| Recommendation |
ID |
Data Information |
Model Information |
Application Information |
Reference |
| Rank |
Total_Score |
Model_ID |
Dataset_Name |
Element_type |
Data_features |
Model_name |
Algorithm_name |
Prediction_type |
Code_source |
Study_types |
Disease_name |
Target_name |
Drug_name |
Interaction_type |
Recommended_Number |
PMID |
Journal |
Publication_Year |
| 1 |
90.6 |
1539 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/TheWall9/DRHGCN |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
34378011 |
Brief Bioinform |
2021 |
| 1 |
90.6 |
1539 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/TheWall9/DRHGCN |
Case studies |
Alzheimer's disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
34378011 |
Brief Bioinform |
2021 |
| 2 |
86.5 |
1868 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
GLGMPNN |
Message Passing Neural Network (MPNN), Gated Fusion Mechanism |
Drug Disease Association (DDA) |
https://github.com/bdtree/GLGMPNN |
Case studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
36305457 |
Brief Bioinform |
2022 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Gabapentin |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Doxorubicin |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Frovatriptan |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Dexamethasone |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Amantadine |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 3 |
85 |
1566 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
BGMSDDA |
K nearest known neighbors (WKNKN) |
Drug Disease Association (DDA) |
https://github.com/kk-2010000/BGMSDDA |
Case studies |
NA |
NA |
Flecainide |
NA |
Top 20 diseases |
34610633 |
Mol Omics |
2021 |
| 4 |
84.04 |
289 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
MBiRW |
Random Walk |
Drug Disease Association (DDA) |
http://github.com//bioinfomaticsCSU/MBiRW |
Case studies |
NA |
NA |
Doxorubicin |
NA |
Top 5 diseases |
27153662 |
Bioinformatics |
2016 |
| 4 |
84.04 |
289 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
MBiRW |
Random Walk |
Drug Disease Association (DDA) |
http://github.com//bioinfomaticsCSU/MBiRW |
Case studies |
NA |
NA |
Amantadine |
NA |
Top 5 diseases |
27153662 |
Bioinformatics |
2016 |
| 4 |
84.04 |
289 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
MBiRW |
Random Walk |
Drug Disease Association (DDA) |
http://github.com//bioinfomaticsCSU/MBiRW |
Case studies |
NA |
NA |
Cabergoline |
NA |
Top 5 diseases |
27153662 |
Bioinformatics |
2016 |
| 4 |
84.04 |
289 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
MBiRW |
Random Walk |
Drug Disease Association (DDA) |
http://github.com//bioinfomaticsCSU/MBiRW |
Case studies |
NA |
NA |
Levodopa |
NA |
Top 5 diseases |
27153662 |
Bioinformatics |
2016 |
| 4 |
84.04 |
289 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
MBiRW |
Random Walk |
Drug Disease Association (DDA) |
http://github.com//bioinfomaticsCSU/MBiRW |
Case studies |
NA |
NA |
Flecainide |
NA |
Top 5 diseases |
27153662 |
Bioinformatics |
2016 |
| 5 |
81.9 |
1643 |
Fdataset |
Drug, Disease |
Drug: Hashed fingerprints, Disease: MeSH |
springD²A |
Encoder,Neural networks |
Drug Disease Association (DDA) |
https://github.com/wangyuanhao/springD2A |
Case studies |
NA |
NA |
Fenoldopam |
NA |
Top 10 diseases |
34864881 |
Bioinformatics |
2022 |
| 5 |
81.9 |
1643 |
Fdataset |
Drug, Disease |
Drug: Hashed fingerprints, Disease: MeSH |
springD²A |
Encoder,Neural networks |
Drug Disease Association (DDA) |
https://github.com/wangyuanhao/springD2A |
Case studies |
NA |
NA |
Diltiazem |
NA |
Top 10 diseases |
34864881 |
Bioinformatics |
2022 |
| 5 |
81.9 |
1643 |
Fdataset |
Drug, Disease |
Drug: Hashed fingerprints, Disease: MeSH |
springD²A |
Encoder,Neural networks |
Drug Disease Association (DDA) |
https://github.com/wangyuanhao/springD2A |
Case studies |
NA |
NA |
Indomethacin |
NA |
Top 10 diseases |
34864881 |
Bioinformatics |
2022 |
| 6 |
81.88 |
1407 |
Fdataset |
Drug, Disease |
Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. |
MSBMF |
Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MSBMF |
Case studies |
NA |
NA |
Risperidone |
NA |
Top 10 diseases |
33147616 |
Brief Bioinform |
2021 |
| 6 |
81.88 |
1407 |
Fdataset |
Drug, Disease |
Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. |
MSBMF |
Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MSBMF |
Case studies |
NA |
NA |
Doxorubicin |
NA |
Top 10 diseases |
33147616 |
Brief Bioinform |
2021 |
| 6 |
81.88 |
1407 |
Fdataset |
Drug, Disease |
Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. |
MSBMF |
Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MSBMF |
Case studies |
NA |
NA |
Gemcitabine |
NA |
Top 10 diseases |
33147616 |
Brief Bioinform |
2021 |
| 6 |
81.88 |
1407 |
Fdataset |
Drug, Disease |
Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. |
MSBMF |
Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MSBMF |
Case studies |
NA |
NA |
Vincristine |
NA |
Top 10 diseases |
33147616 |
Brief Bioinform |
2021 |
| 6 |
81.88 |
1407 |
Fdataset |
Drug, Disease |
Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. |
MSBMF |
Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MSBMF |
Case studies |
NA |
NA |
Methotrexate |
NA |
Top 10 diseases |
33147616 |
Brief Bioinform |
2021 |
| 7 |
81.8 |
795 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
SKCNN |
Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) |
Drug Disease Association (DDA) |
https://github.com/HanJingJiang/SKCNN |
Case studies |
Obesity |
NA |
NA |
NA |
Top 20 drugs |
31747915 |
J Transl Med |
2019 |
| 7 |
81.8 |
795 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
SKCNN |
Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) |
Drug Disease Association (DDA) |
https://github.com/HanJingJiang/SKCNN |
Case studies |
Asthma |
NA |
NA |
NA |
Top 20 drugs |
31747915 |
J Transl Med |
2019 |
| 8 |
81.4 |
1718 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
MLMC |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MLMC |
Case studies |
NA |
NA |
Methotrexate |
NA |
Top 5 diseases |
35289352 |
Brief Bioinform |
2022 |
| 8 |
81.4 |
1860 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/hwh7301/EMPHCN |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
36359016 |
Biomolecules |
2022 |
| 8 |
81.4 |
1860 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/hwh7301/EMPHCN |
Case studies |
NA |
NA |
Felodipine |
NA |
Top 5 diseases |
36359016 |
Biomolecules |
2022 |
| 8 |
81.4 |
1718 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
MLMC |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MLMC |
Case studies |
NA |
NA |
Leucovorin |
NA |
Top 5 diseases |
35289352 |
Brief Bioinform |
2022 |
| 8 |
81.4 |
1718 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
MLMC |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MLMC |
Case studies |
NA |
NA |
Doxorubicin |
NA |
Top 5 diseases |
35289352 |
Brief Bioinform |
2022 |
| 8 |
81.4 |
1860 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/hwh7301/EMPHCN |
Case studies |
Breast carcinoma |
NA |
NA |
NA |
Top 10 drugs |
36359016 |
Biomolecules |
2022 |
| 8 |
81.4 |
1718 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
MLMC |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/MLMC |
Case studies |
NA |
NA |
Gemcitabine |
NA |
Top 5 diseases |
35289352 |
Brief Bioinform |
2022 |
| 9 |
80.4 |
1670 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRWBNCF |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/DRWBNCF |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 10 drugs |
35039838 |
Brief Bioinform |
2022 |
| 9 |
80.4 |
1670 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRWBNCF |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/DRWBNCF |
Case studies |
Small Cell Lung Cancer (SCLC) |
NA |
NA |
NA |
Top 10 drugs |
35039838 |
Brief Bioinform |
2022 |
| 10 |
79.8 |
486 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
DRRS (Drug Repositioning Recommendation System) |
Singular Value Thresholding (SVT) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Zoledronic acid |
NA |
Top 5 diseases |
29365057 |
Bioinformatics |
2018 |
| 10 |
79.8 |
486 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
DRRS (Drug Repositioning Recommendation System) |
Singular Value Thresholding (SVT) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Risperidone |
NA |
Top 5 diseases |
29365057 |
Bioinformatics |
2018 |
| 10 |
79.8 |
486 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
DRRS (Drug Repositioning Recommendation System) |
Singular Value Thresholding (SVT) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Prednisolone |
NA |
Top 5 diseases |
29365057 |
Bioinformatics |
2018 |
| 10 |
79.8 |
486 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
DRRS (Drug Repositioning Recommendation System) |
Singular Value Thresholding (SVT) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Paclitaxel |
NA |
Top 5 diseases |
29365057 |
Bioinformatics |
2018 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Irinotecan |
NA |
Top 1 drug |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Cortisol |
NA |
Top 2 drugs |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Salicylic acid |
NA |
Top 1 drug |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Ephedrine |
NA |
Top 2 drugs |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Podophyllotoxin |
NA |
Top 1 drug |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Testosterone |
NA |
Top 3 drugs |
31138103 |
BMC Bioinformatics |
2019 |
| 11 |
79.71428571 |
687 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
(-)-Prostaglandin E1 |
NA |
Top 1 drug |
31138103 |
BMC Bioinformatics |
2019 |
| 12 |
79.3 |
2179 |
Fdataset |
Drug, Disease, Target |
Drug: SMILES, Target: Sequence, Disease: MesH |
SiSGC (Simplifying Graph Convolution) |
CatBoost |
Drug Disease Association (DDA) |
https://github.com/MrPhil/SiSGC |
Case studies |
Breast neoplasms |
NA |
NA |
NA |
Top 20 drugs |
38103039 |
J Chem Inf Model |
2024 |
| 13 |
78.3 |
1615 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
HINGRL |
Random Forest (RF) |
Drug Disease Association (DDA) |
https://github.com/stevejobws/HINGRL |
Case studies |
Breast neoplasms |
NA |
NA |
NA |
Top 10 drugs |
34891172 |
Brief Bioinform |
2022 |
| 13 |
78.3 |
1615 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
HINGRL |
Random Forest (RF) |
Drug Disease Association (DDA) |
https://github.com/stevejobws/HINGRL |
Case studies |
NA |
Clozapine |
NA |
NA |
Top 10 diseases |
34891172 |
Brief Bioinform |
2022 |
| 14 |
78.1 |
2203 |
Fdataset |
Drug, Disease |
Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties |
WMAGT |
Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron |
Drug Disease Association (DDA) |
https://github.com/ShiHHe/WMAGT |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
38378479 |
BMC Bioinformatics |
2024 |
| 15 |
78 |
1644 |
Fdataset |
Drug, Disease |
Drug: Chemical structure, Disease: MeSH |
NMF-DR (Non-negative Matrix Factorization Drug Repurposing) |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/sshaghayeghs/NMF-DR |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 5 drugs |
34875000 |
Bioinformatics |
2022 |
| 16 |
77.875 |
509 |
Fdataset |
Drug, Disease |
Drug: substructures, Disease: MeSH |
NTSIM (Network Topological Similarity-based Inference Method) |
Label Propagation |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Risperidone |
NA |
Top 10 diseases |
29879508 |
Methods |
2018 |
| 17 |
77.7 |
2133 |
Fdataset |
Drug, Disease |
NA |
DRAGNN |
Multi Layer Perception (MLP) |
Drug Disease Association (DDA) |
https://github.com/1yiw/DRAGNN |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
38019732 |
Brief Bioinform |
2023 |
| 17 |
77.7 |
2133 |
Fdataset |
Drug, Disease |
NA |
DRAGNN |
Multi Layer Perception (MLP) |
Drug Disease Association (DDA) |
https://github.com/1yiw/DRAGNN |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 10 drugs |
38019732 |
Brief Bioinform |
2023 |
| 18 |
77.35 |
1367 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: Phenotype |
DDIPred |
Deep gated recurrent units model |
Drug Disease Association (DDA) |
https://github.com/haichengyi/DDIPre |
Case studies |
NA |
NA |
Zoledronic acid |
NA |
Top 10 diseases |
34074242 |
BMC Bioinformatics |
2021 |
| 18 |
77.35 |
1367 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: Phenotype |
DDIPred |
Deep gated recurrent units model |
Drug Disease Association (DDA) |
https://github.com/haichengyi/DDIPre |
Case studies |
NA |
NA |
Dexamethasone |
NA |
Top 15 diseases |
34074242 |
BMC Bioinformatics |
2021 |
| 19 |
77.25 |
739 |
Fdataset |
Drug, Disease |
Drug: Fingerprint, Diseases: MeSH terms |
GIPAE (Gaussian interaction profile kernel and autoencoder) |
Deep Autoencoder,Support Vector Machine (SVM) |
Drug Disease Association (DDA) |
https://github.com/HanJingJiang/GIPAE |
Case studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 20 drug |
31534955 |
Biomed Res Int |
2019 |
| 19 |
77.25 |
739 |
Fdataset |
Drug, Disease |
Drug: Fingerprint, Diseases: MeSH terms |
GIPAE (Gaussian interaction profile kernel and autoencoder) |
Deep Autoencoder,Support Vector Machine (SVM) |
Drug Disease Association (DDA) |
https://github.com/HanJingJiang/GIPAE |
Case studies |
Obesity |
NA |
NA |
NA |
Top 20 drug |
31534955 |
Biomed Res Int |
2019 |
| 20 |
76.8 |
720 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
BNNR (Bounded Nuclear Norm Regularization) |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/BNNR |
Case studies |
NA |
NA |
Amantadine |
NA |
Top 5 diseases |
31510658 |
Bioinformatics |
2019 |
| 20 |
76.8 |
1532 |
Fdataset |
Drug, Disease |
Drug: Chemical structure, Disease: MeSH |
LMFDA |
Inductive matrix |
Drug Disease Association (DDA) |
https://github.com/hupengwei/LMFDA_Dataset |
Case studies |
Type 2 Diabetes Mellitus (T2DM) |
NA |
NA |
NA |
Top 10 drugs |
34736437 |
BMC Med Inform Decis Mak |
2021 |
| 20 |
76.8 |
720 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
BNNR (Bounded Nuclear Norm Regularization) |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/BNNR |
Case studies |
NA |
NA |
Flecainide |
NA |
Top 5 diseases |
31510658 |
Bioinformatics |
2019 |
| 20 |
76.8 |
720 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
BNNR (Bounded Nuclear Norm Regularization) |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/BNNR |
Case studies |
NA |
NA |
Levodopa |
NA |
Top 5 diseases |
31510658 |
Bioinformatics |
2019 |
| 20 |
76.8 |
1532 |
Fdataset |
Drug, Disease |
Drug: Chemical structure, Disease: MeSH |
LMFDA |
Inductive matrix |
Drug Disease Association (DDA) |
https://github.com/hupengwei/LMFDA_Dataset |
Case studies |
Ischemic stroke |
NA |
NA |
NA |
Top 10 drugs |
34736437 |
BMC Med Inform Decis Mak |
2021 |
| 20 |
76.8 |
720 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
BNNR (Bounded Nuclear Norm Regularization) |
Matrix Completion |
Drug Disease Association (DDA) |
https://github.com/BioinformaticsCSU/BNNR |
Case studies |
NA |
NA |
Doxorubicin |
NA |
Top 5 diseases |
31510658 |
Bioinformatics |
2019 |
| 21 |
76.54 |
1197 |
Fdataset |
Drug, Disease |
Drug: SMILES; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Sparfloxacin |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 21 |
76.54 |
1197 |
Fdataset |
Drug, Disease |
Drug: SMILES; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Dexamethasone |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 21 |
76.54 |
1197 |
Fdataset |
Drug, Disease |
Drug: SMILES; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Triamcinolone |
NA |
Top 6 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 21 |
76.54 |
1197 |
Fdataset |
Drug, Disease |
Drug: SMILES; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Levofloxacin |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 21 |
76.54 |
1197 |
Fdataset |
Drug, Disease |
Drug: SMILES; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Loteprednol |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 22 |
76.425 |
2070 |
Fdataset |
Drug, Disease |
Drug: RDKit fingerprints, Disease: MeSH |
TNA-DR (Tail-Node Augmentation for Drug Repositioning) |
Graph Neural Network (GNN) |
Drug Disease Association (DDA) |
NA |
Case studies |
Lung neoplasms |
NA |
NA |
NA |
Top 10 drugs |
37418410 |
IEEE/ACM Trans Comput Biol Bioinform |
2023 |
| 23 |
76 |
320 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
TP-NRWRH |
Random Walk with Restart (RWR) |
Drug Disease Association (DDA) |
https://github.com/td1799/TP-NRWRH |
Case studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
28155639 |
BMC Bioinformatics |
2016 |
| 24 |
75 |
2066 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: the medical description information |
SSLDR |
Matrix Factorization |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Doxorubicin, Gemcitabine, Vincristine |
NA |
Top 5 diseases |
37028367 |
IEEE/ACM Trans Comput Biol Bioinform |
2023 |
| 25 |
73.7 |
1032 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: Phenotye |
NEDD |
Random Forest (RF),Random Walk (RW) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
NA |
Drug disease interaction |
Top 15 predictions |
32938396 |
BMC Bioinformatics |
2020 |
| 26 |
71.7 |
771 |
Fdataset |
Drug, Disease |
Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms |
RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) |
Random Walk |
Drug Disease Association (DDA) |
NA |
Case studies |
Lung cancer |
NA |
NA |
NA |
Top 5 drugs |
29994051 |
IEEE/ACM Trans Comput Biol Bioinform |
2019 |
| 26 |
71.7 |
771 |
Fdataset |
Drug, Disease |
Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms |
RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) |
Random Walk |
Drug Disease Association (DDA) |
NA |
Case studies |
Huntington Disease (HD) |
NA |
NA |
NA |
Top 5 drugs |
29994051 |
IEEE/ACM Trans Comput Biol Bioinform |
2019 |
| 26 |
71.7 |
771 |
Fdataset |
Drug, Disease |
Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms |
RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) |
Random Walk |
Drug Disease Association (DDA) |
NA |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 5 drugs |
29994051 |
IEEE/ACM Trans Comput Biol Bioinform |
2019 |
| 26 |
71.7 |
771 |
Fdataset |
Drug, Disease |
Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms |
RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) |
Random Walk |
Drug Disease Association (DDA) |
NA |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 5 drugs |
29994051 |
IEEE/ACM Trans Comput Biol Bioinform |
2019 |
| 27 |
70.4 |
1866 |
Fdataset |
Drug, Disease, Target |
Drug: SMILES, Disease: MeSH, Target: sequence |
DDAGDL |
Geometric Deep Learning (GDL),XGBoost |
Drug Disease Association (DDA) |
https://github.com/stevejobws/DDAGDL |
Case studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
36125202 |
Brief Bioinform |
2022 |
| 27 |
70.4 |
1866 |
Fdataset |
Drug, Disease, Target |
Drug: SMILES, Disease: MeSH, Target: sequence |
DDAGDL |
Geometric Deep Learning (GDL),XGBoost |
Drug Disease Association (DDA) |
https://github.com/stevejobws/DDAGDL |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 10 drugs |
36125202 |
Brief Bioinform |
2022 |
| 28 |
70 |
14 |
Fdataset |
Drug, Disease |
Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic |
PREDICT (PREdicting Drug IndiCaTions) |
Logistic Regression |
Drug Disease Association (DDA) |
NA |
Case studies |
Migrane |
NA |
NA |
NA |
1 drug |
21654673 |
Mol Syst Biol |
2011 |
| 28 |
70 |
14 |
Fdataset |
Drug, Disease |
Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic |
PREDICT (PREdicting Drug IndiCaTions) |
Logistic Regression |
Drug Disease Association (DDA) |
NA |
Case studies |
Non-papillary renal cell cancer |
NA |
NA |
NA |
1 drug |
21654673 |
Mol Syst Biol |
2011 |
| 29 |
65.6 |
573 |
Fdataset |
Drug, Disease |
Drug: chemical substructures, Disease: MeSH |
RLSDR (Regularized Least Square for Drug Repositioning) |
Regularized Least Square |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
NA |
Drug disease interaction |
Top 19 predictions |
29700660 |
Acta Biotheor |
2018 |
| 29 |
65.6 |
573 |
Fdataset |
Drug, Disease |
Drug: chemical substructures, Disease: MeSH |
RLSDR (Regularized Least Square for Drug Repositioning) |
Regularized Least Square |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
NA |
Drug disease interaction |
Top 19 predictions |
29700660 |
Acta Biotheor |
2018 |
| 30 |
62.5 |
736 |
Fdataset |
Drug, Disease |
Drug: SMILES, Diseases: MeSH terms |
ANMF |
Additional Neural Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/MortySn/ANMF |
NA |
NA |
NA |
NA |
NA |
NA |
31412762 |
BMC Bioinformatics |
2019 |
| 31 |
59.2 |
140 |
Fdataset |
Drug, Disease |
NA |
NA |
ProbS and HeatS |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Aspirin |
NA |
Top 10 diseases |
25969690 |
Comput Math Methods Med |
2015 |
| 31 |
59.2 |
140 |
Fdataset |
Drug, Disease |
NA |
NA |
ProbS and HeatS |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Tamoxifen |
NA |
Top 10 diseases |
25969690 |
Comput Math Methods Med |
2015 |
| 31 |
59.2 |
140 |
Fdataset |
Drug, Disease |
NA |
NA |
ProbS and HeatS |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Felodipine |
NA |
Top 10 diseases |
25969690 |
Comput Math Methods Med |
2015 |
| 32 |
58.5 |
1132 |
Fdataset |
Drug, Disease |
Drug: SMILES, Disease: medical description data |
HAMN (Hybrid Attentional Memory Network) |
Collaborative Filtering,Autoencoder |
Drug Disease Association (DDA) |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
33297947 |
BMC Bioinformatics |
2020 |
| 33 |
49 |
64 |
Fdataset |
Drug, Disease |
Drug: structure chemical, target, side-effect, Diseases: MeSH terms |
PreDR (Predict Drug Repositioning) |
Support Vector Machine (SVM) |
Drug Disease Association (DDA) |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
24244318 |
PLoS One |
2013 |
| 34 |
46.75 |
2132 |
Fdataset |
Drug, Disease |
NA |
IDDI-DNN |
Convolutional Neural Network (CNN) |
Drug Disease Association (DDA) |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
37993777 |
BMC Bioinformatics |
2023 |
| 35 |
44 |
1886 |
Fdataset |
Drug, Disease |
NA |
NMFDR (Neural Metric Factorization model for computational Drug Repositioning) |
Matrix Factorization |
Drug Disease Association (DDA) |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
35061591 |
IEEE/ACM Trans Comput Biol Bioinform |
2023 |