb Haemost. 2017" "mean(SD)" "NA" "Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients" "The increased serum miRNAs manifested predictive and discriminative potentials as novel biomarker for ischaemic stroke." "1241" "MID_1118" "29353353" "hsa-miR-25-3p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "NO" "Tabriz, Iran, Asia" "30" "11" "19" "67.3(8.9)" "peripheral blood mononuclear cells" "Real-time PCR" "NA" "Dolati, S et al. Neurol Sci. 2018" "mean(SD)" "NA" "Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke" "MiR-25 was upregulated in ischemic stroke patients." "1242" "MID_1119" "28251236" "hsa-miR-29b-3p" "microRNA" "Ischemic stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "227" "160" "67" "60.1(11.3)" "serum" "qRT-PCR" "AUC=0.791(95% CI: 0.734-0.848, p<0.001)" "Wu, J et al. Thromb Haemost. 2017" "mean(SD)" "NA" "Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients" "The increased serum miRNAs manifested predictive and discriminative potentials as novel biomarker for ischaemic stroke." "123" "MID_112" "22370758" "hsa-miR-10b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "1243" "MID_1120" "24237608" "hsa-miR-30a-5p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "38/42/40/38/39" "19/20/21/20/20" "19/22/19/18/19" "62.45(6)/64(6)/64(2.2)/64.97(6)/64.77(6.7)" "plasma" "qRT-PCR" "AUC is 0.91 (95% CI=0.869-0.979), 0.91 (95% CI=0.848-0.971), 0.92(95% CI=0.856-0.976) and 0.93 (95%CI=0.875-0.984),sensitivity of 94%, 93%, 90% and 92% and a specificity of 80%, 84%, 84% and 84% at 24 h, 1 w, 4 w and 24 w." "Long, G et al. BMC Neurol. 2013" "mean(SD)" "24h/1 week/4 week/24 week/48 week" "Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans" "The study suggest that miR-30a might be useful biomarkers for ischemic stroke in humans." "1244" "MID_1121" "29807362" "hsa-miR-30d-5p" "microRNA" "Acute ischemic stroke" "down" "Treatment" "YES" "Shanghai, China, Asia" "70" "40" "30" "68.2(12.8)" "serum" "real-time polymerase chain reaction (RT-PCR)" "NA" "Jiang, M et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization" "MiR-30d-5p could be a promising therapeutic strategy for ameliorating cerebral injury by inhibiting the inflammatory response in acute ischemic stroke patients." "1245" "MID_1122" "25287657" "hsa-miR-320d" "microRNA" "Acute stroke" "down" "Diagnosis" "YES" "Suzhou, China, Asia" "60/76" "35/40" "25/36" "50(13)" "plasma" "Real-time reverse transcription polymerase chain reaction (RT-PCR) assays" "ROC curves:hsa-miR-320d MRI(-), 0.977 (95% CI, 0.952-1.000; P=0.000);hsa-miR-320d MRI(+), 0.987 (95% CI, 00.972-1.000; P=0.000). " "Wang, W et al. J Stroke Cerebrovasc Dis. 2014" "mean(SD)" "MRI(+)/MRI(?) If the patient suffered from acute stroke that was detected with diffusion-weighted imaging, the patient was defined as an MRI(+) patient. Otherwise, it was defined as an MRI(?) patient." "Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans" "Regarding a lack of biomarkers in acute stroke thus far, the availability of miRNAs such as hsa-miR-106b-5P, hsa-miR-4306, hsa-miR-320e, and hsa-miR-320d might facilitate the diagnosis and clinical management of acute stroke." "1246" "MID_1123" "24911610" "hsa-miR-320d" "microRNA" "Ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-320d (FC=-1.70, FDR p-value 0.020)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1247" "MID_1124" "25287657" "hsa-miR-320e" "microRNA" "Acute stroke" "down" "Diagnosis" "YES" "Suzhou, China, Asia" "60/76" "35/40" "25/36" "50(13)" "plasma" "Real-time reverse transcription polymerase chain reaction (RT-PCR) assays" "ROC curves:hsa-miR-320e MRI(-), 0.953 (95% CI, 0.913-0.994; P=0.000); hsa-miR-320e MRI(+), 0.981 (95% CI, 0.963-0.998; P=0.000);" "Wang, W et al. J Stroke Cerebrovasc Dis. 2014" "mean(SD)" "MRI(+)/MRI(?) If the patient suffered from acute stroke that was detected with diffusion-weighted imaging, the patient was defined as an MRI(+) patient. Otherwise, it was defined as an MRI(?) patient." "Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans" "Regarding a lack of biomarkers in acute stroke thus far, the availability of miRNAs such as hsa-miR-106b-5P, hsa-miR-4306, hsa-miR-320e, and hsa-miR-320d might facilitate the diagnosis and clinical management of acute stroke" "1248" "MID_1125" "25410304" "hsa-miR-32-3p" "microRNA" "Ischemia stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "31" "22" "68(1.5)" "serum" "qRT-PCR, MicroRNA Microarray Analysis" "NA" "Li, P et al. Cell Mol Neurobiol. 2015" "mean(SEM)" "NA" "Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke" "MiR-32-3p may serve as potential diagnostic biomarkers for ischemic stroke." "1249" "MID_1126" "29353353" "hsa-miR-326" "microRNA" "Ischemia stroke" "up" "Diagnosis" "NO" "Tabriz, Iran, Asia" "30" "11" "19" "67.3(8.9)" "peripheral blood mononuclear cells" "Real-time PCR" "NA" "Dolati, S et al. Neurol Sci. 2018" "mean(SD)" "NA" "Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke" "MiR-326 was upregulated in ischemic stroke patients." "1250" "MID_1127" "27856935" "hsa-miR-335-5p " "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Tianjin, China, Asia" "168" "88" "80" "70(8)" "plasma" "qPCR, Luciferase Reporter Assays, Western blot analysis" "OR:0.79; 95% CI:0.68-0.87 P=0.028; The area under the curve was 0.898 (95% CI:0.855-0.931), the optimal sensitivity and specificity were 97.6% and 69.2%. " "Zhao, B et al. J Int Med Res. 2016" "NA" "NA" "Decreased plasma miR-335 expression in patients with acute ischemic stroke and its association with calmodulin expression" "Plasma miR-335 was down-regulated in acute ischemic stroke patients and represents a potential noninvasive circulating biomarker." "1251" "MID_1128" "27545688" "hsa-miR-34a-5p" "microRNA" "Acute ischemic stroke" "up" "Prognosis, Treatment" "YES" "Zhengzhou, China, Asia" "102" "69" "33" "65.1(10.0)" "blood" "qRT-PCR" "MiR-34a-5p expression levels were negatively associated with NIHSS scores (r=-0.692, p<0.05) and infarct volume (r=-0.719, p<0.05)." "Liang, T Y et al. Med Sci Monit. 2016" "mean(SD)" "Blood samples were obtained from patients within 72 h after cerebral ischemia. " "Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model" "The results suggest there is a potential regulatory role of miRNA-34a-5p in acute ischemic stroke, which could as prognosis and treatment marker in patients." "1252" "MID_1129" "24911610" "hsa-miR-363-3p " "microRNA" "Ischemic stroke" "up" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-363 (FC=3.61, FDR p-value 0.037)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "124" "MID_113" "26159918" "hsa-miR-100-5p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Jinan, China, Asia" "3" "3" "0" "18-25" "tissue" "Fluorescent labeling, microarray hybridization, Real-time RT-PCR" "Average (ratio scale) 1.805; P-VALUE 0.006; Standard devition 0.482." "Wang, R et al. Biochem Biophys Res Commun. 2015" "NA" "NA" "Unique MicroRNA signatures associated with early coronary atherosclerotic plaques" "The study show that miR-100 can serve as potential indicators in the detection of early atherosclerosis." "1253" "MID_1130" "28111007" "hsa-miR-382-5p" "microRNA" "Acute ischemic stroke" "down" "Diagnosis" "YES" "Tianjin, China, Asia" "78" "55" "23" "60(10.47)" "serum" "real-time PCR" "AUC=0.7483 (P<0.001; 95% CI:0.6300-0.8655)" "Wang, Y et al. J Stroke Cerebrovasc Dis. 2017" "mean(SD)" "NA" "The Diagnostic Value of Serum miRNA-221-3p, miRNA-382-5p, and miRNA-4271 in Ischemic Stroke" "MiRNA-382-5p might be used as potential noninvasive biomarkers for the diagnosis of ischemic stroke." "1254" "MID_1131" "25287657" "hsa-miR-4306" "microRNA" "Acute stroke" "up" "Diagnosis" "YES" "Suzhou, China, Asia" "60/76" "35/40" "25/36" "50(13)" "plasma" "Real-time reverse transcription polymerase chain reaction (RT-PCR) assays" "ROC curves: hsa-miR-4306 MRI(-), 0.877 (95% CI, 0.799-0.954; P=0.000); hsa-miR-4306 MRI(+), 0.952 (95% CI, 0.922-0.982; P=0.000)" "Wang, W et al. J Stroke Cerebrovasc Dis. 2014" "mean(SD)" "MRI(+)/MRI(?) If the patient suffered from acute stroke that was detected with diffusion-weighted imaging, the patient was defined as an MRI(+) patient. Otherwise, it was defined as an MRI(?) patient." "Circulating microRNAs as novel potential biomarkers for early diagnosis of acute stroke in humans" "Regarding a lack of biomarkers in acute stroke thus far, the availability of miRNAs such as hsa-miR-106b-5P, hsa-miR-4306, hsa-miR-320e, and hsa-miR-320d might facilitate the diagnosis and clinical management of acute stroke." "1255" "MID_1132" "25738515" "hsa-miR-433" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "1256" "MID_1133" "24911610" "hsa-miR-4429" "microRNA" "Ischemic stroke" "down" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-4429 (FC=-1.61, FDR p-value 0.034)" "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1257" "MID_1134" "27151415" "hsa-miR-455-5p" "microRNA" "Ischemia stroke" "down" "Treatment" "YES" "Shantou, China, Asia" "5" "2" "3" "50-83" "peripheral blood " "qRT-PCR" "NA" "He, W et al. J Stroke Cerebrovasc Dis. 2016" "NA" "microarray expression profile data were downloaded from the Gene Expression Omnibus database" "Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke." "In the present study, miR-455-5p were significantly deregulated in ischemic stroke." "1258" "MID_1135" "24911610" "hsa-miR-487b" "microRNA" "Ischemic Stroke " "up" "Diagnosis" "NO" "California, USA, North America" "24" "12" "12" "62.4(8.1)" "blood" "Microarray, qRT-PCR" "miR-487b (FC=2.66, FDR p-value 0.044). " "Jickling, GC et al. PLoS One. 2014" "mean(SD)" "The study population was ethnically diverse with 68.7% Caucasian, 12.5% African American, 6.3% Asian, and 12.5% of other race" "MicroRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets" "In conclusion, several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA are predicted to regulate gene expression and pathways in blood that are associated with ischemic stroke." "1259" "MID_1136" "24178064" "hsa-mir-499a-5p SNP rs3746444" "microRNA" "Ischemic Stroke " "NA" "Diagnosis" "NO" "Nanchong, China, Asia" "296" "180" "116" "67.52(10.29)" "blood" "polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)" "Higher frequencies of hsa-miR-499/rs3746444 AG genotypes (32.43% vs25.32%, P?=?0.024, OR=1.489, 95%CI=1.063-2.087)" "Liu, Y et al. J Mol Neurosci. 2014" "mean(SD)" "NA" "Genetic polymorphisms in pre-microRNAs and risk of ischemic stroke in a Chinese population" "The present study provided evidence that hsa-mir-499/rs3746444 A/G polymorphism might be associated with a significantly increased risk of ischemic stroke in a Chinese population, indicating that the common genetic polymorphism in pre-microRNAs contribute" "1260" "MID_1137" "25127724" "hsa-miR-523-3p" "microRNA" "Acute ischemic stroke" "only in stroke patients" "Diagnosis" "YES" "Hiller?d, Denmark, Europe" "10" "5" "5" "NA" "cerebrospinal fluid" "Real-Time qPCR" "OR: 21; Sensitivity(%):50；Specificity(%):100 " "S?rensen, SS et al. Transl Stroke Res. 2014" "NA" "NA" "MiRNA expression profiles in cerebrospinal fluid and blood of patients with acute ischemic stroke" "The results show upregulation in the cerebrospinal fluid(CSF) of miRNAs that have previously been associated with stroke, and we suggest that miRNA profiles of CSF have potential usefulness as biomarkers of stroke." "1261" "MID_1138" "25410304" "hsa-miR-532-5p" "microRNA" "Ischemia stroke" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "21" "22" "68(1.5)" "serum" "qRT-PCR, MicroRNA Microarray Analysis" "NA" "Li, P et al. Cell Mol Neurobiol. 2015" "mean(SEM)" "NA" "Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke" "MiR-532-5p may serve as potential diagnostic biomarkers for ischemic stroke." "1262" "MID_1139" "27151415" "hsa-miR-542-3p" "microRNA" "Ischemia stroke" "up" "Treatment" "YES" "Shantou, China, Asia" "5" "2" "3" "50-83" "peripheral blood " "qRT-PCR" "NA" "He, W et al. J Stroke Cerebrovasc Dis. 2016" "NA" "NA" "Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke." "In the present study, miR-542-3p were significantly deregulated in ischemic stroke." "125" "MID_114" "22370758" "hsa-miR-105-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "1263" "MID_1140" "27011381" "hsa-miR-618 SNP rs2682818" "microRNA" "Ischemia stroke" "NA" "Prognosis" "YES" "Nanjing, China, Asia" "854/74" "599/57" "254/17" "NA" "NA" "Improved Multiple Ligase Detection Reaction (iMLDR) " "Among these microRNA polymorphisms, only miR-618 rs2682818 was significantly associated with recurrence risk in dominantmodel(log-rankP=0.006). .Cox regression analysis showed that the GT/TT genotypes were significantly unfavorable prognostic factor for s" "Zhang, Z et al. Mol Neurobiol. 2017" "NA" "patients/recurrence" "Genetic Variants in MicroRNAs Predict Recurrence of Ischemic Stroke" "miR-618 SNP rs2682818 GT/TT genotypes were significantly prognostic factor for stroke recurrence." "1264" "MID_1141" "22147268" "hsa-miR-770-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6918" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1265" "MID_1142" "25257664" "hsa-miR-9-5p" "microRNA" "Acute ischemic stroke" "down" "Treatment" "YES" "Wuhan, China, Asia" "31" "21" "10" "66.32(12.56)" "serum, plasma" "real-time polymerase chain reaction and serum levels of metalloproteinase-9, high-sensitivity C-reactive protein (hs-CRP) levels " "serum miR-9 levels within 48hours after symptom onset in the eight patients assessed were also negatively correlated with infarct lesion volume (r=-0.738, p=0.037)." "Liu, Y et al. J Clin Neurosci. 2015" "mean(SD)" "NA" "Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke" "In conclusion, serum miR-124, miR-9 and miR-219 were suppressed in acute ischemic stroke thus facilitating neuroinflammation and brain injury, ST-elevation myocardial infarctionc administration of these miRNAa in the acute period of stroke might be a prom" "1266" "MID_1143" "27151415" "hsa-miR-99b-5p" "microRNA" "Ischemia stroke" "up" "Treatment" "YES" "Shantou, China, Asia" "5" "2" "3" "50-83" "peripheral blood " "qRT-PCR" "NA" "He, W et al. J Stroke Cerebrovasc Dis. 2016" "NA" "NA" "Bioinformatic Analysis of Potential microRNAs in Ischemic Stroke." "In the present study, miR-99b were significantly deregulated in ischemic stroke." "1267" "MID_1144" "26096228" "hsa-miR-145-5p with hs-CRP" "microRNA" "Acute ischemic stroke" "NA" "Prognosis" "YES" "Liaocheng, China, Asia" "146" "112" "34" "67.29(14.16)" "serum, plasma" "quantitative real time-PCR" "The combination of hs-CRP and miR-145 won the highest sensitivity/specificity (AUC=0.896, 95% confidence interval 0.804-0.951, p<0.001), which was 12.5% higher than that of plasma hs-CRP alone." "Jia, LH et al. Cell Biochem Funct. 2015" "mean(SD)" "NA" "Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients" "Serum miR-145 correlated with plasma hs-CRP also can reflect the severity of AIS and might be useful as a clinical tool for predicting outcome." "1268" "MID_1145" "23154383" "hsa-miR-210, FDP, IL-6" "microRNA" "Acute ischemic stroke" "NA" "Prognosis" "YES" "Shanghai, China, Asia" "40/65" "26/47" "14/18" "66(54-74)/68(57-78)" "plasma" "real-time PCR" "Using a combination of biomarkers including FDP, IL-6 and miR-210, the prognostic sensitivity of ischemic stroke was 95.2%." "Zeng, L et al. Eur Neurol. 2013" "NA" "Good outcomes/Poor outcomes" "Cocktail blood biomarkers: prediction of clinical outcomes in patients with acute ischemic stroke." "The combination of FDP, IL-6 and miR-210 has a high sensitivity for predicting stroke recovery, it serves as a potential cocktail blood biomarker. It provides a novel approach for stroke prognosis." "1269" "MID_1146" "28875333" "A combination of hsa-miR-126-3p, hsa-miR-130a-3p, hsa-miR-2222, hsa-miR-218-5p, hsa-miR-185-5p" "microRNA" "Acute ischemic stroke" "NA" "Diagnosis" "YES" "Cangzhou, China, Asia" "10/106" "5/48" "5/58" "59.8(8.9)/60.8(9.7)" "plasma" "Real-time qPCR" "AUC=0.767 (95% CI:0.705-0.829), sensitivity:87.7%, Specificity:54.5%" "Jin, F et al. Neurol Sci. 2017" "mean(SD)" "exploring stage/validating stage" "Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity" "The miRNA could be served as promising and independent biomarkers for risk of acute ischemic stroke." "1270" "MID_1147" "29402769" "A combination of hsa-miR-146b-5p and hs-CRP" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Nanning, China, Asia" "128" "109" "19" "68.42(17.26)" "serum" "quantitative real time PCR" "AUC=0.863, (95% confidence interval 0.801-0.936, p<0.001)" "Chen, Z et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke" "Combination of miR-146b and hs-CRP has better value in diagnosis od acute ischemic stroke." "1271" "MID_1148" "28724745" "A combination of miR-125a-5p, miR-125b-5p, and miR-143-3p" "microRNA" "Acute ischemic stroke" "up" "Diagnosis" "YES" "Taipei, China, Asia" "20/40/200" "8/22/113" "12/18/87" "74.7(9.7)/74.7(13.8)/74.1(13.4)" "plasma" "RNA Sequencing, qRT-PCR" "AUC=0.90 (sensitivity: 85.6%; specificity: 76.3%)" "mean(SD)" "Discovery Sample/Validation Sample/Replication Sample" "RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke" "A set of circulating microRNAs (miR-125a-5p, miR-125b-5p, and miR-143-3p) associates with acute ischemic stroke and might have clinical utility as an early diagnostic marker." "1272" "MID_1149" "28251236" "A combination of miR-23b-3p, miR-29b-3p, miR-181a-5p and miR-21-5p" "microRNA" "Ischemic stroke" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "227" "160" "67" "60.1(11.3)" "serum" "qRT-PCR" "AUC=0.883 (95% CI: 0.841-0.925, p<0.001)" "Wu, J et al. Thromb Haemost. 2017" "mean(SD)" "NA" "Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients" "These increased serum miRNAs manifested predictive and discriminative potentials as novel biomarkers for ischaemic stroke." "126" "MID_115" "27270534" "hsa-miR-106b-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Beijing, China, Asia" "9" "6" "3" "57(6)" "tissue" "real-time RT-PCR, Luciferase reporter assay" "The significant (P<0.001) 1000-fold elevated expression levels of miR-106b-5p in HUVEC were confirmed at all-time points" "Zhang, J et al. Chin Med J (Engl). 2016" "mean(SEM)" "NA" "MiR-106b-5p Inhibits Tumor Necrosis Factor-α-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells" "MiR-106b-5p could inhibit the expression of PTEN in vascular ECs, which could block TNF-α-induced activation of caspase-3." "1278" "MID_1150" "23597742" "hsa-let-7b-5p" "microRNA" "Sudden infant death syndrome" "up" "Diagnosis, Prognosis" "NO" "Bonn, Germany, Europe" "11" "9" "2" "98 days" "brainstem tissue" "qPCR" "NA" "Courts, C et al. Forensic Sci Int. 2013" "NA" "NA" "Dysregulation of heart and brain specific micro-RNA in sudden infant death syndrome" "Heart and brain specific dysregulation of let-7b might be involved in sudden infant death syndrome pathogenesis." "1279" "MID_1151" "23597742" "hsa-miR-1-3p" "microRNA" "Sudden infant death syndrome" "up" "Diagnosis" "NO" "Bonn, Germany, Europe" "14" "9" "5" "109 days" "tissue" "qPCR" "NA" "Courts, C et al. Forensic Sci Int. 2013" "NA" "NA" "Dysregulation of heart and brain specific micro-RNA in sudden infant death syndrome" "Heart and brain specific dysregulation of miR-1 might be involved in sudden infant death syndrome pathogenesis." "1280" "MID_1152" "28693530" "hsa-miR-1233-3p" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "1281" "MID_1153" "28693530" "hsa-miR-181d-5p" "microRNA" "Tetralogy of Fallot" "up" "Diagnosis" "YES" "Homburg, Germany, Europe" "37" "NA" "NA" "30.2(10.8)" "blood" "Microarray, RT-qPCR" "AUC=0.9874" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA can discriminate between tetralogy of fallot patients and healthy controls with high accuracy." "1282" "MID_1154" "28693530" "hsa-miR-206" "microRNA" "Tetralogy of Fallot" "up" "Diagnosis" "YES" "Homburg, Germany, Europe" "37" "NA" "NA" "30.2(10.8)" "blood" "Microarray, RT-qPCR" "AUC=0.9928" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA can discriminate between tetralogy of fallot patients and healthy controls with high accuracy." "1283" "MID_1155" "28693530" "hsa-miR-421" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "1284" "MID_1156" "28693530" "hsa-miR-625-5p" "microRNA" "Tetralogy of Fallot" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "37" "NA" "NA" "30.2(10.8)" "blood" "Microarray, RT-qPCR" "AUC=0.7694" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA can discriminate between tetralogy of fallot patients and healthy controls with high accuracy." "1285" "MID_1157" "28693530" "hsa-miR-625-5p" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "1286" "MID_1158" "22147268" "hiv1-miR-H1" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.85" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1287" "MID_1159" "22147268" "hsa-let-7b-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6281" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "127" "MID_116" "24848278" "hsa-miR-122-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "1288" "MID_1160" "22147268" "hsa-let-7f-1-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6853" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1289" "MID_1161" "22147268" "hsa-miR-101-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8253" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1290" "MID_1162" "22147268" "hsa-miR-10b-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.035" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1291" "MID_1163" "22147268" "hsa-miR-1224-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7563" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1292" "MID_1164" "22147268" "hsa-miR-1225-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7185" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1293" "MID_1165" "22147268" "hsa-miR-1228-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5435" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1294" "MID_1166" "22147268" "hsa-miR-1234-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7766" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1295" "MID_1167" "22147268" "hsa-miR-1237-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5174" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1296" "MID_1168" "22147268" "hsa-miR-1238-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.9622" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1297" "MID_1169" "22147268" "hsa-miR-125a-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8057" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "128" "MID_117" "22370758" "hsa-miR-125a-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "1298" "MID_1170" "22147268" "hsa-miR-125a-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6583" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1299" "MID_1171" "22147268" "hsa-miR-1274a" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5632" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1300" "MID_1172" "22147268" "hsa-miR-132-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6485" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In valvular heart disease, the miRNA was different expression in left atrial." "1301" "MID_1173" "22147268" "hsa-miR-134" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8815" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1302" "MID_1174" "22147268" "hsa-miR-146a-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8735" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1303" "MID_1175" "22147268" "hsa-miR-146b-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "54(8)/74(1)" "right atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.625" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-RA-SR/VHD-RA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in right atrial." "1304" "MID_1176" "22147268" "hsa-miR-148b-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.624" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1305" "MID_1177" "22147268" "hsa-miR-149-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6048" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1306" "MID_1178" "22147268" "hsa-miR-150-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7914" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1307" "MID_1179" "28888871" "hsa-miR-15a-5p" "microRNA" "Valvular heart disease" "down" "Treatment" "NO" "Peshawar, Pakistan, Asia" "50" "23" "27" "32.9(11.6)" "tissue" "qRT-PCR" "NA" "Jan, MI et al. Arch Biochem Biophys. 2017" "mean(SD)" "NA" "Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease" "Down regulation of miR-15a is linked with up regulation of PUMA and DRP1." "129" "MID_118" "24517143" "hsa-miR-125a-5p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Jinan, China, Asia" "22/20/21/22" "5/3/3/4" "17/17/18/18" "45.27(1.55)/42.00(2.80)/47.95(2.35)/50.41(1.47)" "serum" "real-time PCR" "ROC curves for the ability of the six candidate serum miRNAs to differentiate the all SCH patients (SCH+ATH and SCH) from the cases (NC and ATH) miR-125-3p. AUC: 0.882[subclinical hypothyroidism(SCH); atherosclerosis(ATH)]" "Zhang, X et al. J Clin Endocrinol Metlab. 2014" "mean(SEM) or raw numbers" "normal control subjects (NC; n = 22); patients with subclinical hypothyroidism alone (SCH; n = 20); SCH patients plus atherosclerosis (SCH+ATH; n = 21); and patients with atherosclerosis but without subclinical hypothyroidism (ATH; n = 22)." "Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study" "Down-regulation of miR-125a-5p, miR-126-3p, miR-221-3p, and miR-222-3p may be a manifestation of atherosclerosis either in patients." "1308" "MID_1180" "22147268" "hsa-miR-17-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 3.714" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1309" "MID_1181" "22147268" "hsa-miR-191-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.9862" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1310" "MID_1182" "22147268" "hsa-miR-193a-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.6307" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1311" "MID_1183" "22147268" "hsa-miR-197-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.3636" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1312" "MID_1184" "22147268" "hsa-miR-199b-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7073" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1313" "MID_1185" "22147268" "hsa-miR-202-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.2536" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1314" "MID_1186" "22147268" "hsa-miR-20a-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray,, qRT-PCR" "Flod change: 1.8141" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1315" "MID_1187" "22147268" "hsa-miR-20a-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7044" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1316" "MID_1188" "22147268" "hsa-miR-212-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.5486" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1317" "MID_1189" "22147268" "hsa-miR-21-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 4.764" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "130" "MID_119" "27870587" "hsa-miR-126-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "NO" "Guangzhou, China, Asia" "12" "0" "12" "23-26" "serum, human umbilical vascular endothelial cells" "qRT-PCR " "NA" "Li, P et al. J Clin Endocrinol Metab. 2017" "NA" "NA" "17β-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis" "E2 upregulates miR-126-3p expression and promotes endothelial proliferation, migration, and tube formation and inhibits monocyte adhesion, and thus it may provide a beneficial effect against the development of atherosclerosis." "1318" "MID_1190" "28888871" "hsa-miR-214-3p" "microRNA" "Valvular heart disease" "up" "Treatment" "NO" "Peshawar, Pakistan, Asia" "50" "23" "27" "32.9(11.6)" "tissue" "qRT-PCR" "NA" "Jan, MI et al. Arch Biochem Biophys. 2017" "mean(SD)" "NA" "Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease" "MiR-214 targets anti-apoptotic ARC." "1319" "MID_1191" "22147268" "hsa-miR-21-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "54(8)/74(1)" "right atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.0131" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-RA-SR/VHD-RA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in right atrial." "1320" "MID_1192" "22147268" "hsa-miR-221-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6357" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1321" "MID_1193" "22147268" "hsa-miR-23a-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6226" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1322" "MID_1194" "22147268" "hsa-miR-26b-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5006" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1323" "MID_1195" "28888871" "hsa-miR-29a-3p" "microRNA" "Valvular heart disease" "down" "Treatment" "NO" "Peshawar, Pakistan, Asia" "50" "23" "27" "32.9(11.6)" "tissue" "qRT-PCR" "NA" "Jan, MI et al. Arch Biochem Biophys. 2017" "mean(SD)" "NA" "Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease" "Down regulation of miR-29a is linked with up regulation of PUMA and DRP1." "1324" "MID_1196" "22147268" "hsa-miR-301a-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6556" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1325" "MID_1197" "22147268" "hsa-miR-320a" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.793" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1326" "MID_1198" "22147268" "hsa-miR-324-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.0791" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1327" "MID_1199" "22147268" "hsa-miR-33b-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8077" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "12" "MID_12" "25933289" "hsa-miR-140-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Beijing, China, Asia" "16/90/377" "10/65/281" "6/25/96" "NA/NA/NA" "plasma" "Microarray, qRT-PCR" "Fold change=14.7, AUC=0.818, 95%CI: 0.762-0.873, P<0.001" "Li, X et al. PLoS One. 2015" "NA" "Microarrey/qRT-PCR cohort I/II" "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome" "Plasma miR-140-3p is potentially biomarkers for acute coronary syndrome." "131" "MID_120" "24848278" "hsa-miR-126-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "atherosclerosis/pre-atherosclerosis" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "1328" "MID_1200" "22147268" "hsa-miR-34b-5p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 3.1768" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1329" "MID_1201" "22147268" "hsa-miR-371a-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.9069" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1330" "MID_1202" "22147268" "hsa-miR-376a-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "54(8)/74(1)" "right atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5402" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-RA-SR/VHD-RA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in right atrial." "1331" "MID_1203" "22147268" "hsa-miR-376c-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "54(8)/74(1)" "right atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6797" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-RA-SR/VHD-RA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in right atrial." "1332" "MID_1204" "22147268" "hsa-miR-423-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5483" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1333" "MID_1205" "22147268" "hsa-miR-425-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7516" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1334" "MID_1206" "22147268" "hsa-miR-454-3p" "microRNA" "Valvular heart disease" "up" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8914" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1335" "MID_1207" "22147268" "hsa-miR-487b" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5819" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1336" "MID_1208" "22147268" "hsa-miR-490-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8668" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1337" "MID_1209" "22147268" "hsa-miR-490-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "54(8)/74(1)" "right atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7982" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-RA-SR/VHD-RA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in right atrial." "132" "MID_121" "24848278" "hsa-miR-126-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20/20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "atherosclerosis/pre-atherosclerosis" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "1338" "MID_1210" "22147268" "hsa-miR-550a-3p ; hsa-miR-550a-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5771" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1339" "MID_1211" "22147268" "hsa-miR-563" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.7139" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1340" "MID_1212" "22147268" "hsa-miR-602" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.5031" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1341" "MID_1213" "22147268" "hsa-miR-605" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.714" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1342" "MID_1214" "22147268" "hsa-miR-663a" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 2.8861" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1343" "MID_1215" "22147268" "hsa-miR-770-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.6918" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1344" "MID_1216" "22147268" "hsa-miR-886-3p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 5.8884" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1345" "MID_1217" "22147268" "hsa-miR-939-5p" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 3.1014" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "1346" "MID_1218" "22147268" "hsa-miR-940" "microRNA" "Valvular heart disease" "down" "Diagnosis" "NO" "Melbourne, Australia, Oceania" "4/7" "1/2" "3/5" "73(6)/74(2.5)" "left atrial tissue" "Microarray, qRT-PCR" "Flod change: 1.8519" "Cooley, N et al. Physiol Genomics. 2012" "mean(SEM)" "VHD-LA-SR/VHD-LA-AF" "Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease" "In valvular heart disease, the miRNA was different expression in left atrial." "133" "MID_122" "24517143" "hsa-miR-126-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jinan, China, Asia" "22/20/21/22" "5/3/3/4" "17/17/18/18" "45.27(1.55)/42.00(2.80)/47.95(2.35)/50.41(1.47)" "serum" "real-time PCR" "ROC curves for the ability of the six candidate serum miRNAs to differentiate the all SCH patients (SCH+ATH and SCH) from the cases (NC and ATH) miR-126-3p had the largest AUC: 0.888 (95% confidence interval 0.819-0.958)[subclinical hypothyroidism(SCH); a" "Zhang, X et al. J Clin Endocrinol Metlab. 2014" "mean(SEM) or raw numbers" "normal control subjects (NC; n = 22); patients with subclinical hypothyroidism alone (SCH; n = 20); SCH patients plus atherosclerosis (SCH+ATH; n = 21); and patients with atherosclerosis but without subclinical hypothyroidism (ATH; n = 22)." "Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study" "Down-regulation of miR-125a-5p, miR-126-3p, miR-221-3p, and miR-222-3p may be a manifestation of atherosclerosis either in patients. MiR-126-3p has the most specific expression patterns in all atherosclerosis patients." "134" "MID_123" "29203244" "hsa-miR-126-3p" "microRNA" "Atherosclerosis" "NA" "Treatment" "YES" "Changsha, China, Asia" "NA" "NA" "NA" "NA" "human umbilical vascular endothelial cells (HUVECs)" "Reverse transcription-quantitative polymerase chain reaction (RT-qPCR), MTT assay, Lactate dehydrogenase (LDH) release assays, Annexin V-FITC/Propidium Iodide (PI) assay, Hoechst 33258 staining, Western blot analysis" "P<0.05" "Tang, F et al. Biochem Biophys Res Commun. 2018" "mean(SD)" "NA" "MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway" "MiR-126 mimics alleviated ox-LDL-induced cytotoxicity and apoptosis in HUVECs, suggesting the miR-126 have potential therapeutic target on atherosclerosis." "135" "MID_124" "26159918" "hsa-miR-1273a" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Jinan, China, Asia" "3" "3" "0" "18-25" "tissue" "Fluorescent labeling, microarray hybridization, Real-time RT-PCR" "Average (ratio scale) 0.94; P-VALUE 0.032; Standard devition 0.503." "Wang, R et al. Biochem Biophys Res Commun. 2015" "NA" "NA" "Unique MicroRNA signatures associated with early coronary atherosclerotic plaques" "The study show that miR-1273 can serve as potential indicators in the detection of early atherosclerosis." "136" "MID_125" "24848278" "hsa-miR-130a-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "137" "MID_126" "24848278" "hsa-miR-130a-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "138" "MID_127" "20888330" "hsa-miR-130a-3p" "microRNA" "Arteriosclerosis obliterans" "up" "Diagnosis" "YES" "Beijing, China, Asia" "104" "NA" "NA" "NA" "serum" "real-time PCR" "NA" "Li, T et al. Clin Chim Acta. 2011" "mean(SD)" "NA" "Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans" "A significant difference in the levels of miR-130a was observed between stages 1 and 3 in arteriosclerosis obliterans, the serum levels of miR-130a may serve as potential biomarkers for diagnosis of early stage arteriosclerosis obliterans." "139" "MID_128" "26184978" "hsa-miR-135b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Jinan, China, Asia" "13" "NA" "NA" "NA" "serum, endothelial cells, vascular smooth muscle cells" "qRT-PCR, 3′-UTR Luciferase Reporter Assays" "2.7-fold increase in miR-135b-5p (P<0.0001) in atherosclerotic patients." "Xu, Z et al. Sci Rep. 2015" "mean(SD)" "NA" "MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C" "MiR-135b-5p regulation cell function by targeting MEF2 Cand could serve as a novel therapeutic target for atherosclerosis." "140" "MID_129" "25409743" "hsa-miR-136-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Harbin, China, Asia" "NA" "NA" "NA" "NA" "tissue, vascular smooth muscle cells, serum" "Quantitative Real-Time Reverse Transcription-PCR, Dual Luciferase Assays, Western blot analysis" "NA" "Zhang, CF et al. Curr Vasc Pharmacol. 2015" "mean(SD)" "NA" "MicroRNA-136 Promotes Vascular Muscle Cell Proliferation Through the ERK1/2 Pathway by Targeting PPP2R2A in Atherosclerosis." "The study also suggested that regulation of miR-136 in human vascular smooth muscle cells may provide a potential approach for the treatment of atherosclerosis." "13" "MID_13" "24461990" "hsa-miR-146a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50–76.00)/60.00(53.00–69.00)/54.00(46.00–79.75)/58.00(53.00–65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 2.49 (1.63-3.79); SCAD group 2.06 (1.33-3.18); Intermediate-risk group 1.61 (0.93-2.76); Low-risk group 2.39 (1.57-3.63);] Multivariate analyses: OR (95% CI): [ACS group 2.43 (1.37-4.32); SCAD group" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "It was indicated that these 4 serum miRNAs may be available as the novel and complementary biomarkers for cardiovascular risk stratification, further contributing to early implementation of medical treatment regimen and management strategies in individual" "141" "MID_130" "29949787" "hsa-miR-142-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Guangzhou, China, Asia" "NA" "NA" "NA" "NA" "human aortic endothelial cells" "qRT-PCR, Luciferase Assays" "NA" "Qin, B et al. Cell Physiol Biochem. 2018" "NA" "NA" "MicroRNA-142-3p Induces Atherosclerosis-Associated Endothelial Cell Apoptosis by Directly Targeting Rictor" "Down-regulation of miR-142-3p inhibited ECs apoptosis and atherosclerotic development by up-regulating the expression of Rictor and activating the Akt/eNOS signaling pathway." "142" "MID_131" "27775792" "hsa-miR-143-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Changchun, China, Asia" "NA" "NA" "NA" "NA" "tissue" "qRT-PCR" "NA" "Xu, RH et al. Eur Rev Med Pharmacol Sci. 2016" "NA" "NA" "MiR-143 is involved in endothelial cell dysfunction through suppression of glycolysis and correlated with atherosclerotic plaques formation" "MiR-143 was upregulated in clinical atherosclerotic plaque samples, suggesting that miR-143 might play important roles in the atherosclerotic plaque formation." "143" "MID_132" "22370758" "hsa-miR-143-MM2" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array、Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "144" "MID_133" "26992033" "hsa-miR-145-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Harbin, China, Asia" "11/42" "6/23" "5/19" "55.4(1.1)/50.7(1.7)" "tissue" "Immunohistochemistry, Real-time qPCR, Western blotting, miRNA inhibitor transduction, Cell proliferation analysis" "NA" "Zhang, YN et al. J Cell Mol Med.2016" "mean(SD)" "aortic dissection disease/coronary heart disease" "Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145" "This study demonstrate that miR-145 modulates the phenotypic switch of vascular smooth muscle cells from a contractile to a proliferative state via KLF5 and MYOCD and show that miR-145 inhibits human vascular smooth muscle cells proliferation in cells fro" "145" "MID_134" "29710501" "hsa-miR-145-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Jining, China, Asia" "NA" "NA" "NA" "NA" "monocytes" "RT-PCR, Luciferase assays" "NA" "Li, S et al. Biomed Pharmacother. 2018" "NA" "NA" "Microrna-145 accelerates the inflammatory reaction through activation of NF-κB signaling in atherosclerosis cells and mice" "MiR-145 accelerates the inflammatory reaction through activation of NF-KB signaling." "146" "MID_135" "21820659" "hsa-miR-146a-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Tempere, Finland, Europe" "18/50/38" "14/37/31" "4/13/7" "68/69/68" "tissue" "Microarray, qRT-PCR, Genome-wide expression (GWE) analysis " "Atherosclerotic arteries versus left internal thoracic arteries (p<0.001, fold changes 2.87). " "Raitoharju, E et al. Atherosclerosis. 2011 " "NA" "Microarray/qPCR/GWE" "MiR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study" "The miRNA are upregulated between human atherosclerotic plaques and control arteries, and involved in development connected to atherosclerosis." "147" "MID_136" "26875519" "hsa-miR-146a-5p SNP rs2910164" "microRNA" "Atherosclerotic cerebral infarction(ACI)" "down" "Diagnosis, Treatment" "YES" "Zhanjiang, China, Asia" "297" "177" "120" "62.6(8.63)" "blood" "real-time PCR" "Power analysis revealed that 93.2% power for rs2910164 to detect a genotype relative risk with an OR of 1.5 at a signifiance level of 0.05." "Zhong, H et al. J Atheroscler Thromb. 2017" "mean(SD)" "NA" "Apolipoprotein E Epsilon 4 Enhances the Association between the rs2910164 Polymorphism of miR-146a and Risk of Atherosclerotic Cerebral Infarction" "The findings indicated that the C allele of rs2910164 miR-146a is an important risk factor for acute cerebral infarction, and potential therapeutic target." "148" "MID_137" "26505665" "hsa-miR-146a-5p SNP rs2910164" "microRNA" "Type 2 diabetes mellitus with carotid vulnerable plaque risk" "NA" "Diagnosis" "NO" "Chongqing, China, Asia" "596/379" "336/204" "260/175" "66.12(10.00)/58.39(9.73)" "blood" "real-time PCR" "The increased risk of vulnerable plaque associated with the miR-146aCC genotype was confined to the older patients (GG+GC versus CC: AOR, 1.971, 95% CI, 1.156-3.361), females (GG+GC versus CC: AOR, 1.881, 95% CI, 1.039-3.408), those with a diabetes durati" "Shen, J et al. Thromb Res. 2015 " "NA" "type 2 diabetes mellitus patients with carotid atherosclerosis/without " "The relationship of miR-146a gene polymorphism with carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus" "The CC genotype of rs2910164 in miR-146a was associated with an increased risk of carotid vulnerable plaque in the Chinese type 2 diabetes mellitus patients but that this association was not present in the type 2 diabetes mellitus patients with carotid at" "149" "MID_138" "21820659" "hsa-miR-146b-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Tempere, Finland, Europe" "18/50/38" "14/37/31" "4/13/7" "68/69/68" "tissue" "Microarray, qRT-PCR, Genome-wide expression (GWE) analysis " "Atherosclerotic arteries versus left internal thoracic arteries (p<0.001, fold changes 2.82). " "Raitoharju, E et al. Atherosclerosis. 2011 " "NA" "Microarray/qPCR/GWE" "MiR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study" "The miRNA are upregulated between human atherosclerotic plaques and control arteries, and involved in development connected to atherosclerosis." "150" "MID_139" "22370758" "hsa-miR-147a" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "14" "MID_14" "27519051" "hsa-miR-146a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "151" "MID_140" "28254813" "hsa-miR-150-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Quebec, Canada, North America" "NA" "NA" "NA" "NA" "human umbilical vein endothelial cells" "qRT-PCR" "NA" "Desjarlais, M et al. Arterioscler Thromb Vasc Biol. 2017" "mean(SEM)" "NA" "MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions" "Reduced miR-150 expression contributes to reduce angiogenesis and ischemia-induced neovascularization in atherosclerotic conditions." "152" "MID_141" "22370758" "hsa-miR-152" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "153" "MID_142" "26899994" "hsa-miR-155-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "NO" "Wuhan, China, Asia" "70" "NA" "NA" "NA" "foam cells, tissue, plasma" "qRT-PCR, Western blot, Luciferase reporter assay" "NA" "Li, X et al. Sci Rep. 2016" "mean(SD)" "NA" "MiR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1" "Increased miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role during atherosclerosis-associated foam cell formation through the miR-155-CARHSP1-TNF-α pathway." "154" "MID_143" "26159918" "hsa-miR-155-5p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Jinan, China, Asia" "3" "3" "0" "18-25" "tissue" "Fluorescent labeling, microarray hybridization, Real-time RT-PCR" "Average (ratio scale) 2.113; P-VALUE 0.003; Standard devition 0.657." "Wang, R et al. Biochem Biophys Res Commun. 2015" "NA" "NA" "Unique MicroRNA signatures associated with early coronary atherosclerotic plaques" "The study shaw that miR-155 can serve as potential indicators in the detection of early atherosclerosis." "155" "MID_144" "22370758" "hsa-miR-15b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "156" "MID_145" "22370758" "hsa-miR-17-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "157" "MID_146" "26134369" "hsa-miR-17-5p" "microRNA" "Coronary atherosclerosis" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "33/59" "18/40" "15/19" "65.23(7.46)/65.07(10.55)" "plasma" "real-time PCR" "The ROC curve of miR-17-5p reflected strong separation between the CAD and non-CAD groups, with an area under curve (AUC) of 0.894 (95% confidence interval, 0.780-0.968)." "Chen, J et al. Int J Cardiol. 2015" "mean(SD)" "Non significant CAD/CAD" "MiR-17-5p as circulating biomarkers for the severity of coronary atherosclerosis in coronary artery disease" "The present study still provides the clinical evidence of circulating miR-17-5p as a promising predictor of severity of coronary atherosclerosis." "158" "MID_147" "27460740" "hsa-miR-181a-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Tianjin, China, Asia" "NA" "NA" "NA" "NA" "human umbilical vein endothelial cells, tissue" "qRT-PCR, Western blot" "NA" "Liu, G et al. Eur Rev Med Pharmacol Sci. 2016" "NA" "NA" "MicroRNA-181a is upregulated in human atherosclerosis plaques and involves in the oxidative stress-induced endothelial cell dysfunction through direct targeting Bcl-2" "MiR-181a could prevent the H2O2-induced human umbilical vein endothelial cells apoptosis, providing a mechanism for the treatment of atherosclerosis." "159" "MID_148" "22370758" "hsa-miR-181a-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "160" "MID_149" "26420120" "hsa-miR-181b-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Shanghai, China, Asia" "50" "NA" "NA" "78.1(8.9)" "serum" "RT-PCR " "The proliferation and migration of vascular smooth muscle cell were significantly downregulated by forced expression of miR-181b (1.57±0.18 vs. 2.66±0.16, P<0.05; 8.7±1.1 vs. 21.4±2.3, P<0.05), while these effects could be abolished by inhibition of miR-1" "Li, X et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2015" "NA" "NA" "Potential role of microRNA-181b on atherosclerosis" "MiR-181b may function as an atherosclerosis suppressor by interupting the NF-κB pathway in endothelial cells and inhibiting the proliferation and migration of vascular smooth muscle cells." "15" "MID_15" "21804579" "hsa-miR-155-5p" "microRNA" "Acute coronary syndrome" "down" "Diagnosis" "NO" "Wuhan, China, Asia" "62" "47" "15" "59(9)" "blood" "qRT-PCR" "NA" "Yao, R et al. Cell Mol Immunol. 2011" "mean(SD)" "NA" "The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome" "MiR-155 may be associated with Th17 cell differentiation." "161" "MID_150" "29136944" "hsa-miR-181b-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Kaifeng, China, Asia" "20" "12" "8" "50-70" "serum" "Luciferase activity assays, RNA immunoprecipitation (RIP) assays, CCK-8 assays, " "P<0.05" "Zhong, X et al. Biomed Pharmacother. 2018" "mean(SD)" "NA" "MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models" "MIAT promote atherosclerosis(AS) progression by modulating miR-181b, it may be employed as potential therapeutic target for atherosclerosis." "162" "MID_151" "27756793" "hsa-miR-181b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Bristol, England, Europe" "NA/NA" "NA/NA" "NA/NA" "56(2)/59(2)" "tissue" "Q-PCR, Luciferase reporter assays" "NA" "Di Gregoli, K et al. Circ Res. 2017" "mean(SEM)" "stable plaques/unstable plaques" "MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin" "MiR-181b expression in atherosclerotic plaques is higher, and it could serve as a therapeutic approach in atherosclerosis." "163" "MID_152" "22370758" "hsa-miR-185-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "164" "MID_153" "22370758" "hsa-miR-186-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "165" "MID_154" "27497158" "hsa-miR-19a-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Harbin, China, Asia" "20" "10" "10" "49-64" "peripheral blood mononuclear cells" "real-time RT-PCR" "negative correlation between IL-10 and miR-19a (r=-0.6544, p<0.01)" "Ren, ZQ et al. Cytokine. 2016" "NA" "NA" "Micro RNA-19a suppresses IL-10 in peripheral B cells from patients with atherosclerosis" "MiR-19a mediated the effect of proinflammatory cytokines on suppression IL-10 expression in peripheral B cells for atherosclerosis patients." "166" "MID_155" "27895035" "hsa-miR-210" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Stockholm, Sweden, Europe" "7/7" "NA/NA" "NA/NA" "NA/NA" "plasma" "qRT-PCR, In situ hybridization" "NA" "Eken,S M et al. Circ Res. 2017" "mean(SEM)" "discovery/validation cohort" "MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions" "MiR-210 contributes to stabilizing carotid plaques, ensuring smooth muscle cell survival, It can as a therapeutic approach for prevention of atherothrombotic vascular events." "167" "MID_156" "21820659" "hsa-miR-210" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Tempere, Finland, Europe" "18/50/38" "14/37/31" "4/13/7" "68/69/68" "tissue" "Microarray, qRT-PCR, Genome-wide expression (GWE) analysis " "Atherosclerotic arteries versus left internal thoracic arteries (p<0.001, fold changes 3.92). " "Raitoharju, E et al. Atherosclerosis. 2011 " "NA" "Microarray/qPCR/GWE" "MiR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study" "The miRNA are upregulated between human atherosclerotic plaques and control arteries, and involved in development connected to atherosclerosis." "168" "MID_157" "20888330" "hsa-miR-210" "microRNA" "Arteriosclerosis obliterans" "up" "Diagnosis" "YES" "Beijing, China, Asia" "104" "NA" "NA" "NA" "serum" "real-time PCR" "NA" "Li, T et al. Clin Chim Acta. 2011" "mean(SD)" "NA" "Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans" "The serum levels of miR-210 signifiantly increased, and it may serve as potential biomarkers for dignosis of early stage arteriosclerosis obliterans." "169" "MID_158" "26159918" "hsa-miR-211-5p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Jinan, China, Asia" "3" "3" "0" "18-25" "tissue" "Fluorescent labeling, microarray hybridization, Real-time RT-PCR" "Average (ratio scale) 1.772; P-VALUE 0.04; Standard devition 0.56." "Wang, R et al. Biochem Biophys Res Commun. 2015" "NA" "NA" "Unique MicroRNA signatures associated with early coronary atherosclerotic plaques" "The study shaw that miR-211 can serve as potential indicators in the detection of early atherosclerosis." "170" "MID_159" "24848278" "hsa-miR-211-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "16" "MID_16" "24530761" "hsa-miR-15a-5p" "microRNA" "Acute coronary syndrome" "down" "Diagnosis" "NO" "Beijing, China, Asia" "19" "19" "0" "NA" "blood" "real-time PCR" "miR-15a were decreased by 37% in ACS patients compared with controls (0.76±0.14 versus 1.21±0.14, P<0.05)" "Liu, X et al. Atherosclerosis. 2014" "NA" "NA" "Coactivator-associated arginine methyltransferase 1 targeted by miR-15a regulates inflammation in acute coronary syndrome" "CARM1 targeted by miR-15a played an important role in chemokine activation in the pathogenesis of acute coronary syndrome." "171" "MID_160" "28557988" "hsa-miR-212-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Daejeon, South korea, Asia" "32" "19" "13" "71.4(5.8)" "serum" "Microarray, Real-time RT-PCR" "AUC of MiR-212 is 0.6866, specificity is 81.8%, sensitivity is 46.9%, accracy is 64.6%; The AUC of Combination of HbA1c, lipoprotein(a), HDL-C, miR-212 is 0.8646, specificity is 87.9%, sensitivity is 81.3%, accracy is 84.6%." "Jeong, HS et al. PLoS One. 2017" "mean(SD)" "NA" "Synergy of circulating miR-212 with markers for cardiovascular risks to enhance estimation of atherosclerosis presence" "Circulating miR-212 as a marker of atherosclerosis." "172" "MID_161" "24848278" "hsa-miR-21-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "173" "MID_162" "21820659" "hsa-miR-21-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Tempere, Finland, Europe" "18/50/38" "14/37/31" "4/13/7" "68/69/68" "tissue" "Microarray, qRT-PCR, Genome-wide expression (GWE) analysis " "Atherosclerotic arteries versus left internal thoracic arteries (p<0.001, fold changes 4.61). " "Raitoharju, E et al. Atherosclerosis. 2011 " "NA" "Microarray/qPCR/GWE" "MiR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study" "The miRNA are upregulated between human atherosclerotic plaques and control arteries, and involved in development connected to atherosclerosis." "174" "MID_163" "30205366" "hsa-miR-21-5p rs145204276" "microRNA" "Atherosclerosis" "NA" "Treatment" "YES" "Chongqing, China, Asia" "681" "NA" "NA" "NA" "tissue" "real-time PCR, Luciferase Assays" "NA" "Shen, Z et al. Cell Physiol Biochem. 2018" "NA" "NA" "Association Between the Deletion Allele of Ins/Del Polymorphism (Rs145204276) in the Promoter Region of GAS5 with the Risk of Atherosclerosis" "Rs145204276 was associated with the risk of atherosclerosis by affecting the proliferation and apoptosis of endothelial cells via regulating the GAS5/miR-21/PDCD4 signaling pathway." "175" "MID_164" "24848278" "hsa-miR-21-5p, hsa-miR-126-3p with NT-pro-BNP 0r cTN-I" "microRNA" "Atherosclerosis" "NA" "Diagnosis" "YES" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood、serun" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Serum levels of NT-pro-BNP and cTN-I correlated with each other and increased with the progression of atherosclerosis. Moreover, the levels of cTN-I and NT-pro-BNP were positively correlated with miR-21 and negatively correlated with miR-126." "176" "MID_165" "29461880" "hsa-miR-217" "microRNA" "Atherosclerosis with hyperhomocysteinemia" "up" "Diagnosis, Prognosis" "YES" "Wuhan, China, Asia" "30/25" "20/15" "10/10" "49.00(5.47)/46.92(5.20)" "plasma" "Quantitative real-time PCR" "AUC=0.851, 95% CI,0.781-0.922, p<0.001" "Liu, K et al. DNA Cell Biol. 2018" "mean(SD)" "Hhcy+ATH/ATH" "Expression Profiles of Six Atherosclerosis-Associated microRNAs That Cluster in Patients with Hyperhomocysteinemia: A Clinical Study" "MiR-217 has a diagnostic value for Hhcy complicated with atherosclerosis, and may be helpful in predicting the progress of atherosclerosis in Hhcy patients." "177" "MID_166" "22370758" "hsa-miR-218-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "178" "MID_167" "22370758" "hsa-miR-220" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "179" "MID_168" "24517143" "hsa-miR-221-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jinan, China, Asia" "22/20/21/22" "5/3/3/4" "17/17/18/18" "45.27(1.55)/42.00(2.80)/47.95(2.35)/50.41(1.47)" "serum" "real-time PCR" "ROC curves for the ability of the six candidate serum miRNAs to differentiate the all SCH patients (SCH+ATH and SCH) from the cases (NC and ATH) miR-221-3p AUC: 0.859[subclinical hypothyroidism(SCH); atherosclerosis(ATH)]" "Zhang, X et al. J Clin Endocrinol Metlab. 2014" "mean(SEM) or raw numbers" "normal control subjects (NC; n = 22); patients with subclinical hypothyroidism alone (SCH; n = 20); SCH patients plus atherosclerosis (SCH+ATH; n = 21); and patients with atherosclerosis but without subclinical hypothyroidism (ATH; n = 22)." "Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study" "Down-regulation of miR-125a-5p, miR-126-3p, miR-221-3p, and miR-222-3p may be a manifestation of atherosclerosis either in patients." "180" "MID_169" "26451018" "hsa-miR-221-3p" "microRNA" "Atherosclerosis" "down" "Prognosis" "NO" "Los Angeles, USA, North America" "31/25/20" "19/18/13" "12/7/7" "68.2(2.9)/66.8(2.6)/64.5(5.30)" "vascular smooth muscle cells" "PCR assay" "Linear regression analysis demonstrated a direct correlation between expression of miR-221/222 and increasing time between carotid plaque rupture/acute neurologic symptom onset and the time when CEA occurred (R2=0.44, p<0.001 for miR-221 and R2=0.45, p<0." "Bazan, H A et al. Stroke. 2015" "mean(SEM)" "Asymptomatic(n=31)/Urgent(n=25)/Symptomatic(n=20)" "Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture" "Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder, suggesting an association between these miRNAs and atherosclerotic plaque stability." "17" "MID_17" "29350392" "hsa-miR-16-5p" "microRNA" "Acute coronary syndrome" "down" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is downregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "181" "MID_170" "29695561" "hsa-miR-221-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Istanbul, Turkey, Asia" "89" "NA" "NA" "58.97(13.79)" "serum" "Real-time PCR" "AUC=0.623, p=0.0086" "Yilmaz, SG et al. In Vivo. 2018" "mean(SD)" "NA" "Circulating microRNAs as Novel Biomarkers for Atherosclerosis" "MiRNA-221could be convenient biomarkers for diagnosis of atherosclerosis." "182" "MID_171" "26451018" "hsa-miR-222-3p" "microRNA" "Atherosclerosis" "down" "Prognosis" "NO" "Los Angeles, USA, North America" "31/25/20" "19/18/13" "12/7/7" "68.2(2.9)/66.8(2.6)/64.5(5.30)" "vascular smooth muscle cells" "PCR assay" "Linear regression analysis demonstrated a direct correlation between expression of miR-221/222 and increasing time between carotid plaque rupture/acute neurologic symptom onset and the time when CEA occurred (R2=0.44, p<0.001 for miR-221 and R2=0.45, p<0." "Bazan, H A et al. Stroke. 2015" "mean(SEM)" "Asymptomatic(n=31)/Urgent(n=25)/Symptomatic(n=20)" "Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture" "Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder, suggesting an association between these miRNAs and atherosclerotic plaque stability." "183" "MID_172" "24848278" "hsa-miR-222-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "184" "MID_173" "24848278" "hsa-miR-222-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "185" "MID_174" "24517143" "hsa-miR-222-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jinan, China, Asia" "22/20/21/22" "5/3/3/4" "17/17/18/18" "45.27(1.55)/42.00(2.80)/47.95(2.35)/50.41(1.47)" "serum" "real-time PCR" "ROC curves for the ability of the six candidate serum miRNAs to differentiate the all SCH patients (SCH+ATH and SCH) from the cases (NC and ATH) miR-222-3p AUC: 0.851[subclinical hypothyroidism(SCH); atherosclerosis(ATH)]" "Zhang, X et al. J Clin Endocrinol Metlab. 2014" "mean(SEM) or raw numbers" "normal control subjects (NC; n = 22); patients with subclinical hypothyroidism alone (SCH; n = 20); SCH patients plus atherosclerosis (SCH+ATH; n = 21); and patients with atherosclerosis but without subclinical hypothyroidism (ATH; n = 22)." "Expression profiles of six circulating microRNAs critical to atherosclerosis in patients with subclinical hypothyroidism: a clinical study" "Down-regulation of miR-125a-5p, miR-126-3p, miR-221-3p, and miR-222-3p may be a manifestation of atherosclerosis either in patients." "186" "MID_175" "29695561" "hsa-miR-222-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Istanbul, Turkey, Asia" "89" "NA" "NA" "58.97(13.79)" "serum" "Real-time PCR" "AUC=0.654, p=0.0006" "Yilmaz, SG et al. In Vivo. 2018" "mean(SD)" "NA" "Circulating microRNAs as Novel Biomarkers for Atherosclerosis" "MiRNA-222could be convenient biomarkers for diagnosis of atherosclerosis." "187" "MID_176" "28683362" "hsa-miR-223-3p" "microRNA" "Atherosclerotic cerebral infarction" "up" "Diagnosis, Treatment" "NO" "Changsha, China, Asia" "23" "17" "6" "62.6(11.5)" "blood" "Reverse transcription and real-time quantitative PCR" "Li, Z et al. Atherosclerosis. 2017" "mean(SEM)" "NA" "Promoter hypomethylation of microRNA223 gene is associated with atherosclerotic cerebral infarction" "Hypomethylation of MIR-223 promoter in atherosclerotic cerebral infarction(ACI) patients may lead to high expression of miR-223, and the latter exerts a protective effect on the occurrence of ACI." "188" "MID_177" "29250154" "hsa-miR-24-3p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Cangzhou, China, Asia" "30" "20" "10" "60-70" "blood" "RT-qPCR, Dual luciferase reporter assay" "NA" "Zheng, Y et al. Exp Ther Med. 2018" "age range" "NA" "MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-α3 and regulating inflammatory responses" "MiR-24 inhibits the proliferation and migration of endothelial cells by targeting importin-α3 and regulating inflammatory responses in endothelial cells." "189" "MID_178" "25801675" "hsa-miR-26a-5p" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Harbin, China, Asia" "NA" "NA" "NA" "NA" "human aortic endothelial cells" "Real-time RT-PCR, Western blotting, Immunofluorescence, MTT assay and TUNEL staining" "NA" "Zhang, Y et al. Sci Rep. 2015" "mean(SEM)" "NA" "MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis." "Overexpression of miR-26a inhibit endothelial cell apoptosis through targeting TRPC6." "190" "MID_179" "22370758" "hsa-miR-26b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "18" "MID_18" "24461990" "hsa-miR-186-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50–76.00)/60.00(53.00–69.00)/54.00(46.00–79.75)/58.00(53.00–65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 22.29 (10.53-47.21); SCAD group 21.04 (9.93-44.54); Intermediate-risk group 9.96 (4.47-22.19); Low-risk group 4.12 (2.01-8.44);] Multivariate analyses: OR (95% CI): [ACS group 82.12 (22.77-269.11" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "It was indicated that these 4 serum miRNAs may be available as the novel and complementary biomarkers for cardiovascular risk stratification, further contributing to early implementation of medical treatment regimen and management strategies in individual" "191" "MID_180" "20888330" "hsa-miR-27b-3p " "microRNA" "Arteriosclerosis obliterans" "up" "Diagnosis" "YES" "Beijing, China, Asia" "104" "NA" "NA" "NA" "serum" "real-time PCR" "NA" "Li, T et al. Clin Chim Acta. 2011" "mean(SD)" "NA" "Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans" "MiR-27b, the levels in stage 3 were significantly higher than that in stage 1 or 2, the serum levels of miR-27b may serve as potential biomarkers for diagnosis early stage arteriosclerosis obliterans." "192" "MID_181" "28250354" "hsa-miR-29a-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Guangzhou, China, Asia" "85" "41" "44" "52.34(5.68) " "plasma" "RT-qPCR" "P value: 0.004; OP: 1.136; 95%CI: 1.042-1.240" "Liu, CZ et al. Tohoku J Exp Med. 2017" "mean(SD)" "NA" "Elevated Plasma miR-29a Levels Are Associated with Increased Carotid Intima-Media Thickness in Atherosclerosis Patients" "Higher plasma miR-29a levels may increase the risk for atherosclerosis, We found that plasma miR-29a were associated with carotid intima-media thickness(cIMT), which were related to atherosclerosis." "193" "MID_182" "29197872" "hsa-miR-29b-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Ghangzhou, China, Asia" "85" "41" "44" "50.48(5.78)" "plasma" "S-Poly (T) RT-qPCR" "AUC=0.867, sensitivity=92.2%, specificity=81.2%" "Huang, YQ et al. Cell Physiol Biochem. 2017" "mean(SD)" "NA" "The Association of Circulating MiR-29b and Interleukin-6 with Subclinical Atherosclerosis" "Upregulation of circulating miR-29b may serve as new biomarkers for subclinical or clinical atherosclerosis." "194" "MID_183" "30308507" "hsa-miR-29c-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Guangzhou, China, Asia" "85" "41" "44" "50.48(5.78)" "plasma" "quantitative real-time PCR" "AUC=0.870; 95%CI: 0.818-0.922; sensitivity=96.3%, specificity=56.9%; p<0.001" "Huang, YQ et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis" "Increased miR-29c may serve as a biomarker for identifying atherosclerotic patients." "195" "MID_184" "27379414" "hsa-miR-30" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Guangzhou, China, Asia" "26" "15" "11" "46.23(4.88)" "plasma" "RT-qPCR" "We observed lower expression level of miR-30 (25.09±1.84 vs. 27.81±2.37; p<0.001) in iCIMT group compared with nCIMT(carotid intima-media thickness)group" "Huang, Y et al. Clin Exp Hypertens. 2016" "mean(SD)" "NA" "Circulating miR-30 is related to carotid artery atherosclerosis" "MiR-30 may be a biomarker of diagnosis for atherosclerosis patients." "196" "MID_185" "29016810" "hsa-miR-30c-5p" "microRNA" "Atherosclerosis" "down" "Diagnosis, Treatment" "YES" "Milan, Italy, Europe" "53/46" "22/16" "31/30" "63.3(1.2)/66.7(1.1)" "plasma" "qRT-PCR" "AUC=0.90, Sensitivity=0.89, Specificity=0.83" "Ceolotto, G et al. Cardiovasc Res. 2017" "NA" "No plaque/Plaque" "MiR-30c-5p regulates macrophage-mediated inflammation and pro-atherosclerosis pathways" "Reduction of miR-30c-5p is a promoter of early atherosclerosis, stimulation of miR-30c-5p is a candidate direct antiatherosclerotic therapy." "197" "MID_186" "22370758" "hsa-miR-30e-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "198" "MID_187" "29442044" "hsa-miR-3188" "microRNA" "Atherosclerosis" "down" "Diagnosis, Treatment" "YES" "Shijiazhuang, China, Asia" "45" "25" "20" "55.63(5.72)" "plasma" "Luciferase Reporter Assay, Quantitative RT-PCR" "NA" "Li, N et al. Pharmazie. 2017" "mean(SD)" "NA" "MicroRNA-3188 targets ETS-domain protein 4 and participates in RhoA/ROCK pathway to regulate the development of atherosclerosis" "MiR-3188 may serve as a target for atherosclerosis treatment." "199" "MID_188" "27460454" "hsa-miR-320b" "microRNA" "Carotid atherosclerosis" "down" "Diagnosis" "YES" "Tianjin, China, Asia" "177/332" "NA/NA" "NA/NA" "65.64(11.02)/NA" "serum" "Microarray, real-time PCR" "The receiver operating characteristics (ROC) showed that the area under the ROC curve of miR-320b was 0.565; P=0.144; 95%CI lower=0.479, upper=0.650; miR-320b+Traditional risk factors: ROC=0.834, P=0.000,95% CI lower=0.765, upper=0.903." "Zhang, R et al. J Clin Neurosci.2016" "mean(SD)" "NA" "Low serum miR-320b expression as a novel indicator of carotid atherosclerosis" "Overall, this study showed that miR-320b is a specific and reliable serum biomarker for predicting the risk of atherosclerosis and ischemic cerebrovascular diseases." "200" "MID_189" "27664032" "hsa-miR-33a-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Seoul, South Korea, Asia" "54" "NA" "NA" "NA" "plasma" "RT-PCR" "Area under curves and 95 % CIs for miR-33a was 0.82 (0.70-0.94), 0.79 (0.66-0.91),In the ROC analysis for miR-33a, sensitivity, specificity, positive predictive value, negative predictive value, and odds ratio to detect atherosclerosis were 66.7, 86.1, 70" "Kim,S H et al. Mol Biol Rep. 2017" "mean(SD)" "NA" "Aberrant expression of plasma microRNA-33a in an atherosclerosis-risk group" "The plasma levels of miR-33a were significantly increased in athero-risk group,Accordingly, plasma miR-33a can be a candidate biomarker for the early detection of atherosclerosis." "19" "MID_19" "26720041" "hsa-miR-197-3p" "microRNA" "Acute coronary syndrome, Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "533/340" "424/276" "109/64" "64/63" "serum" "RT-qPCR" "MiRNA-197: hazard ratio (HR) 1.77 per one standard deviation(SD) increase(95% confidence interval(CI) 1.20; 2.60), p=0.004, C-index 0.78; " "Schulte, C et al. PLoS One. 2015" "mean(SD)" "CAD: stable angina pectoris/acute coronary syndrome " "MiRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease" "Serum-derived circulating miRNA-197 were identified as predictors for cardiovascular death in a large patients with coronary artery disease." "201" "MID_190" "25445880" "hsa-miR-33b-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Chieti, Italy, Europe " "16" "12" "4" "75.6(8.0)" "atherosclerotic plaques " "RT-PCR, Western blot" "Fold change:3.3-fold, p=0.002" "Mandolini, C et al. Nutr Metab Cardiovasc Dis. 2015" "NA" "Hypercholesterolemic Group" "Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques" "The identification miR-33b as key regulators of ABCA1 protein expression in human atherosclerotic plaques, can be a therapeutic target." "202" "MID_191" "21820659" "hsa-miR-34a-5p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "NO" "Tempere, Finland, Europe" "18/50/38" "14/37/31" "4/13/7" "68/69/68" "tissue" "Microarray, qRT-PCR, Genome-wide expression (GWE) analysis " "Atherosclerotic arteries versus left internal thoracic arteries (p<0.001, fold changes 2.55). " "Raitoharju, E et al. Atherosclerosis. 2011 " "NA" "Microarray/qPCR/GWE" "MiR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study" "The miRNA are upregulated between human atherosclerotic plaques and control arteries, and involved in development connected to atherosclerosis." "203" "MID_192" "29328474" "hsa-miR-34a-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Hangzhou, China, Asia" "NA" "NA" "NA" "NA" "human aortic endothelial cells, tissue" "RNA extraction and reverse transcription?quantitative PCR, Luciferase reporter assay" "NA" "Li, Y et al. Mol Med Rep. 2018" "NA" "NA" "Inhibition of miR?34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis" "MiR-34a inhibition could promote the proliferation and induce apoptosis of endothelial cells through targeting HDAC1." "204" "MID_193" "28890348" "hsa-miR-362-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis, Treatment" "YES" "Chongqing, China, Asia" "110" "66" "44" "66.96(9.98)" "plasma" "Quantitative real-time PCR, Dual-luciferase reporter assay" "NA" "Li, M et al. Biochem Biophys Res Commun. 2017" "mean(SD)" "NA" "MiR-362-3p inhibits the proliferation and migration of vascular smooth muscle cells in atherosclerosis by targeting ADAMTS1" "Upregulation of miR-362-3p suppressed the vascular smooth muscle cell proliferation, may be have therapeutic and diagnostic value for the treatment of atherosclerosis." "205" "MID_194" "28051250" "hsa-miR-365a-3p" "microRNA" "Coronary atherosclerosis" "down" "Diagnosis" "NO" "Zhengzhou, China, Asia" "38" "21" "17" "65" "tissue、blood" "qRT-PCR, Western blot" "MiR-365 expression was significantly down-regulated in coronary plaque, serum, and blood monocytes when compared with control samples (p<0.05). " "Lin, B et al. Eur Rev Med Pharmacol Sci. 2016" "mean(SD)" "NA" "MiR-365 participates in coronary atherosclerosis through regulating IL-6" "MiR-365 expression was significantly down-regulated in blood and tissue, involved in atherosclerosis by targeting IL-6." "206" "MID_195" "24848278" "hsa-miR-370" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "207" "MID_196" "22370758" "hsa-miR-378a-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "208" "MID_197" "22370758" "hsa-miR-422a" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "209" "MID_198" "22370758" "hsa-miR-489" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "210" "MID_199" "23257658" "hsa-miR-491-5p SNP rs1056629" "microRNA" "Atherosclerotic cerebral infarction" "NA" "Diagnosis" "NO" "Changsha, China, Asia" "340" "207" "133" "60.96(10.82)" "blood" "RT-PCR" "NA" "Yuan, M et al. Atherosclerosis. 2013" "mean(SD)" "NA" "A functional polymorphism at miR-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population" "The miR-491-5p rs1056629A→C variation contributes to an increased risk of atherosclerotic cerebral infarction by increasing Matrix metalloproteinases 9(MMP-9) expression through affecting binding of miR-491 to the polymorphic site in the 3'-UTR of MMP-9." "2" "MID_2" "25933289" "hsa-miR-122-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Beijing, China, Asia" "16/90/377" "10/65/281" "6/25/96" "NA/NA/NA" "plasma" "Microarray, qRT-PCR" "Fold change=20.7, AUC=0.838, 95%CI: 0.787-0.89, P<0.001" "Li, X et al. PLoS One. 2015" "NA" "Microarrey/qRT-PCR cohort I/II" "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome" "Plasma miR-122 is potentially novel biomarkers for acute coronary syndrome." "20" "MID_20" "24461990" "hsa-miR-208b" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50–76.00)/60.00(53.00–69.00)/54.00(46.00–79.75)/58.00(53.00–65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 3.35 (2.18-5.13); SCAD group 3.28 (2.14-5.03); Intermediate-risk group 2.79 (1.77-4.12); Low-risk group 1.67 (1.06-2.63);] Multivariate analyses: OR (95% CI): [ACS group 5.85 (2.79-12.28); SCAD grou" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "MiR-208b and miR-499 may not only be considered as potential biomarkers in the diagnosis of cardiovascular disease but may also be associated with the presence and severity of coronary atherosclerosis." "211" "MID_200" "26583674" "hsa-miR-494" "microRNA" "Atherosclerosis" "up" "Treatment" "NO" "Leiden, The Netherlands, Europe" "NA" "NA" "NA" "NA" "tissue" "cDNA synthesis, qPCR" "NA" "Wezel, A et al. Ann Surg. 2015" "NA" "NA" "Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability" "Inhibition of miR-494 can decrease the risk of carotid artery atherosclerotic lesion and elevate the plaque stability." "212" "MID_201" "26184978" "hsa-miR-499a-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Jinan, China, Asia" "13" "NA" "NA" "NA" "serum, endothelial cells, vascular smooth muscle cells" "qRT-PCR, 3′-UTR Luciferase Reporter Assays" "9.7-fold increase in miR-499a-3p (P<0.0001)" "Xu, Z et al. Sci Rep. 2015" "mean(SD)" "NA" "MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C" "MiR-499a-3p regulation cell function by targeting MEF2Cand could serve as a novel therapeutic target for atherosclerosis." "213" "MID_202" "22370758" "hsa-miR-520b" "microRNA" "Atherosclerosis" "down" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "214" "MID_203" "22370758" "hsa-miR-524-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "215" "MID_204" "29419680" "hsa-miR-664a-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "YES" "Beijing, China, Asia" "92" "70" "22" "48.63(11.94)" "serum" "RT-qPCR assay" "NA" "Li, K et al. Medicine (Baltimore). 2018" "mean(SEM)" "3 groups:obstructive sleep apnea, obstructive sleep apnea and carotid intima-media thickness, carotid intima-media thickness" "MiR-664a-3p expression in patients with obstructive sleep apnea: A potential marker of atherosclerosis" "MiR-664a-3p has possible role in the pathogenesis of atherosclerosis in obstructive sleep apnea patients and as a noninvasive marker." "216" "MID_205" "25445880" "hsa-miR-758-3p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Chieti, Italy, Europe " "16" "14" "4" "75.6(8.0)" "atherosclerotic plaques " "RT-PCR, Western blot" "Fold change: 4.6-fold, p<0.001" "Mandolini, C et al. Nutr Metab Cardiovasc Dis. 2015" "NA" "Hypercholesterolemic Group" "Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques" "The identification miR-758 as key regulators of ABCA1 protein expression in human atherosclerotic plaques, can be a therapeutic target." "217" "MID_206" "24848278" "hsa-miR-92a-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and/or diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "218" "MID_207" "24848278" "hsa-miR-92a-3p" "microRNA" "Atherosclerosis" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." "219" "MID_208" "27629245" "hsa-miR-92a-3p" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Ghangzhou, China, Asia" "60/60/60/60" "32/28/34/32" "28/32/26/28" "49.65(5.79)/50.65(6.01)/50.00((5.74)/51.08(4.69)" "plasma" "real-time reverse transcription PCR" "NA" "Huang, Y et al. J Hum Hypertens. 2017" "mean(SD)" "hypertensive patients with normal carotid intima-media thickness(nCIMT)/healthy volunteers with increased CIMT (iCIMT)/hypertensive patients with normal nCIMT/hypertensive patients with increased CIMT(iCIMT)/" "Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis" "Circulating miR-92a represents a potential noninvasive atherosclerosis marker in essential hypertensive patients." "220" "MID_209" "22370758" "hsa-miR-98-5p" "microRNA" "Atherosclerosis" "up" "Treatment" "YES" "Munich, Germany, Europe" "10" "NA" "NA" "NA" "tissue" "Chip array, Reverse transcription-PCR and real time-PCR" "NA" "Bidzhekov, K et al. Thromb Haemost. 2012" "NA" "NA" "MicroRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans" "This study found some candidate miRNAs, which may facilitate understanding of monocyte recruitment and fate during atherosclerosis, and may serve as therapeutic targets for treating inflammatory vascular diseases." "21" "MID_21" "29350392" "hsa-miR-208b-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is upregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "221" "MID_210" "25728006" "N1" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Beijing, China, Asia" "15/80" "NA" "NA" "NA" "serum" "qRT-PCR" "N1 had an area under curve (AUC) of 0.811 (95% confidence interval 0.743-0.880) for AS." "Sun, Q et al. Exp Cell Res. 2015" "mean(SEM)" "Experiment/Validate" "Identification and characterization of novel serum microRNAs in unstable angina pectoris and subclinical atherosclerotic patients" "N1 was differentially expressed in atherosclerosis patients, may be new biomarkers for atherosclerosis." "222" "MID_211" "25728006" "N3" "microRNA" "Atherosclerosis" "up" "Diagnosis" "YES" "Beijing, China, Asia" "15/80" "NA" "NA" "NA" "serum" "qRT-PCR" "AUC=0.748(95% confidence interval 0.664-0.833) for AS." "Sun, Q et al. Exp Cell Res. 2015" "mean(SEM)" "Experiment/Validate" "Identification and characterization of novel serum microRNAs in unstable angina pectoris and subclinical atherosclerotic patients" "N3 was differentially expressed in atherosclerosis patients, may be new biomarkers for atherosclerosis." "223" "MID_212" "28674224" "pre-miR-146a rs2910164" "microRNA" "Atherosclerosis" "NA" "Diagnosis" "YES" "Istanbul, Turkey, Asia" "150" "108" "42" "68.01" "blood" "PCR" "NA" "Oner, T et al. J Genet. 2017" "NA" "NA" "Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis" "The GG genotype and G allele of mir-146a rs2910164 have an increase risk for susceptibility to atherosclerosis, and the model (GG/CC+CG) is also found to be a risk factor for atherosclerotic patients." "224" "MID_213" "28674224" "pre-miR-499 rs3746444" "microRNA" "Atherosclerosis" "NA" "Diagnosis" "YES" "Istanbul, Turkey, Asia" "150" "108" "42" "68.01" "blood" "PCR" "NA" "Oner, T et al. J Genet. 2017" "NA" "NA" "Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis" "Pre-miR-499 rs3746444 may represent novel markers of atherosclerotic susceptibility." "225" "MID_214" "21325063" "hsa-miR-1202" "microRNA" "Atrial fibrillation" "up" "Diagnosis" "NO" "Shanghai, China, Asia" "9/4" "2/0" "7/4" "19-55/19-46" "tissue" "Microarray, qRT-PCR" "Flod change: 2.455, P=0.011" "Xiao, J et al. Physiol Genomics. 2011" "NA" "mitral stenosis with atrial fibrillation/mitral stenosis without atrial fibrillation" "MicroRNA expression signature in atrial fibrillation with mitral stenosis" "MiR-1202 was upregulated in atrial fibrillation patients." "226" "MID_215" "26313139" "hsa-miR-126-3p" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "YES" "Laiwu, China, Asia" "35" "18" "17" "65.62(12.72)" "serum" "RNA extraction and quantitative real-time PCR" "MiR-126 level (fold change)AF group(n=35) 3.35±0.67; Control group (n=32):11.44±2.95" "Wei, XJ et al. Braz J Med Biol Res. 2015" "mean(SD)" "NA" "Biological significance of miR-126 expression in atrial fibrillation and heart failure" "Serum miR-126 levels could serve as a potential candidate biomarker for evaluating the severity of atrial fibrillation." "227" "MID_216" "28731126" "hsa-miR-132-3p" "microRNA" "Atrial fibrillation" "down" "Treatment" "NO" "Zhengzhou, China, Asia" "6" "3" "3" "59.47(5.34)" "tissue" "RT-qPCR, Luciferase reporter assay" "NA" "Qiao, G et al. Mol Med Rep. 2017" "mean(SD)" "NA" "MiR132 in atrial fibrillation directly targets connective tissue growth factor" "MiR-132 was decreased in patients with atrial fibrillation, and it upregulated in Ang II?treated cardiac fibroblasts." "228" "MID_217" "21325063" "hsa-miR-143-5p" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "NO" "Shanghai, China, Asia" "9/4" "2/0" "7/4" "19-55/19-46" "tissue" "Microarray, qRT-PCR" "Flod change: 1.960, P=0.004" "Xiao, J et al. Physiol Genomics. 2011" "NA" "mitral stenosis with atrial fibrillation/mitral stenosis without atrial fibrillation" "MicroRNA expression signature in atrial fibrillation with mitral stenosis" "MiR-143* was downregulated in atrial fibrillation patients." "229" "MID_218" "25008481" "hsa-miR-146a-5p SNP rs2431697" "microRNA" "Anticoagulated atrial fibrillation" "NA" "Prognosis" "YES" "Murcia, Spain, Europe" "901" "440" "461" "76(70-81)" "blood" "Real-time PCR" "In the multivariate analysis, rs2431697 TT genotype [HR: 1.64 (1.09–2.47); p=0.017] remained significantly associated with ACE(adverse cardiovascular events). Similar results were obtained after adjusting for the CHA2DS2 -VASc score, whereby CHA2DS2 -VASc" "Roldan V et al. Thromb Haemost. 2014" "mean(SD) or median" "NA" "Prognostic role of MIR146A polymorphisms for cardiovascular events in atrial fibrillation" "MIR146A rs2431697 genotype is an indicator of ACE in atrial fibrillation anticoagulated patients in the medium term after starting therapy. " "230" "MID_219" "25617731" "hsa-miR-146b-5p" "microRNA" "Atrial fibrillation" "up" "Diagnosis" "NO" "Beijing, China, Asia" "30" "19" "11" "47.3(6.8)" "left atrial appendage" "Microarray, TaqMan Low Density Arrays Quantitative PCR, Quantitative Real-Time PCR, Dual Luciferase Reporter Gene Assay" "NA" "Wang, J et al. Heart Rhythm. 2015" "mean(SD)" "NA" "Integrated analysis of microRNA and mRNA expression profiles in the left atrium of patients with nonvalvular paroxysmal atrial fibrillation: Role of miR-146b-5p in atrial fibrosis" "Upregulation of miR-146b-5p leads to downregulation of TIMP-4, which in turn can activate MMP-9, resulting in increased collagen synthesis, which enhances atrial fibrosis." "22" "MID_22" "27357355" "hsa-miR-210" "microRNA" "Acute coronary syndrome" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "430" "349" "81" "63(55-68)" "serum" "RT-qPCR" "AUC=0.754" "Karakas, M et al. Eur Heart J. 2017" "NA" "acute coronary syndrome" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "231" "MID_220" "24462065" "hsa-miR-150-5p" "microRNA" "Atrial Fibrillation in Patients With Chronic Systolic Heart Failure" "down" "Prognosis" "NO" "Rehovot, Israel, Asia" "15/26" "14/21" "1/5" "67.4(10.2)/57.3(9.8)" "platelet, serum" "Microarray, polymerase chain reaction" "MiR-150 expression levels were 3.2-fold lower in platelets of patients with AF, with a p value of 0.0003 and area under the receiver operating characteristic curve of 0.83 " "Goren, Y et al. Am J Cardiol. 2014" "mean(SD)" "heart failure with and without atrial fibrillation " "Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure" "The demonstrated a clear and significant association between both lower circulating and lower platelet levels of miR-150 levels with atrial fibrillation in chronic systolic heart failure." "232" "MID_221" "25257092" "hsa-miR-150-5p" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "YES" "Worcester, United States of America, North America " "112" "73" "39" "60(11)" "tissue, plasma" "quantitative reverse transcriptase-polymerase chain reaction" "2-fold lower in patients, and it increased 3-fold after atrial fibrillation ablation in plasma" "McManus, DD et al. Heart Rhythm. 2015" "mean(SD)" "NA" "Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study)" "The miRNA can be markers of susceptibility to atrial fibrillation." "233" "MID_222" "25257092" "hsa-miR-21-5p" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "YES" "Worcester, United States of America, North America " "112" "73" "39" "60(11)" "tissue, plasma" "quantitative reverse transcriptase-polymerase chain reaction" "2-fold lower in patients, and it increased 3-fold after atrial fibrillation ablation in plasma" "McManus, DD et al. Heart Rhythm. 2015" "mean(SD)" "NA" "Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study)" "The miRNA can be markers of susceptibility to atrial fibrillation." "234" "MID_223" "24069193" "hsa-miR-21-5p" "microRNA" "Atrial fibrillation" "up" "Diagnosis, Treatment" "YES" "Osaka, Japan, Asia" "6/10" "4/6" "2/4" "70.0(5.2)/72.5(5.0)" "tissue" "Microarray, Reverse transcriptase-polymerase chain reaction" "3.3-fold in microarray, 1.9-fold in RT-PCR" "Nishi, H et al. PLoS One. 2013" "mean(SD)" "Preoperative atrial fibrillation group A/ B" "Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery" "MiRNA-21 expression in human atrial tissue is potentially associated with atrial fibrosis and might affect atrial fibrillation occurrence, which would indicate its potential usefulness as a biomarker for cardiac surgery management and targets for future c" "235" "MID_224" "27855199" "hsa-miR-3149" "microRNA" "Atrial fibrillation" "up" "Diagnosis" "YES" "Beijing, China, Asia" "90" "NA" "NA" "72.17(4.76)" "plasma" "microarray, real-time PCR" "Fold change: 2.346, P=0.0154" "Xu, G et al. PLoS One. 2016" "NA" "NA" "The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation" "The miRNA may be used as biomarkers for earlier diagnosis in atrial fibrillation patients." "236" "MID_225" "27855199" "hsa-miR-3171" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "YES" "Beijing, China, Asia" "90" "NA" "NA" "72.17(4.76)" "plasma" "microarray, real-time PCR" "Fold change: 0.21, P=0.0018" "Xu, G et al. PLoS One. 2016" "NA" "NA" "The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation" "The miRNA may be used as biomarkers for earlier diagnosis in atrial fibrillation patients." "237" "MID_226" "21098446" "hsa-miR-328" "microRNA" "Atrial fibrillation" "up" "Treatment" "YES" "Harbin, China, Asia" "NA" "NA" "NA" "NA" "tissue" "real-time RT-PCR" "Flod change: 3.5" "Lu, Y et al. Circulation. 2010" "NA" "NA" "MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation" "MiR-328 can as a potential therapeutic target for atrial fibrillation." "238" "MID_227" "24444445" "hsa-miR-328" "microRNA" "Atrial fibrillation" "down" "Diagnosis" "NO" "Framingham, United States of America, North America" "2445" "1076" "1369" "66.3(8.9)" "blood" "high-throughput quantitative reverse transcriptase polymerase chain reaction" "odds ratio (OR), 1.21; 95% confidence interval (CI), 1.09-1.33; P=0.00018" "McManus, DD et al. Heart Rhythm. 2014" "mean(SD)" "NA" "Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study" "MiR-328 promote atrial electrical remodeling by reducing L-type Ca(2+) channel density, is associated with prevalent atrial fibrillation." "239" "MID_228" "25782451" "hsa-miR-409-3p" "microRNA" "Atrial fibrillation" "down" "Diagnosis, Prognosis" "YES" "Guangdong, China, Asia" "100" "72" "28" "53.9(13.4)" "plasma" "Solexa sequencing, quantitative reverse transcription polymerase chain reaction" "MiR-409-3p is associated with atrial fibrillation, 95% CI: 1.02-2.22, P=0.040" "Liu, T et al. Europace. 2016" "mean(SD)" "NA" "Catheter ablation restores decreased plasma miR-409-3p and miR-432 in atrial fibrillation patients" "Plasma miR-409-3p is potential markers of atrial fibrillation, and catheter ablation restores their decreased levels in atrial fibrillation patients." "240" "MID_229" "25782451" "hsa-miR-432-5p" "microRNA" "Atrial fibrillation" "down" "Diagnosis, Prognosis" "YES" "Guangdong, China, Asia" "100" "72" "28" "53.9(13.4)" "plasma" "Solexa sequencing, quantitative reverse transcription polymerase chain reaction" "MiR-409-3p is associated with atrial fibrillation, 95% CI: 1.09-2.43, P=0.018" "Liu, T et al. Europace. 2016" "mean(SD)" "NA" "Catheter ablation restores decreased plasma miR-409-3p and miR-432 in atrial fibrillation patients" "Plasma miR-432 is potential markers of atrial fibrillation, and catheter ablation restores their decreased levels in atrial fibrillation patients." "23" "MID_23" "27590242" "hsa-miR-21-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Isfahan, Iran, Asia" "50" "32" "18" "63.16(1.66)" "serum" "Reverse transcription polymerase chain reaction" "AUC=0.775 (95 %CI 0.677-0.860, P<0.001)" "Darabi, F et al. Mol Cell Biochem. 2016" "mean(SEM)" "NA" "The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome" "Circulating miR-21 can as biomarkers for identifying patients with acute coronary syndrome." "241" "MID_230" "27855199" "hsa-miR-892a" "microRNA" "Atrial fibrillation" "up" "Diagnosis" "YES" "Beijing, China, Asia" "90" "NA" "NA" "72.17(4.76)" "plasma" "microarray, real-time PCR" "Fold change: 2.3182, P=0.0081" "Xu, G et al. PLoS One. 2016" "NA" "NA" "The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation" "The miRNA may be used as biomarkers for earlier diagnosis in atrial fibrillation patients." "242" "MID_231" "26209011" "miR-192-5p" "microRNA" "Atrial fibrillation" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "6" "1" "5" "53.3" "tissue" "qPCR, real-time quantitative RT-PCR analysis; ISH, in situ hybridization; Immunohis, immunohistochemical analysis" "Flod change: 3.9, P=0.020" "Zhao, Y et al. Biochim Biophys Acta. 2015" "mean" "NA" "Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p" "MiR-192-5p was up-regulated in atrial fibrillation patients, and miR-192-5p may be an attractive target for novel antiarrhythmia therapies for treating cardiac diseases." "253" "MID_232" "29335596" "hsa-let-7f-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.894" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "254" "MID_233" "29335596" "hsa-let-7g-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.874" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "255" "MID_234" "22041329" "hsa-let-7i-5p" "microRNA" "Dilated cardiomyopathy" "down" "Prognosis" "YES" "Iwate, Japan, Asia" "103" "74" "29" "57.1(11.4)" "tissue" "real-time RT-PCR" "Levels of let-7i in the myocardium were lower in the dilated cardiomyopathy group than in control subjects (let-7i: 0.40±0.31 vs 1.30±0.45;)" "Satoh, M et al. J Card Fail. 2011" "mean(SD)" "NA" "A cellular microRNA, let-7i, is a novel biomarker for clinical outcome in patients with dilated cardiomyopathy" "A decrease in let-7i may be related to poor clinical outcomes in patients with human dilated cardiomyopathy." "256" "MID_235" "18582896" "hsa-miR-100-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "NO" "Denver, USA, North America" "10" "NA" "NA" "NA" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "NA" "MiRNA expression in the failing human heart: functional correlates" "In conclusion, some miRNA expression patterns appear to be unique to the etiology of cardiomyopathy and changes in the expression level of miRs 100 and 133b contribute to regulation of the fetal gene program." "257" "MID_236" "18582896" "hsa-miR-100-5p" "microRNA" "Cardiomyopathy" "up" "Diagnosis" "NO" "Denver, USA, North America" "5/5" "NA/NA" "NA/NA" "12(3.1)/18.6(3.5)" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "idiopathic dilated cardiomyopathy/ischemic dilated cardiomyopathy" "MiRNA expression in the failing human heart: functional correlates" "The miRNA was upregulated in idiopathic dilated cardiomyopathy and ischemic dilated cardiomyopathy patients." "258" "MID_237" "20484156" "hsa-miR-107" "microRNA" "Ischemic cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "8/15" "7/13" "1/2" "66.1(2.0)/67.0(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by nonischemic dilated cardiomyopathy and ischemic cardiomyopathy patients versus control subjects, might have a " "259" "MID_238" "20484156" "hsa-miR-107" "microRNA" "Nonischemic dilated cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "7/19" "5/13" "1/2" "66.6(2.1)/63.8(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells derived from both nonischemic dilated cardiomyopathy and ischemic cardiomyopathy patients versus control subjects, suggesting a possible discrimination between healthy indivi" "260" "MID_239" "24083979" "hsa-miR-10a-3p" "microRNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:-3.0 [-1.4 to -2.9] ; p-Value：0.203； Fold change array [range±SD]： -7.9 [-2.4 to -26.7]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "24" "MID_24" "26720041" "hsa-miR-223-3p" "microRNA" "Acute coronary syndrome, Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "533/340" "424/276" "109/64" "64/63" "serum" "RT-qPCR" "MiRNA-223: HR 2.23 per one SD increase(1.20; 4.14), p=0.011, C-index 0.80)" "Schulte, C et al. PLoS One. 2015" "mean(SD)" "CAD: stable angina pectoris/acute coronary syndrome " "MiRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease" "Serum-derived circulating miRNA-223 were identified as predictors for cardiovascular death in a large patients with coronary artery disease." "261" "MID_240" "24083979" "hsa-miR-10b-3p" "microRNA" "Hypertrophic cardiomyopathy" "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:-4.1 [-1.4 to -12.6] ; p-Value：0.024； Fold change array [range±SD]：-2.7 [-1.8 to -4.2]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "262" "MID_241" "24083979" "hsa-miR-10b-5p" "microRNA" "Hypertrophic cardiomyopathy " "down" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:-2.1 [-1.3 to -3.3]; p-Value：0.048； Fold change array [range±SD]：-7.2 [-2.3 to -22.3]" "Kuster, DW et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "263" "MID_242" "23247724" "hsa-miR-124-5p" "microRNA" "Diabetic cardiomyopathy" "up" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 4.9- to 6.3-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-124-5p is highly upregulated in dilated cardiomyopathy patients." "264" "MID_243" "23247724" "hsa-miR-1246" "microRNA" "Diabetic cardiomyopathy" "up" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 4006- to 4724-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-1246 is highly upregulated in dilated cardiomyopathy patients." "265" "MID_244" "27307080" "hsa-miR-1251" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.978" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly increased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "266" "MID_245" "20484156" "hsa-miR-125b-5p" "microRNA" "Ischemic cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "8/15" "7/13" "1/2" "66.1(2.0)/67.0(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by ischemic cardiomyopathy patients versus control subjects, might have a potential diagnosis or prognosis of chr" "267" "MID_246" "29335596" "hsa-miR-126-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.950" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "268" "MID_247" "24161319" "hsa-miR-133a" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR" "AUC: 0.7114" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "269" "MID_248" "27922664" "hsa-miR-133a" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "miR?133a was significantly downregulated in the a pex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group (P<0.05, P<0.01, P<0.05)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "270" "MID_249" "27292200" "hsa-miR-133a" "microRNA" "Inflammatory cardiomyopathy" "up" "Treatment" "YES" "Leipzig, Germany, Europe" "76" "61" "15" "45(15)" "tissue" "real-time RT-PCR" "Besler, C et al. Eur J Heart Fail. 2016" "mean(SD)" "NA" "Endomyocardial miR-133a levels correlate with myocardial inflammation, improved left ventricular function, and clinical outcome in patients with inflammatory cardiomyopathy" "MiR-133a levels correlate with macrophage infiltration, cardiac injury, and clinical outcome in patients with inflammatory cardiomyopathy(ischemic cardiomyopathy), it may serve as a potential novel biomarker and therapeutic target in human ischemic cardio" "25" "MID_25" "27519051" "hsa-miR-223-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "271" "MID_250" "24910366" "hsa-miR-133a-2" "microRNA" "Chronic Chagas disease Cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "S?o Paulo, Brazil, South America" "10" "6" "4" "49.4" "tissue" "real-time reverse transcriptase (RT)-PCR" "NA" "Ferreira, LR et al. Int J Cardiol. 2014" "mean(SD)" "NA" "MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy" "These results suggest that miRNAs may play a major role in the regulation of gene expression in chronic chagas disease cardiomyopathy pathogenesis, with potential implication as diagnostic and prognostic tools." "272" "MID_251" "24910366" "hsa-miR-133b" "microRNA" "Chronic Chagas disease Cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "S?o Paulo, Brazil, South America" "10" "6" "4" "49.4" "tissue" "real-time reverse transcriptase (RT)-PCR" "NA" "Ferreira, LR et al. Int J Cardiol. 2014" "mean(SD)" "NA" "MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy" "These results suggest that miRNAs may play a major role in the regulation of gene expression in chronic chagas disease cardiomyopathy pathogenesis, with potential implication as diagnostic and prognostic tools." "273" "MID_252" "18582896" "hsa-miR-133b" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Denver, USA, North America" "10" "NA" "NA" "NA" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "NA" "MiRNA expression in the failing human heart: functional correlates" "In conclusion, some miRNA expression patterns appear to be unique to the etiology of cardiomyopathy and changes in the expression level of miRs 100 and 133b contribute to regulation of the fetal gene program." "274" "MID_253" "27922664" "hsa-miR-133b" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "miR?133b was significantly dpwnregulated in the apex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group (P<0.01,P<0.01, P<0.05)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "275" "MID_254" "18582896" "hsa-miR-133b" "microRNA" "Cardiomyopathy" "down" "Diagnosis" "NO" "Denver, USA, North America" "5/5" "NA/NA" "NA/NA" "12(3.1)/18.6(3.5)" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "idiopathic dilated cardiomyopathy/ischemic dilated cardiomyopathy" "MiRNA expression in the failing human heart: functional correlates" "The miRNA was downregulated in idiopathic dilated cardiomyopathy and ischemic dilated cardiomyopathy patients." "276" "MID_255" "25761932" "hsa-miR-135b-5p" "microRNA" "Enterovirus cardiomyopathy" "up(at progressive clinical deterioration (CVB3-PERS))" "Prognosis" "YES" "Berlin, Germany, Europe" "7/10" "5/13" "2/6" "50.2(7.3)/50.8(7.5)" "blood" "RT-PCR, Microarray" "Area under the curve was 0.880" "Kuehl, U et al. Circ Heart Fail. 2015" "mean(SD)" "CVB3-PERS Test/Validation" "Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy" "An immediate clinical application of the data is cardiac miR profiling to assess the risk of virus persistence and progressive clinical deterioration in CVB3 cardiomyopathy." "277" "MID_256" "27307080" "hsa-miR-135b-5p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.936" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly associated with both the myocardium adipose and fibrosis, which was a potential useful therapeutic targets for arrhythmogenic right ventricular cardiomyopathy." "278" "MID_257" "25791397" "hsa-miR-138-5p" "microRNA" "Cardiomyopathy" "up" "Diagnosis, Treatment" "YES" "Harbin, China, Asia" "78" "78" "0" "52.72(6.37)" "plasma" "microarray, real-time RT-PCR" "NA" "Jing, L et al. Cardiology. 2015" "mean(SD)" "NA" "Investigation of microRNA expression profiles associated with human alcoholic cardiomyopathy" "Specific miRNAs, such as miR-138, may be considered as a new target for the early diagnosis and treatment of human acute cardiomyopathy." "279" "MID_258" "27307080" "hsa-miR-138-5p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.758" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "280" "MID_259" "20484156" "hsa-miR-139-5p" "microRNA" "Ischemic cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "8/15" "7/13" "1/2" "66.1(2.0)/67.0(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by ischemic cardiomyopathy patients versus control subjects, might have a potential diagnosis or prognosis of chr" "26" "MID_26" "25124998" "hsa-miR-27b-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Auckland, New Zealand, Oceania" "18/17" "16/16" "2/1" "65.3(13.6)/65.2(13.4)" "plasma" "real-time quantitative PCR" "AUC=0.799, 95% CI:0.745-0.852" "Pilbrow, AP et al. Int J Cardiol. 2014" "mean(SD)" "Mild phenotype/Severe phenotype" "Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes" "Circulating levels of miR-323-3p were higher in acute coronary syndromes patients." "281" "MID_260" "20484156" "hsa-miR-139-5p" "microRNA" "Nonischemic dilated cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "7/19" "5/13" "1/2" "66.6(2.1)/63.8(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by nonischemic dilated cardiomyopathy patients versus control subjects, might have a potential diagnosis or progn" "282" "MID_261" "24910366" "hsa-miR-1-3p" "microRNA" "Chronic Chagas disease Cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "S?o Paulo, Brazil, South America" "10" "6" "4" "49.4" "tissue" "real-time reverse transcriptase (RT)-PCR" "Flod change: -6.39" "Ferreira, LR et al. Int J Cardiol. 2014" "mean(SD)" "NA" "MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy" "These results suggest that miRNAs may play a major role in the regulation of gene expression in chronic chagas disease cardiomyopathy pathogenesis, with potential implication as diagnostic and prognostic tools." "283" "MID_262" "24046434" "hsa-miR-1-3p, hsa-miR-16-5p, hsa-miR-26a-5p, hsa-miR-133a" "microRNA" "Takotsubo cardiomyopathy" "NA" "Diagnosis" "YES" "Zurich, Heidelberg, Gdansk, Lucerne, and Hannover" "36/27" "3/4" "33/23" "68.7(12.0)/67.1(7.4)" "plasma" "Microarray, qRT-PCR" "A unique signature comprising miR-1, miR-16, miR-26a, and miR-133a differentiated TTC from healthy subjects [area under the curve (AUC) 0.835, 95% CI 0.733-0.937, P<0.0001] and from ST-elevation myocardial infarction patients (AUC 0.881, 95% CI 0.793-0.96" "Jaguszewski, M et al. Eur Heart J. 2014" "mean(SD)" "Takotsubo cardiomyopathy/ST-segment elevation Acute myocardial infarction" "A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from Acute myocardial infarction" "The present study for the first time describes a signature of four circulating miRNAs as a robust biomarker to distinguish Takotsubo cardiomyopathy(TTC) from ST-elevation myocardial infarction patients." "284" "MID_263" "20484156" "hsa-miR-142-3p" "microRNA" "Nonischemic dilated cardiomyopathy" "up" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "7/19" "5/13" "1/2" "66.6(2.1)/63.8(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by nonischemic dilated cardiomyopathy patients versus control subjects, might have a potential diagnosis or progn" "285" "MID_264" "23247724" "hsa-miR-142-3p" "microRNA" "Diabetic cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 0.15- to 0.3-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-142-3p is downregulated in dilated cardiomyopathy patients." "286" "MID_265" "20484156" "hsa-miR-142-5p" "microRNA" "Nonischemic dilated cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "7/19" "5/13" "1/2" "66.6(2.1)/63.8(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by nonischemic dilated cardiomyopathy patients versus control subjects, might have a potential diagnosis or progn" "287" "MID_266" "20484156" "hsa-miR-142-5p" "microRNA" "Ischemic cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "8/15" "7/13" "1/2" "66.1(2.0)/67.0(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by ischemic cardiomyopathy patients versus control subjects, might have a potential diagnosis or prognosis of chr" "288" "MID_267" "29335596" "hsa-miR-142-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.983" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "289" "MID_268" "24161319" "hsa-miR-143-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR、2?ΔΔCt" "AUC: 0.8877" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "Twelve miRNAs (miR-27a, -199a-5p, -26a, -145, -133a, -143, -199a-3p, -126-3p, -29a, -155, -30a, and -21) were significantly increased in hypertrophic cardiomyopathy plasma." "290" "MID_269" "29335596" "hsa-miR-143-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.992" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "27" "MID_27" "25933289" "hsa-miR-2861" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Beijing, China, Asia" "16/90/377" "10/65/281" "6/25/96" "NA/NA/NA" "plasma" "Microarray, qRT-PCR" "Fold change=27.6, AUC=0.852, 95%CI: 0.806-0.899, P<0.001" "Li, X et al. PLoS One. 2015" "NA" "Microarrey/qRT-PCR cohort I/II" "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome" "Plasma miR-2861 is potentially biomarkers for acute coronary syndrome." "291" "MID_270" "24161319" "hsa-miR-145-5p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Milano, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR" "AUC: 0.8130" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "292" "MID_271" "23619365" "hsa-miR-146a-5p" "microRNA" "Peripartum cardiomyopathy" "up" "Treatment" "YES" "Liege, Belgium, Europe" "38" "NA" "NA" "NA" "plasma, tissue" "quantitative real-time PCR, microarray" "NA" "Halkein, J et al. J Clin Invest. 2013" "mean(SEM)" "NA" "MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy" "MiR-146a was elevated in the plasma and hearts of peripartum cardiomyopathy(PPCM) patients, miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM." "293" "MID_272" "26631154" "hsa-miR-147a" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold changge 2.76,p=0.052" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "294" "MID_273" "25840506" "hsa-miR-155-5p" "microRNA" "Pediatric dilated cardiomyopathy" "down(pre-transplant)" "Prognosis" "YES" "Colorado, USA, North America" "34" "21" "13" "6.5" "plasma" "Microarray, RT-PCR" "Pre-transplant: Area under the curve (any one miRNA=0.875; any two miRNAs=0.773; any three miRNAs=0.714; any four miRNAs=0.658); Day of transplant: Area under the curve (any one miRNA=1; any two miRNAs=0.929; any three miRNAs=0.8; any four miRNAs=0.7); Da" "Miyamoto, SD et al. J Heart Lung Transplant. 2015" "mean(SD)" "NA" "Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy" "The study demonstrate that in patients the miRNA are highly predictive of the need for transplant in the pediatric dilated cardiomyopathy population，may represent a novel biomarker of outcome in the pediatric dilated cardiomyopathy population." "295" "MID_274" "24083979" "hsa-miR-181a-2-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:2.4 [1.2 to 4.9]; p-Value：0.102； Fold change array [range±SD]：2.07 [1.7 to 2.6]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "296" "MID_275" "24083979" "hsa-miR-184" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:10.2 [2.9 to 36.3]; p-Value：0.002； Fold change array [range±SD]：5.5 [3.6 to 8.3]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "297" "MID_276" "27645404" "hsa-miR-185-5p" "microRNA" "Dilated cardiomyopathy" "up" "Prognosis, Treatment" "YES" "Wuhan, China, Asia" "22/24" "12/13" "10/11" "43(0.64)/46(0.61)" "plasma, peripheral blood mononuclear cells" "quantitative PCR" "NA" "Yu, M et al. Sci Rep. 2016" "mean(SEM)" "miR-185 high/low" "Circulating miR-185 might be a novel biomarker for clinical outcome in patients with dilated cardiomyopathy" "High miR-185 levels might be associated with a favorable prognosis by repressing B cell function in dilated cardiomyopathy." "298" "MID_277" "26404540" "hsa-miR-18a-5p, hsa-miR-30d-5p, hsa-miR-21-5p, hsa-miR-193-5p, hsa-miR-10b-5p, hsa-miR-15a-5p, hsa-miR-296-5p, hsa-miR-29a-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Prognosis" "YES" "Melbourne, Australia, Oceania" "28/27" "22/22" "6/5" "49.1(14.0)/49.9(10.8) " "plasma" "microarray, real-time PCR" "ROC analysis of the complex of 8 miRNAs are: AUC=0.87, Sensitivity:81.5%, Specificity:82.1%, cutoff:0.49." "Fang L et al. J Transl Med. 2015" "mean(SD)" "T1≥470/T1<470; Postcontrast myocardial longitudinal relaxation time (T1) mapping is an emerging CMR technique to evaluate diffuse myocardial fibrosis, a number of T1 mapping techniques have been shown to correlate with histologically-quantified fibrosis." "Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy" "Individual miRNA had moderate diagnostic value for diffuse myocardial fibrosis (AUC: 0.663-0.742), but the diagnostic value was greatly improved (AUC: 0.87) for a combination of 8 miRNAs." "299" "MID_278" "26404540" "hsa-miR-18a-5p, hsa-miR-30d-5p, hsa-miR-21-5p, hsa-miR-193-5p, hsa-miR-10b-5p, hsa-miR-15a-5p, hsa-miR-296-5p, hsa-miR-29a-3p" "microRNA" "Myocardial fibrosis in hypertrophic cardiomyopathy" "up" "Diagnosis" "YES" "Melbourne, Australia, Oceania" "28/27" "22/22" "6/5" "49.1(14.0)/49.9(10.8) " "plasma" "microarray, real-time PCR" "ROC analysis of the complex of 8 miRNAs are: AUC=0.87, Sensitivity:81.5%, Specificity:82.1%, cutoff:0.49." "Fang L et al. J Transl Med. 2015" "mean(SD)" "T1≥470/T1<470; Postcontrast myocardial longitudinal relaxation time (T1) mapping is an emerging CMR technique to evaluate diffuse myocardial fibrosis, a number of T1 mapping techniques have been shown to correlate with histologically-quantified fibrosis." "Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy" "Individual miRNA had moderate diagnostic value for diffuse myocardial fibrosis (AUC: 0.663-0.742), but the diagnostic value was greatly improved (AUC: 0.87) for a combination of 8 miRNAs." "300" "MID_279" "26631154" "hsa-miR-194-5p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 13.64(-),p=0.002" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "28" "MID_28" "25933289" "hsa-miR-3149" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Beijing, China, Asia" "16/90/377" "10/65/281" "6/25/96" "NA/NA/NA" "plasma" "Microarray, qRT-PCR" "Fold change=12.5, AUC=0.670, 95%CI: 0.604-0.736, P<0.001" "Li, X et al. PLoS One. 2015" "NA" "Microarrey/qRT-PCR cohort I/II" "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome" "Plasma miR-3149 is potentially novel biomarkers for acute coronary syndrome." "301" "MID_280" "18582896" "hsa-miR-195-5P" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "NO" "Denver, USA, North America" "10" "NA" "NA" "NA" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "NA" "MiRNA expression in the failing human heart: functional correlates" "In conclusion, some miRNA expression patterns appear to be unique to the etiology of cardiomyopathy and changes in the expression level of miRs 100 and 133b contribute to regulation of the fetal gene program." "302" "MID_281" "18582896" "hsa-miR-195-5p" "microRNA" "Cardiomyopathy" "up" "Diagnosis" "NO" "Denver, USA, North America" "5/5" "NA/NA" "NA/NA" "12(3.1)/18.6(3.5)" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "idiopathic dilated cardiomyopathy/ischemic dilated cardiomyopathy" "MiRNA expression in the failing human heart: functional correlates" "The miRNA was upregulated in idiopathic dilated cardiomyopathy and ischemic dilated cardiomyopathy patients." "303" "MID_282" "20488170" "hsa-miR-196a2 SNP rs11614913" "microRNA" "Dilated cardiomyopathy" "NA" "Diagnosis" "YES" "Chengdu, China, Asia" "221" "137" "84" "52.2(12.8)" "blood" "PCR-restriction fragment length polymorphism (RFLP) assay." "Significantly increased dilated cardiomyopathy risks were found to be associated with variant allele of has-mir-196a2 rs11614913 C/T (T allele) (P<0.0001, OR=1.730, 95% CI=1.345-2.227)" "Zhou, B et al. Clin Chim Acta. 2010" "NA" "NA" "Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy" "The has-mir-196a2 rs11614913 C/T,are associated with a significantly increased risk of dilated cardiomyopathy, and may be useful biomarkers for dilated cardiomyopathy." "304" "MID_283" "23360823" "hsa-miR-199" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Berlin, Germany, Europe" "42" "38" "4" "45.4(2)" "tissue" "qRT-PCR" "miR-199a was reduced by 38±9% (p=0.053), miR-199b by 36±13% (p=0.019)" "Baumgarten, A et al. Int J Cardiol. 2013" "mean(SEM)" "NA" "TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy" "The TWIST1/miR-199/214 axis is down-regulated in dilated cardiomyopathy, which is likely to play a role in the increased activity of the ubiquitin-proteasome-system may contribute to the loss of cardiac mass during dilatation of the heart." "305" "MID_284" "24161319" "hsa-miR-199a-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR、2?ΔΔCt" "AUC: 0.8387" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "306" "MID_285" "24161319" "hsa-miR-199a-5p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR、2?ΔΔCt" "AUC: 0.8323" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "307" "MID_286" "24083979" "hsa-miR-204-5p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:2.7 [1.6 to 4.8]; p-Value：0.010； Fold change array [range±SD]：2.4 [1.8 to 3.1]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "308" "MID_287" "26631154" "hsa-miR-205-5p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 5.45(-),p=0.002" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "309" "MID_288" "24910366" "hsa-miR-208a" "microRNA" "Chronic Chagas disease Cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "S?o Paulo, Brazil, South America" "10" "6" "4" "49.4" "tissue" "real-time reverse transcriptase (RT)-PCR" "NA" "Ferreira, LR et al. Int J Cardiol. 2014" "mean(SD)" "NA" "MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy" "These results suggest that miRNAs may play a major role in the regulation of gene expression in chronic chagas disease cardiomyopathy pathogenesis, with potential implication as diagnostic and prognostic tools." "310" "MID_289" "20447577" "hsa-miR-208a-3p" "microRNA" "Dilated cardiomyopathy" "up" "Prognosis" "NO" "Iwate, Japan, Asia" "82" "59" "23" "55.8(12.1)" "tissue" "qRT-PCR" "High levels of miR-208 (miR-208 levels=1.15 to 2.79) were a strong independent predictor of cardiac death and HF (RR 3.4, 95% CI 1.1-11.2)." "Satoh, M et al. J Card Fail. 2010" "mean(SD)" "NA" "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy" "This study suggests that myocardial expression of miR-208 is associated with poor clinical outcomes in patients with dilated cardiomyopathy." "29" "MID_29" "25124998" "hsa-miR-323-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis, Prognosis" "YES" "Auckland, New Zealand, Oceania" "18/17" "16/16" "2/1" "65.3(13.6)/65.2(13.4)" "plasma" "real-time quantitative PCR" "AUC=0.806, 95% CI:0.753-0.858" "Pilbrow, AP et al. Int J Cardiol. 2014" "mean(SD)" "Mild phenotype/Severe phenotype" "Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes" "Circulating levels of miR-323-3p were markedly higher in patients compared with controls across the spectrum of mild to severe acute coronary syndromes(ACS), and that levels remained elevated for at least a year after ACS." "311" "MID_290" "24910366" "hsa-miR-208b" "microRNA" "Chronic Chagas disease Cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "S?o Paulo, Brazil, South America" "10" "6" "4" "49.4" "tissue" "real-time reverse transcriptase (RT)-PCR" "NA" "Ferreira, LR et al. Int J Cardiol. 2014" "mean(SD)" "NA" "MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy" "These results suggest that miRNAs may play a major role in the regulation of gene expression in chronic chagas disease cardiomyopathy pathogenesis, with potential implication as diagnostic and prognostic tools." "312" "MID_291" "28065693" "hsa-miR-208b" "microRNA" "Dilated cardiomyopathy" "up" "Treatment" "YES" "Tuebingen, Germany, Europe" "10" "6" "4" "52.2(15)" "issue" "Microarray, Quantitative Reverse Transcription-PCR (qPCR)" "NA" "Zhou, Q et al. Int J Cardiol. 2017" "mean(SD)" "Patients undergoing left ventricular assist device implantation" "Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy" "Inhibition of microRNA-208b might be a novel therapeutic target for dilated cardiomyopathy." "313" "MID_292" "27307080" "hsa-miR-212-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.910" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly increased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "314" "MID_293" "27307080" "hsa-miR-21-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.936" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly increased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "315" "MID_294" "23360823" "hsa-miR-214-3p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Berlin, Germany, Europe" "42" "38" "4" "45.4(2)" "tissue" "qRT-PCR" "miR-214 was reduced by 41±11% (p=0.0158) in dilated cardiomyopathy myocardium " "Baumgarten, A et al. Int J Cardiol. 2013" "mean(SEM)" "NA" "TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy" "The TWIST1/miR-199/214 axis is down-regulated in dilated cardiomyopathy, which is likely to play a role in the increased activity of the ubiquitin-proteasome-system may contribute to the loss of cardiac mass during dilatation of the heart." "316" "MID_295" "24804616" "hsa-miR-21-5p" "microRNA" "Dilated cardiomyopathy" "up" "Treatment" "YES" "Shanghai, China, Asia" "6" "4" "2" "44.83" "tissue" "qPCR, Western blotting" "It was revealed that the expression level of miRNA-21 increased by 800% in cardiac ventricle tissues of dilated cardiomyopathy (relative expression: 16±0.315 vs. 2±0.273, P<0.05)." "Xu, HF et al. Mol Med Rep. 2014" "mean(SD)" "NA" "MicroRNA21 regulation of the progression of viral myocarditis to dilated cardiomyopathy" "In summary, the present study demonstrated that miRNA-21 levels are increased in viral myocarditis and dilated cardiomyopathy.The regulation of miRNAs may contribute to the pathogenic progression of viral myocarditis to dilated cardiomyopathy. " "317" "MID_296" "27922664" "hsa-miR-21-5p" "microRNA" "Dilated cardiomyopathy" "up" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "miR-21 was significantly upregulated in the apex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group ( P<0.05,P<0.01, P<0.05)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "318" "MID_297" "27307080" "hsa-miR-21-5p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "up" "Diagnosis, Treatment" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.944" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly associated with both the myocardium adipose and fibrosis, which was a potential useful therapeutic targets for arrhythmogenic right ventricular cardiomyopathy." "319" "MID_298" "24083979" "hsa-miR-222-5p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:1.6 [1.0 to 2.4]; p-Value：0.041； Fold change array [range±SD]：2.2 [1.5 to 3.3]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "320" "MID_299" "29335596" "hsa-miR-26a-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.915" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "3" "MID_3" "27519051" "hsa-miR-122-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "30" "MID_30" "29350392" "hsa-miR-34a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is upregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "321" "MID_300" "24161319" "hsa-miR-27a-3p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR" "AUC: 0.7792" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "322" "MID_301" "29335596" "hsa-miR-27a-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.731" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "323" "MID_302" "24161319" "hsa-miR-27a-3p " "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR" "AUC:0.8939" "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "8 of these 12 miRNAs had an ROC curve that distinguished the hypertrophic cardiomyopathy group from the healthy group (AUC>0.70). " "324" "MID_303" "29335596" "hsa-miR-27b-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "30" "NA" "NA" "4.15(3.85)" "serum" "qRT-PCR" "AUC=0.915" "Jiao, M et al. Sci Rep. 2018" "mean(SD)" "NA" "Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy" "The miRNA may be a potential biomarker for diagnosing dilated cardiomyopathy." "325" "MID_304" "24161319" "hsa-miR-29a-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "YES" "Milan, Italy, Europe" "41" "41" "0" "50(13)" "blood" "reverse transcription PCR" "AUC: 0.8365 " "Roncarati, R et al. J Am Coll Cardiol. 2014" "mean(SD)" "NA" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy" "Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy, miR-29a is significantly associated with both hypertrophy and fibrosis, identifying it as a pote" "326" "MID_305" "27922664" "hsa-miR-29a-3p" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "MiR-29a was significantly dpwnregulated in the apex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group (P<0.05, P<0.01, P<0.01, respectively)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "327" "MID_306" "28684219" "hsa-miR-29a-3p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Thessaloniki, Greece, Europe" "50" "NA" "NA" "44(14)" "tissue, plasma" "RT-qPCR" "NA" "Ntelios, D et al. Clin Chim Acta. 2017" "NA" "NA" "Elevated plasma levels of miR-29a are associated with hemolysis in patients with hypertrophic cardiomyopathy" "MiR-29a is highly expressed in myocardial tissue and plasma from patients with hypertrophic cardiomyopathy." "328" "MID_307" "20484156" "hsa-miR-29b-3p" "microRNA" "Nonischemic dilated cardiomyopathy" "up" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "7/19" "5/13" "1/2" "66.6(2.1)/63.8(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by nonischemic dilated cardiomyopathy patients versus control subjects, might have a potential diagnosis or progn" "329" "MID_308" "27922664" "hsa-miR-29b-3p" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "MiR-29b was significantly dpwnregulated in the apex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group (P<0.05, P<0.05, P<0.05, respectively)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "330" "MID_309" "27922664" "hsa-miR-29c-3p" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Weifang, China, Asia" "3" "NA" "NA" "46.57(9.06)" "tissue" "Terminal deoxynucleotidyl-mediated dUTP nick end labeling(TUNEL) assay, RT-qPCR" "MiR-29c was significantly dpwnregulated in the apex, and the left and right ventricles of patients with dilated cardiomyopathy when compared with the normal group (P<0.05, P<0.05, P<0.05, respectively)" "Wang, Y et al. Mol Med Rep. 2017" "mean(SEM)" "NA" "Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy" "The present study suggested that Bcl?2 and specific microRNAs may be involved in dilated cardiomyopathy pathogenesis, with a potential implication as therapeutic targets." "31" "MID_31" "27519051" "hsa-miR-486-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "331" "MID_310" "26631154" "hsa-miR-302a-3p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "RT-qPCR" "fold change 4.96(-),p=0.004" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "332" "MID_311" "27307080" "hsa-miR-302b-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.991" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "333" "MID_312" "27307080" "hsa-miR-302c-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.992" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "334" "MID_313" "27748501" "hsa-miR-3135b" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "4/19" "4/16" "0/3" "53.7(7.6)/59.2(13.1)" "plasma" "Microarray, qRT-PCR" "AUC=1.00" "Wang, H et al. Cardiol J. 2017" "mean(SD)" "screening/validation" "Circulating microRNAs as novel biomarkers for dilated cardiomyopathy" "The circulating miRNAs miR-3135b have potential as diagnostic biomarkers for dilated cardiomyopathy. " "335" "MID_314" "27307080" "hsa-miR-338-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.970" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "336" "MID_315" "23998897" "hsa-miR-340-3p ; hsa-miR-340-5p" "microRNA" "End-stage heart failure because of dilated cardiomyopathy." "up" "Treatment" "YES" "Beijing, China, Asia" "14" "11" "3" "40.5" "tissue" "qRT-PCR" "NA" "Zhu, X et al. J Cell Mol Med. 2013" "mean(SD)" "NA" "Identification of micro-RNA networks in end-stage heart failure because of dilated cardiomyopathy" "The study identified miR-340 as a key miRNA contributing to the occurrence of heart failure and provide novel therapeutic targets for patients with heart failure." "337" "MID_316" "27307080" "hsa-miR-34a-5p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.819" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly increased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "338" "MID_317" "24083979" "hsa-miR-34b-5p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:4.7 [2.1 to 11.0]; p-Value：0.008； Fold change array [range±SD]：11.5 [7.8 to 16.9]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "339" "MID_318" "24083979" "hsa-miR-371a-3p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:2.8 [1.0 to 8.2]; p-Value：0.135； Fold change array [range±SD]：34.3 [5.6 to 209.8]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "340" "MID_319" "24083979" "hsa-miR-383" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:1.0 [0.4 to 2.4]; p-Value：0.991； Fold change array [range±SD]：7.2 [2.6 to 20.1]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "32" "MID_32" "24461990" "hsa-miR-499a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50–76.00)/60.00(53.00–69.00)/54.00(46.00–79.75)/58.00(53.00–65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 5.55 (2.96-10.41); SCAD group 4.03 (2.17-7.50); Intermediate-risk group 4.19 (1.95-9.02); Low-risk group 1.42 (0.76-2.67);] Multivariate analyses: OR (95% CI): [ACS group 26.14 (7.97-85.70); SCAD gr" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "MiR-208b and miR-499 may not only be considered as potential biomarkers in the diagnosis of cardiovascular disease but may also be associated with the presence and severity of coronary atherosclerosis." "341" "MID_320" "27748501" "hsa-miR-3908 " "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "4/19" "4/16" "0/3" "53.7(7.6)/59.2(13.1)" "plasma" "Microarray, qRT-PCR" "AUC=0.83 (95% CI 0.70-0.96)" "Wang, H et al. Cardiol J. 2017" "mean(SD)" "screening/validation" "Circulating microRNAs as novel biomarkers for dilated cardiomyopathy" "The circulating miRNAs miR-3908 have potential as diagnostic biomarkers for dilated cardiomyopathy. " "342" "MID_321" "25761932" "hsa-miR-422a" "microRNA" "Enterovirus cardiomyopathy" "up(at progressive clinical deterioration (CVB3-PERS))" "Prognosis" "YES" "Berlin, Germany, Europe" "7/10" "5/13" "2/6" "50.2(7.3)/50.8(7.5)" "blood" "RT-PCR, Microarray" "Area under the curve was 0.867" "Kuehl, U et al. Circ Heart Fail. 2015" "mean(SD)" "CVB3-PERS Test/Validation" "Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy" "An immediate clinical application of the data is cardiac miR profiling to assess the risk of virus persistence and progressive clinical deterioration in CVB3 cardiomyopathy." "343" "MID_322" "23438607" "hsa-miR-423-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "45" "32" "13" "47.76(12.28)" "plasma" "qRT-PCR" "MiR-423-5p distinguished dilated cardiomyopathy cases from controls with an area under the curve (AUC) receiver operating characteristic (ROC) curve of 0.674 (95% CI, 0.555-0.793)." "Fan, K L et al. Indian Heart J. 2013" "mean(SD)" "NA" "Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy" "Plasma concentration of miR-423-5p may reflect the severity of dilated cardiomyopathy, circulating levels of miR-423-5p could be served as a diagnostic biomarker for heart failure caused by dilated cardiomyopathy." "344" "MID_323" "27307080" "hsa-miR-4254" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.838" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "345" "MID_324" "25209900" "hsa-miR-451a" "microRNA" "Hypertrophic cardiomyopathy " "down(病的人)" "Treatment" "YES" "Beijing, China, Asia" "16" "12" "4" "39.5" "tissue" "qRT-PCR, MicroRNAs microarray assay" "more than 4 fold." "Song, L et al. J Cell Mol Med. 2014" "mean(SD)" "NA" "MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1" "The down-regulation of miR-451 may contribute to the development of hypertrophic cardiomyopathy and may be a potential therapeutic target for this disease." "346" "MID_325" "27974462" "hsa-miR-451a" "microRNA" "Dilated cardiomyopathy" "down" "Treatment" "YES" "Wuhan, China, Asia" "5/45" "3/30" "2/20" "54(9)/50(14)" "peripheral blood mononuclear cells" "Microarray, Quantitative real time (RT)-PCR" "NA" "Zeng, Z et al. J Biol Chem. 2017" "mean(SD)" "Microarray group/Validation group" "Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4(+) T cells by targeting Myc in patients with dilated cardiomyopathy" "The expression of miR-451a is down-regulated in CD4 T cells from dilated cardiomyopathy(dilated cardiomyopathy) patients and that this down-regulation contributes to increasing Myc expression and inducing the aberrantTcell activation in dilated cardiomyo" "347" "MID_326" "26631154" "hsa-miR-454-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 36.73(+),p=0.016" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "348" "MID_327" "23247724" "hsa-miR-454-3p" "microRNA" "Diabetic cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 19- to 33.6-fold(p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-454 is highly downregulated in dilated cardiomyopathy patients." "349" "MID_328" "27307080" "hsa-miR-4643" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.966" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "350" "MID_329" "23199551" "hsa-miR-483-5p" "microRNA" "Hypertrophic cardiomyopathy" "up" "Diagnosis" "NO" "Oviedo, Spain, Europe" "24" "17" "7" "48.33(14-75)" "plasma" "PCR" "NA" "Palacin, M et al. Int J Cardiol. 2013" "NA" "NA" "Profile of microRNAs in the plasma of hypertrophic cardiomyopathy patients compared to healthy controls" "Overexpression of miR-483-5p in blood plasma from hypertrophic cardiomyopathy patients compared to healthy controls." "33" "MID_33" "29350392" "hsa-miR-499a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is upregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "351" "MID_330" "27307080" "hsa-miR-491-3p" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.837" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "352" "MID_331" "24083979" "hsa-miR-497-5p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:4.7 [1.4 to 15.7]; p-Value：0.032； Fold change array [range±SD]：2.0 [1.6 to 2.5]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "353" "MID_332" "20484156" "hsa-miR-497-5p" "microRNA" "Ischemic cardiomyopathy" "down" "Diagnosis, Prognosis" "YES" "Milano, Italy, Europe" "8/15" "7/13" "1/2" "66.1(2.0)/67.0(1.8)" "peripheral blood mononuclear cells " "qRT-PCR" "NA" "Voellenkle, C et al. Physiol Genomics. 2010" "mean(SEM)" "Profiling set/Validation set" "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients" "In conclusion, miRNA expression is altered in peripheral blood mononuclear cells(PBMCs) derived from chronic heart failure patients affected by ischemic cardiomyopathy patients versus control subjects, might have a potential diagnosis or prognosis of chr" "354" "MID_333" "20488170" "hsa-miR-499a-5p SNP rs3746444" "microRNA" "Dilated cardiomyopathy" "NA" "Diagnosis" "YES" "Chengdu, China, Asia" "221" "137" "84" "52.2(12.8)" "blood" "PCR-restriction fragment length polymorphism (RFLP) assay." "Significantly increased dilated cardiomyopathy risks were found to be associated with variant allele of hsa-mir-499 rs3746444 A/G (G allele) (P<0.0001, OR=1.794, 95% CI=1.350–2.385). " "Zhou, B et al. Clin Chim Acta. 2010" "NA" "NA" "Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy" "The hsa-mir-499 rs3746444 A/G are associated with a significantly increased risk of dilated cardiomyopathy, and may be useful biomarkers for dilated cardiomyopathy." "355" "MID_334" "23247724" "hsa-miR-500a-3p ; hsa-miR-500a-5p" "microRNA" "Diabetic cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 106.5- to 177.4-fold(p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-500 is highly downregulated in dilated cardiomyopathy patients." "356" "MID_335" "26631154" "hsa-miR-518f-3p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 8.58(+),p=0.004" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "357" "MID_336" "25761932" "hsa-miR-532-5p" "microRNA" "Enterovirus cardiomyopathy" "down(at progressive clinical deterioration (CVB3-PERS))" "Prognosis" "YES" "Berlin, Germany, Europe" "7/10" "5/13" "2/6" "50.2(7.3)/50.8(7.5)" "blood" "RT-PCR, Microarray" "Area under the curve was 0.850" "Kuehl, U et al. Circ Heart Fail. 2015" "mean(SD)" "CVB3-PERS Test/Validation" "Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy" "An immediate clinical application of the data is cardiac miR profiling to assess the risk of virus persistence and progressive clinical deterioration in CVB3 cardiomyopathy." "358" "MID_337" "26631154" "hsa-miR-544a" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 2.65(-),p=0.042" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "359" "MID_338" "23735785" "hsa-miR-548c-3p " "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "YES" "Cleveland, USA, North Ameica" "48/44" "25/24" "23/20" "55.2(9.0)/51.9(8.6)" "peripheral blood mononuclear cells" "quantitative real-time PCR, microarray" "Fold change=-2.47379; AUC=0.8551" "Gupta, MK et al. J Mol Cell Cardiol. 2013" "mean(SD) " "dilated cardiomyopathy/chronic stable heart failure with dilated cardiomyopathy " "MiRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients" "The study suggest that miRNA-548 family signature in peripheral blood mononuclear cells can therefore be used to detect early heart failure. " "360" "MID_339" "27748501" "hsa-miR-5571-5p" "microRNA" "Dilated cardiomyopathy" "up" "Diagnosis" "YES" "Beijing, China, Asia" "4/19" "4/16" "0/3" "53.7(7.6)/59.2(13.1)" "plasma" "Microarray, qRT-PCR" "AUC=0.91 (95% CI 0.82-1.00)" "Wang, H et al. Cardiol J. 2017" "mean(SD)" "screening/validation" "NA" "The circulating miRNAs miR-5571-5p have potential as diagnostic biomarkers for dilated cardiomyopathy, Additionally, miR-5571-5p correlated with NYHA classification." "34" "MID_34" "25124998" "hsa-miR-652-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis, Prognosis" "YES" "Auckland, New Zealand, Oceania" "18/17" "16/16" "2/1" "65.3(13.6)/65.2(13.4)" "plasma" "real-time quantitative PCR" "AUC=0.861, 95% CI:0.816-0.90" "Pilbrow, AP et al. Int J Cardiol. 2014" "mean(SD)" "Mild phenotype/Severe phenotype" "Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes" "Higher levels of miR-652 were associated with better clinical outcome." "361" "MID_340" "27307080" "hsa-miR-575" "microRNA" "Arrhythmogenic right ventricular cardiomyopathy" "down" "Diagnosis" "YES" "Beijing, China, Asia" "24" "16" "8" "36(13)" "tissue" "qRT-PCR" "AUC=0.922" "Zhang, H et al. Sci Rep. 2016" "mean(SEM)" "NA" "Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy" "The miRNA is significantly decreased in arrhythmogenic right ventricular cardiomyopathy patients compared to healthy people." "362" "MID_341" "25761932" "hsa-miR-590-5p" "microRNA" "Enterovirus cardiomyopathy" "up(at progressive clinical deterioration (CVB3-PERS))" "Prognosis" "YES" "Berlin, Germany, Europe" "7/10" "5/13" "2/6" "50.2(7.3)/50.8(7.5)" "blood" "RT-PCR, Microarray" "Area under the curve was 0.863" "Kuehl, U et al. Circ Heart Fail. 2015" "mean(SD)" "CVB3-PERS Test/Validation" "Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy" "An immediate clinical application of the data is cardiac miR profiling to assess the risk of virus persistence and progressive clinical deterioration in CVB3 cardiomyopathy." "363" "MID_342" "25840506" "hsa-miR-636" "microRNA" "Pediatric dilated cardiomyopathy" "up(pre-transplant)" "Prognosis" "YES" "Colorado, USA, North America" "34" "21" "13" "6.5" "plasma" "Microarray, RT-PCR" "Pre-transplant: Area under the curve (any one miRNA=0.875; any two miRNAs=0.773; any three miRNAs=0.714; any four miRNAs=0.658); Day of transplant: Area under the curve (any one miRNA=1; any two miRNAs=0.929; any three miRNAs=0.8; any four miRNAs=0.7); Da" "Miyamoto, SD et al. J Heart Lung Transplant. 2015" "mean(SD)" "NA" "Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy" "The study demonstrate that in patients the miRNA are highly predictive of the need for transplant in the pediatric dilated cardiomyopathy population，may represent a novel biomarker of outcome in the pediatric dilated cardiomyopathy population." "364" "MID_343" "25840506" "hsa-miR-639" "microRNA" "Pediatric dilated cardiomyopathy" "down(pre-transplant)" "Prognosis" "YES" "Colorado(USA)" "34" "21" "13" "6.5" "plasma" "Microarray, RT-PCR" "Pre-transplant: Area under the curve (any one miRNA=0.875; any two miRNAs=0.773; any three miRNAs=0.714; any four miRNAs=0.658); Day of transplant: Area under the curve (any one miRNA=1; any two miRNAs=0.929; any three miRNAs=0.8; any four miRNAs=0.7); Da" "Miyamoto, SD et al. J Heart Lung Transplant. 2015" "mean(SD)" "NA" "Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy" "The study demonstrate that in patients these miRNA are highly predictive of the need for transplant in the pediatric dilated cardiomyopathy population，may represent a novel biomarker of outcome in the pediatric dilated cardiomyopathy population." "365" "MID_344" "25840506" "hsa-miR-646" "microRNA" "Pediatric dilated cardiomyopathy" "up(pre-transplant)" "Prognosis" "YES" "Colorado(USA)" "34" "21" "13" "6.5" "plasma" "Microarray, RT-PCR" "Pre-transplant: Area under the curve (any one miRNA=0.875; any two miRNAs=0.773; any three miRNAs=0.714; any four miRNAs=0.658); Day of transplant: Area under the curve (any one miRNA=1; any two miRNAs=0.929; any three miRNAs=0.8; any four miRNAs=0.7); Da" "Miyamoto, SD et al. J Heart Lung Transplant. 2015" "mean(SD)" "NA" "Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy" "The study demonstrate that in patients the miRNA are highly predictive of the need for transplant in the pediatric dilated cardiomyopathy population，may represent a novel biomarker of outcome in the pediatric dilated cardiomyopathy population." "366" "MID_345" "24083979" "hsa-miR-708-5p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:1.8 [1.1 to 2.8]; p-Value：0.300； Fold change array [range±SD]：2.1 [1.7 to 2.7]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "367" "MID_346" "26631154" "hsa-miR-875-3p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Gaziantep, Turkey, Asia" "23" "13" "10" "48.78(43)" "plasma" "qRT-PCR" "fold change 2.85(-),p=0.017" "Enes Coskun M et al. Biomarkers. 2016" "NA" "Children" "Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy" "The miRNA is deregulated in dilated cardiomyopathy patients, involved in the biological processes." "368" "MID_347" "18582896" "hsa-miR-92a-3p" "microRNA" "Dilated cardiomyopathy" "down" "Diagnosis" "NO" "Denver(USA)" "10" "NA" "NA" "NA" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "NA" "MiRNA expression in the failing human heart: functional correlates" "In conclusion, some miRNA expression patterns appear to be unique to the etiology of cardiomyopathy and changes in the expression level of miRs 100 and 133b contribute to regulation of the fetal gene program." "369" "MID_348" "18582896" "hsa-miR-92a-3p" "microRNA" "Cardiomyopathy" "down" "Diagnosis" "NO" "Denver, USA, North America" "5/5" "NA/NA" "NA/NA" "12(3.1)/18.6(3.5)" "tissue" "Microarray, RT-PCR" "NA" "Sucharov, C et al. J Mol Cell Cardiol. 2008" "mean(SEM)" "idiopathic dilated cardiomyopathy/ischemic dilated cardiomyopathy" "MiRNA expression in the failing human heart: functional correlates" "The miRNA was downregulated in idiopathic dilated cardiomyopathy and ischemic dilated cardiomyopathy patients." "370" "MID_349" "26898797" "hsa-miR-9-5p" "microRNA" "Diabetic cardiomyopathy" "down" "Treatment" "NO" "Texas, USA, North America" "NA" "NA" "NA" "NA" "tissue" "qRT-PCR, Western blot" "NA" "Jeyabal, P et al. Biochem Biophys Res Commun. 2016" "mean(SEM)" "NA" "MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1" "Modulating miR-9 expression serves as a novel therapeutic option for regulating ELAVL1-mediated disease processes, including diabetes-induced cardiomyocyte cell death and inflammation and cancer." "35" "MID_35" "25933289" "hsa-miR-720" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Beijing, China, Asia" "16/90/377" "10/65/281" "6/25/96" "NA/NA/NA" "plasma" "Microarray, qRT-PCR" "Fold change=49.3, AUC=0.865, 95%CI: 0.818-0.913, P<0.001" "Li, X et al. PLoS One. 2015" "NA" "Microarrey/qRT-PCR cohort I/II" "Plasma miR-122 and miR-3149 Potentially Novel Biomarkers for Acute Coronary Syndrome" "Plasma miR-720 is potentially biomarkers for acute coronary syndrome." "371" "MID_350" "24083979" "hsa-miR-96-5p" "microRNA" "Hypertrophic cardiomyopathy " "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "6" "6" "0" "43.8" "tissue" "RT-qPCR" "Fold change [range±SD]:3.4 [1.2 to 9.7]; p-Value：0.069； Fold change array [range±SD]：18.6 [3.8 to 90.8]" "Kuster, D W et al. J Mol Cell Cardiol. 2013" "mean(SD)" "NA" "MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations" "The miRNA is deregulated in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutation." "393" "MID_351" "24211202" "hsa-miR-138-5p" "microRNA" "Cyanotic congenital heart disease" "up" "Treatment" "NO" "Chongqing, China, Asia" "10" "4" "6" "17.5(8.2-33.7)month" "tissue" "qRT-PCR" "The expression of miR-138 was found to be gradually increased in a time-dependent manner (p<0.05), and peaked by 5.34-fold at 72?h after the onset of hypoxia." "He, S et al. Biochem Biophys Res Commun.2013" "mean(SEM)" "NA" "MiR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway" "Up-regulation of miR-138 plays a protective role in myocardial adaptation to chronic hypoxia, which is mediated mainly by MLK3/JNK/c-jun signaling pathway." "394" "MID_352" "26397753" "hsa-miR-146b-5p" "microRNA" "Congenital heart disease" "up" "Treatment" "NO" "Chongqing, China, Asia" "21" "NA" "NA" "17.1 months" "tissue" "RT-qPCR, Luciferase reporter assay, Western blotting" "NA" "Li, JW et al. Mol Med Rep. 2015" "mean(SD)" "NA" "MicroRNA-146b inhibition augments hypoxia-induced cardiomyocyte apoptosis" "The present study indicated that the inhibition of miR-146b increased hypoxia-induced apoptosis by targeting RNase L, miR-146b has a protective role in cardiac chronic hypoxia." "395" "MID_353" "26823736" "hsa-miR-184" "microRNA" "Cyanotic congenital heart disease " "down" "Diagnosis, Treatment" "NO" "Shijiazhuang, China, Asia" "10/10" "NA" "NA" "NA" "cell" "qRT-PCR, MTT assay， TUNEL， western bolt" "NA" "Huang, J et al. Int J Clin Exp Pathol. 2015" "mean(SD)" "10 CHD patients with cyanotic cardiac defects and 10 controls with acyanotic cardiac defects" "Down-regulation of microRNA-184 contributes to the development of cyanotic congenital heart diseases" "The study indicate that inhibition of microRNA-184 may contribute to the development of cyanotic coronary heart disease via decreasing proliferation and inducing apoptosis of cardiomyocytes,Congenital down-regulation of miR-184 may be a mechanism leading " "396" "MID_354" "27813602" "hsa-miR-196a2 SNP rs11614913" "microRNA" "Congenital heart disease" "NA" "Diagnosis" "YES" "Nanjing, China, Asia" "174/63/60" "44/25/15" "130/37/45" "40.81(13.56)/34.84(11.81)/34.75(12.36)" "blood" "SNP selection and genotyping assays, PCR" "The homozygous CC variant of miR-196a2 (rs11614913, T>C) was negatively associated with ASD(atrial septal defect) compared with the wild-type TT variant (OR=0.379, 95%CI=0.209-0.686, P=0.001). The miR-196a2 C allele was negatively associated with ASD comp" "Yu, K et al. Genet Mol Res. 2016" "mean(SD)" "atrial septal defect/ventricular septal defect/patent ductus arteriosus" "Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population" "The homozygous CC variant and the C allele of the rs11614913 (T>C) SNP of miR-196a2 are associated with a significantly reduced risk of atrial septal defect in cogential heart disease." "397" "MID_355" "19514064" "hsa-miR-196a2 SNP rs11614913" "microRNA" "Congenital heart disease" "NA" "Diagnosis" "NO" "Nanjing, China, Asia" "1003" "528" "475" "6.78(9.73)" "blood、tissue" "qRT-PCR, Luciferase Assays" "MiR-196a2 expression plasmid carrying the rs11614913 C allele (CHO cells: 0.559±0.062 for T allele vs. 0.392±0.053 for C allele, P=0.023; 293T cells: 0.787±0.114 for T vs. 0.573±0.033 for C, P= 0.036)." "Xu, J et al. Hum Mutat. 2009" "mean(SD)" "NA" "Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population" "This study revealed that the rs11614913 variant in the miR-196a2 sequence affects HOXB8 binding to mature miR-196a, indicates miR-196a2 rs11614913 plays a role in sporadic congenital heart disease susceptibility." "398" "MID_356" "23707860" "hsa-miR-19b-3p" "microRNA" "Congenital heart disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "27" "NA" "NA" "27.74(4.68)/24.99(1.29)" "serum" "Reverse transcription (RT) and quantitative PCR (qPCR)" "An area under the receiver operating characteristic (ROC) curve (AUC) of 0.79." "Zhu, S et al. Clin Chim Acta. 2013" "mean(SD)" "mother age/gestational weeks" "Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects" "MiR-19b could act as novel non-invasive biomarkers for the prenatal detection of fetal congenital heart defects." "399" "MID_357" "23707860" "hsa-miR-19b-3p, hsa-miR-22-3p, hsa-miR-29c-3p, hsa-miR-375" "microRNA" "Congenital heart disease" "NA" "Diagnosis" "YES" "Nanjing, China, Asia" "27" "NA" "NA" "27.74(4.68)/24.99(1.29)" "serum" "Reverse Transcription (RT)、Quantitative Real-Time PCR (qPCR)" " an area under the receiver operating characteristic (ROC) curve (AUC) of 0.813." "Zhu, S et al. Clin Chim Acta. 2013" "mean(SD)" "mother age/gestational weeks" "Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects" "A combination of several miRNAs could act as novel non-invasive biomarkers for the prenatal detection of fetal coronary heart disease." "400" "MID_358" "23707860" "hsa-miR-22-3p" "microRNA" "Congenital heart disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "27" "NA" "NA" "27.74(4.68)/24.99(1.29)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "An area under the receiver operating characteristic (ROC) curve (AUC) of 0.671." "Zhu, S et al. Clin Chim Acta. 2013" "mean(SD)" "mother age/gestational weeks" "Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects" "MiR-22 could act as novel non-invasive biomarkers for the prenatal detection of fetal congenital heart defects." "401" "MID_359" "29078258" "hsa-miR-23b-3p" "microRNA" "Cyanotic congenital heart disease" "up" "Treatment" "NO" "Hefei, China, Asia" "20/15" "NA" "NA" "6(12)" "tissue" "Quantitative real-time PCR, Dual-luciferase reporter assay " "NA" "He, W et al. Biomed Pharmacother. 2017" "NA" "cyanotic/acyanotic" "Effects of miR-23b on hypoxia-induced cardiomyocytes apoptosis" "Smad3 is a target gene of miR-23b for the clinical treatment of the patients with cyanotic congenital heart disease." "36" "MID_36" "27519051" "hsa-miR-92a-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "402" "MID_360" "25847058" "hsa-miR-27b-3p " "microRNA" "Pulmonary arterial hypertension secondary to congenital heart disease in children" "up" "Treatment" "YES" "Beijing, China, Asia" "6" "3" "3" "3.08" "tissue, human pulmonary artery endothelial cells" "RT-PCR, Western blot, Luciferase Cloning and Transfection" "NA" "Ma, K et al. Pediatr Pulmonol. 2015" "mean(SEM)" "NA" "Human lung microRNA profiling in pulmonary arterial hypertension secondary to congenital heart defect" "The study highlighted the potential importance of microRNAs in disease progression and suggested microR-27b has the potential to be a biomarker and therapeutic target in patients." "403" "MID_361" "23707860" "hsa-miR-29c-3p" "microRNA" "Congenital heart disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "27" "NA" "NA" "27.74(4.68)/24.99(1.29)" "serum" "Reverse transcription (RT) and quantitative PCR (qPCR)" " an area under the receiver operating characteristic (ROC) curve (AUC) of 0.767." "Zhu, S et al. Clin Chim Acta. 2013" "mean(SD)" "mother age/gestational weeks" "Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects" "MiR-29c could act as novel non-invasive biomarkers for the prenatal detection of fetal congenital heart defects." "404" "MID_362" "23707860" "hsa-miR-375" "microRNA" "Congenital heart disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "27" "NA" "NA" "27.74(4.68)/24.99(1.29)" "serum" "Reverse transcription (RT) and quantitative PCR (qPCR)" "An area under the receiver operating characteristic (ROC) curve (AUC) of 0.693." "Zhu, S et al. Clin Chim Acta. 2013" "mean(SD)" "mother age/gestational weeks" "Identification of maternal serum microRNAs as novel non-invasive biomarkers for prenatal detection of fetal congenital heart defects" "MiR-375 could act as novel non-invasive biomarkers for the prenatal detection of fetal congenital heart defects." "405" "MID_363" "28583401" "hsa-miR-873-5p" "microRNA" "Congenital heart disease" "up" "Diagnosis" "YES" "Shenyang, China, Asia" "61" "NA" "NA" "NA" "serum" "qRT-PCR, Dual-luciferase reporter assays, Cell proliferation assay, Flow cytometry analysis" "There was a significant decrease in cells in S phase (8.91±1.03 vs 16.59±1.44, p<0.01)" "Zhang, J S et al. Gene. 2017" "mean(SD)" "NA" "MiR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1" "MiR-873 is a novel miRNA that regulates H9C2 cell proliferation via targeting GLI1, and miR-873 may serve as a new potential biomarker diagnosis in congenital heart disease in the future." "406" "MID_364" "28583401" "hsa-miR-873-5p" "microRNA" "Congenital Heart Disease" "up" "Diagnosis, Treatment" "YES" "Shenyang, China, Asia" "61" "NA" "NA" "NA" "serum" "qRT-PCR" "NA" "Zhang, JS et al. Gene. 2017" "mean(SD)" "NA" "MiR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1" "MiR-873 is a novel miRNA that regulates H9C2 cell proliferation via targeting GLI1, and miR-873 may serve as a new potential biomarker diagnosis and therapeutic target in congenital heart disease in the future." "407" "MID_365" "29298094" "pre-miR-138 rs139365823" "microRNA" "Congenital heart disease" "NA" "Diagnosis" "NO" "Fuzhou, China, Asia" "857" "419" "438" "9.46(13.89)" "HEK293ET cells" "real-time quantitative RT-PCR, Luciferase assay" "Allele A of rs139365823 displayed a 103.5% increase in CHD risk (OR=2.035; 95% CI=1.033-4.010; p=0.0361), rs139365823 genotype AC was associated with a significantly increased CHD risk (AC vs. CC, OR=2.050; 95% CI=1.037-4.052; p=0.0351)" "Gao, X et al. DNA Cell Biol. 2018" "NA" "NA" "A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population" "The study identified the variant rs139365823 in pre-miR-138 altered the expression of mature miR-138 and increased the risk for congenital heart disease in chinese population." "419" "MID_366" "24877885" "hsa-miR-125a-5p" "microRNA" "Atherosclerotic coronary artery" "down" "Diagnosis" "NO" "Guangzhou, China, Asia" "12" "11" "1" "46.25(11.73)" "tissue" "Reverse transcription and qPCR" "NA" "Hao, L et al. Cardiovasc Pathol. 2014" "mean(SD)" "NA" "The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a/b-3p in human atherosclerotic coronary artery" "In conclusion, the up-regulation of ET-1, regulated by miR-125a-5p, miR-155, and miR-199a/b-3p, indicated that ET-1 played a crucial role in human coronary atherosclerosis." "420" "MID_367" "25349183" "hsa-miR-126-3p" "microRNA" "Coronary artery disease" "up(reduce risk of cardiovascular events)" "Prognosis" "YES" "Bonn, Germany, Europe" "176/34" "123/4" "53/30" "66.7(10.2)/62.2(1.72)" "microvesicles, exosomes, plasma" "qPCR" "In univariate analysis, above-median levels of miR-126 in circulating MVs were predictors of major adverse CV event-free survival (hazard ratio: 0.485 [95% CIAUTHOR: Is 95% CI correct?: 0.278 to 0.846]; P=0.007) and percutaneous coronary interventions (ha" "Jansen, F et al. J Am Heart Assoc. 2014" "mean(SD)" "Discovery /Validation cohort" "MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease" "Increased miR-126 expression in circulating MVs(microvesicles) is associated with reduced risk of cardiovascular events in stable coronary artery disease patients. " "421" "MID_368" "20595655" "hsa-miR-126-3p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "422" "MID_369" "28628920" "hsa-miR-130a-3p" "microRNA" "Coronary heart disease" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "932" "681" "251" "60" "plasma" "RT-qPCR" "AUC=0.566 (95% CI: 0.525-0.606, p=0.001)" "Jia, QW et al. Cell Physiol Biochem. 2017" "median age" "NA" "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China" "MiR-130a is significant predictors of coronary heart disease prevalence, and it may be an independent predictor for coronary heart disease prevalence after adjustment for conventional confounding factors." "37" "MID_37" "29332918" "A combination of mir-3162-3p and mir-1207-5p" "microRNA" "Unstable angina" "up, down" "Diagnosis" "YES" "Beijing, China, Asia" "10" "5" "5" "73.8(5.5)" "plasma" "Microarray, Real-time(RT) PCR" "AUC: 0.817, 95% CI: 0.712-0.922" "Cui, J et al. Int Heart J. 2018" "NA" "NA" "Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina" "Multi-miRNA panel could provide higher diagnostic value for the diagnosis of elderly patients with unstable angina." "423" "MID_370" "24053180" "hsa-miR-133a" "microRNA" "Coronary heart disease" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "16" "6" "59.8(9.8)" "blood" "qRT-PCR" "Receiver operating characteristic (ROC) analysis revealed that circulating miR-133a had considerable diagnostic accuracy for CHD with an AUC of 0.918 (95% confidence interval 0.877-0.960)." "Wang, F et al. J Transl Med. 2014" "mean(SD)" "NA" "Plasma microRNA-133a is a new marker for both Acute myocardial infarction and underlying coronary artery stenosis" "These results showed that circulating miR-133a is superior to cTnI in detecting the severity of coronary artery lesions." "424" "MID_371" "20595655" "hsa-miR-133a" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is upregulated in coronary artery diseases patients." "425" "MID_372" "20230787" "hsa-miR-135a-5p" "microRNA" "Coronary artery disease" "up" "Prognosis" "NO" "Oslo, Norway, Europe" "25/25" "19/18" "6/7" "61(2)/60(8)" "peripheral blood mononuclear cells" "quantitative real-time RT-PCR" "5-fold increased (P<0.001) in the relative expression level" "Hoekstra, M et al. Biochem Biophys Res Commun. 2010" "mean(SEM)" "stable angina/unstable angina" "The peripheral blood mononuclear cell microRNA signature of coronary artery disease" "The miRNA is upregulated in coronary artery diseases patients." "426" "MID_373" "20595655" "hsa-miR-145-5p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "427" "MID_374" "24461990" "hsa-miR-146a-5p" "microRNA" "Atherosclerotic coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50-76.00)/60.00(53.00-69.00)/54.00(46.00-79.75)/58.00(53.00-65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 2.49 (1.63-3.79); SCAD group 2.06 (1.33-3.18); Intermediate-risk group 1.61 (0.93-2.76); Low-risk group 2.39 (1.57-3.63);] Multivariate analyses: OR (95% CI): [ACS group 2.43 (1.37-4.32); SCAD group" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "Thus, it was indicated that these 4 serum miRNAs may be available as the novel and complementary biomarkers for cardiovascular risk stratification, further contributing to early implementation of medical treatment regimen and management strategies in indi" "428" "MID_375" "29357324" "hsa-miR-146a-5p" "microRNA" "Coronary heart disease" "up" "Diagnosis" "YES" "Xian, China, Asia" "73" "42" "31" "65.67(11.59)" "plasma" "Reverse transcription (RT) and quantitative PCR (qPCR)" "The AUCs of miR-146a was 0.779 (95% CI 0.711-0.848; P<0.001)" "Quan, X et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism" "MiR-146a has good predictive value for coronary heart disease." "429" "MID_376" "20230787" "hsa-miR-147a" "microRNA" "Coronary artery disease" "down" "Prognosis" "NO" "Oslo, Norway, Europe" "25/25" "19/18" "6/7" "61(2)/60(8)" "peripheral blood mononuclear cells" "quantitative real-time RT-PCR" "4-fold decreased (P<0.05) in the relative expression level" "Hoekstra, M et al. Biochem Biophys Res Commun. 2010" "mean(SEM)" "stable angina/unstable angina" "The peripheral blood mononuclear cell microRNA signature of coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "430" "MID_377" "24877885" "hsa-miR-155-5p" "microRNA" "Atherosclerotic coronary artery" "down" "Diagnosis" "NO" "Guangzhou, China, Asia" "12" "11" "1" "46.25(11.73)" "tissue" "Reverse transcription and qPCR" "NA" "Hao, L et al. Cardiovasc Pathol. 2014" "mean(SD)" "NA" "The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a/b-3p in human atherosclerotic coronary artery" "In conclusion, the up-regulation of ET-1, regulated by miR-125a-5p, miR-155, and miR-199a/b-3p, indicated that ET-1 played a crucial role in human coronary atherosclerosis." "431" "MID_378" "28628920" "hsa-miR-155-5p" "microRNA" "Coronary heart disease" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "932" "681" "251" "60" "plasma" "RT-qPCR" "AUC=0.504 (95% CI:0.501-0.579, p=0.049)" "Jia, QW et al. Cell Physiol Biochem. 2017" "median age" "NA" "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China" "MiR-155 is significant predictors of coronary heart disease prevalence in this population." "432" "MID_379" "20595655" "hsa-miR-155-5p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "38" "MID_38" "29332918" "A combination of mir-3162-3p and mir-1225-5p" "microRNA" "Unstable angina" "up, down" "Diagnosis" "YES" "Beijing, China, Asia" "10" "5" "5" "73.8(5.5)" "plasma" "Microarray, Real-time(RT) PCR" "AUC: 0.833, 95% CI: 0.732- 0.934" "Cui, J et al. Int Heart J. 2018" "NA" "NA" "Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina" "Multi-miRNA panel could provide higher diagnostic value for the diagnosis of elderly patients with unstable angina." "433" "MID_380" "29411649" "hsa-miR-155-5p" "microRNA" "Coronary heart disease" "up" "Diagnosis" "YES" "Wenzhou, China, Asia" "99/98/102/101" "67/70/78/80" "32/28/24/21" "57.3(8.3)/59.8(7.8)/60.3(9.0)/59.4(8.7)" "serum" "qRT-PCR" "The odds ratio of miR-155 solely was 0.16 (95%CI, 0.06-0.43)" "Qiu, XK et al. Scand J Clin Lab Invest. 2018" "mean(SD)" "Gensini score 0-32/32-68/68-110/110-254" "Alteration in microRNA-155 level correspond to severity of coronary heart disease" "Serum miR-155 content may serve as a novel biomarker for evaluating severity of coronary heart disease." "434" "MID_381" "20595655" "hsa-miR-17-5p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "435" "MID_382" "24461990" "hsa-miR-186-5p" "microRNA" "Atherosclerotic coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50-76.00)/60.00(53.00-69.00)/54.00(46.00-79.75)/58.00(53.00-65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 22.29 (10.53-47.21); SCAD group 21.04 (9.93-44.54); Intermediate-risk group 9.96 (4.47-22.19); Low-risk group 4.12 (2.01-8.44);] Multivariate analyses: OR (95% CI): [ACS group 82.12 (22.77-269.11" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "Thus, it was indicated that these 4 serum miRNAs may be available as the novel and complementary biomarkers for cardiovascular risk stratification, further contributing to early implementation of medical treatment regimen and management strategies in indi" "436" "MID_383" "24877885" "hsa-miR-199a-3p" "microRNA" "Atherosclerotic coronary artery" "down" "Diagnosis" "NO" "Guangzhou, China, Asia" "12" "11" "1" "46.25(11.73)" "tissue" "Reverse transcription and qPCR" "NA" "Hao, L et al. Cardiovasc Pathol. 2014" "mean(SD)" "NA" "The up-regulation of endothelin-1 and down-regulation of miRNA-125a-5p, -155, and -199a/b-3p in human atherosclerotic coronary artery" "In conclusion, the up-regulation of ET-1, regulated by miR-125a-5p, miR-155, and miR-199a/b-3p, indicated that ET-1 played a crucial role in human coronary atherosclerosis." "437" "MID_384" "25349183" "hsa-miR-199a-5p" "microRNA" "Coronary artery disease" "up(reduce risk of cardiovascular events)" "Prognosis" "YES" "Bonn, Germany, Europe" "176/34" "123/4" "53/30" "66.7(10.2)/62.2(1.72)" "microvesicles, exosomes, plasma" "qPCR" "Likewise, an increased level of miR-199a in circulating MVs was associated with a reduced risk of major adverse CV events (hazard ratio: 0.518 [95% CI: 0.299 to 0.898]; P=0.01) and revascularization (hazard ratio: 0.439 [95% CI: 0.232 to 0.832]; P=0.01) i" "Jansen, F et al. J Am Heart Assoc. 2014" "mean(SD)" "Discovery /Validation cohort" "MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease" "Increased miR-199a expression in circulating MVs(microvesicles) is associated with reduced risk of cardiovascular events in stable coronary artery disease patients. " "438" "MID_385" "27573160" "hsa-miR-200a-3p" "microRNA" "Ischemic heart disease" "down" "Treatment" "YES" "Xianyang, China, Asia" "NA" "NA" "NA" "NA" "tissue" "RT-qPCR, Weatern Blot" "NA" "Sun, X et al.Int J Mol Med. 2016" "mean(SD)" "Human adult cardiomyocytes were purchased from ScienCell Research Laboratories" "Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis" "It have demonstrated that overexpression of miR-200a can decreases cell apoptosis, so it's a promising therapeutic strategy for the treatment of ischemic heart disease." "439" "MID_386" "28554251" "hsa-miR-208a" "microRNA" "Coronary heart disease" "up" "Diagnosis" "YES" "Mudanjiang, China, Asia" "99/98/102/101" "75/72/80/84" "24/27/22/17" "57.2(11.3)/57.8(10.8)/58.3(11.0)/58.8(11.2)" "plasma" "quantitative reverse transcriptase-polymerase chain reaction" "AUC=0.919(95% CI, 0.893-0.945), specificity=93.6%, sensitivity=75.5%" "Zhang, Y et al. Scand J Clin Lab Invest. 2017" "mean(SD)" "Gensini score:0-22/22-55/55-96/96-254" "Association between circulating microRNA-208a and severity of coronary heart disease" "Expression of miR-208a is increased following severity of coronary heart disease, it may serve as a novel biomarker." "440" "MID_387" "20595655" "hsa-miR-208a" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is upregulated in coronary artery diseases patients." "441" "MID_388" "24461990" "hsa-miR-208b" "microRNA" "Atherosclerotic coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50-76.00)/60.00(53.00-69.00)/54.00(46.00-79.75)/58.00(53.00-65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 3.35 (2.18-5.13); SCAD group 3.28 (2.14-5.03); Intermediate-risk group 2.79 (1.77-4.12); Low-risk group 1.67 (1.06-2.63);] Multivariate analyses: OR (95% CI): [ACS group 5.85 (2.79-12.28); SCAD grou" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "MiR-208b and miR-499 may not only be considered as potential biomarkers in the diagnosis of CAD but may also be associated with the presence and severity of coronary atherosclerosis." "442" "MID_389" "23610572" "hsa-miR-214-3p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "YES" "Shanghai, China, Asia" "40" "30" "15" "66.8(11.1)" "plasma" "quantitative PCR" "NA" "Lu, HQ et al. J Geriatr Cardiol. 2013" "mean(SEM)" "NA" "Circulating miR-214 is associated with the severity of coronary artery disease" "MiR-214 as a promising biomarker for coronary artery disease, because of the downregulated in patients and correlated well with the severity of coronary stenosis." "39" "MID_39" "29332918" "A combination of mir-3162-3p, mir-1225-5p and mir-1207-5p" "microRNA" "Unstable angina" "up, down, down" "Diagnosis" "YES" "Beijing, China, Asia" "10" "5" "5" "73.8(5.5)" "plasma" "Microarray, Real-time(RT) PCR" "AUC of 0.91 (95% CI: 0.84-0.98)" "Cui, J et al. Int Heart J. 2018" "NA" "NA" "Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina" "Multi-miRNA panel could provide higher diagnostic value for the diagnosis of elderly patients with unstable angina." "443" "MID_390" "28628920" "hsa-miR-221-3p" "microRNA" "Coronary heart disease" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "932" "681" "251" "60" "plasma" "RT-qPCR" "AUC=0.569 (95% CI: 0.529-0.609, p=0.001)" "Jia, QW et al. Cell Physiol Biochem. 2017" "median age" "NA" "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China" "MiR-221 is significant predictors of coronary heart disease prevalence in this population." "444" "MID_391" "19371267" "hsa-miR-221-3p" "microRNA" "Coronary artery disease" "up" "Diagnosis, Treatment" "NO" "Iwate, Japan, Asia" "44" "36" "8" "66.1(12.8)" "peripheral blood mononuclear cells" "real-time RT-PCR" "NA" "Minami, Y et al. Eur J Clin Invest. 2009" "mean(SD)" "NA" "Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease" "MiR-221 was upregulated in coronary artery disease patients and decreased after lipid lowering therapy(LLT) with atorvastatin." "445" "MID_392" "19371267" "hsa-miR-222-3p" "microRNA" "Coronary artery disease" "up" "Diagnosis, Treatment" "NO" "Iwate, Japan, Asia" "44" "36" "8" "66.1(12.8)" "peripheral blood mononuclear cells" "real-time RT-PCR" "NA" "Minami, Y et al. Eur J Clin Invest. 2009" "mean(SD)" "NA" "Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease" "MiR-222 was upregulated in coronary artery disease patients and decreased after lipid lowering therapy(LLT) with atorvastatin." "446" "MID_393" "27537567" "hsa-miR-22-3p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Zhuhai, China, Asia" "14/17/29" "10/12/23" "4/5/6" "64.3(7.1)/66.5(9.5)/63.9(9.0)" "peripheral blood mononuclear cells" "qRT-PCR, Luciferase assays" "NA" "Chen, B et al. Medicine (Baltimore). 2016" "mean(SD)" "STEMI/NSTEMI/SAP" "MiR-22 contributes to the pathogenesis of patients with coronary artery disease by targeting MCP-1: An observational study" "MiR-22 expression is significantly lower in peripheral blood mononuclear cells from coronary artery disease patients and is negatively correlated with MCP-1." "447" "MID_394" "24634009" "hsa-miR-2909" "microRNA" "Coronary heart disease" "up" "Diagnosis, Prognosis, Treatment" "YES" "Chandigarh, India, Asia" "80" "80" "0" "50(4)" "blood" "quantitative real time PCR, RT-PCR" "The results of this study revealed a significant and highly correlative gradual increase in miR-2909 expression with respect to the severity of the coronary occlusion in CHD subjects under study :Gensini: r=0.943, p<0.01." "Arora, M et al. Mol Cell Biochem. 2014" "mean(SD)" "NA" "Human coronary heart disease: importance of blood cellular miR-2909 RNomics" "The present study shows for the first time that miR-2909 expression displays positive correlation with respect to the increasing severity of coronary occlusion." "448" "MID_395" "29074464" "hsa-miR-29a-3p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "YES" "Shijiazhuang, China, Asia" "44/40" "36/25" "4/15" "56.5(5.67)/62.5(7.21)" "plasma" "qPCR" "NA" "Zheng, B et al. Biochim Biophys Acta. 2018" "mean(SEM)" "Study cohort/Validation cohort" "Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development" "MiR-29a increases KLF5 stability by directly targeting Fbw7/CDC4, and it likely a biomarker for coronary artery disease." "449" "MID_396" "22022480" "hsa-miR-340-3p" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/40/27" "NA" "NA" "45.7(6.5)/51.4(4.7)/59.4(9.8)" "platelet" "microarray, real-time PCR" "NA" "Sondermeijer, BM et al. PLoS One. 2011" "mean(SD)" "microarray/real-time PCR validation cohort I/II" "Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*" "MiR-340* is significantly upregulated in patients with coronary artery disease." "450" "MID_397" "26485305" "hsa-miR-486-5p" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "30/39/26" "20/28/22" "10/11/4" "62.23(1.48)/62.49(1.56)/57.31(2.33)" "blood" "PCR array" "NA" "Niculescu, LS et al. PLoS One. 2015" "mean(SEM)" "stable angina/unstable angina/myocardial infarction" "MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients" "The miRNA can be used as an additional tool to designate vulnerable coronary artery disease patients when association with some lipid metabolism biomarkers." "451" "MID_398" "24461990" "hsa-miR-499a-5p" "microRNA" "Atherosclerotic coronary artery disease" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "89/86/40/112" "66/58/35/93" "23/28/5/19" "66.00(53.50-76.00)/60.00(53.00-69.00)/54.00(46.00-79.75)/58.00(53.00-65.00)" "serum" "TaqMan Low Density Array (TLDA) screening, RT-qPCR" "Univariate analyses:[Unadjusted OR (95% CI): ACS group 5.55 (2.96-10.41); SCAD group 4.03 (2.17-7.50); Intermediate-risk group 4.19 (1.95-9.02); Low-risk group 1.42 (0.76-2.67);] Multivariate analyses: OR (95% CI): [ACS group 26.14 (7.97-85.70); SCAD gr" "Wu, J et al. Int J Cardiol. 2014" "mean(SD)" "high risk(acute coronary syndromes (ACS)/stable CAD)/intermediate-risk/low-risk" "Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects" "MiR-208b and miR-499 may not only be considered as potential biomarkers in the diagnosis of CAD but may also be associated with the presence and severity of coronary atherosclerosis." "452" "MID_399" "22022480" "hsa-miR-624-5p" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Amsterdam, The Netherlands, Europe" "12/40/27" "NA" "NA" "45.7(6.5)/51.4(4.7)/59.4(9.8)" "platelet" "microarray, real-time PCR" "NA" "Sondermeijer, BM et al. PLoS One. 2011" "mean(SD)" "microarray/real-time PCR validation cohort I/II" "Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340* and miRNA624*" "MiR-624* is significantly upregulated in patients with coronary artery disease." "4" "MID_4" "29350392" "hsa-miR-122-5p" "microRNA" "Acute coronary syndrome" "down" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is downregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "40" "MID_40" "26474612" "hsa-miR-106b-5p" "microRNA" "Unstable angina" "down" "Treatment" "YES" "Beijing, China, Asia" "6/26" "3/15" "3/11" "63(8)/63(13)" "plasma" "microarray, real-time PCR" "Fold change: 8.19" "Zhang, J et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2015" "mean(SD)" "Discovery /Validation cohort" "Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina" "The miRNA could be decreased by treatment with statins and may be used as a novel biomarker for effectiveness of statins therapy in patients with unstable angina." "453" "MID_400" "20595655" "hsa-miR-92a-3p" "microRNA" "Coronary artery disease" "down" "Diagnosis" "NO" "Frankfurt, Germany, Europe" "8/36" "NA" "NA" "NA" "plasma" "quantitative PCR" "NA" "Fichtlscherer, S et al. Circ Res. 2010" "NA" "Discovery /Validation cohort" "Circulating microRNAs in patients with coronary artery disease" "The miRNA is downregulated in coronary artery diseases patients." "454" "MID_401" "26485305" "hsa-miR-92a-3p" "microRNA" "Coronary artery disease" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "30/39/26" "20/28/22" "10/11/4" "62.23(1.48)/62.49(1.56)/57.31(2.33)" "blood" "PCR array" "NA" "Niculescu, LS et al. PLoS One. 2015" "mean(SEM)" "stable angina/unstable angina/myocardial infarction" "MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients" "The miRNA can be used as an additional tool to designate vulnerable coronary artery disease patients when association with some lipid metabolism biomarkers." "455" "MID_402" "28727754" "hsa-miR-146a-5p/RHOJ " "microRNA" "Coronary artery disease" "up" "Treatment" "YES" "Taipei, China, Asia" "8/10" "NA/NA" "NA/NA" "NA/NA" "plasma, endothelial colony forming cells" "RT-qPCR, Luciferase reporter assays" "NA" "Chang, TY et al. PLoS One. 2017" "NA" "plasma/endothelial colony forming cells" "Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients" "MiR-146a-5p/RHOJ and miR-146b-5p/RHOJ axis in the plasma and endothelial colony forming cells of coronary artery disease patients that could be used as biomarkers or therapeutic targets." "456" "MID_403" "28727754" "hsa-miR-146b-5p/RHOJ " "microRNA" "Coronary artery disease" "up" "Treatment" "YES" "Taipei, China, Asia" "8/10" "NA/NA" "NA/NA" "NA/NA" "plasma, endothelial colony forming cells" "RT-qPCR, Luciferase reporter assays" "NA" "Chang, TY et al. PLoS One. 2017" "NA" "plasma/endothelial colony forming cells" "Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients" "MiR-146b-5p/RHOJ and miR-146b-5p/RHOJ axis in the plasma and endothelial colony forming cells of coronary artery disease patients that could be used as biomarkers or therapeutic targets." "457" "MID_404" "26446730" "hsa-miR-125b-5p with age" "microRNA" "Coronary heart disease" "down" "Diagnosis" "NO" "Nanjing, China, Asia" "66" "54" "12" "62.20(8.95)" "plasma" "RT-qPCR" "MiR-125b showed the lowest AUC (0.405; 95% CI: 0.305 -0.506, p=0.070), Sensitivity: 0.534; Specificity: 0.621." "Ding, XQ et al. Sci Rep. 2015" "mean(SD)" "NA" "Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease" "Several synergistic effects between miR-125b and classical risk factors, such as age, sex, CR, FBG and HDL-C; the proportion of coronary heart disease attributable to the interaction of miR-125b and age was as high as 80%." "458" "MID_405" "27725938" "hsa-miR-451a/hsa-miR-23a-3p" "microRNA" "Coronary artery disease, Heart failure" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "25" "19" "6" "62.0(6.6)" "plasma" "qPCR" "MiR-451a/miR-23a ratio<60 indicated <0.12% hemolysis with 100% sensitivity and 100% specificity" "Wu, CS et al. Biomed Res Int. 2016" "mean(SD)" "NA" "Optimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease" "The miR-425a/miR-23a ratio increased as hemolysis grade increased, is a indicator of hemolysis." "459" "MID_406" "29357324" "A combination of miR-146a-5p and thyroid stimulating hormone" "microRNA" "Coronary heart disease" "up" "Diagnosis" "YES" "Xian, China, Asia" "60" "35" "25" "69.83(9.21)" "plasma" "Reverse transcription (RT) and quantitative PCR (qPCR)" "The combination of thyroid stimulating hormone and miR-146a was 0.858 (95% CI 0.808-0.908; P<0.001)" "Quan, X et al. Cell Physiol Biochem. 2018" "mean(SD)" "NA" "Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism" "A combination of miR-146a and thyroid stimulating hormone have good predictive value for coronary heart disease." "476" "MID_407" "25176944" "hsa-miR-10a-5p" "microRNA" "Heart transplant rejection" "down(with rejecting allografts)" "Diagnosis" "YES" "Paris, France, Europe" "30/30/22/31" "17/21" "9/13" "41(32-48)/43(33-51)" "serum" "real-time PCR" "Test cohort: AUC=0.975, CI95%=(0.946-1.005); Validation cohort: AUC=0.981, CI95%=(0.947-1.015)." "Duong Van Huyen JP et al. Eur Heart J. 2014" "NA" "Rejecting allografts/Normal allografts/valiable normal grafts/validate rejecting grafts" "MicroRNAs as non-invasive biomarkers of heart transplant rejection" "This suggests that miRNAs may represent relevant and non-invasive biomarkers that may serve to better investigate heart transplant rejection and guide the clinical management of heart recipients." "477" "MID_408" "23384889" "hsa-miR-101-3p" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "NA" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "478" "MID_409" "28125729" "hsa-miR-101-3p" "microRNA" "Acute cellular rejection after heart transplantation" "up" "Diagnosis" "YES" "Lund, Sweden, Europe" "26/37" "17/29" "9/8" "52(37-61)/56(45-61)" "serum" "quantitative PCR" "AUC=0.75" "Sukma Dewi I et al. PLoS One. 2017" "NA" "Acute Cellular Rejection/Non Rejection" "Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation" "MiR-101-3p can accurately discriminate heart transplant patients with acute cellular rejection from those with no rejection, it is promising serum biomarkers for noninvasive surveillance of rejection post transplantation." "41" "MID_41" "24260372" "hsa-miR-126-3p" "microRNA" "Stable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "34" "30" "4" "60.0(10.6)" "plasma" "RT-qPCR" "AUC values:0.929" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-126 have the potential to accurately discriminate patients with angiographically stable angina from matched controls." "479" "MID_410" "23384889" "hsa-miR-142-3p" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "cut-off<1.7, AUC=0.86, p<0.01)" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "480" "MID_411" "28125729" "hsa-miR-142-3p" "microRNA" "Acute cellular rejection after heart transplantation" "up" "Diagnosis" "YES" "Lund, Sweden, Europe" "26/37" "17/29" "9/8" "52(37-61)/56(45-61)" "serum" "quantitative PCR" "AUC=0.78" "Sukma Dewi I et al. PLoS One. 2017" "NA" "Acute Cellular Rejection/Non Rejection" "Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation" "MiR-142-3p can accurately discriminate heart transplant patients with acute cellular rejection from those with no rejection, it is promising serum biomarkers for noninvasive surveillance of rejection post transplantation." "481" "MID_412" "23384889" "hsa-miR-144-3p" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "NA" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "482" "MID_413" "25176944" "hsa-miR-155-5p" "microRNA" "Heart transplant rejection" "up(with rejecting allografts)" "Diagnosis" "YES" "Paris, France, Europe" "30/30/22/31" "17/21" "9/13" "41(32-48)/43(33-51)" "serum" "real-time PCR" "Test cohort: AUC=0.998, CI95%=(0.993–1.003); Validation cohort: AUC=0.974, CI95%=(0.940–1.007)." "Duong Van Huyen JP et al. Eur Heart J. 2014" "NA" "Rejecting allografts/Normal allografts/valiable normal grafts/validate rejecting grafts" "MicroRNAs as non-invasive biomarkers of heart transplant rejection" "This suggests that miRNAs may represent relevant and non-invasive biomarkers that may serve to better investigate heart transplant rejection and guide the clinical management of heart recipients." "483" "MID_414" "23384889" "hsa-miR-27a-3p " "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "NA" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "484" "MID_415" "25176944" "hsa-miR-31-5p" "microRNA" "Heart transplant rejection" "up" "Diagnosis" "YES" "Paris, France, Europe" "30/30/22/31" "17/21" "9/13" "41(32-48)/43(33-51)" "serum" "real-time PCR" "Test cohort: AUC=0.932, CI95%=(0.876–0.989); Validation cohort: AUC=0.867, CI95%=(0.771–0.963)." "Duong Van Huyen JP et al. Eur Heart J. 2014" "NA" "Rejecting allografts/Normal allografts/valiable normal grafts/validate rejecting grafts" "MicroRNAs as non-invasive biomarkers of heart transplant rejection" "This suggests that miRNAs may represent relevant and non-invasive biomarkers that may serve to better investigate heart transplant rejection and guide the clinical management of heart recipients." "485" "MID_416" "23384889" "hsa-miR-326" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "cut-off<2.3, AUC=0.80, p<0.05" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "486" "MID_417" "23384889" "hsa-miR-339-3p" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "NA" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "487" "MID_418" "23384889" "hsa-miR-424-5p" "microRNA" "Acute rejection after heart transplantation" "up" "Prognosis" "YES" "Lund, Sweden, Europe" "10" "8" "2" "45.2(13-69)" "serum" "qPCR" "NA" "Sukma Dewi I, et al. J Heart Lung Transplant. 2013" "NA" "NA" "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance" "The increase in these miRNAs is a true reflection of an immune reaction, but it also indicates that it may be used to predict rejection prior to when organ damage has occurred." "488" "MID_419" "25176944" "hsa-miR-92a-3p" "microRNA" "Heart transplant rejection" "up" "Diagnosis" "YES" "Paris, France, Europe" "30/30/22/31" "17/21" "9/13" "41(32-48)/43(33-51)" "serum" "real-time PCR" "Test cohort: AUC=0.989, CI95%=(0.971-1.007); Validation cohort: (AUC=0.959, CI95%=(0.908–1.009)." "Duong Van Huyen JP et al. Eur Heart J. 2014" "NA" "Rejecting allografts/Normal allografts/valiable normal grafts/validate rejecting grafts" "MicroRNAs as non-invasive biomarkers of heart transplant rejection" "This suggests that miRNAs may represent relevant and non-invasive biomarkers that may serve to better investigate heart transplant rejection and guide the clinical management of heart recipients." "42" "MID_42" "24260372" "hsa-miR-126-3p" "microRNA" "Unstable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "19" "15" "4" "64.7(11.8)" "plasma" "RT-qPCR" "AUC values: 0.867" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-126 have the potential to accurately discriminate patients with angiographically unstable angina from matched controls." "489" "MID_420" "28415669" "hsa-miR-98-5p" "microRNA" "Immune tolerance after heart transplantation" "up(after heart transplantation)" "Treatment" "NO" "Beijing, China, Asia" "20" "10" "10" "54.2(15.8)" "peripheral blood mononuclear cells (PBMC)" "RT-qPCR" "NA" "Song, J et al. Oncotarget. 2017" "mean(SD)" "NA" "Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation" "Inhibition of miR-98, or adoptive transfer with B10 cells, significantly improved the allograft heart survival, have the potential to be used in clinical heart transplantation." "490" "MID_421" "26498537" "hsa-miR-1-3p" "microRNA" "Symptomatic heart failure " "down" "Prognosis" "YES" "Warsaw, Poland, Europe" "35/26" "28/20" "7/6" "68.8(13.0)/72.0(10.4)" "serum" "Circulating miRNA reverse transcription and amplification, qRT-PCR" "We observed significant negative correlation between decreasing miR-1 expression and serum NT-proBNP concentration (r=-0.389; P=0.023) in patients in NYHA class II/III." "Sygitowicz G et al. Arch Cardiovasc Dis. 2015" "mean(SD)" "NYHA class II, III/IV " "Circulating microribonucleic acids miR-1, miR-21 and miR-208a in patients with symptomatic heart failure: Preliminary results" "MiR-1 may become a biomarker for predicting the worsen of heart failure." "491" "MID_422" "25738515" "hcmv-miR-UL22A-5p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "13" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "492" "MID_423" "17606841" "hsa-let-7a-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.55, P value=0.190" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "493" "MID_424" "25763857" "hsa-let-7b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "reverse transcription real-time qPCR" "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The microRNAs was abundant in pericardial fluid." "494" "MID_425" "17606841" "hsa-let-7b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.18, P value=0.011" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "495" "MID_426" "17606841" "hsa-let-7c" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.22, P value=0.021" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "496" "MID_427" "25763857" "hsa-let-7d-3p" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "497" "MID_428" "17606841" "hsa-let-7d-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.91, P value=0.006" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "498" "MID_429" "17606841" "hsa-let-7e-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.83, P value=0.006" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "43" "MID_43" "27497911" "hsa-miR-126-5p" "microRNA" "Stable angina pectoris" "down" "Diagnosis" "YES" "Zhengzhou, China, Asia" "40/30" "24/17" "16/13" "67.4(9.7)/68.9(11.3)" "plasma" "qRT-PCR" "A higher SYNTAX score was significantly associated with lower miR-126-5p levels (estimate, -0.011; standard error, 0.002; p<0.001 and estimate, -0.011; standard error, 0.002; p<0.001, respectively)" "Li, H Y et al. Cell Physiol Biochem. 2016" "mean(SD), mean(SEM)" "Syntax Scores>22 and <=32 / >32" "Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris" "The study indicated that circulating miR-126-5p might be as a novel predictive biomarker for the severity and complexity of stable angina pectoris." "499" "MID_430" "17606841" "hsa-let-7f-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.99, P value=0.058" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "500" "MID_431" "26430739" "hsa-let-7i-5p" "microRNA" "Heart failure with LVAD support" "down" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "Let-7i was significantly decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "501" "MID_432" "25736855" "hsa-miR-100-5p" "microRNA" "Heart failure" "up" "Diagnosis, Treatment" "NO" "Singapore, Signapore, Asia " "54" "39" "15" "59.6(10.8)" "blood" "Microarray, RT-PCR and quantitative stem-loop RT-PCR, " "1.7 fold higher in heart failure patients" "Wong, LL et al. J Mol Cell Cardiol. 2015" "mean(SD)" "NA" "Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100" "Down-regulation of NPR3 by miR-100 may be a therapeutic mechanism in heart failure patients." "502" "MID_433" "23696613" "hsa-miR-103a-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort，miR-103 (β = 0.64, 95% CI = 0.44-0.93, P=0.019),In ROC analyses, miR-103 (AUC=0.642, P=0.007), " "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "503" "MID_434" "17606841" "hsa-miR-106b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.64, P value=0.284" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "504" "MID_435" "17606841" "hsa-miR-107" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.64, P value=0.107" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "505" "MID_436" "21367584" "hsa-miR-10a-5p" "microRNA" "Chronic heart failure" "down(Group II compared to the Group I)" "Treatment" "YES" "Showa-ku, Japan, Asia" "7/7" "6/7" "1/0" "50(17)/49(14)" "tissue" "Microarray" "NA" "Funahashi, H et al. J Cardiol. 2011" "mean(SD)" "Group Ⅱ：ΔLV dP/dtmax<90%/Group Ⅱ：ΔLV dP/dtmax>90%" "Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure" "Altered expression of the miRNA was associated with the reduced catecholamine sensitivity in mildly symptomatic patients with dilated cardiomyopathy ,these miRNA can be therapeutic target for chronic heart failure." "506" "MID_437" "17606841" "hsa-miR-10b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.64, P value=0.238" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "507" "MID_438" "23864135" "hsa-miR-122-3p" "microRNA" "Systolic heart failure" "up" "Diagnosis, Prognosis" "YES" "Heidelberg, Germany, Europe" "53" "44" "9" "60(16)" "blood" "genome-wide miRNA expression profiles" "AUC=0.7" "Vogel, B et al. Eur Heart J. 2013" "NA" "NA" "Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure" "The miRNA is related to the degree of left ventricular dysfunction, it may serve as objective molecular tools to assess disease severity and prognosis." "508" "MID_439" "25619197" "hsa-miR-1233-3p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "MiRNA microarray, qPCR" "AUC values: Individual marker 0.63; 95% Confidence interval 0.500-0.752;Combined (miRNA+NT-proBNP) 0.96; 95% Confidence interval 0.884-0.993." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "44" "MID_44" "27357355" "hsa-miR-132-3p" "microRNA" "Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "682" "545" "137" "64(58-69)" "serum" "RT-qPCR" "AUC=0.737" "Karakas, M et al. Eur Heart J. 2017" "NA" "stable angina pectoris" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "509" "MID_440" "25619197" "hsa-miR-1233-3p" "microRNA" "Heart Failure with preserved left ventricular ejection fraction" "up" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.69; 95% Confidence interval 0.514-0.789;Combined (miRNA+NT-proBNP) 0.93; 95% Confidence interval 0.812-0.983." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "510" "MID_441" "28693530" "hsa-miR-1233-3p" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "511" "MID_442" "23247724" "hsa-miR-1246" "microRNA" "Congestive heart failure secondary to dilated cardiomyopathy" "up" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 1511- to 1633-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-124-5p is highly upregulated in congestive heart failure secondary to dilated cardiomyopathy patients." "512" "MID_443" "20185794" "hsa-miR-1254" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the circulating miRNAs provide attractive candidates as novel biomarkers for heart failure." "513" "MID_444" "25619197" "hsa-miR-125a-5p" "microRNA" "heart failure with reduced left ventricular ejection fraction" "up" "Diagnosis" "NO" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.70; 95% Confidence interval 0.601-0.894;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.872-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "514" "MID_445" "17606841" "hsa-miR-125a-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.97, P value=0.002" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "515" "MID_446" "25763857" "hsa-miR-125b-5p" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "516" "MID_447" "25763857" "hsa-miR-125b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "reverse transcription real-time qPCR" "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The microRNAs was abundant in pericardial fluid." "517" "MID_448" "26313139" "hsa-miR-126-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Laiwu, China, Asia" "32" "17" "15" "63.95(19.71)" "serum" "RNA extraction and quantitative real-time PCR" "MiR-126 level (fold change)heart failure group(n=32) 1.65±0.46; Control group(n=32):11.44 ± 2.95" "Wei, XJ et al. Braz J Med Biol Res. 2015" "mean(SD)" " " "Biological significance of miR-126 expression in atrial fibrillation and heart failure" "Serum miR-126 levels could serve as a potential candidate biomarker for evaluating the severity of heart failure." "518" "MID_449" "23465244" "hsa-miR-126-3p" "microRNA" "Chronic heart failure" "down" "Diagnosis, Prognosis, Treatment" "YES" "Hangzhou, China, Asia" "55/51" "40/39" "12/15" "68.2(8.0)(55-82)/66.4(7.9)(53-82)" "mononuclear cells " "Microarray, real-time RT-PCR" "MiR-126 levels in EPCs were independent prognostic factors (P=0.003; HR (hazard ratio): 0.19; 95% CI (confidence intervals) for the outcome of ICM or NICM patients with Cheart failure." "Qiang, L et al. Int J Cardiol. 2013" "mean(SEM)" "ischemic cardiomyopathy/non-ischemic cardiomyopathy" "Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients" "In this study, miR-126 was independent prognostic factors for patients with chronic heart failure(CHF) caused by ischemic cardiomyopathy and nonischemic cardiomyopathy, and might provide novel targets for prevention and treatment of CHF." "45" "MID_45" "24727883" "hsa-miR-132-3p, hsa-miR-150-5p, hsa-miR-186-5p" "microRNA" "Unstable angina" "NA" "Diagnosis" "YES" "Mainz, Germany, Europe" "10/48/46" "6/34/32" "4/14/14" "65.3(12)/65.6(11.4)/65.5(10.1)" "serum" "real-time PCR、single miRNA assays (Applied Biosystems)" "A panel of three miRNAs including miR-132, miR-150, and miR-186 showed the highest AUC (0.91; CI: 0.84–0.98), " "Zeller, T et al. Eur Heart J. 2014" "mean(SD)" "profiling/replication/validation" "Assessment of microRNAs in patients with unstable angina pectoris" "The highest diagnostic accuracy for unstable angina was achieved by applying the 3-miRNA combination of miR-132, miR-150, and miR-186. " "519" "MID_450" "23136161" "hsa-miR-126-3p" "microRNA" "Chronic heart failure" "down" "Diagnosis, Treatment" "YES" "Zurich, Switzerland, Europe" "45" "38" "7" "58.6(1.0)" "CD34(+) cells" "RT-PCR" "NA" "Jakob, P et al. Circulation. 2012" "mean(SEM)" "Cheart failure caused by ICM" "Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity" "The study reveals a loss of angiomiR-126 in angiogenic EOCs and circulating CD34(+) cells from patients with chronic heart failure, and these miRNAs can be therapeutic target for chronic heart failure." "520" "MID_451" "21157109" "hsa-miR-126-3p" "microRNA" "Congestive heart failure" "down" "Diagnosis, Prognosis" "YES" "Suita, Japan, Asia" "7/6/10" "4/5/9" "3/1/1" "68.3/73.5/70.2" "plasma" "Microarray, RT-qPCR" "NA" "Fukushima, Y et al. Circ J. 2011" "mean(SD)" "NYHA Ⅱ/Ⅲ/Ⅳ" "Assessment of plasma miRNAs in congestive heart failure" "The plasma concentration of miR-126 was negatively correlated with NYHA class, the concentration of miR-126 decreased along with increased NYHA,it could be a useful biomarker for heart failure." "521" "MID_452" "17606841" "hsa-miR-126-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.57, P value=0.506" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "522" "MID_453" "29344661" "hsa-miR-126-3p" "microRNA" "Acute heart failure" "down" "Prognosis" "YES" "Porto alegre, Brazil, South America" "48" "33" "15" "62(13)" "plasma" "Real-time PCR " "NA" "Schneider, SIDR et al. Mol Med Rep. 2018" "mean(SD)" "NA" "Plasma levels of microRNA-21, -126 and -423-5p alter during clinical improvement and are associated with the prognosis of acute heart failure" "The plasma levels of miR-126 altered during clinical improvement and were associated with the prognosis of acute heart failure." "523" "MID_454" "17606841" "hsa-miR-126-AS" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.48, P value=0.013" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "524" "MID_455" "26683101" "hsa-miR-1285-3p" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "14" "NA" "NA" "NA" "plasma、heart" "Microarray, qRT-PCR" "High accuracy for diagnosis(> 0.9)." "Li, H et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of cardiac-related circulating microRNA profile in human chronic heart failure" "MiR-1285-3p significantly upregulated in chronic heart failure and correlated to severity, holding function as diagnostic biomarker for chronic heart failure." "525" "MID_456" "20185794" "hsa-miR-129-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the miRNA provides attractive candidates as novel biomarkers for heart failure." "526" "MID_457" "28859128" "hsa-miR-129-5p" "microRNA" "Heart failure" "Diagnosis" "YES" "San Francisco, USA, North America" "51/18/2" "29/14/1" "22/4/1" "16(2-80)/44(3-78)/60(56-66)" "plasma" "Dual-luciferase assay" "AUC=0.98" "Ramachandran, S et al. PLoS One. 2017" "NA" "Plasma microvesicle analysis identifies microRNA 129-5p as a biomarker of heart failure in univentricular heart disease" "MiR-129-5p appears to serve as a potential biomarker for heart failure in univentricular heart disease." "527" "MID_458" "17606841" "hsa-miR-129-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.43, P value=0.178" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "528" "MID_459" "26188824" "hsa-miR-130" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=2.568; SD=2.094; P Value=0.0053" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "46" "MID_46" "24260372" "hsa-miR-133a" "microRNA" "Unstable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "19" "15" "4" "64.7(11.8) " "plasma" "RT-qPCR" "AUC values: 0.906" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-133a have the potential to accurately discriminate patients with angiographically unstable angina from matched controls." "529" "MID_460" "25738515" "hsa-miR-1306-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "530" "MID_461" "23136161" "hsa-miR-130a-3p" "microRNA" "Chronic heart failure" "down" "Diagnosis, Treatment" "NO" "Zurich, Switzerland, Europe" "45" "38" "7" "58.6(1.0)" "CD34(+) cells" "RT-PCR" "NA" "Jakob, P et al. Circulation. 2012" "mean(SEM)" "Cheart failure caused by ICM" "Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity" "The present study reveals a loss of angiomiR-130a in angiogenic EOCs and circulating CD34(+) cells from patients with chronic heart failure." "531" "MID_462" "17606841" "hsa-miR-130a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.50, P value=0.006" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "532" "MID_463" "26211628" "hsa-miR-130b-3p" "microRNA" "Obese Heart Failure" "down" "Diagnosis" "NO" "Porto alegre(Brazil)" "20" "13" "7" "54.9(11.9)" "blood" "qRT-PCR" "MiR-130b levels were reduced in obese heart failure patients compared with heart failure lean(P=0.036) and controls(P=0.025). " "Thomé J G et al. Gene. 2015" "mean(SD)" "NA" "Circulating microRNAs in obese and lean heart failure patients: A case-control study with computational target prediction analysis" "A differential expression of miR-130b is related to the presence of obesity ih heart failure patients." "533" "MID_464" "17606841" "hsa-miR-130b-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.57, P value=0.688" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "534" "MID_465" "29027324" "hsa-miR-132-3p" "microRNA" "Heart failure" "up" "Prognosis" "YES" "Milan, Italy, Europe" "953" "762" "191" "67.1(10.76)" "plasma" "quantitative RT-PCR" "MiR-132 remained associated with cardiovascular mortality [hazard ratio (HR) 0.87, 95% confidence interval (CI) 0.76-0.99 for 1 unit increase in log-transformed miR-132, P=0.048] and heart failure hospitalization (HR 0.80, 95% CI 0.66-0.96 for 1 unit incr" "Masson, S et al. Eur J Heart Fail. 2018" "mean(SD)" "NA" "Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure" "The miRNA-132 predicted long-term cardiovascular mortality and readmission to hospital for worsening of heart failure, and improved risk prediction over clinical risk factors for the outcome." "535" "MID_466" "17606841" "hsa-miR-132-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.76, P value=0.030" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "536" "MID_467" "29682535" "hsa-miR-132-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Shenyang, China, Asia" "67" "30" "35" "62.17(3.22)" "blood" "Real-time fluorescence quantitative PCR" "NA" "Liu, X et al. Biomed Res Int. 2018" "mean(SD)" "NA" "The Role of miRNA-132 against Apoptosis and Oxidative Stress in Heart Failure" "MicroRNA-132 expression was downregulated in heart failure patients' blood." "537" "MID_468" "23711953" "hsa-miR-133" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Essen, Germany, Europe" "26/29/21/7" "68" "15" "64(13)/66(8)/71(7)/66(12)" "tissue" "real-time PCR" "NA" "Danowski, N et al. Cardiology. 2013" "mean(SD)" "NA" "Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery" "Decreased miR-133 expression is associated with variables characteristic of heart failure." "538" "MID_469" "19059107" "hsa-miR-133a" "microRNA" "Ischemia heart failure repairing with LVADs" "down(up after LVAD support)" "Diagnosis" "NO" "Utrecht, The Netherlands, Europe" "8/9" "15" "2" "40(13)" "tissue" "qRT-PCR" "NA" "Schipper, M E et al. J Heart Lung Transplant. 2008" "NA" "Ishemia heart failure/Dilated cardiomyopathy" "Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support" "The miRNA deceresed in ischemia heart failure patients, and increased after left ventricular assist devices." "47" "MID_47" "24260372" "hsa-miR-1-3p" "microRNA" "Stable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "34" "30" "4" "60.0(10.6)" "plasma" "RT-qPCR" "AUC values: 0.918" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-1 have the potential to accurately discriminate patients with angiographically stable angina from matched controls." "539" "MID_470" "19059107" "hsa-miR-133b" "microRNA" "Ischemia heart failure repairing with LVADs" "down(up after LVAD support)" "Diagnosis" "NO" "Utrecht, The Netherlands, Europe" "8/9" "15" "2" "40(13)" "tissue" "qRT-PCR" "NA" "Schipper, M E et al. J Heart Lung Transplant. 2008" "NA" "Ishemia heart failure/Dilated cardiomyopathy" "Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support" "The miRNA deceresed in ischemia heart failure patients, and increased after left ventricular assist devices." "540" "MID_471" "17606841" "hsa-miR-135a-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.55, P value=0.156" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "541" "MID_472" "17606841" "hsa-miR-136-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.86, P value=0.232" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "542" "MID_473" "23640964" "hsa-miR-137" "microRNA" "Heart failure" "down" "Treatment" "YES" "Utrecht, The Netherlands, Europe" "18" "NA" "NA" "NA" "tissue" "In Situ Hybridization , Luciferase Assay" "NA" "Lok, SI et al. Circ Heart Fail. 2013" "mean(SEM)" "NA" "Post-transcriptional regulation of alpha-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support" "MiR-137 can play an important role in the pathophysiology of heart failure and could possibly serve as a therapeutic target." "543" "MID_474" "26188824" "hsa-miR-1-3p" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=2.573; SD=2.018; P Value=0.0209" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "544" "MID_475" "19059107" "hsa-miR-1-3p" "microRNA" "Ischemia heart failure repairing with LVADs" "down(up after LVAD support)" "Diagnosis" "NO" "Utrecht, The Netherlands, Europe" "8/9" "15" "2" "40(13)" "tissue" "qRT-PCR" "NA" "Schipper, M E et al. J Heart Lung Transplant. 2008" "NA" "Ishemia heart failure/Dilated cardiomyopathy" "Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support" "The miRNA deceresed in ischemia heart failure patients, and increased after left ventricular assist devices." "545" "MID_476" "17606841" "hsa-miR-1-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.87, P value=0.024" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "546" "MID_477" "29905364" "hsa-miR-1-3p" "microRNA" "Symptomatic heart failure" "down" "Diagnosis" "NO" "Warsaw, Poland, Europe" "59" "NA" "NA" "NA" "serum" "qPCR" "NA" "Tomaniak, M et al. Kardiol Pol. 2018" "NA" "NA" "MiR-1, miR-21, and galectin-3 in hypertensive patients with symptomatic heart failure and left ventricular hypertrophy" "Downregulation of miR-1 expression may be associated with LVH intensity." "547" "MID_478" "23696613" "hsa-miR-142-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort,miR-142-3p (β=0.75, 95% CI=0.60-0.94, P=0.012), miR-142-3p (AUC=0.668, P=0.002)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "548" "MID_479" "23247724" "hsa-miR-142-3p" "microRNA" "Congestive heart failure secondary to dilated cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "13" "NA" "NA" "51.85(16.00)" "blood" "Microarray, qRT-PCR" "fold change ranging from 0.1- to 0.2-fold(p<0.05)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-142-3p is downregulated in congestive heart failure secondary to dilated cardiomyopathy patients." "48" "MID_48" "24260372" "hsa-miR-1-3p" "microRNA" "Unstable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "19" "15" "4" "64.7(11.8)" "plasma" "RT-qPCR" "AUC values: 0.920" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-1 have the potential to accurately discriminate patients with angiographically unstable angina from matched controls." "549" "MID_480" "28051023" "hsa-miR-145-5p" "microRNA" "Heart failure" "down" "Prognosis" "YES" "Beijing, China, Asia" "100" "65" "35" "58(12)" "plasma" "real-time PCR" "NA" "Zhang, M et al. Chin Med J(Engl). 2017" "mean(SD)" "NA" "Circulating MicroRNA-145 is Associated with Acute myocardial infarction and Heart Failure" "Circulating miRNA?145 might not only be of use in diagnosing myocardial infarction but also could potentially be helpful in prognosticating cardiac function and the risk of developing heart failure." "550" "MID_481" "26636106" "hsa-miR-145-5p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Naples, Italy, Europe" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Sardu, C et al. J Diabetes Res. 2016" "NA" "NA" "Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes" "MiR-145-5p levels has a significant increase in the improved myocardial performance in CRT responders." "551" "MID_482" "29258606" "hsa-miR-146a-5p/hsa-miR-16-5p ratio" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Indianapolis, United States, North America" "40" "40" "40" "66.5(10.5)" "plasma, H9c2 cells" "qRT-PCR" "NA" "Beg, F et al. BMC Res Notes. 2017" "mean(SD)" "NA" "Inflammation-associated microRNA changes in circulating exosomes of heart failure patients" "MiR-146a/miR-16 ratio was higher in heart failure patients." "552" "MID_483" "17606841" "hsa-miR-148a-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.89, P value=0.171" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "553" "MID_484" "27505319" "hsa-miR-148b-3p" "microRNA" "Heart failure with mitral regurgitation" "down" "Diagnosis" "YES" "Taiwan, China, Asia" "32" "17" "15" "56(12)" "tissue" "real-time RT-PCR" "AUC=0.818(95% confidence interval, 0.637-0.998, p=0.010)" "Chen, MC et al. Int J Cardiol. 2016" "mean(SD)" "NA" "Circulating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitation" "Circulating miR-409-3p might serve as biomarker for incident heart failure in mitral regurgitation patients." "554" "MID_485" "25103110" "hsa-miR-15 family" "microRNA" "Heart failure " "up" "Diagnosis, Treatment" "NO" "Amsterdam， The Netherlands, Europe" "8/5/10" "NA" "NA" "NA" "tissue" "real-time PCR" "Real-time PCR shows comparable expression levels of the miR-15 family in cultured cardiomyocytes and fibroblasts, except for miR-322 which is higher expressed in fibroblasts" "Tijsen, AJ et al. Cardiovasc Res. 2014" "mean(SEM)" "end-stage hypertrophic cardiomyopathy (HCM), end-stage dilated cardiomyopathy, and aorta stenosis. " "The microRNA-15 family inhibits the TGFbeta-pathway in the heart" "It identified the miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGFβ-pathway." "555" "MID_486" "24239242" "hsa-miR-150-5p" "microRNA" "Chronic heart failure" "down(with atrial fibrillation)" "Treatment" "YES" "Heidelberg, Germany, Europe" "12" "NA" "NA" "43.6(15.8) " "tissue" "qPCR, Western blotting" "MicroRNA-150 was substantially expressed in both normal and Cheart failure myocardium, with a 1.7-fold higher expression in Cheart failure." "Kreth, S et al. J Heart Lung Transplant. 2014" "mean(SEM)" "NA" "MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure" "MicroRNA-150 counteracts ADIPOR2 up-regulation in Cheart failure and thus may contribute to adiponectin resistance. Targeting microRNA-150 may be a future strategy to restore cardioprotective adiponectin effects." "556" "MID_487" "28259597" "hsa-miR-150-5p" "microRNA" "Advanced heart failure" "down" "Diagnosis" "YES" "Bari, Italy, Europe" "25/29" "21/23" "4/6" "60(12)/60(10)" "blood" "RT-qPCR" "AUC=0.73(95% CI: 0.59-0.87, Sensitivity:79%, Specificity:68%)" "Scrutinio, D et al. J Heart Lung Transplant. 2017" "mean(SD)" "Mild to moderate heart failure/Advanced heart failure" "Circulating microRNA-150-5p as a novel biomarker for advanced heart failure: A genome-wide prospective study" "The downregulation of miR-150-5p can be a novel circulating biomarker for advanced heart failure." "557" "MID_488" "17606841" "hsa-miR-150-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.30, P value=0.220" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "558" "MID_489" "22939041" "hsa-miR-155-5p AT1R-1166CC genotype" "microRNA" "Chronic heart failure" "down(experienced ICD therapy)" "Prognosis" "YES" "Atlanta, Georgia, USA" "299/186" "230/154" "69/32" "61(13)/59(14)" "blood" "qRT-PCR" "MiR-155 had a statistically significantly elevated odds ratio (6.9, p=0.015, Fisher’s exact test)." "Blanco, RR et al. J Card Fail. 2012" "mean(SEM)" "No implantable cardioverter defibrillator therapy/implantable cardioverter defibrillator therapy" "Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure" "In conclusion, the risk for arrhythmias in chronic heart failure patients is significantly associated with AT1-1166 CC genotype,and this genotype is associated with decreased miR-155 in patients." "49" "MID_49" "23641832" "hsa-miR-1-3p, hsa-miR-134, hsa-miR-186-5p, hsa-miR-208a-3p, hsa-miR-223-3p, hsa-miR-499a-5p" "microRNA" "Angina" "NA" "Diagnosis" "YES" "Nanjing, China, Asia" "182" "133" "49" "65.30(9.98)" "serum" "RT-qPCR" "AUC=0.830; 95% CI, 0.751-0.910" "Li, C et al. BMC Med Genomics. 2013" "mean(SD)" "NA" "Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of Acute myocardial infarction and angina pectoris" "The six-miRNAs may serves as a biomarker for angina diagnosis." "559" "MID_490" "26430739" "hsa-miR-15b-5p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-15b was significantly decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "560" "MID_491" "25033200" "hsa-miR-16-5p" "microRNA" "Heart failure" "down" "Treatment" "NO" "Minnesota, United States of America, North America" "9" "8" "1" "60.1" "peripheral blood, tissue" "RT-qPCR, Dual Luciferase Reporter Assay" "NA" "Adhikari, N et al. PLoS One. 2014" "NA" "NA" "Identification of a new target of miR-16, Vacuolar Protein Sorting 4a" "Loss of miR-16 in patients with end stage heat failure may lead to a significant decrease in circulating platelets and/or reticulocytes with end stage disease, but it increase when treatment with a left ventricular assist device." "561" "MID_492" "25763857" "hsa-miR-16-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "reverse transcription real-time qPCR" "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The microRNAs was abundant in pericardial fluid." "562" "MID_493" "17606841" "hsa-miR-16-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.43, P value=0.052" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "563" "MID_494" "17606841" "hsa-miR-17-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.85, P value=0.053" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "564" "MID_495" "17606841" "hsa-miR-181a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.57, P value=0.009" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "565" "MID_496" "23258801" "hsa-miR-181c-5p" "microRNA" "Chronic heart failure" "down" "Diagnosis" "YES" "Frankfurt, Germany, Europe" "18" "16" "2" "64" "blood" "quantitative real-time PCR" "miR-181c: -2.4-fold, P<0.01" "Seeger, T etal. Eur J Heart Fail. 2013" "mean(SEM)" "NA" "Immunosenescence-associated microRNAs in age and heart failure" "MiR-181c may serve as a marker for reduced immune functions in chronic heart failure patients." "566" "MID_497" "25643195" "hsa-miR-182-5p" "microRNA" "Congestive heart failure " "up" "Prognosis" "YES" "Istanbul, Turkey, Asia" "42" "30" "12" "56.57(10.35) " "serum" "Microarray" "The prognostic value of miR-182 [area under the curve (AUC)=0.695]" "Cakmak, HA et al. J Cardiovasc Med(Hagerstown). 2015" "mean(SD)" "NA" "The prognostic value of circulating microRNAs in heart failure: preliminary results from a genome-wide expression study" "The study demonstrated the increased expression levels of circulating miRNAs in congestive heart failure as compared with controls and the miR-182 was found to be a potential prognostic marker in congestive heart failure." "567" "MID_498" "17606841" "hsa-miR-182-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.77, P value=0.024" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "568" "MID_499" "25619197" "hsa-miR-183-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.62; 95% Confidence interval 0.492-0.744;Combined (miRNA+NT-proBNP) 0.92; 95% Confidence interval 0.824-0.977." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "5" "MID_5" "29350392" "hsa-miR-124-3p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Krakow, Poland, Europe" "43" "34" "9" "57.6(10.1)" "tissue" "real-time PCR" "NA" "Gacon, J et al. Kardiol Pol. 2018" "mean(SD)" "NA" "Diagnostic and prognostic micro-RNAs in ischaemic stroke due to carotid artery stenosis and in acute coronary syndrome: a four-year prospective study" "The miRNA is upregulated in acute coronary syndrome patients compared to cerebral ischaemic events." "50" "MID_50" "27357355" "hsa-miR-140-3p" "microRNA" "Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "682" "545" "137" "64(58-69)" "serum" "RT-qPCR" "AUC=0.756" "Karakas, M et al. Eur Heart J. 2017" "NA" "stable angina pectoris" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "569" "MID_500" "25619197" "hsa-miR-183-3p" "microRNA" "heart failure with reduced left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.72; 95% Confidence interval 0.486-0.786;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.905-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "570" "MID_501" "25619197" "hsa-miR-183-3p" "microRNA" "heart failure with preserved left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.60; 95% Confidence interval 0.456-0.751;Combined (miRNA+NT-proBNP) 0.87; 95% Confidence interval 0.737-0.953." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "571" "MID_502" "17606841" "hsa-miR-186-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.89, P value=0.268" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "572" "MID_503" "20185794" "hsa-miR-18b-3p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "With an area under the curve (AUC) of 0.86" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the miRNA provide attractive candidates as novel biomarkers for heart failure." "573" "MID_504" "25619197" "hsa-miR-190a" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.59; 95% Confidence interval 0.438-0.734;Combined (miRNA+NT-proBNP) 0.94; 95% Confidence interval 0.820-0.989." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "574" "MID_505" "25619197" "hsa-miR-190a" "microRNA" "heart failure with preserved left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.62; 95% Confidence interval 0.513-0.835;Combined (miRNA+NT-proBNP) 0.88; 95% Confidence interval 0.715-0.972." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "575" "MID_506" "23743335" "hsa-miR-192-5p" "microRNA" "Heart failure" "up(in heart failure)" "Diagnosis" "YES" "Osaka, Japan, Asia" "21" "17" "4" "69(9)" "serum" "Reverse transcription (RT) and preamplification, real-time PCR" "Rorrelated with left ventricular diastolic dimension: miR-192: r=0.09, P=0.52" "Matsumoto, S et al. Circ Res. 2013" "mean(SD)" "NA" "Circulating p53-responsive microRNAs are predictive indicators of heart failure after Acute myocardial infarction" "In conclusion, the microRNA was upregulated in the serum of post-acute myocardial infarction patients who experienced development of heart failure within 1 year of acute myocardial infarction onset." "576" "MID_507" "25619197" "hsa-miR-193b-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.67; 95% Confidence interval 0.553-0.782;Combined (miRNA+NT-proBNP) 0.95; 95% Confidence interval 0.866-0.988." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "577" "MID_508" "25619197" "hsa-miR-193b-3p" "microRNA" "heart failure with reduced left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.80; 95% Confidence interval 0.505-0.888;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.918-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "578" "MID_509" "25619197" "hsa-miR-193b-3p" "microRNA" "heart failure with preserved left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.69; 95% Confidence interval 0.556-0.820;Combined (miRNA+NT-proBNP) 0.91; 95% Confidence interval 0.792-0.976." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "51" "MID_51" "25760478" "hsa-miR-155-5p" "microRNA" "Unstable angina" "up" "Diagnosis, Treatment" "YES" "Nanning, China, Asia" "53" "40" "13" "61.2(8.3)" "CD4(+) T cells" "Microarray, qRT-PCR" "The expression of miR-155 was positively correlated with the levels of IFN-γ (r=0.81, P<0.001)" "Chen, Y et al. J Cell Physiol. 2015" "mean(SD)" "NA" "Upregulation of miR-155 in CD4(+) T Cells Promoted Th1 Bias in Patients With Unstable Angina" "The study indicated that upregulation of miR-155 in circulating CD4(+) T cells in patients with UA promoted a shift in the Th1/Th2 balance toward Th1 dominance by repressing IFN-gamma Ralpha, which may subsequently enhance plaque instability." "579" "MID_510" "25619197" "hsa-miR-193b-5p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.60; 95% Confidence interval 0.466-0.735;Combined (miRNA+NT-proBNP) 0.93; 95% Confidence interval 0.837-0.982." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "580" "MID_511" "25619197" "hsa-miR-193b-5p" "microRNA" "heart failure with preserved left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.68; 95% Confidence interval 0.483-0.782;Combined (miRNA+NT-proBNP) 0.88; 95% Confidence interval 0.742-0.961." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "581" "MID_512" "23743335" "hsa-miR-194-5p" "microRNA" "Heart failure" "up(in heart failure)" "Diagnosis" "YES" "Osaka, Japan, Asia" "21" "17" "4" "69(9)" "serum" "Reverse transcription (RT) and preamplification, real-time PCR" "Rorrelated with left ventricular diastolic dimension: miR-194: r=0.33, P=0.01" "Matsumoto, S et al. Circ Res. 2013" "mean(SD)" "NA" "Circulating p53-responsive microRNAs are predictive indicators of heart failure after Acute myocardial infarction" "In conclusion, the microRNA was upregulated in the serum of post-acute myocardial infarction patients who experienced development of heart failure within 1 year of acute myocardial infarction onset." "582" "MID_513" "28618405" "hsa-miR-195-3p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Shenzhen, China, Asia" "8/8/60/48" "8/8/42/30" "0/0/18/18" "61.13(4.85)/50.38(19.83)/68.73(11.82)/55.98(18.16)" "plasma" "NGS technique, qRT-PCR" "AUC=0.831" "He, X et al. Cardiology. 2017" "mean(SD)" "Experiment 1(ischemic heart failure/nonischemic heart failure), Experiment 2(ischemic heart failure/nonischemic heart failure)" "Upregulation of Circulating miR-195-3p in Heart Failure" "The circulating miR-195-3p was found to be overexpressed in heart failure patients and could be a potential biomarker of heart failure." "583" "MID_514" "26188824" "hsa-miR-195-5P" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=2.622; SD=1.875; P Value=0.0076" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "584" "MID_515" "22093502" "hsa-miR-195-5P" "microRNA" "Heart failure at the time of ventricular assist device (VAD) placement" "down" "Prognosis" "YES" "Pittsburgh, USA, North America" "7/7/7/7" "NA/NA/NA/NA" "NA/NA/NA/NA" "NA/NA/NA/NA" "tissue" "Microarray, polymerase chain reaction (PCR) array and real-time PCR " "Screening Microarray (Test Cohort):fold change -2.91(P<0.029); Confirmatory PCR (Test Cohort): fold change -1.8(P<0.01); Confirmatory PCR (Validation Cohort): fold change -1.5(P<0.03)." "Ramani, R et al. J Am Coll Cardiol. 2011" "mean(SD)" "Test cohort recovered/dependent/Validation recovered/dependent" "A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure" "Lower cardiac expression of miR-195 at the time of ventricular assist device placement have the potential to provide markers to assess left ventricular recovery." "585" "MID_516" "26430739" "hsa-miR-195-5p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-195 was significantly decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "586" "MID_517" "17606841" "hsa-miR-196a-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.64, P value=0.258" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "587" "MID_518" "26188824" "hsa-miR-199" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=2.808; SD=2.310; P Value=0.0027" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "588" "MID_519" "26569364" "hsa-miR-199a-3p" "microRNA" "Worsen renal function with acute heart failure" "down" "Prognosis" "YES" "Groningen, The Netherlands, Europe" "81/17" "45/4" "36/13" "68.8(11.3)/69.5(12.7) " "blood" "quantitative real-time PCR" "MiR-199a-3p was a significant predictor of WRF, with an Odds Ratio (OR) of 1.48 (1.061-2.065; p=0.021) and a C-index of 0.701." "Bruno N et al. Int J Cardiol. 2016" "mean(SD)" "no worsening renal function/worsening renal function" "MicroRNAs relate to early worsening of renal function in patients with acute heart failure." "The results show that the levels of circulating miR-199a-3p was the best predictor of worsening renal function in heart failure patients." "52" "MID_52" "24727883" "hsa-miR-186-5p" "microRNA" "Unstable angina" "NA" "Diagnosis" "YES" "Mainz, Germany, Europe" "10/48/46" "6/34/32" "4/14/14" "65.3(12)/65.6(11.4)/65.5(10.1)" "serum" "real-time PCR, single miRNA assays (Applied Biosystems)" "AUC (0.78; CI: 0.67–0.88)" "Zeller, T et al. Eur Heart J. 2014" "mean(SD)" "profiling/replication/validation" "Assessment of microRNAs in patients with unstable angina pectoris" "The highest diagnostic accuracy for unstable angina was achieved by applying the 3-miRNA combination of miR-132, miR-150, and miR-186. " "589" "MID_520" "23696613" "hsa-miR-199a-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort, miR-199a-3p (β = 0.81, 95% CI = 0.69–0.96, P = 0.012), miR-199a-3p (AUC = 0.668, P = 0.002)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "590" "MID_521" "17606841" "hsa-miR-199a-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.99, P value=0.065" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "591" "MID_522" "22427379" "hsa-miR-199b-5p" "microRNA" "Diabetic ischemic heart failure " "up" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "592" "MID_523" "17606841" "hsa-miR-199b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.24, P value=0.056" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "593" "MID_524" "17606841" "hsa-miR-19b-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.32, P value=0.276" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "594" "MID_525" "17606841" "hsa-miR-200c-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.21, P value=0.140" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "595" "MID_526" "17606841" "hsa-miR-204-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.54, P value=0.241" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "596" "MID_527" "17606841" "hsa-miR-205-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.78, P value=0.196" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "597" "MID_528" "25012294" "hsa-miR-208a" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "New York, United States of America, North America" "34" "NA" "NA" "NA" "tissue, serum, plasma" "sRNAseq" "78-fold higher in advanced heart failure at LVAD implantation" "Akat, KM et al. Proc Natl Acad Sci U S A. 2014" "NA" "NA" "Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers" "MiR-208a was 78-fold higher in advanced heart failure at left ventricular assist device implantation." "598" "MID_529" "25012294" "hsa-miR-208a" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "New York, United States of America, North America" "34" "NA" "NA" "NA" "tissue, serum, plasma" "sRNAseq" "28-fold higher in advanced heart failure at LVAD implantation" "Akat, KM et al. Proc Natl Acad Sci U S A. 2014" "NA" "NA" "Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers" "MiR-208a was 28-fold higher in advanced heart failure at left ventricular assist device implantation." "53" "MID_53" "26720041" "hsa-miR-197-3p" "microRNA" "Acute coronary syndrome, Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "533/340" "424/276" "109/64" "64/63" "serum" "RT-qPCR" "MiRNA-197: hazard ratio (HR) 1.77 per one standard deviation(SD) increase(95% confidence interval(CI) 1.20; 2.60), p=0.004, C-index 0.78; " "Schulte, C et al. PLoS One. 2015" "mean(SD)" "CAD: stable angina pectoris/acute coronary syndrome " "MiRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease" "Serum-derived circulating miRNA-197 were identified as predictors for cardiovascular death in a large patients with coronary artery disease." "599" "MID_530" "17606841" "hsa-miR-208a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.59, P value=0.063" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "600" "MID_531" "25012294" "hsa-miR-208b" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "New York, United States of America, North America" "34" "NA" "NA" "NA" "tissue, serum, plasma" "sRNAseq" "143-fold higher in advanced heart failure at LVAD implantation" "Akat, KM et al. Proc Natl Acad Sci U S A. 2014" "NA" "NA" "Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers" "MiR-208b was 143-fold higher in advanced heart failure at left ventricular assist device implantation." "601" "MID_532" "23660476" "hsa-miR-210" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "22" "17" "5" "59.1(11.1)" "serum" "Quantitative reverse transcription polymerase chain reaction (qRT-PCR)" "With AUC values of 0.725 in heart failure groups,0.824 in male" "Zhao, DS et al. Cardiovasc Pathol. 2013" "NA" "NA" "Serum miR-210 and miR-30a expressions tend to revert to fetal levels in Chinese adult patients with chronic heart failure" "The serum expression levels of miR-210 were elevated in the heart failure patients." "602" "MID_533" "22427379" "hsa-miR-210" "microRNA" "Diabetic ischemic heart failure " "up" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "603" "MID_534" "17606841" "hsa-miR-210" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.01, P value=0.115" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "604" "MID_535" "25619197" "hsa-miR-211-5p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.66; 95% Confidence interval 0.497-0.824;Combined (miRNA+NT-proBNP) 0.93; 95% Confidence interval 0.819-0.981." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and heart failureREF from heart failurePEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "605" "MID_536" "25619197" "hsa-miR-211-5p" "microRNA" "heart failure with reduced left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.73; 95% Confidence interval 0.535-0.895;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.894-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "606" "MID_537" "17606841" "hsa-miR-211-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.91, P value=0.240" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "607" "MID_538" "17606841" "hsa-miR-212-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=8.10, P value=0.020" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "608" "MID_539" "25656649" "hsa-miR-214-3p" "microRNA" "Cardiac hypertrophy and heart failure " "up" "Diagnosis" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "serum, tissue" "real-time quantitative PCR" "NA" "Duan, Q et al. J Cell Physiol. 2015" "mean(SD)" "NA" "MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis" "MiR-214 expression was gradually increased in human failing heart tissue and blood samples, suggesting miR-214 may be a circulating biomarker and a diagnostic predictor for heart failure in future." "54" "MID_54" "24998411" "hsa-miR-19b-3p" "microRNA" "Unstable angina" "up" "Treatment" "NO" "Beijing, China, Asia" "45" "21" "24" "63.3(9.3)" "plasma, endothelial cells" "MiRNA TaqMan low density array (TLDA), real-time PCR, Luciferase reporter assays" "Fold change:39.28 " "Li, S et al. J Mol Cell Cardiol. 2014" "mean(SD), mean(SEM)" "NA" "MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor" "Decreased tissue factor expression may delay the process of atherosclerosis and consequently thrombosis in patients with unstable angina and acute myocardial infarction, Overexpression of miR-19b inhibited TF expression and procoagulant activity. " "609" "MID_540" "26572862" "hsa-miR-214-3p" "microRNA" "Cardiac hypertrophy and heart failure " "down" "Treatment" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "blood, tissue" "Real time PCR assay" "NA" "Duan, Q et al. J Transl Med. 2015" "mean(SD)" "NA" "MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo" "The study found that deregulation of of miR-214 in the hypertrophic and failing hearts inhibits XBP1 and XBP1-induced angiogenesis results in the transition of hypertrophic hearts into heart failure." "610" "MID_541" "26498537" "hsa-miR-21-5p" "microRNA" "Symptomatic heart failure " "up" "Prognosis" "YES" "Warsaw, Poland, Europe" "35/26" "28/20" "7/6" "68.8(13.0)/72.0(10.4)" "serum" "Circulating miRNA reverse transcription and amplification, qRT-PCR" "Overexpression of miR-21 was significantly correlated with serum galectin-3 concentration in patients in NYHA class IV (r=0.422; P=0.032)." "Sygitowicz G et al. Arch Cardiovasc Dis. 2015" "mean(SD)" "NYHA class II, III/IV " "Circulating microribonucleic acids miR-1, miR-21 and miR-208a in patients with symptomatic heart failure: Preliminary results" "The observed correlation between miR-21 expression and galectin-3 confirms its role of predicting the exacerbation in heart failure progression and cardiac remodelling." "611" "MID_542" "26188824" "hsa-miR-21-5p" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=2.402; SD=2.368; P Value=0.0069" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "612" "MID_543" "28944900" "hsa-miR-21-5p" "microRNA" "Heart failure" "up" "Diagnosis, Prognosis" "YES" "Urumqi, China, Asia" "80" "57" "23" "59.68(10.24)" "serum from peripheral vein(PV) and coronary sinus(CS)" "qPCR" "MiRNA-21-PV: AUC=0.948, sensitivity=100%, a specificity=97.5%; miRNA-21-CS: AUC=0.940, sensitivity=100%, specificity=97.5%; miRNA?21?PV significantly correlated with the endpoint [relative risk (RR)=1.936, 95% confidence interval (CI)=1.310-2.865, P=0.001" "mean(SD)" "NA" "Circulating miRNA21 is a promising biomarker for heart failure" "Circulating miRNA-21 correlated with the diagnosis and prognosis of heart failure(HF), it has potential to become a novel biomarker of human heart failure." "613" "MID_544" "25763857" "hsa-miR-21-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "reverse transcription real-time qPCR" "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The microRNAs was abundant in pericardial fluid." "614" "MID_545" "26430739" "hsa-miR-21-5p" "microRNA" "Heart failure with LVAD support" "down" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-21 was decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "615" "MID_546" "17606841" "hsa-miR-21-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=5.01, P value=0.023" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "616" "MID_547" "29344661" "hsa-miR-21-5p" "microRNA" "Acute heart failure" "down" "Prognosis" "YES" "Porto alegre, Brazil, South America" "48" "33" "15" "62(13)" "plasma" "Real-time PCR " "NA" "Schneider, SIDR et al. Mol Med Rep. 2018" "mean(SD)" "NA" "Plasma levels of microRNA-21, -126 and -423-5p alter during clinical improvement and are associated with the prognosis of acute heart failure" "The plasma levels of miR-21 altered during clinical improvement and were associated with the prognosis of acute heart failure." "617" "MID_548" "17606841" "hsa-miR-218-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.52, P value=0.345" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "618" "MID_549" "26430739" "hsa-miR-221-3p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-221 was up-regulated in pre-left ventricular assist device and decreased upon implantation in heart failure patients." "55" "MID_55" "27357355" "hsa-miR-210" "microRNA" "Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "682" "545" "137" "64(58-69)" "serum" "RT-qPCR" "AUC=0.754" "Karakas, M et al. Eur Heart J. 2017" "NA" "stable angina pectoris" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "619" "MID_550" "29255073" "hsa-miR-221-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Maastricht, The Netherlands, Europe" "NA" "NA" "NA" "NA" "tissue" "NA" "NA" "Verjans, R et al. Hypertension. 2018" "NA" "NA" "MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure" "Downregulation of the miRNA-221/222 family enables profibrotic signaling in the pressure-overloaded heart." "620" "MID_551" "26211628" "hsa-miR-221-3p/hsa-miR-130b-3p ratio" "microRNA" "Obese Heart Failure" "up" "Diagnosis" "NO" "Porto alegre, Brazil, South America" "20" "13" "7" "54.9(11.9)" "blood" "qRT-PCR" "Positively associated with body fat percentage (r=0.43; P=0.002), body mass index (r=0.44; P=0.002), and waist circumference (r=0.40; P=0.020). " "Thomé J G et al. Gene. 2015" "mean(SD)" "NA" "Circulating microRNAs in obese and lean heart failure patients: A case-control study with computational target prediction analysis" "A differential expression of miR-221/-130b ratio is related to the presence of obesity ih heart failure patients. " "621" "MID_552" "26430739" "hsa-miR-222-3p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-222 was up-regulated in pre-left ventricular assist device and decreased upon implantation in heart failure patients." "622" "MID_553" "29255073" "hsa-miR-222-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Maastricht, The Netherlands, Europe" "NA" "NA" "NA" "NA" "tissue" "NA" "NA" "Verjans, R et al. Hypertension. 2018" "NA" "NA" "MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure" "Downregulation of the miRNA-221/222 family enables profibrotic signaling in the pressure-overloaded heart." "623" "MID_554" "22427379" "hsa-miR-223-3p" "microRNA" "Diabetic ischemic heart failure " "down" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "624" "MID_555" "22120965" "hsa-miR-22-3p" "microRNA" "Heart failure" "up" "Diagnosis, Prognosis" "YES" "Rehovot, Israel, Asia" "30" "26" "4" "64.5(9.3)" "serum" "qRT-PCR" "Fold change:1.4; AUC: 0.80" "Goren, Y et al. Eur J Heart Fall. 2012" "mean(SD)" "NA" "Serum levels of microRNAs in patients with heart failure" "Elevated serum levels of specific miR-22, and miR-92b can identify systolic heart failure patients and correlate with important clinical prognostic parameters." "625" "MID_556" "28274577" "hsa-miR-22-3p" "microRNA" "Chronic heart failure" "down" "Prognosis" "YES" "Alkmaar, The Netherlands, Europe" "263" "189" "74" "67(13)" "blood" "Bio-SHiFT" "The temporal pattern of miR-22-3p was independently associated with the primary endpoint(PE) (HR [95% CI] per doubling of level: 0.64[0.47-0.77]). The instantaneous change in level (slope of the temporal miR pattern) of miR-22-3p was also independently as" "Van Boven N et al. Int J Cardiol. 2017" "mean(SD)" "NA" "Serially measured circulating miR-22-3p is a biomarker for adverse clinical outcome in patients with chronic heart failure: The Bio-SHiFT study" "The temporal pattern of circulating miR-22-3p is a strong and independent predictor of prognosis for chronic heart failure patients." "626" "MID_557" "17606841" "hsa-miR-22-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.71, P value=0.062" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "627" "MID_558" "26188824" "hsa-miR-23" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "13" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=13.951; SD=19.749; P Value=0.0002" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "628" "MID_559" "23696613" "hsa-miR-23a-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort,miR-23a (β=0.80, 95% CI=0.6-0.96, P=0.016), miR-23a (AUC=0.637, P=0.010)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD) " "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "56" "MID_56" "26474612" "hsa-miR-21-5p" "microRNA" "Unstable angina" "down" "Treatment" "YES" "Beijing, China, Asia" "43642" "43539" "43535" "63(8)/63(13)" "plasma" "microarray, real-time PCR" "Fold change: 8.16" "Zhang, J et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2015" "mean(SD)" "Discovery /Validation cohort" "Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina" "The miRNA could be decreased by treatment with statins and may be used as a novel biomarker for effectiveness of statins therapy in patients with unstable angina." "629" "MID_560" "22093502" "hsa-miR-23a-3p" "microRNA" "Heart failure at the time of ventricular assist device (VAD) placement" "down" "Prognosis" "YES" "Pittsburgh, USA, North America" "7/7/7/7" "NA/NA/NA/NA" "NA/NA/NA/NA" "NA/NA/NA/NA" "tissue" "Microarray, polymerase chain reaction (PCR) array and real-time PCR " "Screening Microarray (Test Cohort):fold change -4.52(P<0.032); Confirmatory PCR (Test Cohort): fold change -2.2(P<0.03); Confirmatory PCR (Validation Cohort): fold change -1.8(P<0.01)." "Ramani, R et al. J Am Coll Cardiol. 2011" "mean(SD)" "A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure" "A micro-ribonucleic acid signature associated with recovery from assist device support in 2 groups of patients with severe heart failure" "Lower cardiac expression of miR-23a at the time of ventricular assist device placement have the potential to provide markers to assess left ventricular recovery." "630" "MID_561" "26430739" "hsa-miR-23a-3p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-23a was significantly decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "631" "MID_562" "17606841" "hsa-miR-23b-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.51, P value=0.223" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "632" "MID_563" "23405000" "hsa-miR-24-3p" "microRNA" "Heart failure" "up" "Treatment" "NO" "Beijing, China, Asia" "8/5" "NA/NA" "NA/NA" "41.1(5.3)/56.4(4.9)" "tissue" "real-time PCR" "NA" "Zhang, HB et al. Cardiovasc Res. 2013" "mean(SEM)" "dilated cardiomyopathy/ischaemic cardiomyopathy" "Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure" "MiR-24 suppresses JP2 expression, was up-regulated in both heart failure tissues." "633" "MID_564" "17606841" "hsa-miR-24-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.72, P value=0.265" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "634" "MID_565" "24161931" "hsa-miR-25-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Maastricht, The Netherlands, Europe" "NA" "NA" "NA" "NA" "tissue" "Quantitative real-time PCR, In situ hybridization" "NA" "Dirkx, E et al. Nat Cell Biol. 2013" "mean(SEM)" "NA" "Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure" "Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure" "635" "MID_566" "26430739" "hsa-miR-26a-5p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-26a was significantly decreased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "636" "MID_567" "17606841" "hsa-miR-26a-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.03, P value=0.110" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "637" "MID_568" "26636106" "hsa-miR-26b-5p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Naples, Italy, Europe" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Sardu, C et al. J Diabetes Res. 2016" "NA" "NA" "Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes" "MiR-26b-5p levels has a significant increase in the improved myocardial performance in CRT responders." "638" "MID_569" "17606841" "hsa-miR-27a-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.86, P value=0.513" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "57" "MID_57" "26720041" "hsa-miR-223-3p" "microRNA" "Acute coronary syndrome, Stable angina pectoris" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "533/340" "424/276" "109/64" "64/63" "serum" "RT-qPCR" "MiRNA-223: HR 2.23 per one SD increase(1.20; 4.14), p=0.011, C-index 0.80)" "Schulte, C et al. PLoS One. 2015" "mean(SD)" "CAD: stable angina pectoris/acute coronary syndrome " "MiRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease" "Serum-derived circulating miRNA-223 were identified as predictors for cardiovascular death in a large patients with coronary artery disease." "639" "MID_570" "23696613" "hsa-miR-27b-3p " "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort,miR-27b (β=0.80, 95% CI=0.64-0.99, P = 0.036), miR-27b (AUC=0.642, P=0.008)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis. " "640" "MID_571" "17606841" "hsa-miR-28-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.51, P value=0.394" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "641" "MID_572" "26188824" "hsa-miR-29" "microRNA" "Chronic heart failure" "up" "Diagnosis, Treatment" "YES" "Hongkong, China, Asia" "17" "14" "3" "54(10.3)" "tissue" "Real-time quantitation PCR" "miRNA expression in failing heart patients：Mean=3.657; SD=4.639; P Value=0.0029" "Lai, KB et al. Int J Cardiol. 2015" "mean(SD)" "NA" "Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure" "These specific miRNAs may be the most suitable for circulating biomarkers in the early stages of chronic heart failure and possibly future therapeutic targets." "642" "MID_573" "17606841" "hsa-miR-296-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.74, P value=0.137" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "643" "MID_574" "17606841" "hsa-miR-299-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-3.16, P value=0.387" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "644" "MID_575" "26636106" "hsa-miR-29a-3p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Naples, Italy, Europe" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Sardu, C et al. J Diabetes Res. 2016" "NA" "NA" "Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes" "MiR-29a-3p levels has a significant increase in the improved myocardial performance in CRT responders." "645" "MID_576" "17606841" "hsa-miR-29a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=3.28, P value=0.023" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "646" "MID_577" "17606841" "hsa-miR-29b-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.73, P value=0.170" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "647" "MID_578" "17606841" "hsa-miR-29c-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.17, P value=0.086" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "648" "MID_579" "26572862" "hsa-miR-30* family" "microRNA" "Cardiac hypertrophy and heart failure " "down" "Treatment" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "blood, tissue" "Real time PCR assay" "NA" "Duan, Q et al. J Transl Med. 2015" "mean(SD)" "NA" "MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo" "The study found that deregulation of of miR-30* in the hypertrophic and failing hearts inhibits XBP1 and XBP1-induced angiogenesis results in the transition of hypertrophic hearts into heart failure." "58" "MID_58" "26474612" "hsa-miR-25-3p" "microRNA" "Unstable angina" "down" "Treatment" "YES" "Beijing, China, Asia" "6/26" "3/15" "3/11" "63(8)/63(13)" "plasma" "microarray, real-time PCR" "Fold change: 3.98" "Zhang, J et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2015" "mean(SD)" "Discovery /Validation cohort" "Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina" "The miRNA could be decreased by treatment with statins and may be used as a novel biomarker for effectiveness of statins therapy in patients with unstable angina." "649" "MID_580" "21367584" "hsa-miR-300" "microRNA" "Chronic heart failure" "down(Group II compared to the Group I)" "Treatment" "YES" "Showa-ku, Japan, Asia" "7/7" "6/7" "1/0" "50(17)49(14)" "tissue" "Microarray" "NA" "Funahashi, H et al. J Cardiol. 2011" "mean(SD)" "Group Ⅱ：ΔLV dP/dtmax<90%/Group Ⅱ：ΔLV dP/dtmax>90%" "Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure" "Altered expression of the miRNA was associated with the reduced catecholamine sensitivity in mildly symptomatic patients with dilated cardiomyopathy ,these miRNA can be therapeutic target for chronic heart failure. " "650" "MID_581" "17606841" "hsa-miR-302a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.51, P value=0.047" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "651" "MID_582" "17606841" "hsa-miR-302b-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.66, P value=0.085" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "652" "MID_583" "17606841" "hsa-miR-302c-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-3.27, P value=0.074" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "653" "MID_584" "21367584" "hsa-miR-302d-3p" "microRNA" "Chronic heart failure" "down(Group II compared to the Group I)" "Treatment" "YES" "Showa-ku, Japan, Asia" "7/7" "6/7" "1/0" "50(17)/49(14)" "tissue" "Microarray" "NA" "Funahashi, H et al. J Cardiol. 2011" "mean(SD)" "Group Ⅱ：ΔLV dP/dtmax<90%/Group Ⅱ：ΔLV dP/dtmax>90%" "Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure" "Altered expression of the miRNA was associated with the reduced catecholamine sensitivity in mildly symptomatic patients with dilated cardiomyopathy ,these miRNA can be therapeutic target for chronic heart failure." "654" "MID_585" "23660476" "hsa-miR-30a-5p" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "22" "17" "5" "59.1(11.1)" "serum" "Quantitative reverse transcription polymerase chain reaction (qRT-PCR)" "With AUC values of 0.725 in heart failure groups" "Zhao, DS et al. Cardiovasc Pathol. 2013" "NA" "NA" "Serum miR-210 and miR-30a expressions tend to revert to fetal levels in Chinese adult patients with chronic heart failure" "The serum expression levels of miR-30a were elevated in the chronic heart failure patients" "655" "MID_586" "17606841" "hsa-miR-30a-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.14, P value=0.042" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "656" "MID_587" "23696613" "hsa-miR-30b-5p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort, miR-30b (AUC=0.629, P=0.016)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "657" "MID_588" "17606841" "hsa-miR-30b-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.93, P value=0.050" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "658" "MID_589" "17606841" "hsa-miR-30c-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.31, P value=0.075" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "59" "MID_59" "25704294" "hsa-miR-28-5p" "microRNA" "Unstable angina" "up" "Diagnosis, Prognosis" "YES" "Tangshan, China, Asia" "27/24" "14/14" "10/13" "56(11)/59(6)" "plasma" "quantitative PCR" "MiR-28-5p distinguished UA cases with T2DM or without from control subjects with an area under the curve (AUC) of 0.802 (95% confidence interval (CI), 0.675 to 0.928) and 0.672 (95%CI, 0.514 to 0.830)." "Liu, J et al. Heart Lung Circ. 2015" "mean(SEM)" "UA/UA+T2DM" "MiR-28-5p Involved in LXR-ABCA1 Pathway is Increased in the Plasma of Unstable Angina Patients" "The study suggest that circulating miR-28-5p, involved in LXRα-ABCA1 pathway, may be a potential biomarker for diagnosis and prognosis of unstable angina." "659" "MID_590" "25739750" "hsa-miR-30c-5p, hsa-miR-146a-5p, hsa-miR-221-3p, hsa-miR-328, hsa-miR-375" "microRNA" "Heart failure with preserved ejection fraction(heart failurepEF)" "NA" "Diagnosis" "YES" "Dublin, Ireland, Europe" "75" "46" "29" "75(7)" "serum" "RT-PCR" "AUC(95% CI)=0.80(0.72-0.87)" "Watson, CJ et al. Eur J Heart Fail. 2015" "mean(SD)" "NA" "MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure" "The combination of these miRNAs can be useful biomarker for heart failure." "660" "MID_591" "28214846" "hsa-miR-30d-5p" "microRNA" "Acute heart failure (Aheart failure)" "down（dead people is lower）" "Prognosis" "YES" "Nanjing, China, Asia" "79/17" "52/8" " 27/9" "61(16)/62(17)" "serum" "qRT-PCR" "AUC = 0.806" "Xiao, J et al. Cell Physilo Biochem. 2017" "mean(SD)" "Survival/Death" "Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure" "The expression level of miR-30d in serum was significantly lower in those patients that expired compared to patients who survived during the 1 year follow up, have progonosis value in heart failure patients." "661" "MID_592" "25995320" "hsa-miR-30d-5p" "microRNA" "Heart Failure" "up" "Prognosis" "NO" "Boston, USA, North America" "40" "32" "8" "67.1(13.2)" "plasma" "Reverse Transcription-qPCR, Western Blotting" "In an ROC analysis, miR-30d was a significant discriminator of CRT responsiveness (C-statistic: 0.744, 95%CI=0.589-0.899, with sensitivity and specificity for the Youden optimal cut point for miR-30d 57.1% and 89.5%, respectively)." "Melman, YF et al. Circulation. 2015" "NA" "NA" "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study" "Plasma miR-30d level is associated with response to cardiac resynchronization therapy in heart failure patients with dyssynchrony, miR-30d increase in cardiomyocytes correlates with areas of increased wall stress in patients." "662" "MID_593" "26636106" "hsa-miR-30e-5p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Naples, Italy, Europe" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Sardu, C et al. J Diabetes Res. 2016" "NA" "NA" "Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes" "MiR-30e-5p levels has a significant increase in the improved myocardial performance in CRT responders." "663" "MID_594" "17606841" "hsa-miR-30e-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.93, P value=0.146" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "664" "MID_595" "25738515" "hsa-miR-3130-5p" "microRNA" "Heart failure following MI" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "665" "MID_596" "22120965" "hsa-miR-320a" "microRNA" "Heart failure" "up" "Diagnosis, Prognosis" "YES" "Rehovot, Israel, Asia" "30" "26" "4" "64.5(9.3)" "serum" "qRT-PCR" "Fold change:1.2; AUC: 0.86" "Goren, Y et al. Eur J Heart Fall. 2012" "mean(SD)" "NA" "Serum levels of microRNAs in patients with heart failure" "Elevated serum levels of specific miR-320a can identify systolic heart failure patients and correlate with important clinical prognostic parameters." "666" "MID_597" "17606841" "hsa-miR-320a" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=3.38, P value=0.003" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "667" "MID_598" "25763857" "hsa-miR-320b" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "668" "MID_599" "21367584" "hsa-miR-323a-3p" "microRNA" "Chronic heart failure" "down(Group II compared to the Group I)" "Treatment" "YES" "Showa-ku, Japan, Asia" "7/7" "6/7" "1/0" "50(17)/49(14)" "tissue" "Microarray" "NA" "Funahashi, H et al. J Cardiol. 2011" "mean(SD)" "Group Ⅱ：ΔLV dP/dtmax<90%/Group Ⅱ：ΔLV dP/dtmax>90%" "Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure" "Altered expression of the miRNA was associated with the reduced catecholamine sensitivity in mildly symptomatic patients with dilated cardiomyopathy ,these miRNA can be therapeutic target for chronic heart failure." "6" "MID_6" "27519051" "hsa-miR-125a-5p" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "NO" "Bucharest, Romania, Europe" "72" "47" "25" "60.65(1.55)" "serum" "Real-time quantitation PCR" "NA" "Simionescu, N et al. PLoS One. 2016" "mean(SEM)" "NA" "Hyperglycemia Determines Increased Specific MicroRNAs Levels in Sera and HDL of Acute Coronary Syndrome Patients and Stimulates MicroRNAs Production in Human Macrophages" "The miRNA levels was higher in the hyperglycemic acute coronary syndrome." "60" "MID_60" "29332918" "hsa-miR-3162-3p" "microRNA" "Unstable angina" "up" "Diagnosis" "YES" "Beijing, China, Asia" "10" "5" "5" "73.8(5.5)" "plasma" "Microarray, Real-time(RT) PCR" "AUC: 0.79, 95% CI: 0.675-0.905, sensitivity: 76.7%, specificity: 70%" "Cui, J et al. Int Heart J. 2018" "NA" "NA" "Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina" "The miRNA has diagnosis value in unstable angina patients." "669" "MID_600" "17606841" "hsa-miR-32-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.84, P value=0.013" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "670" "MID_601" "17606841" "hsa-miR-331-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.79, P value=0.060" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "671" "MID_602" "17606841" "hsa-miR-339-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.54, P value=0.081" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "672" "MID_603" "27920122" "hsa-miR-33a-5p" "microRNA" "Heart failure" "up" "Treatment" "YES" "Osaka, Japan, Asia" "11/17" "9/9" "8/2" "54.8(14.2)/58.4(10.8) " "tissue" "Quantitative real-time PCR, Western blot, Microarray and Gene Ontology analysis " "NA" "Nishiga, M et al. Circ Res. 2017" "mean(SEM)" "Low-stage heart failure/High-stage heart failure" "MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol" "MiR-33a expression levels in patients with high-stage heart failure were significantly lower than its expression in patients with low-stage heart failure, involved in cardiac remodeling." "673" "MID_604" "17606841" "hsa-miR-340-3p ; hsa-miR-340-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.79, P value=0.001" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "674" "MID_605" "23998897" "hsa-miR-340-5p" "microRNA" "End-stage heart failure because of dilated cardiomyopathy." "up" "Treatment" "YES" "Beijing, China, Asia" "14" "11" "3" "40.5" "tissue" "qRT-PCR" "NA" "Zhu, X et al. J Cell Mol Med. 2013" "mean(SD)" "NA" "Identification of micro-RNA networks in end-stage heart failure because of dilated cardiomyopathy" "The study identified miR-340 as a key miRNA contributing to the occurrence of heart failure and provide novel therapeutic targets for patients with heart failure." "675" "MID_606" "23696613" "hsa-miR-342-3p" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "Within the dyspnoea cohort, miR-324-5p (β=0.70, 95% CI=0.51-0.96, P=0.026), miR-342-3p (AUC=0.644, P=0.007)" "Ellis, K L et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "676" "MID_607" "17606841" "hsa-miR-342-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.88, P value=0.137" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "677" "MID_608" "25763857" "hsa-miR-34a-5p" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "678" "MID_609" "23743335" "hsa-miR-34a-5p" "microRNA" "Heart failure" "up(in heart failure)" "Diagnosis" "YES" "Osaka, Japan, Asia" "21" "17" "4" "69(9)" "serum" "Reverse transcription (RT) and preamplification, real-time PCR" "Rorrelated with left ventricular diastolic dimension: miR-34a: r=0.38, P=0.003" "Matsumoto, S et al. Circ Res. 2013" "mean(SD)" "NA" "Circulating p53-responsive microRNAs are predictive indicators of heart failure after Acute myocardial infarction" "In conclusion, the microRNA was upregulated in the serum of post-acute myocardial infarction patients who experienced development of heart failure within 1 year of acute myocardial infarction onset." "61" "MID_61" "26474612" "hsa-miR-451a" "microRNA" "Unstable angina" "down" "Treatment" "YES" "Beijing, China, Asia" "6/26" "3/15" "3/11" "63(8)/63(13)" "plasma" "microarray, real-time PCR" "Fold change: 10.90" "Zhang, J et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2015" "mean(SD)" "Discovery /Validation cohort" "Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina" "The miRNA could be decreased by treatment with statins and may be used as a novel biomarker for effectiveness of statins therapy in patients with unstable angina." "679" "MID_610" "17606841" "hsa-miR-34b-3p ; hsa-miR-34b-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.96, P value=0.002" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "680" "MID_611" "22427379" "hsa-miR-34b-3p; hsa-miR-34b-5p" "microRNA" "Diabetic ischemic heart failure " "up" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "681" "MID_612" "22427379" "hsa-miR-34c-5p" "microRNA" "Diabetic ischemic heart failure" "up" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "682" "MID_613" "25738515" "hsa-miR-3615" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis, Volcano plots" "NA" "NA" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "683" "MID_614" "17606841" "hsa-miR-365a-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.79, P value=0.001" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "684" "MID_615" "17606841" "hsa-miR-367-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.66, P value=0.116" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "685" "MID_616" "25738515" "hsa-miR-369-3p" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "686" "MID_617" "17606841" "hsa-miR-372" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.34, P value=0.002" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "687" "MID_618" "17606841" "hsa-miR-373-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.12, P value=0.007" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "688" "MID_619" "17606841" "hsa-miR-377-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.68, P value=0.173" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "62" "MID_62" "24260372" "hsa-miR-485-3p" "microRNA" "Stable angina" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "34" "30" "4" "60.0(10.6)" "plasma" "RT-qPCR" "AUC values:0.851" "D'Alessandra, Y et al. PLoS One. 2013" "mean(SEM)" "NA" "Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina" "This work showed that the miR-485-3p have the potential to accurately discriminate patients with angiographically stable angina from matched controls." "689" "MID_620" "26430739" "hsa-miR-378a-3p ; hsa-miR-378a-5p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-378 was increased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "690" "MID_621" "26430739" "hsa-miR-378a-5p" "microRNA" "Heart failure with LVAD support" "up" "Prognosis" "NO" "Utrecht, The Netherlands, Europe" "15/52" "11/44" "4/8" "NA/NA" "tissue, plasma" "Microarray, Q-PCR" "NA" "Lok, SI et al. PLoS One. 2015" "mean(SD)" "Discovery /Validation cohort" "MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices" "MiR-378* was increased in the left ventricle of the recovery hearts when compared to left ventricular assist devices dependent hearts." "691" "MID_622" "17606841" "hsa-miR-381-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=2.13, P value=0.386" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "692" "MID_623" "17606841" "hsa-miR-382-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.73, P value=0.150" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "693" "MID_624" "28693530" "hsa-miR-421" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "694" "MID_625" "21367584" "hsa-miR-422" "microRNA" "Chronic heart failure" "up(Group II compared to the Group I)" "Treatment" "YES" "Showa-ku, Japan, Asia" "7/7" "6/7" "1/0" "50(17)/49(14)" "tissue" "Microarray" "NA" "Funahashi, H et al. J Cardiol. 2011" "mean(SD)" "Group Ⅱ：ΔLV dP/dtmax<90%/Group Ⅱ：ΔLV dP/dtmax>90%" "Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure" "Altered expression of the miRNA was associated with the reduced catecholamine sensitivity in mildly symptomatic patients with dilated cardiomyopathy ,these miRNA can be therapeutic target for chronic heart failure." "695" "MID_626" "17606841" "hsa-miR-423-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=5.06, P value<0.001" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "696" "MID_627" "26580972" "hsa-miR-423-5p" "microRNA" "Acute heart failure" "down" "Prognosis" "YES" "Besancon, France, Europe" "236" "93" "143" "76" "plasma" "quantitative PCR" "Adjusted odds ratio[95% confidence interval] for one-year readmission was 0.70[0.53-0.93] for miR-423-5p(p=0.01). In the validation cohort, admission levels of miR-423-5p predicted 1-year mortality with an adjusted odds ratio[95% confidence interval] of 0" "Seronde, MF et al. PLoS One. 2015" "NA" "NA" "Circulating microRNAs and Outcome in Patients with Acute Heart Failure" "In patients, low circulating levels of miR-423-5p at presentation are related to a poor long-term outcome, miR-423-5p can as a prognostic biomarker of acute heart failure." "697" "MID_628" "25776937" "hsa-miR-423-5p" "microRNA" "Congestive heart failure" "up" "Diagnosis" "NO" "Chengdu, China, Asia" "51" "NA" "NA" "NA" "plasma" "qPCR, Luciferase assays, TUNEL assay" "NA" "Luo, P et al. Mol Med Rep. 2015" "mean(SD)" "NA" "MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes" "The results of the present study demonstrated that the expression of miR-423-5p was positively correlated with congestive heart failure diagnosis." "698" "MID_629" "24506564" "hsa-miR-423-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Porto Alegre, Brazil, South America " "17" "13" "4" "58(10)" "plasma" "qRT-PCR" "NA" "Goldraich, LA et al. Biomarkers. 2014" "mean(SD)" "NA" "Transcoronary gradient of plasma microRNA 423-5p in heart failure: evidence of altered myocardial expression" "These findings suggest that myocardial production of miR-423-5p is up-regulated in the setting of systolic heart failure, the transcoronary gradient of miR-423-5p was correlated with the BNP transcoronary gradient. " "63" "MID_63" "26474612" "hsa-miR-92a-3p" "microRNA" "Unstable angina" "down" "Treatment" "YES" "Beijing, China, Asia" "6/26" "3/15" "3/11" "63(8)/63(13)" "plasma" "microarray, real-time PCR" "Fold change: 5.53" "Zhang, J et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2015" "mean(SD)" "Discovery /Validation cohort" "Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina" "The miRNA could be decreased by treatment with statins and may be used as a novel biomarker for effectiveness of statins therapy in patients with unstable angina." "699" "MID_630" "22120965" "hsa-miR-423-5p" "microRNA" "Heart failure" "up" "Diagnosis, Prognosis" "YES" "Rehovot, Israel, Asia" "30" "26" "4" "64.5(9.3)" "serum" "qRT-PCR" "Fold change:1.5; AUC: 0.88" "Goren, Y et al. Eur J Heart Fall. 2012" "mean(SD)" "NA" "Serum levels of microRNAs in patients with heart failure" "Elevated serum levels of specific microRNAs: miR-423-5p can identify systolic heart failure patients and correlate with important clinical prognostic parameters." "700" "MID_631" "20185794" "hsa-miR-423-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "MiR-423-5p distinguished heart failure cases from healthy controls with an area under the curve (AUC) of 0.91 (95% confidence interval, 0.84 to 0.98). " "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the miRNA provides attractive candidates as novel biomarkers for heart failure." "701" "MID_632" "29344661" "hsa-miR-423-5p" "microRNA" "Acute heart failure" "down" "Prognosis" "YES" "Porto alegre, Brazil, South America" "48" "33" "15" "62(13)" "plasma" "Real-time PCR " "NA" "Schneider, SIDR et al. Mol Med Rep. 2018" "mean(SD)" "NA" "Plasma levels of microRNA-21, -126 and -423-5p alter during clinical improvement and are associated with the prognosis of acute heart failure" "The plasma levels of miR-423-5p altered during clinical improvement and were associated with the prognosis of acute heart failure." "702" "MID_633" "17606841" "hsa-miR-424-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=3.02, P value=0.001" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "703" "MID_634" "17606841" "hsa-miR-429" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.91, P value=0.00" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "704" "MID_635" "17606841" "hsa-miR-432-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.50, P value=0.175" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "705" "MID_636" "25738515" "hsa-miR-433" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "706" "MID_637" "26683101" "hsa-miR-4491" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "14" "NA" "NA" "NA" "plasma、heart" "Microarray, qRT-PCR" "High accuracy for diagnosis (>0.9)." "Li, H et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of cardiac-related circulating microRNA profile in human chronic heart failure" "MiR-4491 were found significantly upregulated in heart and plasma during heart failure." "707" "MID_638" "25763857" "hsa-miR-451a" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "reverse transcription real-time qPCR" "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The microRNAs was abundant in pericardial fluid." "708" "MID_639" "27725938" "hsa-miR-451a/hsa-miR-23a-3p ratio" "microRNA" "Coronary artery disease, Heart failure" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "25" "19" "6" "62.0(6.6)" "plasma" "qPCR" "MiR-451a/miR-23a ratio<60 indicated <0.12% hemolysis with 100% sensitivity and 100% specificity" "Wu, CS et al. Biomed Res Int. 2016" "mean(SD)" "NA" "Optimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease" "The miR-425a/miR-23a ratio increased as hemolysis grade increased, is a indicator of hemolysis." "64" "MID_64" "22464573" "hsa-miR-92a-3p" "microRNA" "Stable angina" "up" "Treatment" "YES" "Nanning, China, Asia" "6/20" "NA/NA" "NA/NA" "NA/NA" "cell" "RT-PCR" "Circulating miR-92a expression was significantly higher in patients with stable angina pectoris (SAP) complicated with DM than those without DM (0.492 vs. -0.121, Z = -3.038, P = 0.002). It was found that statin therapy could down regulate miR-92a express" "Wang, H et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012" "mean(SEM)" "Stain therapy/Non-statin therapy" "The influence of statin therapy on circulating microRNA-92a expression in patients with coronary heart disease" "Regulation of circulating miR-92a expression may be considered as a new clinical target for statin treating endothelial dysfunction in patients with CHD." "709" "MID_640" "17606841" "hsa-miR-452-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.85, P value=0.029" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "710" "MID_641" "23247724" "hsa-miR-454-3p" "microRNA" "Congestive heart failure secondary to dilated cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 703- to 805-fold (p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-454 is highly downregulated in congestive heart failure secondary to dilated cardiomyopathy patients." "711" "MID_642" "25738515" "hsa-miR-493-5p" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "712" "MID_643" "25619197" "hsa-miR-494" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.58; 95% Confidence interval 0.422-0.734;Combined (miRNA+NT-proBNP) 0.93; 95% Confidence interval 0.824-0.979." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "713" "MID_644" "25619197" "hsa-miR-494" "microRNA" "heart failure with reduced left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.66; 95% Confidence interval 0.482-0.836;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.907-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "714" "MID_645" "25111814" "hsa-miR-494" "microRNA" "End-stage heart failure" "up" "Treatment" "NO" "Munich, Germany, Europe" "12" "NA" "NA" "43.6(15.8)" "cardiomyocytes" "Quantitative real-time PCR(qPCR)" "NA" "M?hnle, P et al. Biochem Biophys Res Commun. 2014" "mean(SD)" "NA" "MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure" "In conclusion, the results highlight a potential role of myocardial miR-494 in mediating cardioprotective effects via controlling the expression of CB1 receptors." "715" "MID_646" "17606841" "hsa-miR-494" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.57, P value=0.041" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "716" "MID_647" "25738515" "hsa-miR-495-3p" "microRNA" "Heart failure following myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "717" "MID_648" "17606841" "hsa-miR-495-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.52, P value=0.202" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "718" "MID_649" "25763857" "hsa-miR-497-5p" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "66" "MID_65" "25832031" "hsa-let-7e-5p" "microRNA" "Abdominal aortic aneurysms" "down" "Treatment" "YES" "Leicester, England, Europe" "15/40/40/40" "15/40/40/40" "0" "NA" "blood, plasma, tissue" "qPCR" "Fold change：-1.80； P Value<0.001." "Stather, P W et al. Br J Surg. 2015" "mean(SD)" "Discovery /Validation small AAA/large AAA/following AAA repair" "Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease" "Modulation of th miRNA let-7e and its target genes may be a new therapeutic pathway to affect the progression of abdominal aortic aneurysm." "719" "MID_650" "17606841" "hsa-miR-497-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.32, P value=0.207" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "720" "MID_651" "17606841" "hsa-miR-499a-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-4.93, P value=0.178" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "721" "MID_652" "23247724" "hsa-miR-500a-3p" "microRNA" "Congestive heart failure secondary to dilated cardiomyopathy" "down" "Diagnosis, Treatment" "YES" "Temple, USA, North America" "10" "NA" "NA" "47.4(10.13)" "blood" "Microarray, qRT-PCR" "fold change ranging from 554- to 686.8-fold(p<0.001)" "Nair, N et al. Mol Cell Biochem. 2013" "mean(SD)" "NA" "Circulating miRNA as novel markers for diastolic dysfunction" "Expression of miR-500 is highly downregulated in congestive heart failure secondary to dilated cardiomyopathy patients." "722" "MID_653" "17606841" "hsa-miR-500a-3p ; hsa-miR-500a-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.55, P value=0.253" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "723" "MID_654" "17606841" "hsa-miR-507" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.75, P value=0.065" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "724" "MID_655" "23465244" "hsa-miR-508-5p" "microRNA" "Chronic heart failure" "up" "Diagnosis, Prognosis, Treatment" "YES" "Hangzhou, China, Asia" "55/51" "40/39" "12/15" "68.2(8.0)(55-82)/66.4(7.9)(53-82)" "endothelial progenitor cells" "Microarray, real-time RT-PCR" "In the NICM group:According to the optimal cut-off point from the ROC curve, 10.23 was set as the threshold for relative miR-508-5p expression levels in EPCs. Kaplan–Meier survival analysis showed that at the 24-month follow-up, patients with relative miR" "Qiang, L et al. Int J Cardiol. 2013" "mean(SEM)" "ischemic cardiomyopathy/non-ischemic cardiomyopathy" "Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients" "In this study, miR-508-5p was independent prognostic factors for patients with chronic heart failure(CHF) caused by ischemic cardiomyopathy and nonischemic cardiomyopathy, and might provide novel targets for prevention and treatment of CHF." "725" "MID_656" "17606841" "hsa-miR-512-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.50, P value=0.186" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "726" "MID_657" "17606841" "hsa-miR-515-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.55, P value=0.012" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "727" "MID_658" "17606841" "hsa-miR-520c-3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.88, P value=0.143" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "728" "MID_659" "23864135" "hsa-miR-520d-5p" "microRNA" "Systolic heart failure" "up" "Diagnosis, Prognosis" "YES" "Heidelberg, Germany, Europe" "53" "44" "9" "60(16)" "blood" "genome-wide miRNA expression profiles" "AUC=0.71" "Vogel, B et al. Eur Heart J. 2013" "NA" "NA" "Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure" "The miRNA is related to the degree of left ventricular dysfunction, it may serve as objective molecular tools to assess disease severity and prognosis." "67" "MID_66" "23316282" "hsa-let-7f-5p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of let-7f was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "729" "MID_660" "23864135" "hsa-miR-520d-5p, hsa-miR-558, hsa-miR-122-3p, hsa-miR-200b-5p, hsa-miR-622, hsa-miR-519e-5p, hsa-miR-1231, hsa-miR-1228-5p" "microRNA" "Systolic heart failure" "NA" "Diagnosis, Prognosis" "YES" "Heidelberg, Germany, Europe" "53" "44" "9" "60(16)" "blood" "genome-wide miRNA expression profiles" "The eight miRNA signature reached an accuracy of 70%, a specificity of 66%, and a sensitivity of 74%. The best AUC for a signature comprising the eight miRNAs was 0.81." "Vogel, B et al. Eur Heart J. 2013" "NA" "NA" "Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure" "The miRNA is related to the degree of left ventricular dysfunction, it may serve as objective molecular tools to assess disease severity and prognosis." "730" "MID_661" "17606841" "hsa-miR-520d-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.19, P value=0.045" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "731" "MID_662" "17606841" "hsa-miR-520h" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.53, P value=0.143" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "732" "MID_663" "17606841" "hsa-miR-523-3p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.02, P value=0.062" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "733" "MID_664" "17606841" "hsa-miR-525-AS" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.99, P value=0.046" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "734" "MID_665" "17606841" "hsa-miR-526b-5p" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.15, P value=0.090" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "735" "MID_666" "17606841" "hsa-miR-526b-AS" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-3.28, P value=0.057" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "736" "MID_667" "25619197" "hsa-miR-545-5p" "microRNA" "heart failure with preserved left ventricular ejection fraction" "up" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "64.101(9.05)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.62; 95% Confidence interval 0.433-0.744;Combined (miRNA+NT-proBNP) 0.90; 95% Confidence interval 0.768-0.971." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "737" "MID_668" "23864135" "hsa-miR-558" "microRNA" "Systolic heart failure" "down" "Diagnosis, Prognosis" "YES" "Heidelberg, Germany, Europe" "53" "44" "9" "60(16)" "blood" "genome-wide miRNA expression profiles" "AUC=0.7 sensitivity:64%, specificity:74%, accuracy:68%. " "Vogel, B et al. Eur Heart J. 2013" "NA" "NA" "Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure" "The miRNA is related to the degree of left ventricular dysfunction, it may serve as objective molecular tools to assess disease severity and prognosis." "738" "MID_669" "23696613" "hsa-miR-598" "microRNA" "Heart failure" "down" "Diagnosis" "YES" "Christchurch, New Zealand, Oceania" "16/16 22/22" "12/12 17/14" "4/4 5/8" "75.9(10.7)/77.4(12.0) 72.0(14.2)/78.1(11.7)" "plasma" "RT-PCR" "miR-598 (AUC=0.650, P=0.005)" "Ellis, KL et al. Eur J Heart Fail. 2013" "mean(SD)" "heart failure-REF/heart failure-PEF screening/validation" "Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients" "The miRNA was associated with heart failure diagnosis in regression and ROC analysis." "68" "MID_67" "23316282" "hsa-miR-124-3p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-124 was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "739" "MID_670" "20185794" "hsa-miR-622" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "NA" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the miRNA provides attractive candidates as novel biomarkers for heart failure." "740" "MID_671" "28693530" "hsa-miR-625-5p" "microRNA" "Tetralogy of Fallot with heart failure" "down" "Diagnosis" "YES" "Homburg, Germany, Europe" "3" "NA" "NA" "33.0(13.9)" "blood" "Microarray, RT-qPCR" "NA" "Abu-Halima, M et al. J Transl Med. 2017" "mean(SD)" "NA" "Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure" "The miRNA are lower in tetralogy of fallot patients with symptomatic right heart failure and thus may indicate disease progression in these patients." "741" "MID_672" "25619197" "hsa-miR-638" "microRNA" "heart failure with reduced left ventricular ejection fraction" "down" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.67; 95% Confidence interval 0.468-0.769;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.912-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "742" "MID_673" "22427379" "hsa-miR-650" "microRNA" "Diabetic ischemic heart failure" "down" "Prognosis" "NO" "Milano, Italy, Europe" "10" "9" "1" "61.8(2.3)" "tissue" "qRT-PCR" "NA" "Greco, S et al. Diabetes. 2012" "mean(SEM)" "NA" "MicroRNA dysregulation in diabetic ischemic heart failure patients" "The finding shows a dysregulation of miRNAs in heart failure with diabetic patients, it changed specifically in the failing myocardium of diabetic patients." "743" "MID_674" "26683101" "hsa-miR-660-3p" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "14" "NA" "NA" "NA" "plasma, heart" "Microarray, qRT-PCR" "High accuracy for diagnosis (>0.9)." "Li, H et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of cardiac-related circulating microRNA profile in human chronic heart failure" "MiR-660-3p significantly upregulated in chronic heart failure and correlated to severity, holding function as diagnostic biomarker." "744" "MID_675" "26683101" "hsa-miR-665" "microRNA" "Chronic heart failure" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "14" "NA" "NA" "NA" "plasma, heart" "Microarray, qRT-PCR" "High accuracy for diagnosis (>0.9)." "Li, H et al. Oncotarget. 2016" "mean(SD)" "NA" "Identification of cardiac-related circulating microRNA profile in human chronic heart failure" "MiR-665 significantly upregulated in chronic heart failure and correlated to severity, holding function as diagnostic biomarker." "745" "MID_676" "25111814" "hsa-miR-665" "microRNA" "End-stage heart failure" "down" "Treatment" "NO" "Munich, Germany, Europe" "12" "NA" "NA" "43.6(15.8)" "cardiomyocytes" "Quantitative real-time PCR" "In contrast, we found a significantly decreased expression of miR-665 (0.79±0.20 vs. 1.16±0.10; p<0.005) in myocardium samples of patients with end-stage heart failure as compared to normal controls" "M?hnle, P et al. Biochem Biophys Res Commun. 2014" "mean(SD)" "NA" "MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure" "In conclusion, the results highlight a potential role of myocardial miR-665 in mediating cardioprotective effects via controlling the expression of CB2 receptors." "746" "MID_677" "25619197" "hsa-miR-671-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Singapore, Signapore, Asia " "60" "NA" "NA" "64.73(8.18)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.75; 95% Confidence interval 0.591-0.901;Combined (miRNA+NT-proBNP) 0.97; 95% Confidence interval 0.836-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "747" "MID_678" "25619197" "hsa-miR-671-5p" "microRNA" "heart failure with reduced left ventricular ejection fraction" "up" "Diagnosis" "YES" "Singapore, Signapore, Asia " "30" "NA" "NA" "65.38(7.27)" "plasma" "Microarray, qRT-PCR" "AUC values: Individual marker 0.89; 95% Confidence interval 0.646-0.954;Combined (miRNA+NT-proBNP) 1.00; 95% Confidence interval 0.832-1.000." "Wong, LL et al. Eur J Heart Fail. 2015" "mean(SEM)" "NA" "Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction" "The study identified clusters of circulating miRNAs that distinguished heart failure from non-heart failure controls and HFREF from HFPEF and these miRNAs may have the potnetial value of the diagnostic value of heart failure." "748" "MID_679" "20185794" "hsa-miR-675-5p" "microRNA" "Heart failure" "up" "Diagnosis" "YES" "Amsterdam, The Netherlands, Europe" "12/50" "NA/NA" "NA/NA" "NA/NA" "plasma" "microarray, real-time PCR" "with an area under the curve (AUC) of 0.89" "Tijsen, AJ et al. Circ Res. 2010" "mean(SEM)" "heart failure patients/non-heart failure forms of dyspnea patients" "MiR-423-5p as a circulating biomarker for heart failure" "The miRNA is elevated in patients with heart faiure related to the clinical diagnosis of heart failure, the miRNA provides attractive candidates as novel biomarkers for heart failure." "69" "MID_68" "23316282" "hsa-miR-124-3p" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "YES" "Osaka, Japan, Asia" "23" "18" "5" "71.8(8.9)" "plasma" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-124 was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "749" "MID_680" "26177627" "hsa-miR-765" "microRNA" "Heart failure" "up" "Treatment" "YES" "Cincinnati, United States of America, North America" "6" "4" "2" "48-69" "tissue" "Stem-loop PCR and real-time PCR, Luciferase reporter assay" "NA" "Cai, WF et al. Eur J Heart Fail. 2015" "NA" "NA" "Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility" "Down-regulation of miR-765 may serve as an additional therapeutic target to inhibit the increased PP-1 activity and improve calcium handling in failing hearts." "750" "MID_681" "25738515" "hsa-miR-877-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "751" "MID_682" "26636106" "hsa-miR-92a-3p" "microRNA" "Heart failure" "up" "Prognosis" "NO" "Naples, Italy, Europe" "NA" "NA" "NA" "NA" "NA" "NA" "NA" "Sardu, C et al. J Diabetes Res. 2016" "NA" "NA" "Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes" "MiR-92a-3p levels has a significant increase in the improved myocardial performance in CRT responders." "752" "MID_683" "22120965" "hsa-miR-92b-3p" "microRNA" "Heart failure" "up" "Diagnosis, Prognosis" "YES" "Rehovot(Israel)" "30" "26" "4" "64.5(9.3)" "serum" "qRT-PCR" "Fold change:1.3; AUC: 0.76" "Goren, Y et al. Eur J Heart Fall. 2012" "mean(SD)" "NA" "Serum levels of microRNAs in patients with heart failure" "Elevated serum levels of specific microRNAs miR-92b can identify systolic heart failure patients and correlate with important clinical prognostic parameters." "753" "MID_684" "17606841" "hsa-miR-98-5p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.83, P value=0.118" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "754" "MID_685" "25763857" "hsa-miR-99b-5p" "microRNA" "Heart failure" "up" "NA" "NO" "Kuopio, Finland, Europe" "51" "37" "14" "63.8(9.3)" "pericardial fluid" "real-time qPCR " "NA" "Kuosmanen, SM et al. PLoS One. 2015" "mean(SD)" "NA" "MicroRNA profiling of pericardial fluid samples from patients with heart failure" "The miRNA is specific to pericardial fluid in heart failure patients." "755" "MID_686" "25738515" "hsv1-miR-H2-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "756" "MID_687" "17606841" "mmu_let_7d_AS" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.60, P value=0.200" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "757" "MID_688" "17606841" "mmu_miR_129_3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.50, P value=0.236" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "758" "MID_689" "17606841" "mmu_miR_17_3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=4.70, P value<0.001" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "70" "MID_69" "23746831" "hsa-miR-1260a" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "NO" "Hongkong, China, Asia" "6" "6" "0" "69.5(8.2)" "tissue" "Microarray, qPCR" "Hsa-miR-516a-5p and mi-1260 showed the highest fold change (P<0.05)." "Cheuk, BL et al. J Vasc Surg. 2014" "mean(SD)" "NA" "Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms" "Functional annotations of the two miRs via bioinformatics approaches revealed that both are highly involved in some predefined mechanisms of abdominal aortic aneurysms formation." "759" "MID_690" "17606841" "mmu_miR_215" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.53, P value=0.031" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "760" "MID_691" "17606841" "mmu_miR_292_3p" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.81, P value=0.033" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "761" "MID_692" "17606841" "mmu_miR_294" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.50, P value=0.147" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "762" "MID_693" "17606841" "mmu_miR_295" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.69, P value=0.026" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "763" "MID_694" "17606841" "mmu_miR_297" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.68, P value=0.032" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "764" "MID_695" "17606841" "mmu_miR_300" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.89, P value=0.109" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "765" "MID_696" "17606841" "mmu_miR_322" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.72, P value=0.029" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "766" "MID_697" "17606841" "mmu_miR_330" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.74, P value=0.032" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "767" "MID_698" "17606841" "mmu_miR_341" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.79, P value=0.094" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "768" "MID_699" "17606841" "mmu-miR-192" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.56, P value=0.568" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "7" "MID_7" "27357355" "hsa-miR-132-3p" "microRNA" "Acute coronary syndrome" "up" "Prognosis" "YES" "Hamburg, Germany, Europe" "430" "349" "81" "63(55-68)" "serum" "RT-qPCR" "AUC=0.737" "Karakas, M et al. Eur Heart J. 2017" "NA" "acute coronary syndrome" "Circulating microRNAs strongly predict cardiovascular death in patients with coronary artery disease-results from the large AtheroGene study" "The miRNA coule be valuable biomarkers for risk estimation in cardiovascular disease." "71" "MID_70" "23316282" "hsa-miR-126-3p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-126 was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "769" "MID_700" "17606841" "mmu-miR-325" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-2.11, P value=0.195" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "770" "MID_701" "17606841" "Rno_miR_297" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.59, P value=0.046" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "771" "MID_702" "17606841" "Rno_miR_333" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.71, P value=0.026" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "772" "MID_703" "17606841" "Rno_miR_343" "microRNA" "Heart failure" "up" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=1.66, P value=0.053" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is upregulated in failing cardiac tissue." "773" "MID_704" "17606841" "Rno-miR-352" "microRNA" "Heart failure" "down" "Diagnosis" "NO" "Wuerzburg, Germany, Europe" "NA" "NA" "NA" "NA" "cardic tissue" "Microarray, quantitative RT-PCR" "Flod change=-1.80, P value=0.100" "Thum, T et al. Circulation. 2007" "NA" "NA" "MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure" "The miRNA is downregulated in failing cardiac tissue." "791" "MID_705" "27188753" "hsa-let-7a-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.841, 95 CI%： 0.720-0.962， P=0.0001, Sensitivity:0.727, Specificity:0.864, Cutoff value: 1.385" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "792" "MID_706" "27515482" "hsa-miR-103a-3p" "microRNA" "High bllood pressure" "up" "Diagnosis" "YES" "Changsha, China, Asia" "43/38" "30/26" "12/13" "56(12)/55(11.4)" "plasma" "Real-time quantitative PCR, Luciferase reporter assay" "NA" "Huang, L et al. Cardiol J. 2016" "mean(SEM)" "Acute myocardial infarction+High blood pressure/Acute myocardial infarction" "MiR-103a targeting Piezo1 is involved in acute myocardial infarction through regulating endothelium function" "MiR-103a might be a potential biomarker of high bloog pressure." "793" "MID_707" "26569423" "hsa-miR-124-3p" "microRNA" "Pulmonary arterial hypertension" "down" "Treatment" "NO" "Cambridge, United Kingdom, Europe" "17" "7" "10" "32.7" "lung tissue" "Real-time RT-PCR" "NA" "Wang, D et al. Circ Res. 2014" "mean" "NA" "MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts" "MiR-124 expression is suppressed in ulmonary arterial hypertension patients, and treatment of hypertensive fibroblasts with histone deacetylase inhibitors increased miR-124 expression." "794" "MID_708" "24848278" "hsa-miR-126-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "atherosclerosis/pre-atherosclerosis" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "795" "MID_709" "24977625" "hsa-miR-126-3p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis" "NO" "Quebec City, Canada, North America" "20" "5" "15" "46(14)" "muscle tissue" "qRT-PCR" "NA" "Potus, F et al. Am J Respir Crit Care Med. 2014" "mean(SD)" "NA" "Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension" "Downregulation of miR-126 expression leading to SPRED-1 up-regulation as the major actor in this peripheral angiogenic impairment in pulmonary arterial hypertension patients." "72" "MID_71" "22704053" "hsa-miR-133a" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "NO" "Pennsylvania, USA, North America; Dresden, Germany, Europe" "5/25/11" "3/23/10" "2002/2/1" "64(3.9)/70.5(6.1)/71.9(9.1)" "tissue" "Microarray, qRT-PCR" "NA" "Pahl, MC et al. BMC Med Genomics. 2012" "mean(SD)" "elective repair for AAA（microarray）/elective repair for AAA（PCR）/ruptured AAA(PCR)" "MicroRNA expression signature in human abdominal aortic aneurysms" "This study revealed that deregulated miRNAs in human abdominal aortic aneurysm tissue suggesting that miRNAs play a part in pathogenesis." "796" "MID_710" "24960162" "hsa-miR-130" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "NO" "Boston, USA, North America" "NA" "NA" "NA" "NA" "pulmonary arterial smooth muscle cells, pulmonary arterial endothelial cells" "RT-qPCR, Luciferase reporter assay, In situ hybridization" "NA" "Bertero, T et al. J Clin Invest. 2014" "NA" "NA" "Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension" "In endothelial cells, miR-301 modulated apelin-miR-424/503-FGF2 signaling, while in smooth muscle cells, miR-130 modulated STAT3-miR-204 signaling to promote pulmonary hypertension-associated phenotypes." "797" "MID_711" "24848278" "hsa-miR-130a-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "798" "MID_712" "24244340" "hsa-miR-138-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "NO" "Philadelphia, United States of America, North America" "NA" "NA" "NA" "NA" "muscle tissue" "Luciferase assay" "NA" "Sen, A et al. PLoS One. 2013" "NA" "NA" "MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1" "Hypoxia-induced MiR-138 is an essential mediator of endothelial cells dysfunction via its ability to target the 3'UTR of S100A1 in pulmonary arterial hypertension patients." "799" "MID_713" "27648837" "hsa-miR-138-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Treatment" "NO" "Ontario, Canada, North America" "NA" "NA" "NA" "NA" "pulmonary arterial smooth muscle cells" "qPCR" "NA" "Hong, Z et al. Am J Respir Crit Care Med. 2017" "NA" "NA" "MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype" "MicroRNA-138 down-regulate mitochondrial calcium uniporter, causing the pulmonary arterial hypertension cancer phenotype." "800" "MID_714" "27021683" "hsa-miR-140-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Treatment" "NO" "Zhengzhou, China, Asia" "10" "NA" "NA" "NA" "lung tissue, hypoxia-mediated pulmonary artery smooth muscle cells" "Quantitative real-time polymerase chain reaction, Luciferase reporter assay " "NA" "Zhang, Y et al. Biochem Biophys Res Commun. 2016" "NA" "NA" "MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression" "MiR-140-5p targets Dnmt1 and regulates SOD2 expression to inhibit proliferation and promote apoptosis and differentiation of human pulmonary artery smooth muscle cell in hypoxia." "801" "MID_715" "27214554" "hsa-miR-140-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis, Prognosis, Treatment" "YES" "Sheffield, United Kingdom, Europe" "12/20" "1/9" "11/11" "58.75/53.75" "lung tissue, blood" "low-density array, PCR" "AUC=0.74, P=0.0171" "Rothman, AM et al. J Clin Invest. 2016" "mean" "patients/tissue bank" "MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension" "MiR-140-5p is a key regulators of disease pathology and as potential therapeutic targets for the treatment of pulmonary arterial hypertension." "802" "MID_716" "23339529" "hsa-miR-145-5p" "microRNA" "Hypertensive in atherosclerotic" "up" "Diagnosis" "NO" "Chieti, Italy, Europe " "15" "11" "4" "77.0(8.0)" "tissue" "reverse-transcription and real-time PCR " "Higher levels of miR-145 in atherosclerotic plaques from hypertensive patients when compared with plaques from control patients (1.201±0.260 vs 0.483±0.148-fold induction±SE; p =0.026." "Santovito, D et al. Expert Opin Ther Targets. 2013" "mean(SEM)" "NA" "Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients" "This study is the first demonstration that hypertension may upregulate miR-145 expression in human atherosclerotic plaques." "803" "MID_717" "22715469" "hsa-miR-145-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Treatment" "NO" "Glasgow, UK, Europe" "NA" "NA" "NA" "NA" "lung tissue" "qPCR" "NA" "Caruso, P et al. Circ Res. 2012" "NA" "NA" "A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples" "MiR-145 is expressed in remodeled vessels and mutations in BMPR2 lead to upregulation of miR-145 in pulmonary arterial hypertension patients." "804" "MID_718" "23220912" "hsa-miR-150-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Prognosis" "YES" "London, United Kingdom, Europe" "8/130/30" "4/51/11" "4/94/19" "40.0(10)/51.1(17.0)/57.1(17.5)" "microvesicles, blood" "Microarray, qPCR" "Hammersmith patients: AUC=0.782, 95 CI%=0.633-0.932; Sheffield patients: AUC=0.85" "Rhodes, CJ et al. Am J Respir Crit Care Med. 2013" "mean(SD)" "screen cohort/Hammersmith Cohort 1/Sheffield Cohort 2" "Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension" "Reduced circulating miR-150 levels are associated with poor survival in pulmonary arterial hypertension." "805" "MID_719" "24963038" "hsa-miR-193a-3p" "microRNA" "Pulmonary arterial hypertension" "down" "Treatment" "YES" "Quebec City, Canada, North America" "5/1" "1/1" "4/0" "61(16)/52" "lung tissue, pulmonary artery smooth muscle cells" "real-time PCR" "NA" "Sharma, S et al. Circulation. 2014 " "mean(SEM)" "lung tissue/pulmonary artery smooth muscle cells" "Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p" "MiR-193-3p can as downstream effectors of an apolipoprotein A-I mimetic peptide in the rescue of pulmonary arterial hypertension." "73" "MID_72" "22704053" "hsa-miR-133b" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "NO" "Pennsylvania, USA, North America; Dresden, Germany, Europe" "5/25/11" "3/23/10" "2002/2/1" "64(3.9)/70.5(6.1)/71.9(9.1)" "tissue" "Microarray, qRT-PCR" "NA" "Pahl, M C et al. BMC Med Genomics. 2012" "mean(SD)" "elective repair for AAA（microarray）/elective repair for AAA（PCR）/ruptured AAA(PCR)" "MicroRNA expression signature in human abdominal aortic aneurysms" "This study revealed that deregulated miRNAs in human abdominal aortic aneurysm tissue suggesting that miRNAs play a part in pathogenesis." "806" "MID_720" "27188753" "hsa-miR-199a-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.859, 95 CI%： 0.752-0.966， P=0.0001, Sensitivity:0.773, Specificity:0.810, Cutoff value: 1.426" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "807" "MID_721" "27188753" "hsa-miR-199b-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.706, 95 CI%： 0.551-0.860， P=0.0210, Sensitivity:0.727, Specificity:0.619, Cutoff value: 1.153" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "808" "MID_722" "27837306" "hsa-miR-19a-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Beijing, China, Asia" "6" "5" "1" "4.0(1.2)" "tissue, plasma" "Microarray, qRT-PCR" "AUC=0.781(95% confidence interval, CI=0.612-0.950)" "Chen, W et al. Pediatr Cardiol. 2017" "mean(SD)" "Circulating microRNA as a Novel Biomarker for Pulmonary Arterial Hypertension Due to Congenital Heart Disease" "Circulating miR-19a may be a novel biomarker for the diagnosis of pulmonary arterial hypertension due to congenital heart disease." "809" "MID_723" "21321078" "hsa-miR-204-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis, Treatment" "YES" "Quebec City, Canada, North America" "8" "NA" "NA" "NA" "lung tissue, pulmonary artery smooth muscle cells" "Low-density miRNA array, microarray, qRT-PCR, ChiP-PCR" "NA" "Courboulin, A et al. J Exp Med. 2011" "NA" "NA" "Role for miR-204 in human pulmonary arterial hypertension" "Altering miR-204 level promotes the activation of the proproliferative and antiapoptotic Src-STAT3-NFAT pathway in pulmonary arterial hypertension-pulmonary artery smooth muscle cells." "810" "MID_724" "28554172" "hsa-miR-206" "microRNA" "Pulmonary hypertension (PH) due to left heart diseases " "down" "Diagnosis" "YES" "Chongqing, China, Asia" "47/35" "26/17" "21/18" "64(54-72)/64(53-73)" "plasma" "qPCR" "AUC=0.720; Sensitivity:0.686; Specificity: 0.658; 95%CI: 0.624-0.815" "Jin, P et al. Cell Physiol Biochem. 2017" "NA" "47 LHD control patients, and 35 PH-LHD patients" "The Circulating MicroRNA-206 Level Predicts the Severity of Pulmonary Hypertension in Patients with Left Heart Diseases" "MiR-206 was identified as an independent predictor for pulmonary hypertension, associated with increased in left heart diseases patients." "811" "MID_725" "27162619" "hsa-miR-214-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis, Prognosis" "NO" "Edinburgh, UK, Europe" "NA" "NA" "NA" "NA" "pulmonary arterial smooth muscle cells" "In situ hybridization, qRT-PCR" "NA" "Stevens, HC et al. Pulm Circ. 2016" "NA" "NA" "Regulation and function of miR-214 in pulmonary arterial hypertension" "MiR-214 was upregulated in pulmonary arterial hypertension." "812" "MID_726" "26114349" "hsa-miR-21-5p" "microRNA" "Hypertension in atherosclerosis" "up" "Diagnosis" "NO" "Istanbul, Turkey, Asia" "28" "10" "18" "45.1(5.3)" "plasma" "Quantitative RT-PCR" "Plasma miR-21 expression level was found to be significantly higher in the hypertension group when compared to the control group (p=0.002). " "Cengiz, M et al. Clin Exp Hypertens. 2015" "mean(SD)" "NA" "Circulating miR-21 and eNOS in subclinical atherosclerosis in patients with hypertension" "The increased plasma miR-21 expression in patients with increased carotid intima media thickness conclude that this miRNA might be involved in the early stages of atherosclerotic process in hypertensive patients." "813" "MID_727" "24848278" "hsa-miR-222-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "814" "MID_728" "26084306" "hsa-miR-223-3p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis, Treatment" "NO" "Quebec City, Canada, North America" "10" "2" "8" "51(18)" "lung tissue" "Quantitative RT-PCR, immunoblotting" "NA" "Meloche, J et al. Am J Physiol Cell Physiol. 2015" "mean(SD)" "NA" "MiR-223 reverses experimental pulmonary arterial hypertension" "The article indicate that downregulation of miR-223 and subsequent overexpression of PARP-1 in pulmonary arterial hypertension patients, restoring its expression is able to reverse pulmonary arterial hypertension." "815" "MID_729" "27648837" "hsa-miR-25-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Treatment" "NO" "Ontario, Canada, North America" "NA" "NA" "NA" "NA" "pulmonary arterial smooth muscle cells" "qPCR" "NA" "Hong, Z et al. Am J Respir Crit Care Med. 2017" "NA" "NA" "MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype" "MicroRNA-25 down-regulate mitochondrial calcium uniporter, causing the pulmonary arterial hypertension cancer phenotype." "74" "MID_73" "28425970" "hsa-miR-145-5p" "microRNA" "Abdominal aortic aneurysms" "down" "Diagnosis" "NO" "Gainesville, USA, North America" "3" "NA" "NA" "66(1)" "tissue" "Microarray, qRT-PCR" "NA" "Venkatesh, P et al. Int J Mol Sci. 2017" "NA" "NA" "Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms" "The miRNA was downreguated in abdominal aortic aneurysms patients." "816" "MID_730" "27188753" "hsa-miR-26b-5p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.736, 95 CI%： 0.579-0.892， P=0.0075, Sensitivity:0.545, Specificity:1.000, Cutoff value: 1.703" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "817" "MID_731" "27188753" "hsa-miR-27b-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.833, 95 CI%： 0.706-0.959， P=0.0002, Sensitivity:0.773, Specificity:0.864, Cutoff value: 1.440" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "818" "MID_732" "25847058" "hsa-miR-27b-3p " "microRNA" "Pulmonary arterial hypertension secondary to congenital heart disease in children" "up" "Treatment" "YES" "Beijing, China, Asia" "6" "3" "3" "3.08" "tissue, human pulmonary artery endothelial cells" "RT-PCR, Western blot, Luciferase Cloning and Transfection" "NA" "Ma, K et al. Pediatr Pulmonol. 2015" "mean(SEM)" "NA" "Human lung microRNA profiling in pulmonary arterial hypertension secondary to congenital heart defect" "The study highlighted the potential importance of microRNAs in disease progression and suggested microR-27b has the potential to be a biomarker and therapeutic target in patients." "819" "MID_733" "26487756" "hsa-miR-29" "microRNA" "Pulmonary arterial hypertension" "up" "Treatment" "NO" "Houston, USA, North America" "2" "0" "2" "16.5" "lung tissue" "Microarray, qRT-PCR" "NA" "Chen, X et al. Circulation. 2016 " "mean" "NA" "Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism" "16α-hydroxyestrone(16αOHE) promotes the development of human pulmonary arterial hypertension by upregulation of miR-29." "820" "MID_734" "24960162" "hsa-miR-301a-3p" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "NO" "Boston, USA, North America" "NA" "NA" "NA" "NA" "pulmonary arterial smooth muscle cells, pulmonary arterial endothelial cells" "RT-qPCR, Luciferase reporter assay, In situ hybridization" "NA" "Bertero, T et al. J Clin Invest. 2014" "NA" "NA" "Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension" "In endothelial cells, miR-301 modulated apelin-miR-424/503-FGF2 signaling, while in smooth muscle cells, miR-130 modulated STAT3-miR-204 signaling to promote pulmonary hypertension-associated phenotypes." "821" "MID_735" "24848278" "hsa-miR-370" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and or/diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "822" "MID_736" "23263626" "hsa-miR-424-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Treatment" "NO" "Connecticut, USA, North America" "NA" "NA" "NA" "NA" "lung tissue" "Microarray, reverse transcription PCR, In situ hybridization, luciferase assays" "NA" "Kim, J et al. Nat Med. 2013" "NA" "NA" "An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension" "MiR-424 was downregulated and exerted anti-proliferative effects in pulmonary artery endothelial cells in pulmonary areteial hypertension patients, reconstitution of miR-424 can ameliorate pulmonary hypertension." "823" "MID_737" "23263626" "hsa-miR-503-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Treatment" "NO" "Connecticut, USA, North America" "NA" "NA" "NA" "NA" "lung tissue" "Microarray, reverse transcription PCR, In situ hybridization, luciferase assays" "NA" "Kim, J et al. Nat Med. 2013" "NA" "NA" "An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension" "MiR-503 was downregulated and exerted anti-proliferative effects in pulmonary artery endothelial cells in pulmonary areteial hypertension patients, reconstitution of miR-424 can ameliorate pulmonary hypertension." "824" "MID_738" "27188753" "hsa-miR-656" "microRNA" "Pulmonary arterial hypertension" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "22" "7" "15" "46.0(12.4)" "lung tissue" "Microarray, Locked nucleic acid (LNA) in situ hybridization, qRT-PCR" "AUC=0.797, 95 CI%： 0.662-0.931， P=0.001, Sensitivity:0.789, Specificity:0.727, Cutoff value: 1.301" "Wu, D et al. J Mol Med (Berl). 2016" "mean(SD)" "NA" "Identifying microRNAs targeting Wnt/beta-catenin pathway in end-stage idiopathic pulmonary arterial hypertension" "The miRNA influence the pathogenesis of pulmonary arterial hypertension by regulating major pulmonary arterial hypertension-related pathways including Wnt/β-catenin." "825" "MID_739" "24848278" "hsa-miR-92a-3p" "microRNA" "Pre-atherosclerotic(patients with hyperlipidemia, hypertension, and/or diabetes)" "down" "Diagnosis" "NO" "Jilin, China, Asia" "20" "NA" "NA" "NA" "blood" "quantitative PCR" "NA" "Jiang, Y et al. Sci Rep. 2014" "NA" "NA" "Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases" "Unique miRNA signatures were identified for both atherosclerosis and pre-atherosclerosis. The levels of miR-92a, 126, 130a, 222, and 370 levels were decreased in the peripheral blood of pre-atherosclerotic subjects." "75" "MID_74" "23316282" "hsa-miR-146a-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-146a was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "826" "MID_740" "25871906" "hsa-miR-96-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis" "NO" "Glasgow, UK, Europe" "6" "NA" "NA" "NA" "human pulmonary artery smooth muscle cells" "quantitative RT-PCR, Luicferase Reporter Assay, In Situ Hybridization" "NA" "Wallace, E et al. Am J Respir Crit Care Med. 2015" "NA" "NA" "A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension" "Increased 5-HT1BR expression may be a consequence of decreased miRNA-96 expression in female patient pulmonary artery smooth muscle cells, may contribute to the development of pulmonary arterial hypertension." "827" "MID_741" "25277211" "hsa-miR-98-5p" "microRNA" "Pulmonary arterial hypertension" "down" "Diagnosis" "NO" "Beijing, China, Asia" "48" "NA" "NA" "NA" "tissue" "Quantitative reverse transcription-polymerase chain reaction" "NA" "Li, F et al. Exp Mol Med. 2014" "NA" "NA" "MiR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6" "MiR-98 inhibits melanoma metastasis in part through a novel miR-98-IL-6-negative feedback loop." "828" "MID_742" "28554172" "a combination of hsa-miR-206, BNP and LAD" "microRNA" "Pulmonary hypertension (PH) due to left heart diseases " "NA" "Diagnosis" "YES" "Chongqing, China, Asia" "47/35" "26/17" "21/18" "64(54-72)/64(53-73)" "plasma" "qPCR" "AUC=0.930; Sensitivity:0.971; Specificity: 0.803; 95%CI: 0.885-0.976" "Jin, P et al. Cell Physiol Biochem. 2017" "NA" "47 LHD control patients, and 35 PH-LHD patients" "The Circulating MicroRNA-206 Level Predicts the Severity of Pulmonary Hypertension in Patients with Left Heart Diseases" "The level of miR-206 combined with BNP and LAD, might be more helpful in the detection of pulmonary hypertension in left heart diseases patients." "833" "MID_743" "25313674" "hsa-miR-133a" "microRNA" "Cardiac hypertrophy" "down" "Diagnosis" "YES" "Nanjing, China, Asia" "24/40" "14/26" "10/14" "46(29-69)/54(44-85)" "plasma" "qRT-PCR" "NA" "Wen, P et al. PLoS One. 2014" "median age(range)" "hemodialysis without left ventricular hypertrophy/hemodialysis with left ventricular hypertrophy" "Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients" "Plasma miR-133a levels are decreased in hemodialysis with left ventricular hypertrophy." "834" "MID_744" "29073097" "hsa-miR-1-3p" "microRNA" "Cardiac hypertrophy" "NA" "Treatment" "YES" "Verona, Italy, Europe" "NA" "NA" "NA" "NA" "tissue" "Real-time qPCR, Luciferase Assay" "NA" "Zaglia, T et al. Proc Natl Acad Sci U S A. 2017" "mean(SEM)" "NA" "Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy" "MiR-1 represses mitochondrial calcium uniporter(MCU) translation and reduces mitochondrial Ca2+ uptake in cardiomyocytes, miR-1/MCU axis and its involvement in myocardial hypertrophy may be a therapeutic approaches." "835" "MID_745" "20571053" "hsa-miR-1-3p" "microRNA" "Cardiac hypertrophy" "down" "Diagnosis" "NO" "Shanghai, China, Asia" "NA" "NA" "NA" "NA" "human coronary artery smooth muscle cells, endothelial cells, human umbilical vein endothelial cells" "Microarray, qRT-PCR, Northern blot analysis, Luciferase assay" "NA" "Li, Q et al. J Cell Sci. 2010" "NA" "NA" "Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy" "Reduction of miR-1 by hypertrophic stimuli induces the upregulation of twinfilin-1 evokes hypertrophy through the regulation of cardiac cytoskeleton." "836" "MID_746" "25504627" "hsa-miR-21-3p" "microRNA" "Cardiac hypertrophy" "down" "Treatment" "YES" "Wuhan, China, Asia" "12" "9" "1" "51.33" "heart" "real-time PCR" "NA" "Yan, M et al. Cardiovasc Res. 2015" "mean" "NA" "MiR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8" "MiR-21-3p attenuates cardiac hypertrophy by suppressingHDAC8 expression to activate Akt/Gsk3b pathway." "837" "MID_747" "25656649" "hsa-miR-214-3p" "microRNA" "Cardiac hypertrophy and heart failure " "up" "Diagnosis" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "serum, tissue" "real-time quantitative PCR" "NA" "Duan, Q et al. J Cell Physiol. 2015" "mean(SD)" "NA" "MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis" "MiR-214 expression was gradually increased in human failing heart tissue and blood samples, suggesting miR-214 may be a circulating biomarker and a diagnostic predictor for heart failure in future." "838" "MID_748" "26572862" "hsa-miR-214-3p" "microRNA" "Cardiac hypertrophy and heart failure " "down" "Treatment" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "blood, tissue" "Real time PCR assay" "NA" "Duan, Q et al. J Transl Med. 2015" "mean(SD)" "NA" "MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo" "The study found that deregulation of of miR-214 in the hypertrophic and failing hearts inhibits XBP1 and XBP1-induced angiogenesis results in the transition of hypertrophic hearts into heart failure." "839" "MID_749" "28382463" "hsa-miR-21-5p" "microRNA" "Cardiac hypertrophy" "up" "Diagnosis" "YES" "Mexico City, Mexico, North America" "6/5/6/7" "4/2/3/5" "2/3/3/2" "6(2.82)/1.98(0.6)/1.56(3.15)/1.35(1.65)" "plasma, tissue" "Real-Time Quantitative PCR" "Tissue: fold change(1.7); Plasma: circulating level:5.59(0.57)" "Sanchez-Gomez MC et al. Pediatr Cardiol. 2017" "mean(SEM)" "double output of the left ventricle/tetralogy of fallot/persistent ductus arteriosus/transposition of the great vessels" "MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children" "The miRNA could be excellent biomarkers of cardiac damage in pediatric patients with cardiac hypertrophy secondary to complex congenital heart disease." "76" "MID_75" "23316282" "hsa-miR-155-5p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-155 was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "840" "MID_750" "28382463" "hsa-miR-23a-3p" "microRNA" "Cardiac hypertrophy" "up" "Diagnosis" "YES" "Mexico City, Mexico, North America" "6/5/6/7" "4/2/3/5" "2/3/3/2" "6(2.82)/1.98(0.6)/1.56(3.15)/1.35(1.65)" "plasma, tissue" "Real-Time Quantitative PCR" "Plasma: circulating level:5.22(1.1) " "Sanchez-Gomez MC et al. Pediatr Cardiol. 2017" "mean(SEM)" "double output of the left ventricle/tetralogy of fallot/persistent ductus arteriosus/transposition of the great vessels" "MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children" "The miRNA could be excellent biomarkers of cardiac damage in pediatric patients with cardiac hypertrophy secondary to complex congenital heart disease." "841" "MID_751" "28382463" "hsa-miR-24-3p" "microRNA" "Cardiac hypertrophy" "up" "Diagnosis" "YES" "Mexico City, Mexico, North America" "6/5/6/7" "4/2/3/5" "2/3/3/2" "6(2.82)/1.98(0.6)/1.56(3.15)/1.35(1.65)" "plasma, tissue" "Real-Time Quantitative PCR" "Plasma: circulating level:9.90(0.6)" "Sanchez-Gomez MC et al. Pediatr Cardiol. 2017" "mean(SEM)" "double output of the left ventricle/tetralogy of fallot/persistent ductus arteriosus/transposition of the great vessels" "MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children" "The miRNA could be excellent biomarkers of cardiac damage in pediatric patients with cardiac hypertrophy secondary to complex congenital heart disease." "842" "MID_752" "25103110" "hsa-miR-15 family(hsa-miR-15a/b-5p, hsa-miR-16-5p, hsa-miR-195-5p, hsa-miR-497-5p, hsa-miR-322)" "microRNA" "Cardiac hypertrophy" "up" "Diagnosis, Treatment" "NO" "Amsterdam， The Netherlands, Europe" "8/5/10" "NA" "NA" "NA" "tissue" "real-time PCR" "Real-time PCR shows comparable expression levels of the miR-15 family in cultured cardiomyocytes and fibroblasts, except for miR-322 which is higher expressed in fibroblasts" "Tijsen, AJ et al. Cardiovasc Res. 2014" "mean(SEM)" "end-stage hypertrophic cardiomyopathy (HCM), end-stage dilated cardiomyopathy, and aorta stenosis. " "The microRNA-15 family inhibits the TGFbeta-pathway in the heart" "It identified the miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGFβ-pathway." "843" "MID_753" "26572862" "hsa-miR-30* family" "microRNA" "Cardiac hypertrophy and heart failure " "down" "Treatment" "YES" "Shanghai, China, Asia" "104" "72" "32" "62.2(15)" "blood, tissue" "Real time PCR assay" "NA" "Duan, Q et al. J Transl Med. 2015" "mean(SD)" "NA" "MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo" "The study found that deregulation of of miR-30* in the hypertrophic and failing hearts inhibits XBP1 and XBP1-induced angiogenesis results in the transition of hypertrophic hearts into heart failure." "844" "MID_754" "23420161" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Guangzhou, China, Asia" "67/32" "52" "15" "63.84(11.17)/61.75(9.58) " "plasma" "qRT-PCR" "the ROC curves (AUCs) for miR-1 were 0.8265 (95% confidence interval, 0.7441-0.9088)" "Li, Y Q et al.Clinics. 2013" "mean(SD)" "AMI/Control" "Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with Acute myocardial infarction" "The study demonstrate that circulating miR-1 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction." "845" "MID_755" "21701171" "hsa-miR-1-3p" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Lund, Sweden, Europe" "25" "20" "5" "64.56(2.70)" "plasma, urine" "qRT-PCR" "AUC=0.98 (95% CI 0.93-1.03), 300-fold (p<0.01) within 12 h of the onset of symptoms in ST-elevation myocardial infarction patients." "Gidlof,O et al. Cardiology. 2011" "mean(SEM)" "Data from ST-elevation myocardial infarction patients from whom samples were taken within 12 h (n = 9) and healthy controls (n = 11) were included in the statictics analysis" "Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples" "The miRNA can be detectable in plasma and urine, and elevated in patients can be diagnosis of ST elevation myocardial infarction and the prediction of long-term complications." "846" "MID_756" "26526403" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Harbin, China, Asia" "70" "34" "36" "64.2(11.2)" "plasma" "qRT-PCR" "AUC=0.81, a sensitivity of 0.70, and a specificity of 0.90." "Liu, X et al. Exp Gerontol. 2015" "mean(SD)" "NA" "Plasma miR-1, miR-208, miR-499 as potential predictive biomarkers for Acute myocardial infarction: An independent study of Han population" "The study confirmed the predictive values of plasma miR-1 in acute myocardial infarction, can be biomarkers in acute myocardial infarction screening and prediction." "847" "MID_757" "23641832" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "97" "20" "62.70(11.40)" "serum" "RT-qPCR" "AUC=0.657 (95% CI,0.551-0.763)" "Li, C et al. BMC Med Genomics. 2013" "mean(SD)" "NA" "Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of Acute myocardial infarction and angina pectoris" "The miRNA-1 may serves as a fingerprint for acute myocardial infarction diagnosis." "848" "MID_758" "22719221" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "17" "13" "4" "53(12.5)" "plasma" "qRT-PCR" "4h: AUC:0.92, sensitivity:93%, specificity:90%; 8h: AUC:0.90, sensitivity:93%, specificity:90%; 12h: AUC:0.94, sensitivity:94%, specificity:93%; 24h: AUC:0.92, sensitivity:93%, specificity:90%; 48h: AUC:0.96, sensitivity:93%, specificity:90%; 72h: AUC:0.9" "Long, G et al. Int J Biol Sci. 2012" "mean(SD)" "NA" "Human circulating microRNA-1 and microRNA-126 as potential novel indicators for Acute myocardial infarction" "This study suggests that miR-1 may be useful novel potential biomarkers for clinic diagnosis of acute myocardial infarction." "849" "MID_759" "23168196" "hsa-miR-1-3p" "microRNA" "ST-elevation acute myocardial infarction" "up" "Diagnosis" "YES" "Luzhou, Sichuan, China" "20" "14" "6" "67(11)" "urine" "qRT-PCR" "miR-1 in urine (Ct value): 45.50±4.21 vs. 52.63±4.41, P<0.05 or P<0.01, Ct value of urine miR-1 with blood CK-MB：r=-0．81，P<0.01；Ct value ofurine miR-1 with blood cTnI：r=-0．63，P<0.05." "Duan, XX et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue.2012" "mean(SEM)" "NA" "Urine cardiac specific microRNA-1 level in patients with ST segment elevation Acute myocardial infarction" "The results suggest that miR-1 in urine could be a novel sensitive biomarker the early diagnosis of ST segment elevation acute myocardial infarction." "77" "MID_76" "23316282" "hsa-miR-155-5p" "microRNA" "Abdominal aortic aneurysms " "down" "Diagnosis" "YES" "Osaka, Japan, Asia" "23" "18" "5" "71.8(8.9)" "plasma" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-155 was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "850" "MID_760" "23079087" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Prognosis" "YES" "Harbin, China, Asia" "49" "31" "18" "NA" "plasma" "qRT-PCR" "NA" "Zhang, R et al. Int J Cardiol. 2013" "NA" "NA" "Elevated plasma microRNA-1 predicts heart failure after Acute myocardial infarction" "Elevation of plasma miR-1 negatively correlated with heart function in patients with acute myocardial infarction and it may be a novel biomarker for predicting the onset of heart failure secondary to acute myocardial infarction patients." "851" "MID_761" "21956146" "hsa-miR-1-3p" "microRNA" "Myocardial infarction" "change" "Prognosis" "YES" "Charleston, USA, North America" "12" "9" "3" "58(3)" "plasma" "Quantitative reverse transcription-polymerase chain reaction " "miR-1 fell at day 2 post MI,increased at day 5 and remained elevated through day 90 post MI" "Zile, MR et al. Circ Cardiovasc Genet. 2011" "mean(SEM)" "NA" "Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction" "MiR-1 deregulated in patients during the left ventricular (LV) remodeling process that follows a myocardial infarction (post-MI),and provide prognostic significance." "852" "MID_762" "20159880" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "33" "23" "10" "63.5(10.1)" "plasma" "Microarray, qRT-PCR" "an area under curve (AUC) of 0.847 (95% confidence interval 0.751-0.943)" "Wang, G K et al. Eur Heart J. 2010" "mean(SEM)" "NA" "Circulating microRNA: a novel potential biomarker for early diagnosis of Acute myocardial infarction in humans" "This study demonstrated that the levels of miR-1 in blood from patients with acute myocardial infarction are elevated, it has the potential to be a novel biomarker for diagnosis of myocardial injury. " "853" "MID_763" "20534597" "hsa-miR-1-3p" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "8/25" "7/24" "1/1" "57.9(8.6)/61.9(9)" "plasma" "qRT-PCR" "NA" "D'Alessandra, Y et al. Eur Heart J. 2010" "mean(SD)" "one cohort/second cohort" "Circulating microRNAs are new and sensitive biomarkers of myocardial infarction" "Up-regulated miR-1 plasma levels in patients with acute ST-segment elevation myocardial infarction can be novel biomarker of cardiac damage." "854" "MID_764" "19896465" "hsa-miR-1-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Harbin, China, Asia" "93" "67" "25" "58.2(10.2)" "plasma" "qRT-PCR" "When comparison was made between AMI and non-AMI, the area under ROC curve (AUC) was 0.7740 (95% confidence interval; CI=0.7065-0.8414, P<0.0001). When comparison was made between AMI at the time of hospitalization and AMI at the time of discharge, AUC wa" "Ai, J et al. Biochem Biophys Res Commun. 2010" "mean(SD)" "NA" "Circulating microRNA-1 as a potential novel biomarker for Acute myocardial infarction" "In conclusion,this study conclude that circulating miR-1 may be an independent biomarker for diagnosis of acute myocardial infarction and the associated ischemic arrhythmias." "855" "MID_765" "20163779" "hsa-miR-1-3p" "microRNA" "Myocardial infarction" "up" "Diagnosis, Prognosis" "NO" "Ljubljana, Slovenia, Europe" "24" "18" "8" "60-94" "tissue, remote myocardium" "qRT-PCR" "miR-1 up-regulation (3.8-fold) in ten remote myocardium samples when compared to the infarcted tissue (Wilcoxon signed rank test, P=0.03) or healthy adult hearts (Mann-Whitney test, P=0.04)." "Bostjancic E et al. Folia Biol (Praha). 2010" "NA" "The duration of MI at the time of death was estimated on the basis of histological and clinical data. All cases of MI included in our study were up to 7 days old." "MicroRNA miR-1 is up-regulated in remote myocardium in patients with myocardial infarction" "This finding of miR-1 up-regulation in patients with myocardial infarction indicates that the miRNA might be responsible for the higher risk for arrhythmias in myocardial infarction patients." "856" "MID_766" "20029200" "hsa-miR-1-3p" "microRNA" "Myocardial infarction" "down(died in more than 1 day and less than 7 days old))" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "17" "NA" "NA" "NA" "tissue" "qRT-PCR" "Fold change: 3" "Bostjancic, E et al. Cardiology. 2010" "NA" "NA" "MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction" "The study showed miRNAs miR-1 is involved in muscle- and/or cardiac-specific in human myocardial infarction, their expression is changed in different time after the onset of myocardial infarction." "857" "MID_767" "28663047" "hsa-miR-1-3p" "microRNA" "Adverse ventricular remodeling after acute myocardial infarction" "up" "Diagnosis" "YES" "Munich, Germany, Europe" "44" "37" "7" "56(48-66)" "plasma" "quantitative PCR" "NA" "Grabmaier, U et al. Int J Cardiol. 2017" "NA" "post acute myocardial infarction" "Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction - The SITAGRAMI-miR analysis" "MiR-1 can be as biomarkers for adverse ventricular remodeling in patients with acute myocardial infarction." "858" "MID_768" "20075508" "hsa-miR-1-3p" "microRNA" "Myocardial infarction" "down" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "39" "24" "15" "57-94" "tissue" "Microarray, qRT-PCR" "NA" "Bostjancic, E et al. Dis Markers. 2009" "NA" "NA" "MicroRNA microarray expression profiling in human myocardial infarction" "The miRNA is dyregulated in myocardial infarction patients." "859" "MID_769" "29324314" "hsa-miR-1-3p" "microRNA" "Myocardial infarction" "up" "Prognosis, Treatment" "YES" "Ljubljana, Slovenia, Europe" "23/24" "16/15" "7/9" "62.0(11.4)/75.0(9.0)" "tissue" "qPCR" "NA" "Bostjancic E et al. Biomed Pharmacother. 2018" "mean(SD)" "myocardial infarction with ventricular fibrillation/myocardial infarction without ventricular fibrillation" "Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation" "Up-regulation of miR-1 in remote myocardium might play a role in cardiac remodeling after myocardial infarction." "78" "MID_77" "24283299" "hsa-miR-155-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Diagnosis, Treatment" "NO" "Queensland, Australia, Europe" "10/6" "8/5" "2/1" "60(17)/58(7)" "serum" "qPCR" "MiR-155 was the only one differentially expressed in serum samples,with a 2.67 fold up-regulation at borderline significance (FDR=0.554)" "Biros, E et al. Clin Sci (Lond). 2014" "mean(SD)" "discovery/validation" "MicroRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155" "The finding of high levels of miR-155 in abdominal aortic aneurysms(AAA) serum identifies this miRNA as a therapeutic target with implications in post-operative management of AAA, the potential for which requires further investigation." "860" "MID_770" "23236408" "hsa-let-7b-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "18" "13" "5" "55(11.4)" "plasma" "qRT-PCR" "4h: AUC:0.86, sensitivity:82%, specificity:77%; 8h: AUC:0.88, sensitivity:88%, specificity:74%; 12h: AUC:0.89, sensitivity:88%, specificity:84%; 24h: AUC:0.85, sensitivity:82%, specificity:87%; 48h: AUC:0.87, sensitivity:82%, specificity:78%; 72h: AUC:0.8" "Long, G et al. PLoS One. 2012" "mean(SD)" "NA" "Circulating miR-30a, miR-195 and let-7b associated with Acute myocardial infarction" "This study indicate that the concentration of let-7b in plasma can be potential indicators for acute myocardial infarction. " "861" "MID_771" "23967079" "hsa-miR-101-3p" "microRNA" "Acute myocardial infarction" "down" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "150" "116" "44" "64(24-87)" "plasma" "qPCR" "miR-101 (odds ratio [95% confidence interval] 0.19 [0.04-0.97]) " "Devaux, Y et al. PLoS One. 2013" "NA" "NA" "A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after Acute myocardial infarction" "The study indicate that the miRNA may aid in prognostication of outcome after acute myocardial infarction." "862" "MID_772" "27515482" "hsa-miR-103a-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Changsha, China, Asia" "43/38" "30/26" "12/13" "56(12)/55(11.4)" "plasma" "Real-time quantitative PCR, Luciferase reporter assay" "NA" "Huang, L et al. Cardiol J. 2016" "mean(SEM)" "Acute myocardial infarction+High blood pressure/Acute myocardial infarction" "MiR-103a targeting Piezo1 is involved in acute myocardial infarction through regulating endothelium function" "MiR-103a might be a potential biomarker of myocardium infarction and could be used for the diagnosis of acute myocardial infarction." "863" "MID_773" "23066896" "hsa-miR-122-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "6" "3" "3" "71.83(10.83)" "tissue" "qPCR, microarray" "NA" "Bostjancic, E et al. BMC Genomics. 2012" "mean(SD)" "NA" "MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis" "Using qPCR and mocroarray, this study found the miRNA is deregulated in human myocardial infarction tissue." "864" "MID_774" "20534597" "hsa-miR-122-5p" "microRNA" "ST-elevation myocardial infarction" "down" "Diagnosis" "YES" "Milano, Italy, Europe" "8/25" "7/24" "1/1" "57.9(8.6)/61.9(9)" "plasma" "qRT-PCR" "NA" "D'Alessandra, Y et al. Eur Heart J. 2010" "mean(SD)" "one cohort/second cohort" "Circulating microRNAs are new and sensitive biomarkers of myocardial infarction" "Down-regulated miR-122 plasma levels in patients with acute ST-segment elevation myocardial infarction can be novel biomarker of cardiac damage." "865" "MID_775" "26884877" "hsa-miR-122-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Kaifeng, China, Asia" "50" "33" "17" "63.2(11.4)" "plasma" "qRT-PCR" "AUC=0.855(95% CI,0.746-0.964)" "Yao, X L et al. Int J Clin Exp Pathol. 2015" "mean(SD)" "NA" "Circulating miR-122-5p as a potential novel biomarker for diagnosis of Acute myocardial infarction" "The study indicated that circulating miR-122-5p could be a potential biomarker for Acute myocardial infarction." "866" "MID_776" "28338188" "hsa-miR-124-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Qingdao, China, Asia" "90" "48" "42" "35.5(5.6)" "blood" "Real-time PCR" "The area under the curve of ROC of miRNA-124 was 0.86(95% CI: 0.815-0.937), with 52% sensitivity and 91% specificity." "Guo, M L et al. Eur Rev Med Pharmacol Sci. 2017" "mean(SD)" "NA" "Implication of peripheral blood miRNA-124 in predicting Acute myocardial infarction" "MiRNA-124 in peripheral blood can serve as a novel biological marker for early diagnosis of acute myocardial infarction." "867" "MID_777" "29947233" "hsa-miR-124-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Masaryk, Czech Republic, Europe" "47" "36" "11" "NA" "serum" "Real-time RT-PCR " "NA" "Goldbergova, MP et al. Bratisl Lek Listy. 2018" "NA" "NA" "MicroRNAs in pathophysiology of acute myocardial infarction and cardiogenic shock" "MiRNA-124a is markers of injury in acute myocardial infarction." "868" "MID_778" "23255549" "hsa-miR-1254" "microRNA" "Early-stage Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The miRNA is significantly dysregulated both at initial presentation and during the course of acute myocardial infarction. " "869" "MID_779" "27176713" "hsa-miR-125b-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Tianjin, China, Asia" "172" "122" "50" "62" "plasma" "miRNAarray, RT-qPCR" "AUC=0.879 (0.826-0.931); Sensitivity:0.808 (0.740-0.863); Specificity:0.845 (0.721?0.922)" "Jia, K et al. Mol Med Rep. 2016" "mean(SD)" "NA" "Diagnostic value of miR-30d-5p and miR-125b-5p in Acute myocardial infarction" "Kaplan-Meier survival analysis indicated that miR-125b-5p levels were associated with 6?month cardiovascular events in patients with acute myocardial infarction, but not miR?30d?5p. miR-125b-5p and miR-30d-5p presented a diagnostic value for early diagnos" "79" "MID_78" "25832031" "hsa-miR-15a-5p" "microRNA" "Abdominal aortic aneurysms" "down" "Treatment" "YES" "Leicester, England, Europe" "15/40/40/40" "15/40/40/40" "0" "NA" "blood, plasma, tissue" "qPCR" "Flod change:-2.04, P-value 0.019" "Stather, P W et al. Br J Surg. 2015" "mean(SD)" "Discovery /Validation small AAA/large AAA/following AAA repair" "Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease" "Modulation of th miRNA miR-15a and its target genes may be a new therapeutic pathway to affect the progression of abdominal aortic aneurysm." "870" "MID_780" "22995291" "hsa-miR-125b-5p" "microRNA" "Acute myocardial infarction" "up" "Prognosis" "YES" "Suita, Japan, Asia" "19" "14" "5" "72(12)" "serum" "Real-time RT-PCR" "NA" "Matsumoto, S et al. Biochem Biophys Res Commun. 2012" "NA" "cardic death" "A subset of circulating microRNAs are predictive for cardiac death after discharge for Acute myocardial infarction" "The circulating microRNAs are preditor of cardiac death after acute myocardial infarction." "871" "MID_781" "24627568" "hsa-miR-125b-5p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "NO" "Wuhan, China, Asia" "178/150" "134/123" "44/27" "63.54(11.70)/60.93(12.86)" "human umbilical vein endothelial cells, plasma" "Microarray, qRT-PCR" "AUC=0.858 (95%CI, 0.827-0.889)" "Huang, S et al. Circ Cardiovasc Genet. 2014" "mean(SD)" "Validation stage Ⅰ/Ⅱ" "Circulating MicroRNAs and the occurrence of Acute myocardial infarction in Chinese populations" "The plasma levels of miR-320b and miR-125b were significantly lower in patients with acute myocardial infarction when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease." "872" "MID_782" "22813605" "hsa-miR-126-3p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "YES" "London, UK, Europe" "820" "NA" "NA" "NA" "platelet" "real-time PCR" "miR-126 showed a positive association (multivariable hazard ratio: 2.69 [95% confidence interval: 1.45 to 5.01], p = 0.002), " "Zampetaki, A et al. J Am Coll Cardiol. 2012" "mean(SD)" "NA" "Prospective study on circulating MicroRNAs and risk of myocardial infarction" "Endothelial-enriched miR-126 is part of a miRNA signature associated with incidence of myocardial infarction in the general population." "873" "MID_783" "22719221" "hsa-miR-126-3p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Shanghai, China, Asia" "17" "13" "4" "53(12.5)" "plasma" "qRT-PCR" "4h: AUC:0.86, sensitivity:81%, specificity:78%; 8h: AUC:0.87, sensitivity:81%, specificity:84%; 12h: AUC:0.88, sensitivity:81%, specificity:88%; 24h: AUC:0.87, sensitivity:81%, specificity:77%; 48h: AUC:0.84, sensitivity:81%, specificity:80%; 72h: AUC:0.8" "Long, G et al. Int J Biol Sci. 2012" "mean(SD)" "NA" "Human circulating microRNA-1 and microRNA-126 as potential novel indicators for Acute myocardial infarction" "This study suggests that miR-126 may be useful novel potential biomarkers for clinic diagnosis of acute myocardial infarction." "874" "MID_784" "24900964" "hsa-miR-126-3p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Taiwan, China, Asia" "8/31" "8/29" "0/2" "53.3(9.2)/59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "miRNA miR-126-3p, which was downregulated in the AMI samples, showed the second best diagnostic power with an AUC of 0.694 ± 0.070 (P = 0.0087) and a 95% confidence interval of 0.557 to 0.832" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "Exploration cohort/Validation cohort" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "875" "MID_785" "29030746" "hsa-miR-126-3p" "microRNA" "ST-segment elevation myocardial infarction" "down" "Diagnosis" "YES" "Busan, South Korea, Asia" "20" "16" "4" "59.8(12.9)" "platelet" "qRT-PCR" "NA" "Li, S et al. J Thromb Thrombolysis. 2017" "mean(SD)" "NA" "Platelet microRNA for predicting acute myocardial infarction" "MiR-126 exhibited correlation with plasma cardiac troponin I, may serve as a potential novel biomarker for ST-segment elevation myocardial infarction." "876" "MID_786" "24885383" "hsa-miR-1291" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Zhengzhou, China, Asia" "76" "43" "33" "64.6" "plasma" "quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)" "The AUC for miR-1291 was 0.695, with a sensitivity of 78.4% and a specificity of 89.5%." "Peng, L et al. Diagn Pathol. 2014" "mean(SD)" "NA" "Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with Acute myocardial infarction" "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with acute myocardial infarction. Besides, in this study, we found that the expression of miR-133, miR-1291 and miR-663b were significantly reduced after the surgery." "877" "MID_787" "23255549" "hsa-miR-1291" "microRNA" "Early-stage Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The miRNA is significantly dysregulated both at initial presentation and during the course of acute myocardial infarction. " "878" "MID_788" "20886220" "hsa-miR-1291" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "20" "16" "4" "59.3(14)" "blood" "real time-PCR" "Specificity of 85% and a sensitivity of 85% with test accuracy of 85%, AUC:0.91" "Meder, B et al. Basic Res Cardiol. 2011" "NA" "NA" "MicroRNA signatures in total peripheral blood as novel biomarkers for Acute myocardial infarction" "The miRNA can be useful biomarkers for diagnosis of acute myocardial infarction." "879" "MID_789" "25738515" "hsa-miR-1306-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "80" "MID_79" "27756793" "hsa-miR-181b-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Treatment" "YES" "Bristol, England, Europe" "NA/NA" "NA/NA" "NA/NA" "NA" "tissue" "Q-PCR, Luciferase reporter assays" "NA" "Di Gregoli, K et al. Circ Res. 2017" "NA" "NA" "MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin" "MiR-181b expression in abdominal aortic aneurysms is higher, and it could serve as a therapeutic approach in the disease." "880" "MID_790" "25738515" "hsa-miR-1306-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "10/15" "6/8" "4/7" "59.2(6.0)/60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "AMNHF/AMHF" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for acute myocardial infarction." "881" "MID_791" "25738515" "hsa-miR-130a-3p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "10/15" "6/8" "4/7" "59.2(6.0)/60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "AMNHF/AMHF" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for acute myocardial infarction." "882" "MID_792" "24885383" "hsa-miR-133" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Zhengzhou, China, Asia" "76" "43" "33" "64.6" "plasma" "quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)" "MiR-133 showed an AUC of 0.912, with a sensitivity of 81.1% and a specificity of 91.2%" "Peng, L et al. Diagn Pathol. 2014" "mean(SD)" "NA" "Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with Acute myocardial infarction" "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with acute myocardial infarction.,Besides, in this study, we found that the expression of miR-133, miR-1291 and miR-663b were significantly reduced after the surgery." "883" "MID_793" "21881276" "hsa-miR-133" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Beijing, China, Asia" "51" "43" "8" "60.06(11.53)" "plasma, whole blood" "qPCR" "Receiver operating characteristic curve analysis revealed that the areas under the curve of miR-133 in plasma and whole blood were 0.890, 0.702." "Wang, R et al. Intern Med. 2011" "mean(SD)" "NA" "Circulating microRNAs are promising novel biomarkers of Acute myocardial infarction" "The miR-133 levels in plasma and whole blood in acute myocardial infarction patients were increased compared to those in control subjects, the miRNA has high sensitivity and specificity as potential biomarker for the diagnosis of acute myocardial infarcti" "884" "MID_794" "29947233" "hsa-miR-133" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Masaryk, Czech Republic, Europe" "47" "36" "11" "NA" "serum" "Real-time RT-PCR " "NA" "Goldbergova, MP et al. Bratisl Lek Listy. 2018" "NA" "NA" "MicroRNAs in pathophysiology of acute myocardial infarction and cardiogenic shock" "MiRNA-133 is markers of injury in acute myocardial infarction." "885" "MID_795" "26198874" "hsa-miR-133a" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "77/21" "68/14" "9/7" "61(13.7)/67(13.9)" "serum" "qRT-PCR" "Areas under ROC curve (AUC) of miR-133a was 0.787 (95%CI, 0.703-0.871)." "Ji, Q et al. Minerva Cardioangiol. 2015" "mean(SD)" "ST-elevation myocardial infarction/NST-elevation myocardial infarction" "Expression of circulating microRNAs in patients with ST segment elevation Acute myocardial infarction" "In summary, the results of this study show that the expression level of serum miR-133a, miR-133b and miR-499-5p has the potential to become a new marker for the diagnosis of acute myocardial infarction." "886" "MID_796" "23420161" "hsa-miR-133a" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Guangzhou, China, Asia" "67/32" "52" "15" "63.84(11.17)/61.75(9.58) " "plasma" "qRT-PCR" "The ROC curves (AUCs) for miR-133a 0.9468 (95% confidence interval, 0.9057-0.9879) " "Li, Y Q et al.Clinics. 2013" "mean(SD)" "AMI/Control" "Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with Acute myocardial infarction" "The study demonstrate that circulating miR-133a may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction." "887" "MID_797" "21701171" "hsa-miR-133a" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Lund, Sweden, Europe" "25" "20" "5" "64.56(2.70)" "plasma, urine" "qRT-PCR" "AUC=0.86 (95% CI 0.69-1.02), 70-fold within 12 h of the onset of symptoms in ST-elevation myocardial infarction patients." "Gidlof,O et al. Cardiology. 2011" "mean(SEM)" "Data from ST-elevation myocardial infarction patients from whom samples were taken within 12 h (n = 9) and healthy controls (n = 11) were included in the statictics analysis" "Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples" "The miRNA can be detectable in plasma and urine, and elevated in patients can be diagnosis of ST elevation myocardial infarction and the prediction of long-term complications." "888" "MID_798" "24533109" "hsa-miR-133a" "microRNA" "Myocardial infarction" "NA" "Diagnosis" "YES" "Wuhan, China, Asia" "953" "NA" "NA" "NA" "NA" "meta-analysis" "miR-133a: sensitivity: 0.89 (95%CI:0.83-0.94; P?=?0.0047); specificity: 0.87 (95%CI:0.79-0.92; P?=?0.0262). " "Cheng, C et al. PLoS One. 2014" "NA" "Medline, SCI, Embase, and Cochrane databases were searched up to January 2013 for studies " "MiRNAs as biomarkers of myocardial infarction: a meta-analysis" "MiRNAs, especially miR-499 and miR-133a, may be suitable for use as diagnostic biomarkers of myocardial infarction." "889" "MID_799" "24053180" "hsa-miR-133a" "microRNA" "Acute myocardial infarction" "up at 4h" "Diagnosis" "YES" "Shanghai, China, Asia" "13" "9" "4" "54.15(12.54)" "plasma" "qRT-PCR" "NA" "Wang, F et al. J Transl Med. 2013" "mean(SD)" "NA" "Plasma microRNA-133a is a new marker for both Acute myocardial infarction and underlying coronary artery stenosis" "The results demonstrated that circulating miR-133a levels increased in time-dependent manner in the early phase of acute myocardial infarction and exhibited a similar trend as cTnI in acute myocardial infarction patients." "8" "MID_8" "21642241" "hsa-miR-133a" "microRNA" "Acute coronary syndrome" "up" "Diagnosis" "YES" "Kyoto, Japan, Asia" "29" "23" "6" "69.7(2.4)" "serum" "qRT-PCR" "AUC=0.932" "Kuwabara, Y et al. Circ Cardiovasc Genet. 2011" "mean(SEM)" "NA" "Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage" "Circulating miR-133a levels in serum can be used as a biomarker for the diagnosis of acute coronary syndrome and it's less sensitive than miR-1." "81" "MID_80" "27756793" "hsa-miR-181b-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Treatment" "YES" "Bristol, England, Europe" "NA" "NA" "NA" "NA" "Human coronary and aortic samples" "Luciferase Reporter Assay" "NA" "Di Gregoli K et al. Circ Res. 2017" "NA" "NA" "MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin" "Inhibition of miR-181b could serve as a therapeutic approach in reversing the advancement of aortic aneurysms." "890" "MID_800" "21956146" "hsa-miR-133a" "microRNA" "Myocardial infarction" "up" "Prognosis" "YES" "Charleston, USA, North America" "12" "9" "3" "58(3)" "plasma" "Quantitative reverse transcription-polymerase chain reaction " "miR-133a were unchanged at day 2 post MI,increased at day 5 and remained elevated through day 90 post MI" "Zile, M R et al. Circ Cardiovasc Genet. 2011" "mean(SEM)" "NA" "Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction" "MiR-133a deregulated in patients during the left ventricular (LV) remodeling process that follows a myocardial infarction (post-MI),and provide prognostic significance." "891" "MID_801" "20159880" "hsa-miR-133a" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "33" "23" "10" "63.5(10.1)?" "plasma" "Microarray, qRT-PCR" "with an area under curve (AUC) of 0.867 (95% confidence interval, 0.771-0.963)" "Wang, GK et al. Eur Heart J. 2010" "mean(SEM)" "NA" "Circulating microRNA: a novel potential biomarker for early diagnosis of Acute myocardial infarction in humans" "This study demonstrated that the levels of miR-133a in blood from patients with acute myocardial infarction are elevated, it has the potential to be a novel biomarker for diagnosis of myocardial injury." "892" "MID_802" "20534597" "hsa-miR-133a" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "8/25" "7/24" "1/1" "57.9(8.6)/61.9(9)" "plasma" "qRT-PCR" "NA" "D'Alessandra, Y et al. Eur Heart J. 2010" "mean(SD)" "one cohort/second cohort" "Circulating microRNAs are new and sensitive biomarkers of myocardial infarction" "Up-regulated miR-133a plasma levels in patients with acute ST-segment elevation myocardial infarction can be novel biomarker of cardiac damage." "893" "MID_803" "20029200" "hsa-miR-133a" "microRNA" "Myocardial infarction" "down(after died)" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "50" "29" "21" "73(9)" "tissue" "qRT-PCR" "NA" "Bostjancic, E et al. Cardiology. 2010" "NA" "NA" "MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction" "The study showed miRNAs miR-133a is involved in muscle- and/or cardiac-specific in human myocardial infarction, their expression is changed in different time after the onset of myocardial infarction." "894" "MID_804" "23137501" "hsa-miR-133a" "microRNA" "ST-elevation myocardial infarction" "up" "Prognosis" "YES" "Leipzig, Germany, Europe" "108/108" "85/74" "23/34" "64(55-74)/68(55-76)" "serum" "Quantitative reverse transcription polymerase chain reaction" "All prognostic relevant CMR parameters correlated significantly with miR-133a concentrations (MSI r=-0.314, infarct size r=0.285, and MVO r=0.283 [P<0.001], respectively)." "Eitel, I et al. Am Heart J. 2012" "NA" "miR-133a=median " "Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction" "MiR-133a levels can provide prognostic information for prognosis in ST-elevation myocardial infarction but it can not as independent prognostic index to traditional and CMR markers of clinical prognosis in a high-risk ST-elevation myocardial infarction po" "895" "MID_805" "20075508" "hsa-miR-133a" "microRNA" "Myocardial infarction" "down" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "39" "24" "15" "57-94" "tissue" "Microarray, qRT-PCR" "NA" "Bostjancic, E et al. Dis Markers. 2009" "NA" "NA" "MicroRNA microarray expression profiling in human myocardial infarction" "The miRNA is dyregulated in myocardial infarction patients." "896" "MID_806" "29324314" "hsa-miR-133a" "microRNA" "Myocardial infarction" "down" "Prognosis, Treatment" "YES" "Ljubljana, Slovenia, Europe" "23/24" "16/15" "7/9" "62.0(11.4)/75.0(9.0)" "tissue" "qPCR" "Fold change=4.0-fold, p=0.015" "Bostjancic E et al. Biomed Pharmacother. 2018" "mean(SD)" "myocardial infarction with ventricular fibrillation/myocardial infarction without ventricular fibrillation" "Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation" "Down-regulation of miR-133a might contribute to the development of ventricular fibrillation in patients with myocardial infarction." "897" "MID_807" "26198874" "hsa-miR-133b" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "77/21" "68/14" "9/7" "61(13.7)/67(13.9)" "serum" "qRT-PCR" "Areas under ROC curve (AUC) of miR-133b was 0.823 (95% CI, 0.749- 0.896)." "Ji, Q et al. Minerva Cardioangiol. 2015" "mean(SD)" "ST-elevation myocardial infarction/NST-elevation myocardial infarction" "Expression of circulating microRNAs in patients with ST segment elevation Acute myocardial infarction" "In summary, the results of this study show that the expression level of serum miR-133a, miR-133b and miR-499-5p has the potential to become a new marker for the diagnosis of acute myocardial infarction." "898" "MID_808" "27484208" "hsa-miR-133b" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Bialystok, Poland, Europe" "16" "13" "3" "54.9(11.3)" "blood" "RT-qPCR " "The ROC curve analysis revealed that the AUCs of miR-133b were 87.8." "Maciejak, A et al. Mol Med Rep. 2016" "mean(SD), mean(SEM)" "NA" "MiR-22-5p revealed as a potential biomarker involved in the acute phase of myocardial infarction via profiling of circulating microRNAs" "These results suggest that miR-133b is of good diagnostic value for patients with acute myocardial infarction." "899" "MID_809" "20534597" "hsa-miR-133b" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "8/25" "7/24" "1/1" "57.9(8.6)/61.9(9)" "plasma" "qRT-PCR" "NA" "D'Alessandra, Y et al. Eur Heart J. 2010" "mean(SD) " "one cohort/second cohort" "Circulating microRNAs are new and sensitive biomarkers of myocardial infarction" "Up-regulated miR-133b plasma levels in patients with acute ST-segment elevation myocardial infarction can be novel biomarker of cardiac damage." "82" "MID_81" "25832031" "hsa-miR-196b-5p" "microRNA" "Abdominal aortic aneurysms" "down" "Treatment" "YES" "Leicester, England, Europe" "15/40/40/40" "15/40/40/40" "0" "NA" "blood, plasma, tissue" "qPCR " "Fold change: -3.75; P?=?0.029; adjusted P?=?0.115" "Stather, P W et al. Br J Surg. 2015" "mean(SD)" "Discovery /Validation small AAA/large AAA/following AAA repair" "Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease" "Modulation of th miRNA miR-196b and its target genes may be a new therapeutic pathway to affect the progression of abdominal aortic aneurysm." "900" "MID_810" "20029200" "hsa-miR-133b" "microRNA" "Myocardial infarction" "down(after died)" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "50" "29" "21" "73(9)" "tissue" "qRT-PCR" "NA" "Bostjancic, E et al. Cardiology. 2010" "NA" "NA" "MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction" "The study showed miRNAs miR-133b is involved in muscle- and/or cardiac-specific in human myocardial infarction, their expression is changed in different time after the onset of myocardial infarction." "901" "MID_811" "20075508" "hsa-miR-133b" "microRNA" "Myocardial infarction" "down" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "39" "24" "15" "57-94" "tissue" "Microarray, qRT-PCR" "NA" "Bostjancic, E et al. Dis Markers. 2009" "NA" "NA" "MicroRNA microarray expression profiling in human myocardial infarction" "The miRNA is dyregulated in myocardial infarction patients." "902" "MID_812" "29324314" "hsa-miR-133b" "microRNA" "Myocardial infarction" "down" "Prognosis, Treatment" "YES" "Ljubljana, Slovenia, Europe" "23/24" "16/15" "7/9" "62.0(11.4)/75.0(9.0)" "tissue" "qPCR" "NA" "Bostjancic E et al. Biomed Pharmacother. 2018" "mean(SD)" "myocardial infarction with ventricular fibrillation/myocardial infarction without ventricular fibrillation" "Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation" "Down-regulation of miR-133b might contribute to the development of ventricular fibrillation in patients with myocardial infarction." "903" "MID_813" "24833470" "hsa-miR-134" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Zhengzhou, China, Asia" "359" "301" "58" "58(14)" "plasma" "quantitative real-time PCR " "Diagnostic:The ROC curves of plasma miR-134 reflected strong separation between AMI and control groups with an AUC of 0.818 (95?% confidence interval 0.762–0.875; P?0 or ΔEDV≤0 groups, area under the receiver-operating characteristic curve was 0.74 (95% confidence interval [CI], 0.55-0.94) for miR-150 " "Devaux, Y et al. Circ Cardiovasc Genet. 2013" "NA" "Derivation Cohort/Validation Cohort" "MicroRNA-150: a novel marker of left ventricular remodeling after Acute myocardial infarction" "Low circulating levels of miR-150 are associated with left ventricular remodeling after first ST-segment-elevation acute myocardial infarction. miR-150 has potential as a novel biomarker in this progress." "918" "MID_828" "23967079" "hsa-miR-150-5p" "microRNA" "Acute myocardial infarction" "down" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "150" "116" "44" "64(24-87)" "plasma" "qPCR" "miR-150 (odds ratio [95% confidence interval] 0.08 [0.01-0.48]) " "Devaux, Y et al. PLoS One. 2013" "NA" "NA" "A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after Acute myocardial infarction" "The study indicate that the miRNA may aid in prognostication of outcome after acute myocardial infarction." "919" "MID_829" "22048267" "hsa-miR-150-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "50" "27" "23" "72.6(9.5)" "tissue" "RT-qPCR" "NA" "Zidar, N et al. Dis Markers. 2011" "NA" "NA" "MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction" "In conclusion, this study demonstrated that altered expression of miR-150 in mycardial infarction compared to the healthy hearts." "84" "MID_83" "24812324" "hsa-miR-205-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Treatment" "YES" "Atlanta, USA, North America" "5" "NA" "NA" "NA" "tissue" "Microarray, qPCR" "NA" "Kim, CW et al. Arterioscler Thromb Vasc Biol. 2014" "NA" "NA" "Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice" "Inhibit miR-205 may be considered as a potential anti-abdominal aortic aneurysms therapy." "920" "MID_830" "22048267" "hsa-miR-150-5p" "microRNA" "Myocardial infarction with ventricular rupture" "down" "Prognosis" "NO" "Ljubljana, Slovenia, Europe" "23/27" "NA/NA" "NA/NA" "NA/NA" "tissue" "RT-qPCR" "NA" "Zidar, N et al. Dis Markers. 2011" "NA" "with ventricular rupture/without ventricular rupture" "MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction" "MiR-150 is deregulated in patients with ventriculay rupture in myocardial infarction compared with no repture, suggesting these miRNA involved in pathogenesis of ventricular rupture after myocardial infarction in humans." "921" "MID_831" "20075508" "hsa-miR-150-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "39" "24" "15" "57-94" "tissue" "Microarray, qRT-PCR" "NA" "Bostjancic, E et al. Dis Markers. 2009" "NA" "NA" "MicroRNA microarray expression profiling in human myocardial infarction" "The miRNA is dyregulated in myocardial infarction patients." "922" "MID_832" "23189122" "hsa-miR-155-5p" "microRNA" "Acute myocardial infarction" "up" "Prognosis" "YES" "Hangzhou, China, Asia" "30/35" "30/35" "0/0" "NA/NA" "plasma, peripheral blood mononuclear cells" "real-time PCR" "miR-155 was significantly induced in the CAD group both in PBMC (219.05%, P<0.01) and plasma (71.05%, P<0.05)" "Zhu, J et al. PLoS One. 2012" "mean(SD)" "AMI/non-AMI" "Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10" "The study suggested that miR-155 can be a potential marker for predicting the prognosis of coronary artery disease patients." "923" "MID_833" "22995291" "hsa-miR-155-5p" "microRNA" "Acute myocardial infarction" "up" "Prognosis" "YES" "Suita, Japan, Asia" "19" "14" "5" "72(12)" "serum" "Real-time RT-PCR" "4 fold higher in patients who subsequently died of cardiac cause within 1?year." "Matsumoto, S et al. Biochem Biophys Res Commun. 2012" "NA" "cardic death" "A subset of circulating microRNAs are predictive for cardiac death after discharge for Acute myocardial infarction" "The circulating microRNAs are preditor of cardiac death after acute myocardial infarction." "924" "MID_834" "22048267" "hsa-miR-155-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "50" "27" "23" "72.6(9.5)" "tissue" "RT-qPCR" "NA" "Zidar, N et al. Dis Markers. 2011" "NA" "NA" "MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction" "In conclusion, this study demonstrated that altered expression of miR-155 in mycardial infarction compared to the healthy hearts." "925" "MID_835" "22048267" "hsa-miR-155-5p" "microRNA" "Myocardial infarction with ventricular rupture" "down(compared to Myocardial infarction without ventricular rupture)" "Prognosis" "NO" "Ljubljana, Slovenia, Europe" "23/27" "NA/NA" "NA/NA" "NA/NA" "tissue" "RT-qPCR" "NA" "Zidar, N et al. Dis Markers. 2011" "NA" "with ventricular rupture/without ventricular rupture" "MicroRNAs, innate immunity and ventricular rupture in human myocardial infarction" "MiR-155 is deregulated in patients with ventriculay rupture in myocardial infarction compared with no repture, suggesting these miRNA involved in pathogenesis of ventricular rupture after myocardial infarction in humans." "926" "MID_836" "23967079" "hsa-miR-16-5p" "microRNA" "Acute myocardial infarction" "up" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "150" "116" "44" "64(24-87)" "plasma" "qPCR" "miR-16 (odds ratio [95% confidence interval] 15.9 [2.63-0.95.91]) " "Devaux, Y et al. PLoS One. 2013" "NA" "NA" "A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after Acute myocardial infarction" "The study indicate that the miRNA may aid in prognostication of outcome after acute myocardial infarction." "927" "MID_837" "29536180" "hsa-miR-17-5p" "microRNA" "Acute myocardial infarction" "NA" "Prognosis" "NO" "Wuhan, China, Asia" "NA" "NA" "NA" "NA" "human umbilical vein endothelial cells(HUVECs)" "Real-time RT-PCR, Western blotting" "P<0.05" "Yang, S et al. Mol Genet Genomics. 2018" "mean(SEM)" "NA" "Downregulation of microRNA-17-5p improves cardiac function after myocardial infarction via attenuation of apoptosis in endothelial cells" "Downregulation of miR-17-5p protects heart function after acute myocardial infarction through ERK pathway, which is through decreasing the rate of apoptosis and repairing vascular injury." "928" "MID_838" "27997916" "hsa-miR-181a-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "60" "46" "14" "64.1(10.3)" "plasma" "qRT-PCR" "The specificity and sensitivity of miR-181a for the diagnosis of AMI were 0.826 and 0.898, AUC of 0.834 (95%CI: 0.756-0.912, P<0.05)." "Zhu, J et al. Cell Physiol Biochem. 2016" "mean(SD)" "NA" "Circulating miR-181a as a Potential Novel Biomarker for Diagnosis of Acute myocardial infarction" "Circulating miR-181a levels in patients with acute myocardial infarction were significantly upregulated, indicating the value of plasma miR-181a as a novel biomarker for diagnosing acute myocardial infarction." "929" "MID_839" "23255549" "hsa-miR-181c-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The study have identified upregulation of miR-181c* to be present in the very early phase of myocardial infarction." "85" "MID_84" "23316282" "hsa-miR-20a-5p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-20a was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "930" "MID_840" "28272697" "hsa-miR-184" "microRNA" "Acute myocardial infarction" "up" "Prognosis, Treatment" "NO" "Weifang, China, Asia" "72" "40" "32" "NA" "blood" "RT-PCR " "The expression level of miRNA-184 was positively correlated with ?NT-proBNP, ?LVEDd and ?LVEF (r = 0.324, p = 0.027; r = 0.362, p = 0.022; r = 0.411, p = 0.016" "Liu, Z H et al. Eur Rev Med Pharmacol Sci. 2017" "NA" "NA" "Research on the relations between the variation of miRNA-184 before and after treatment of Acute myocardial infarction and prognosis" "The expression level of miRNA-184 was increased during the ischemia, reperfusion, and reconstruction of myocardial cells. " "931" "MID_841" "23493781" "hsa-miR-185-5p" "microRNA" "ST-elevation myocardial infarction" "down" "Diagnosis" "NO" "Lund, Sweden, Europe" "10" "NA" "NA" "NA" "platelet, plasam" "qRT-PCR" "NA" "Gidl?f, O et al. Blood. 2013" "mean(SEM)" "NA" "Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression" "The miRNA in patients with ST-elevation myocardial infarction is distinctly different from that of healthy patients, that miRNAs are shed from activated platelets, and the platelet-derived miRNAs can affect endothelial cell gene expression." "932" "MID_842" "23641832" "hsa-miR-186-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Nanjing, China, Asia" "117" "97" "20" "62.70(11.40)" "serum" "RT-qPCR" "AUC=0.715 (95% CI, 0.614–0.817)" "Li, C et al. BMC Med Genomics. 2013" "mean(SD)" "NA" "Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of Acute myocardial infarction and angina pectoris" "The miRNA-186 may serves as a fingerprint for acute myocardial infarction diagnosis." "933" "MID_843" "26939053" "hsa-miR-186-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Wuhan, China, Asia" "18/32" "10/18" "8/14" "57.86(10.75)/55.62(9.17)" "plasma" "qRT-PCR" "AUC T0:0.824; 4h:0.796; 8h:0.858; 12h:0.722; 24h:0.713; " "Wang, KJ et al. Cell Physiol Biochem. 2016" "mean(SD)" "Discovery/Validation cohort" "Circulating MiR-19b-3p, MiR-134-5p and MiR-186-5p are Promising Novel Biomarkers for Early Diagnosis of Acute myocardial infarction" "Circulating miR-186-5p could be considered promising novel diagnostic biomarkers for the early phase of acute myocardial infarction." "934" "MID_844" "20075508" "hsa-miR-186-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "39" "24" "15" "57-94" "tissue" "Microarray, qRT-PCR" "NA" "Bostjancic, E et al. Dis Markers. 2009" "NA" "NA" "MicroRNA microarray expression profiling in human myocardial infarction" "The miRNA is dyregulated in myocardial infarction patients." "935" "MID_845" "22995291" "hsa-miR-18a-5p" "microRNA" "Acute myocardial infarction" "down" "Prognosis" "YES" "Suita, Japan, Asia" "19" "14" "5" "72(12" "serum" "Real-time RT-PCR" "NA" "Matsumoto, S et al. Biochem Biophys Res Commun. 2012" "NA" "cardic death" "A subset of circulating microRNAs are predictive for cardiac death after discharge for Acute myocardial infarction" "The circulating microRNAs are preditor of cardiac death after acute myocardial infarction." "936" "MID_846" "22995291" "hsa-miR-190b" "microRNA" "Acute myocardial infarction" "down" "Prognosis" "YES" "Suita, Japan, Asia" "19" "14" "5" "72(12" "serum" "Real-time RT-PCR" "NA" "Matsumoto, S et al. Biochem Biophys Res Commun. 2012" "NA" "cardic death" "A subset of circulating microRNAs are predictive for cardiac death after discharge for Acute myocardial infarction" "The circulating microRNAs are preditor of cardiac death after acute myocardial infarction." "937" "MID_847" "23255549" "hsa-miR-1915-3p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real time-PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The study have identified reduced expression of miR-1915 to be present in the very early phase of myocardial infarction." "938" "MID_848" "26044724" "hsa-miR-191-5p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Zhengzhou, China, Asia" "87" "64" "23" "56.93(9.17)" "plasma" "miRNA microarray chip analysis, qRT-PCR, Dual-luciferase reporter assays" "The AUC for miR-191 was 0.669(95% CI, 0.589-0.749; P?80-fold increase in acute NST-elevation myocardial infarction and AUC=0.88." "Olivieri, F et al. Int J Cardiol. 2013" "mean(SD)" "NA" "Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction" "Circulating miR-499-5p is a sensitive biomarker of acute NST-elevation myocardial infarction in the elderly, exhibiting a diagnostic accuracy superior to that of cTnT in patients with modest elevation at presentation." "1051" "MID_961" "20534597" "hsa-miR-499a-5p" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis" "YES" "Milano, Italy, Europe" "8/25" "7/24" "1/1" "57.9(8.6)/61.9(9)" "plasma" "qRT-PCR" "NA" "D'Alessandra, Y et al. Eur Heart J. 2010" "mean(SD)" "one cohort/second cohort" "Circulating microRNAs are new and sensitive biomarkers of myocardial infarction" "Up-regulated miR-499-5p plasma levels in patients with acute ST-segment elevation myocardial infarction can be novel biomarker of cardiac damage." "1052" "MID_962" "25966174" "hsa-miR-499a-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Kaifeng, China, Asia" "59" "34" "25" "60.1(11.3)" "serum" "qPCR" "The AUC of microRNA-499 was 0.915 (95%CI: 0.8261.000), the sensitivity of microRNA-499 was 86.37% and the specificity was 93.47%." "Zhao, CH et al. Genet Mol Res. 2015" "mean(SD)" "MicroRNA-499 could be detected in the serum 3 h after the onset of AMI, reached a peak value after 12 h, and gradually declined after 15 h " "Analysis and clinical significance of microRNA-499 expression levels in serum of patients with Acute myocardial infarction." "The miR-499 was deregulated in acute myocardial infarction patients, have high value for clinical diagnosis." "1053" "MID_963" "25111390" "hsa-miR-499a-5p" "microRNA" "Perioperative myocardial infarction " "up" "Diagnosis" "YES" "Beijing, China, Asia" "28" "23" "5" "61.1(10.9)" "plasma" "qRT-PCR" "PMI after 6 hours after CABG(coronary artery bypass graft ) ROC curve analysis indicated that miR-499 accurately diagnosed PMI, with a sensitivity of 85.7%, specificity of 93.3% and area under the curve (with 95% confidence interval) of 0.939 (0.880-0.975" "Yao, Y et al. PLoS One. 2014" "mean(SD)" "NA" "Plasma levels of microRNA-499 provide an early indication of perioperative myocardial infarction in coronary artery bypass graft patients" "The results demonstrate that circulating miR-499 is a novel, early biomarker for identifying perioperative myocardial infarction in cardiac surgery." "1054" "MID_964" "20159880" "hsa-miR-499a-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Shanghai, China, Asia" "33" "23" "10" "63.5(10.1)" "plasma" "Microarray, qRT-PCR" "With an area under curve (AUC) of 0.822 (95% confidence interval 0.717-0.927)" "Wang, G K et al. Eur Heart J. 2010" "mean(SEM)" "NA" "Circulating microRNA: a novel potential biomarker for early diagnosis of Acute myocardial infarction in humans" "This study demonstrated that the levels of miR-499 in blood from patients with acute myocardial infarction are elevated, it has the potential to be a novel biomarker for diagnosis of myocardial injury." "1055" "MID_965" "29506703" "hsa-miR-499a-5p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Freiburg, Germany, Europe" "24" "NA" "NA" "NA" "serum" "Droplet digital PCR" "AUC=0.9063" "Robinson, S et al. Int J Cardiol. 2018" "NA" "NA" "Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction" "The miRNA can be a diagnosis method for acute myocardial infarction." "1056" "MID_966" "29475914" "hsa-miR-499a-5p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Athens, Greece, Europe" "50" "38" "12" "62.12(10.99)" "plasma" "Reverse Transcription (RT) reaction, Real-Time PCR reaction" "AUC=0.9992 (95% CI=0.9970-1.001, p<0.0001), sensitivity: 98%; specificity: 100%" "Agiannitopoulos, K et al. In Vivo. 2018" "mean(SD)" "NA" "Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction" "Plasma levels of circulating miR-499 could serve as potential acute myocardial infarction biomarkers." "1057" "MID_967" "24850191" "hsa-miR-499a-5p SNP rs3746444" "microRNA" "Myocardial infarction" "NA" "Diagnosis" "YES" "Fuzhou, China, Asia" "919" "554" "365" "60.7(10.2)" "blood" "polymerase chain reaction-ligation detection reaction (PCR-LDR) " "The genotype frequencies of rs3746444 were 7.6% (GG), 25.8% (AG) and 66.6% (AA) among cases, and 4.2% (GG), 27.7% (AG) and 68.2% (AA) among controls, and the difference was statistically significant (P = 0.007). " "Chen, C et al. Tohoku J Exp Med. 2014" "mean(SD)" "NA" "Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population" "These findings indicate that miR-499 rs3746444 and miR-146a rs2910164 may represent novel markers of myocardial infarction susceptibility." "1058" "MID_968" "25184815" "hsa-miR-519e-5p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Wuhan, China, Asia" "9/17" "12/6" "5/3" "52(11)/59(9)" "blood" "Real-time PCR " "T0: AUC.0.798, 95%CI 0.663-0.934,p=0.001; 4h: AUC. 0.801, 95%CI 0.668-0.934,P=0.002; 24H: AUC. 0.908, 95%CI 0.818-0.997, p<0.001." "Wang, F et al. PLoS One. 2014" "mean(SEM)" "first cohort/second cohort" "Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for Acute myocardial infarction" "Finally, ROC analysis suggested that circulating miR-21-5p, miR-361-5p and miR-519e-5p can be novel and sensitive biomarkers for diagnosing acute myocardial infarction." "1059" "MID_969" "23255549" "hsa-miR-566" "microRNA" "Early-stage Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The miRNA is significantly dysregulated both at initial presentation and during the course of acute myocardial infarction. " "98" "MID_97" "25993295" "hsa-miR-489" "microRNA" "Abdominal aortic aneurysms" "up" "Diagnosis" "NO" "Lille, France, Europe" "24" "24" "0" "68.0(6.1)" "tissue, plasma" "Microarray, qRT-PCR" "NA" "Spear, R et al. Int J Mol Sci. 2015" "NA" "NA" "Adventitial Tertiary Lymphoid Organs as Potential Source of MicroRNA Biomarkers for Abdominal Aortic Aneurysm" "MiR-489-3p was highexpression levels in isolated ATLOs, M1 and M2 macrophages and entire aneurysmal biopsies." "1060" "MID_970" "23066896" "hsa-miR-574-3p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "6" "3" "3" "71.83(10.83)" "tissue" "qPCR, microarray" "NA" "Bostjancic, E et al. BMC Genomics. 2012" "mean(SD)" "NA" "MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis" "Using qPCR and mocroarray, this study found the miRNA is deregulated in human myocardial infarction tissue." "1061" "MID_971" "23066896" "hsa-miR-574-5p" "microRNA" "Myocardial infarction" "up" "Diagnosis" "NO" "Ljubljana, Slovenia, Europe" "6" "3" "3" "71.83(10.83)" "tissue" "qPCR, microarray" "NA" "Bostjancic, E et al. BMC Genomics. 2012" "mean(SD)" "NA" "MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis" "Using qPCR and mocroarray, this study found the miRNA is deregulated in human myocardial infarction tissue." "1062" "MID_972" "25738515" "hsa-miR-59" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "10/15" "6/8" "4/7" "59.2(6.0)/60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "AMNHF/AMHF" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for acute myocardial infarction" "1063" "MID_973" "23255549" "hsa-miR-636" "microRNA" "Early-stage Acute myocardial infarction" "up" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The miRNA is significantly dysregulated both at initial presentation and during the course of acute myocardial infarction. " "1064" "MID_974" "25738515" "hsa-miR-657" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "10/15" "6/8" "4/7" "59.2(6.0)/60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "AMNHF/AMHF" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for acute myocardial infarction." "1065" "MID_975" "28011706" "hsa-miR-660-5p" "microRNA" "ST-segment elevation myocardial infarction" "up" "Diagnosis" "NO" "Zurich, Switzerland, Europe" "10/63" "2/12" "8/51" "67.3(13.5)/71.54(13.34)" "plasma" "Real-time qPCR" "AUC=0.683(95 CI%:0.66-0.70)" "Jakob, P et al. Eur Heart J. 2017" "mean(SD)" "derivation cohort/validation cohort" "Profiling and validation of circulating microRNAs for cardiovascular events in patients presenting with ST-segment elevation myocardial infarction" "The MiRNA is associated with adverse cardiovascular events in patients presenting with ST elevation myocardial infarction, and it is involved in pathways regulating cardiomyocyte apoptosis, adverse cardiac remodelling, and active platelet production." "1066" "MID_976" "24885383" "hsa-miR-663b" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Zhengzhou, China, Asia" "76" "43" "33" "64.6" "plasma" "quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)" "The AUC for miR-663b was 0.611, with a sensitivity of 72.4% and a specificity of 76.5%." "Peng, L et al. Diagn Pathol. 2014" "mean(SD)" "NA" "Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with Acute myocardial infarction" "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with acute myocardial infarction.,Besides, in this study, it found that the expression of miR-133, miR-1291 and miR-663b were significantly reduced after the surgery." "1067" "MID_977" "20886220" "hsa-miR-663b" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "20" "16" "4" "59.3(14)" "blood" "real time-PCR" "miR-663b shows even better predictive values, allowing us to classify 19 of 20 cases and 18 of 20 controls correctly, resulting in specificity, sensitivity, and accuracy of 95, 90, and 92.5%,AUC:0.94" "Meder, B et al. Basic Res Cardiol. 2011" "NA" "NA" "MicroRNA signatures in total peripheral blood as novel biomarkers for Acute myocardial infarction" "The miRNA can be useful biomarkers for diagnosis of acute myocardial infarction." "1068" "MID_978" "23255549" "hsa-miR-7-1-3p" "microRNA" "Early-stage Acute myocardial infarction" "down" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "18" "15" "3" "63" "blood" "quantitative real-time PCR" "NA" "Vogel, B et al. Clin Chem. 2013" "mean(SD)" "NA" "Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in Acute myocardial infarction" "The miRNA is significantly dysregulated both at initial presentation and during the course of acute myocardial infarction. " "1069" "MID_979" "28699362" "hsa-miR-874-3p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Changchun, China, Asia" "80" "43" "37" "62.13(8.02)" "plasma" "quantitative reverse transcriptase PCR" "AUC=0.815 (95% CI:0.743-0.892; p<0.01), Cut-off value: 0.1576, Sensitivity:0.80, Specificity: 0.709; OR:0.068, 95%CI: 0.022-0.209, P<0.001" "Yan, Y et al. Biomark Med. 2017" "mean(SD)" "NA" "Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction" "MiR-874-3p was significantly lower in acute myocardial infarction patients, may be potent additional predictors of acute myocardial infarction." "99" "MID_98" "23746831" "hsa-miR-516a-5p" "microRNA" "Abdominal aortic aneurysms" "up" "Diagnosis" "NO" "Hongkong, China, Asia" "6" "6" "0" "69.5(8.2)" "tissue" "Microarray, qPCR" "Hsa-miR-516a-5p and mi-1260 showed the highest fold change (P<0.05)." "Cheuk, BL et al. J Vasc Surg. 2014" "mean(SD)" "NA" "Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms" "Functional annotations of the two miRs via bioinformatics approaches revealed that both are highly involved in some predefined mechanisms of abdominal aortic aneurysms formation." "1070" "MID_980" "25738515" "hsa-miR-877-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "1071" "MID_981" "22153007" "hsa-miR-92a-3p" "microRNA" "ST-elevation myocardial infarction" "up" "Diagnosis, Treatment" "YES" "Nanning, China, Asia" "58/24/116" "48/16/88" "10/8/28" "58.34(11.89)/68.58(12.95)/61.62(10.77)" "tissue" "RT-PCR" "On the day next to admission, ST-elevation myocardial infarction patients received no percutaneous coronary intervention(PCI) were found to have higher level of circulating miR-92a as compared to SAP patients without PCI (0.2869±0.8167 vs. -0.0555±0.9855," "Wang, H et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011" "mean(SD)" "ST-elevation myocardial infarction patients received PCI/ST-elevation myocardial infarction patients received no PCI/stable angina pectoris (SAP) without PCI" "Circulating microRNA-92a in patients with ST-segment elevation myocardial infarction" "This study indicate that miR-92a might have potential for diagnosis and therapeutic application in the prevention and treatment of ST-segment elevation myocardial infarction." "1072" "MID_982" "28213360" "hsa-miR-92a-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis" "YES" "Beijing, China, Asia" "42/37" "28/22" "14/15" "52.8(5.6)/53.7(5.6)" "plasma" "qRT-PCR" "AUC=0.8883" "Zhang, Y et al. Biosci Rep. 2017" "mean(SD)" "acute myocardial infarction/coronary artery disease" "Circulating endothelial microparticles and miR-92a in acute myocardial infarction" "MiR-92a could reflect the extent of endothelial cellsactivation and more importantly, they could serve as novel biomarkers to diagnose patients with acute myocardial infarction fromstable coronary heart disease" "1073" "MID_983" "22995291" "hsa-miR-93-3p" "microRNA" "Acute myocardial infarction" "down" "Prognosis" "YES" "Suita, Japan, Asia" "19" "14" "5" "72(12)" "serum" "Real-time RT-PCR" "NA" "Matsumoto, S et al. Biochem Biophys Res Commun. 2012" "NA" "cardic death" "A subset of circulating microRNAs are predictive for cardiac death after discharge for Acute myocardial infarction" "The circulating microRNAs are preditor of cardiac death after acute myocardial infarction." "1074" "MID_984" "28051249" "hsa-miR-99a-5p" "microRNA" "Acute myocardial infarction" "down" "Diagnosis" "YES" "Tianjin, China, Asia" "54" "NA" "NA" "NA" "plasma" "Quantitative real-time PCR (qPCR), ELISA assays" "The results revealed that a significant negative correlation was found between plasma miR-99a and cTnI (r= -0.8202, p<0.01), similar findings were detected between the expression level of miR-99a and CK-MB (r=-0.6924, p<0.01)." "Yang, S Y et al. Eur Rev Med Pharmacol Sci. 2016" "mean(SEM)" "NA" "The clinical value of circulating miR-99a in plasma of patients with Acute myocardial infarction" "The plasma miR-99a level is reduced in patients with acute myocardial infarction and serves as an indicator of the severity of this disease." "1075" "MID_985" "25738515" "hsv1-miR-H2-3p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "15" "8" "7" "60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "1076" "MID_986" "25738515" "hsv1-miR-H2-3p" "microRNA" "Acute myocardial infarction" "up" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "10/15" "6/8" "4/7" "59.2(6.0)/60.5(6.6)" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "AMNHF/AMHF" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for acute myocardial infarction." "1077" "MID_987" "25738515" "hcmv-miR-UL22A-5p" "microRNA" "Heart failure following myocardial infarction" "down" "Diagnosis, Prognosis" "YES" "Foshan, China, Asia" "13" "8" "7" "60.5(6.6" "plasma" "miRNA analysis,Volcano plots" "NA" "Liang, J et al. Mol Med Rep. 2015" "NA" "NA" "A subset of circulating microRNAs is expressed differently in patients with myocardial infarction" "These miRNAs may be novel diagnostic or prognostic biomarkers for heart failure following myocardial infarction." "1078" "MID_988" "27192016" "hsa-miR-106a-5p, hsa-miR-424-5p, hsa-let-7g-5p, hsa-miR-144-3p, hsa-miR-660-5p" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Trondheim, Norway, Europe" "56/50" "46/28" "10/22" "60.2(8.4)/61.5(7.2)" "serum" "qPCR" "AUC=0.91 (p<0.001)" "Bye, A et al.J Mol Cell Cardiol. 2016" "mean(SD)" "Derivation cohort/Validation cohort" "Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study" "A panel of 5 miRs can increase acute myocardial infarction risk prediction in healthy people." "1079" "MID_989" "27593229" "hsa-miR-122-5p/hsa-miR-133b ratio" "microRNA" "ST-segment elevation Acute myocardial infarction" "NA" "Prognosis" "YES" "Lisbon, Portugal, Europe" "142" "107" "35" "62(12)" "serum" "qRT-PCR " "Death or cardiogenic shock: 1.99(0.85-2.51); Favourable in-hospital outcome: 0.86(0.0-1.80);P Value 0.025; Univariate logistic regression analysis OR= 1.52, 95%CI=1.10-2.08." "Cortez-Dias N et al. Circ J. 2016" "mean(SD)" "NA" "Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute myocardial infarction" "In summary, we showed that miR-122-5p/133b ratio is a predictive biomarker to identify patients at higher risk of an adverse prognosis after ST-segment elevation Acute myocardial infarction." "100" "MID_99" "23316282" "hsa-miR-92a-3p" "microRNA" "Abdominal aortic aneurysms " "up" "Diagnosis" "YES" "Osaka, Japan, Asia" "13" "10" "3" "68.3(6.1)" "tissue" "microarray, real-time PCR" "NA" "Kin, K et al. J Am Heart Assoc. 2012 " "mean(SD)" "NA" "Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm" "The expression of miR-92a was specifically deregulated in abdominal aortic aneurysm tissue and have the possibility of using the microRNA as biomarker for diagnosis of abdominal aortic aneurysm." "1080" "MID_990" "24900964" "hsa-miR-126-3p/hsa-miR-150-3p ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.8429" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "1081" "MID_991" "20886220" "hsa-miR-142-5p, hsa-miR-498, hsa-miR-492, hsa-miR-1281, hsa-miR-497-3p, hsa-miR-151-5p, hsa-miR-802, hsa-miR-23b-5p, hsa-miR-455-3p, hsa-miR-1250, hsa-miR-380-5p, hsa-miR-135b-3p, hsa-miR-345-5p, hsa-miR-566, hsa-miR-631, hsa-miR-1254, hsa-miR-139-5p, hsa" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Heidelberg, Germany, Europe" "20" "16" "4" "59.3(14)" "blood" "real-time PCR" "specificity 96%, sensitivity 90%, and accuracy 93%; AUC?=?0.99" "Meder, B et al. Basic Res Cardiol. 2011" "NA" "NA" "MicroRNA signatures in total peripheral blood as novel biomarkers for Acute myocardial infarction" "The miRNA can be useful biomarkers for diagnosis of acute myocardial infarction." "1082" "MID_992" "26337652" "hsa-miR-146a-5p, hsa-miR-21-5p" "microRNA" "Left ventricular remodeling(LVR) after ST-Elevation Myocardial Infarction" "NA" "Prognosis" "YES" "Harbin, China, Asia" "56/142" "46/110" "10/32" "60.5(59.0-63.0)/67.5(59.0-73.0)" "blood" "RT-qPCR, Biomarker Testing, Echocardiography" "The AUC of miR-146a combined with miR-21 was significantly higher than the AUC of each other biomarker." "Liu, X et al. Cardiology. 2015" "mean(SD)" "LVR group/Non-LVR Group" "Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction" "Circulating miR-146a and miR-21 may be novel biomarkers predictive of LVR after acute myocardial infarction, their combination may better predict value." "1083" "MID_993" "23967079" "hsa-miR-16-5p, hsa-miR-27a-3p, hsa-miR-101-3p, hsa-miR-150-5p" "microRNA" "Acute myocardial infarction" "NA" "Prognosis" "YES" "Luxembourg, Luxembourg, Europe" "79/71" "63/53" "16/18" "61(37-86)/65(24-87)" "plasma" "Nt-proBNP assay" "net reclassification improvement(NRI): 0.66; integrated discrimination improvement(IDI): 0.08 (P = 0.001)." "Devaux, Y et al. PLoS One. 2013" "NA" "AMI follow-up WMIS<=1.2/follow-up WMIS>1.2 (wall motion index score)" "A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after Acute myocardial infarction" "The study indicate that the miRNA may aid in prognostication of outcome after acute myocardial infarction." "1084" "MID_994" "24900964" "hsa-miR-191-5p/hsa-miR-150-3p ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.788" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "1085" "MID_995" "24714087" "hsa-miR-208b, hsa-miR-34a-5p" "microRNA" "Acute myocardial infarction" "up(remodeling)" "Prognosis" "YES" "Zhengzhou, China, Asia" "116/243" "97/204" "19/39" "59(12)/57(15)" "plasma" "quantitative real-time PCR" "The combination of miR-208b and miR-34a showed an AUC of 0.812 (95% confidence interval, 0.767-0.851; p<0.001), The ability of plasma combined miRNAs to discriminate the experienced endpoint group from those with no endpoint was evaluated by the ROC curve" "Lv, P et al. Int J Mol Sci. 2014" "mean(SD)" "Remodeling/Non-remodeling" "Circulating miR-208b and miR-34a are associated with left ventricular remodeling after Acute myocardial infarction" "Results of our study revealed that plasma miR-208b and miR-34a could serve as available predictors for left ventricle remodeling after acute myocardial infarction and were associated with the six months mortality or development of heart failure." "1086" "MID_996" "25184815" "hsa-miR-21-5p, hsa-miR-361-5p, hsa-miR-519e-5p" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Wuhan, China, Asia" "9/17" "12/6" "5/3" "52(11)/59(9)" "blood" "Real-time PCR " "when combining these miRNAs together, the diagnostic accuracy became significantly raised with the AUC of 0.989 (95% confidence interval 0.000–1.000), 1.000 (95% confidence interval 0.000–1.000) and 0.995 (95% confidence interval 0.000–1.000) at T0, 4 h a" "Wang, F et al. PLoS One. 2014" "mean(SEM)" "first cohort/second cohort" "Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for Acute myocardial infarction" "Finally, ROC analysis suggested that circulating miR-21-5p, miR-361-5p and miR-519e-5p can be novel and sensitive biomarkers for diagnosing acute myocardial infarction." "1087" "MID_997" "24900964" "hsa-miR-26a-3p/hsa-miR-150-3p ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.8205" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "1088" "MID_998" "24900964" "hsa-miR-486-3p/hsa-miR-126-3p ratio ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.8491" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction." "1089" "MID_999" "24900964" "hsa-miR-486-3p/hsa-miR-191-5p ratio" "microRNA" "Acute myocardial infarction" "NA" "Diagnosis" "YES" "Taiwan, China, Asia" "31" "29" "2" "59.0(11.5)" "serum" "Reverse Transcription (RT), Quantitative Real-Time PCR (qPCR)" "ROC analysis using the expression ratio of miR-486-3p and miR-191-5p showed an area under the serum concentration time curve of 0.867" "Hsu, A et al. Biomed Res Int. 2014" "mean(SD)" "NA" "SyST-elevation myocardial infarctionc approach to identify serum microRNAs as potential biomarkers for Acute myocardial infarction" "Serum miRNAs may be used as potential diagnostic biomarkers for ST-elevation myocardial infarction."