| Recommendation |
ID |
Data Information |
Model Information |
Application Information |
Reference |
| Rank |
Total_Score |
Model_ID |
Dataset_Name |
Element_type |
Data_features |
Model_name |
Algorithm_name |
Prediction_type |
Code_source |
Study_types |
Disease_name |
Target_name |
Drug_name |
Interaction_type |
Recommended_Number |
PMID |
Journal |
Publication_Year |
| 1 |
90.6 |
1539 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/TheWall9/DRHGCN |
Case studies |
Alzheimer's disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
34378011 |
Brief Bioinform |
2021 |
| 1 |
90.6 |
1539 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) |
Graph Convolutional Network (GCN) |
Drug Disease Association (DDA) |
https://github.com/TheWall9/DRHGCN |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
34378011 |
Brief Bioinform |
2021 |
| 2 |
82.1 |
1842 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
PSGCN (Partner-specific drug repositioning approach based on graph convolutional network) |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/xinliangSun/PSGCN |
Case studies |
Small Cell Lung Cancer (SCLC) |
NA |
NA |
NA |
Top 10 drugs |
35921345 |
IEEE J Biomed Health Inform |
2022 |
| 2 |
82.1 |
1842 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
PSGCN (Partner-specific drug repositioning approach based on graph convolutional network) |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/xinliangSun/PSGCN |
Case studies |
Breast Cancer |
NA |
NA |
NA |
Top 10 drugs |
35921345 |
IEEE J Biomed Health Inform |
2022 |
| 3 |
81.9 |
2175 |
LRSSL |
Drug, Disease |
Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes |
AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) |
Adaptive Graph Convolutional Network (AGCN) |
Drug Disease Association (DDA) |
https://github.com/xinliangSun/AdaDR |
Case studies |
Breast carcinoma |
NA |
NA |
NA |
Top 5 drugs |
38070161 |
Bioinformatics |
2024 |
| 3 |
81.9 |
2175 |
LRSSL |
Drug, Disease |
Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes |
AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) |
Adaptive Graph Convolutional Network (AGCN) |
Drug Disease Association (DDA) |
https://github.com/xinliangSun/AdaDR |
Case studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 5 drugs |
38070161 |
Bioinformatics |
2024 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Imatinib |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Ziprasidone |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Warfarin |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Chloroquine |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Fluconazole |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 4 |
80.6 |
895 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) |
Bayesian inductive matrix |
Drug Disease Association (DDA) |
https://github.com/linwang1982/DRIMC |
Case studies |
NA |
NA |
Citalopram |
NA |
Top 5 diseases |
31999326 |
Bioinformatics |
2020 |
| 5 |
80.4 |
1670 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRWBNCF |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/DRWBNCF |
Case studies |
Small Cell Lung Cancer (SCLC) |
NA |
NA |
NA |
Top 10 drugs |
35039838 |
Brief Bioinform |
2022 |
| 5 |
80.4 |
1670 |
LRSSL |
Drug, Disease |
Drug: SMILES, Disease: MeSH |
DRWBNCF |
Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/DRWBNCF |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 10 drugs |
35039838 |
Brief Bioinform |
2022 |
| 6 |
77.875 |
509 |
LRSSL |
Drug, Disease |
Drug: substructures, Disease: MeSH |
NTSIM (Network Topological Similarity-based Inference Method) |
Label Propagation |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Risperidone |
NA |
Top 10 diseases |
29879508 |
Methods |
2018 |
| 7 |
77.76 |
766 |
LRSSL |
Drug, Disease, Side-effect |
Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology |
DisDrugPred |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/pingxuan-hlju/DisDrugPred |
Case studies |
NA |
NA |
Cefotaxime |
NA |
Top 10 diseases |
30865257 |
Bioinformatics |
2019 |
| 7 |
77.76 |
766 |
LRSSL |
Drug, Disease, Side-effect |
Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology |
DisDrugPred |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/pingxuan-hlju/DisDrugPred |
Case studies |
NA |
NA |
Ciprofloxacin |
NA |
Top 10 diseases |
30865257 |
Bioinformatics |
2019 |
| 7 |
77.76 |
766 |
LRSSL |
Drug, Disease, Side-effect |
Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology |
DisDrugPred |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/pingxuan-hlju/DisDrugPred |
Case studies |
NA |
NA |
Clonidine |
NA |
Top 10 diseases |
30865257 |
Bioinformatics |
2019 |
| 7 |
77.76 |
766 |
LRSSL |
Drug, Disease, Side-effect |
Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology |
DisDrugPred |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/pingxuan-hlju/DisDrugPred |
Case studies |
NA |
NA |
Ampicillin |
NA |
Top 10 diseases |
30865257 |
Bioinformatics |
2019 |
| 7 |
77.76 |
766 |
LRSSL |
Drug, Disease, Side-effect |
Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology |
DisDrugPred |
Non-negative Matrix Factorization (NMF) |
Drug Disease Association (DDA) |
https://github.com/pingxuan-hlju/DisDrugPred |
Case studies |
NA |
NA |
Etoposide |
NA |
Top 10 diseases |
30865257 |
Bioinformatics |
2019 |
| 8 |
77.7 |
2133 |
LRSSL |
Drug, Disease |
NA |
DRAGNN |
Multi Layer Perception (MLP) |
Drug Disease Association (DDA) |
https://github.com/1yiw/DRAGNN |
Case studies |
Parkinson’s Disease (PD) |
NA |
NA |
NA |
Top 10 drugs |
38019732 |
Brief Bioinform |
2023 |
| 8 |
77.7 |
2133 |
LRSSL |
Drug, Disease |
NA |
DRAGNN |
Multi Layer Perception (MLP) |
Drug Disease Association (DDA) |
https://github.com/1yiw/DRAGNN |
Case studies |
Breast cancer |
NA |
NA |
NA |
Top 10 drugs |
38019732 |
Brief Bioinform |
2023 |
| 9 |
76.54 |
1197 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Triamcinolone |
NA |
Top 6 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 9 |
76.54 |
1197 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Dexamethasone |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 9 |
76.54 |
1197 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Levofloxacin |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 9 |
76.54 |
1197 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Loteprednol |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 9 |
76.54 |
1197 |
LRSSL |
Drug, Disease |
Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye |
SNF-NN (Similarity network fusion and neural networks) |
Similarity Network Fusion (SNF),Neural Network |
Drug Disease Association (DDA) |
http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php |
Case studies |
NA |
NA |
Sparfloxacin |
NA |
Top 7 diseases |
33482713 |
BMC Bioinformatics |
2021 |
| 10 |
76.425 |
2070 |
LRSSL |
Drug, Disease |
Drug: RDKit fingerprints, Disease: MeSH |
TNA-DR (Tail-Node Augmentation for Drug Repositioning) |
Graph Neural Network (GNN) |
Drug Disease Association (DDA) |
NA |
Case studies |
Lung neoplasms |
NA |
NA |
NA |
Top 10 drugs |
37418410 |
IEEE/ACM Trans Comput Biol Bioinform |
2023 |
| 11 |
73.5 |
717 |
LRSSL |
Drug, Disease |
Drug: chemical substructure, chemical fingerprints, Disease: MeSH |
CBPred |
Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Ceftriaxone |
NA |
Top 10 diseases |
31336774 |
Cells |
2019 |
| 11 |
73.5 |
717 |
LRSSL |
Drug, Disease |
Drug: chemical substructure, chemical fingerprints, Disease: MeSH |
CBPred |
Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Ofloxacin |
NA |
Top 10 diseases |
31336774 |
Cells |
2019 |
| 11 |
73.5 |
717 |
LRSSL |
Drug, Disease |
Drug: chemical substructure, chemical fingerprints, Disease: MeSH |
CBPred |
Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Ampicillin |
NA |
Top 10 diseases |
31336774 |
Cells |
2019 |
| 11 |
73.5 |
717 |
LRSSL |
Drug, Disease |
Drug: chemical substructure, chemical fingerprints, Disease: MeSH |
CBPred |
Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Levofloxacin |
NA |
Top 10 diseases |
31336774 |
Cells |
2019 |
| 11 |
73.5 |
717 |
LRSSL |
Drug, Disease |
Drug: chemical substructure, chemical fingerprints, Disease: MeSH |
CBPred |
Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) |
Drug Disease Association (DDA) |
NA |
Case studies |
NA |
NA |
Ciprofloxacin |
NA |
Top 10 diseases |
31336774 |
Cells |
2019 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Ziprasidone |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Fenoprofen |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Nimodipine |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Citalopram |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Progesterone |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Dextromethorphan |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Thiopental |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Yohimbine |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Tacrolimus |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 12 |
71.04 |
361 |
LRSSL |
Drug, Disease |
Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH |
LRSSL (Laplacian regularized sparse subspace learning) |
Laplacian regularized sparse subspace learning |
Drug Disease Association (DDA) |
https://github.com/LiangXujun/LRSSL |
Case studies |
NA |
NA |
Tolmetin |
NA |
Top 5 diseases |
28096083 |
Bioinformatics |
2017 |
| 13 |
66.4 |
1990 |
LRSSL |
Drug, Disease |
NA |
NetPro |
Label Propagation |
Drug Disease Association (DDA) |
https://github.com/hyr0771/NetPro |
Case studies |
NA |
NA |
Levodopa, Flecainide, Doxorubicin |
NA |
Top 5 diseases |
37018341 |
IEEE/ACM Trans Comput Biol Bioinform |
2023 |
| 14 |
53 |
856 |
LRSSL |
Drug, Disease |
Drug: chemical structure, drug target domain, drug target gene ontology (GO); Disease: semantic |
DDAPRED |
Logistic Matrix Factorization |
Drug Disease Association (DDA) |
https://github.com/nongdaxiaofeng/DDAPRED |
NA |
NA |
NA |
NA |
NA |
NA |
32062701 |
J Mol Model |
2020 |