| Recommendation |
ID |
Data Information |
Model Information |
Application Information |
Reference |
| Rank |
Total_Score |
Model_ID |
Dataset_Name |
Element_type |
Data_features |
Model_name |
Algorithm_name |
Prediction_type |
Code_source |
Study_types |
Disease_name |
Target_name |
Drug_name |
Interaction_type |
Recommended_Number |
PMID |
Journal |
Publication_Year |
| 1 |
87.8 |
2207 |
Dataset 4 |
Drug, Disease |
Drug: SMILES, Disease: Mesh semantic |
DRDSA (Drug Repositioning Deep Sparse Autoencoder) |
Deep sparse autoencoder,Deep feedforward neural network |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/HDVD |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
38103130 |
Interdiscip Sci |
2024 |
| 1 |
87.8 |
2207 |
Dataset 1 |
Drug, Disease |
Drug: SMILES, Disease: Mesh semantic |
DRDSA (Drug Repositioning Deep Sparse Autoencoder) |
Deep sparse autoencoder,Deep feedforward neural network |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/HDVD |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
38103130 |
Interdiscip Sci |
2024 |
| 1 |
87.8 |
2207 |
Dataset 2 |
Drug, Disease |
Drug: SMILES, Disease: Mesh semantic |
DRDSA (Drug Repositioning Deep Sparse Autoencoder) |
Deep sparse autoencoder,Deep feedforward neural network |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/HDVD |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
38103130 |
Interdiscip Sci |
2024 |
| 1 |
87.8 |
2207 |
Dataset 3 |
Drug, Disease |
Drug: SMILES, Disease: Mesh semantic |
DRDSA (Drug Repositioning Deep Sparse Autoencoder) |
Deep sparse autoencoder,Deep feedforward neural network |
Drug Disease Association (DDA) |
https://github.com/luckymengmeng/HDVD |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
38103130 |
Interdiscip Sci |
2024 |
| 2 |
81 |
2099 |
NA |
Drug, Disease, Target, Side-effect |
Drug: SMILES, Target: the amino acid sequences |
MOVE |
Multi Layer Perception (MLP) |
Drug Target Interaction (DTI) |
https://github.com/scu-kdde/Bioinfo-MOVE2.0 |
Case studies |
COVID-19 |
Peroxisome proliferator-activated receptor gamma(P37231), Peroxisome proliferator-activated receptor alpha(Q07869), Apoptosis regulator Bcl-2(P10415), Angiotensin-converting enzyme 2(Q9BYF1), Cystic fibrosis transmembrane conductance regulator(P13569), Nuclear receptor subfamily 1 group I member 2(O75469), Annexin A1(P04083) |
NA |
NA |
Top 7 drugs |
37586602 |
Methods |
2023 |
| 3 |
77.875 |
2079 |
DrugBank (version 5.1.9) |
Drug, Target |
Drug: SMILES, Target: the amino acid sequences |
MULGA (Multi-view Learning and Graph Autoencoder framework) |
Multi-view Learning and Graph Autoencoder (GAE) |
Drug Target Interaction (DTI) |
https://github.com/jianiM/MULGA |
Case studies |
COVID-19 |
Spike glycoprotein |
NA |
NA |
Top 20 drugs |
37610353 |
Bioinformatics |
2023 |
| 3 |
77.875 |
2079 |
KIBA |
Drug, Target |
Drug: SMILES, Target: the amino acid sequences |
MULGA (Multi-view Learning and Graph Autoencoder framework) |
Multi-view Learning and Graph Autoencoder (GAE) |
Drug Target Interaction (DTI) |
https://github.com/jianiM/MULGA |
Case studies |
COVID-19 |
Spike glycoprotein |
NA |
NA |
Top 20 drugs |
37610353 |
Bioinformatics |
2023 |
| 3 |
77.875 |
2079 |
Davis |
Drug, Target |
Drug: SMILES, Target: the amino acid sequences |
MULGA (Multi-view Learning and Graph Autoencoder framework) |
Multi-view Learning and Graph Autoencoder (GAE) |
Drug Target Interaction (DTI) |
https://github.com/jianiM/MULGA |
Case studies |
COVID-19 |
Spike glycoprotein |
NA |
NA |
Top 20 drugs |
37610353 |
Bioinformatics |
2023 |
| 3 |
77.875 |
2079 |
BindingDB |
Drug, Target |
Drug: SMILES, Target: the amino acid sequences |
MULGA (Multi-view Learning and Graph Autoencoder framework) |
Multi-view Learning and Graph Autoencoder (GAE) |
Drug Target Interaction (DTI) |
https://github.com/jianiM/MULGA |
Case studies |
COVID-19 |
Spike glycoprotein |
NA |
NA |
Top 20 drugs |
37610353 |
Bioinformatics |
2023 |
| 4 |
76.4 |
1394 |
DTINet |
Drug, Disease, Target, Side-effect |
Drug: structure, Target: sequence |
LUNAR |
Graph Convolutional Network (GCN) |
Drug Target Interaction (DTI) |
NA |
Case studies |
COVID-19 |
Tumor necrosis factor |
NA |
NA |
Top 10 drugs |
34081583 |
IEEE/ACM Trans Comput Biol Bioinform |
2021 |
| 4 |
76.4 |
1394 |
DTINet |
Drug, Disease, Target, Side-effect |
Drug: structure, Target: sequence |
LUNAR |
Graph Convolutional Network (GCN) |
Drug Target Interaction (DTI) |
NA |
Case studies |
COVID-19 |
Nterleukin-l beta |
NA |
NA |
Top 5 drugs |
34081583 |
IEEE/ACM Trans Comput Biol Bioinform |
2021 |
| 4 |
76.4 |
1394 |
DTINet |
Drug, Disease, Target, Side-effect |
Drug: structure, Target: sequence |
LUNAR |
Graph Convolutional Network (GCN) |
Drug Target Interaction (DTI) |
NA |
Case studies |
COVID-19 |
ACE2 |
NA |
NA |
Top 8 drugs |
34081583 |
IEEE/ACM Trans Comput Biol Bioinform |
2021 |
| 5 |
76.3 |
2145 |
Davis |
Drug, Target |
Drug: SMILES, Target: The amino acid Sequence. |
MdDTI |
Multi Layer Perception (MLP) |
Drug Target Interaction (DTI) |
https://github.com/lhhu1999/MdDTI |
Case studies |
COVID-19 |
SARS-CoV-2 3C-like protease |
NA |
NA |
Top 5 drugs |
37844375 |
Comput Biol Chem |
2023 |
| 5 |
76.3 |
2145 |
KIBA |
Drug, Target |
Drug: SMILES, Target: The amino acid Sequence. |
MdDTI |
Multi Layer Perception (MLP) |
Drug Target Interaction (DTI) |
https://github.com/lhhu1999/MdDTI |
Case studies |
COVID-19 |
SARS-CoV-2 3C-like protease |
NA |
NA |
Top 5 drugs |
37844375 |
Comput Biol Chem |
2023 |
| 6 |
73.9 |
2102 |
DDKG-V1 |
Drug, Disease, Target, Gene |
NA |
DrugRep-HeSiaGraph |
Siamese Neural Network (SNN) |
Drug Disease Association (DDA) |
https://github.com/CBRC-lab/DrugRep-HeSiaGraph |
Case studies |
COVID-19 |
Dipeptidyl Peptidase 4 (DPP-4) |
NA |
NA |
Top 10 drugs |
37789314 |
BMC Bioinformatics |
2023 |
| 7 |
72.95 |
2134 |
External Set-2 |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 7 |
72.95 |
2134 |
DRH |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 7 |
72.95 |
2134 |
NA |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 7 |
72.95 |
2134 |
External Set-1 |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 8 |
72.3 |
1765 |
BindingDB |
Drug, Target |
Drug: SMILES, Target: binding site |
AttentionSiteDTI |
Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) |
Drug Target Interaction (DTI) |
https://github.com/yazdanimehdi/AttentionSiteDTI |
Case studies |
COVID-19 |
SARS-CoV-2 |
NA |
NA |
Top 7 drugs |
35817396 |
Brief Bioinform |
2022 |
| 8 |
72.3 |
1765 |
DUD-E |
Drug, Target |
Drug: SMILES, Target: binding site |
AttentionSiteDTI |
Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) |
Drug Target Interaction (DTI) |
https://github.com/yazdanimehdi/AttentionSiteDTI |
Case studies |
COVID-19 |
SARS-CoV-2 |
NA |
NA |
Top 7 drugs |
35817396 |
Brief Bioinform |
2022 |
| 8 |
72.3 |
1765 |
Human |
Drug, Target |
Drug: SMILES, Target: binding site |
AttentionSiteDTI |
Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) |
Drug Target Interaction (DTI) |
https://github.com/yazdanimehdi/AttentionSiteDTI |
Case studies |
COVID-19 |
SARS-CoV-2 |
NA |
NA |
Top 7 drugs |
35817396 |
Brief Bioinform |
2022 |
| 9 |
70.85 |
1798 |
dataset 1 |
Drug, Disease, Gene |
NA |
NEDNBI |
Network-Based Inference |
Drug Disease Association (DDA) |
https://github.com/Qli97/NEDNBI |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 20 drugs |
35338586 |
Mol Inform |
2022 |
| 9 |
70.85 |
1798 |
dataset 2 |
Drug, Disease, Gene |
NA |
NEDNBI |
Network-Based Inference |
Drug Disease Association (DDA) |
https://github.com/Qli97/NEDNBI |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 20 drugs |
35338586 |
Mol Inform |
2022 |
| 10 |
67.8 |
2015 |
NA |
Drug, Gene |
NA |
DTSEA (Drug Target Set Enrichment Analysis) |
Random Walk with Restart (RWR) |
Drug Disease Association (DDA) |
https://github.com/hanjunwei-lab/DTSEAData |
Special studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
37105108 |
Comput Biol Med |
2023 |
| 11 |
66.65 |
1973 |
Negative set |
Drug, Disease |
NA |
DrugRep-KG |
Logistic Regression |
Drug Disease Association (DDA) |
https://github.com/CBRC-lab/DrugRep-KG |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 6 drugs |
37023229 |
J Chem Inf Model |
2023 |
| 11 |
66.65 |
1973 |
RepoDB |
Drug, Disease |
NA |
DrugRep-KG |
Logistic Regression |
Drug Disease Association (DDA) |
https://github.com/CBRC-lab/DrugRep-KG |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 6 drugs |
37023229 |
J Chem Inf Model |
2023 |
| 12 |
64.9 |
1306 |
NA |
Drug, Virus |
Drug: chemical structure, Virus: d2* dissimilarity/distance (at k=6) between the viral genome sequences |
DVA (Drug Virus Association) |
Matrix Completion |
Drug Virus Association (DVA) |
www.github.com/AanchalMongia/DVA |
Case studies |
COVID-19 |
SARS-CoV-2 |
NA |
NA |
Top 6 drugs |
33907209 |
Sci Rep |
2021 |
| 13 |
60.6 |
2208 |
BIOKG-One |
Drug, Disease, Target, Side-effect, |
NA |
MLAN (Multi-Level Attention Network) |
Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) |
Drug Disease Association (DDA) |
NA |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 5 drugs |
38244473 |
Comput Biol Med |
2024 |
| 13 |
60.6 |
2208 |
COVID19-One |
NA |
NA |
MLAN (Multi-Level Attention Network) |
Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) |
Drug Disease Association (DDA) |
NA |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 5 drugs |
38244473 |
Comput Biol Med |
2024 |
| 13 |
60.6 |
2208 |
NELL-One |
NA |
NA |
MLAN (Multi-Level Attention Network) |
Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) |
Drug Disease Association (DDA) |
NA |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 5 drugs |
38244473 |
Comput Biol Med |
2024 |
| 14 |
60 |
2001 |
Davis |
Drug, Target |
NA |
BindingSite-AugmentedDTA |
Graph Neural Network (GNN) |
Drug Target binding Affinity (DTA) |
https://github.com/yazdanimehdi/BindingSite-AugmentedDTA |
Case studies |
COVID-19 |
SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex) |
NA |
NA |
Top 10 drugs |
37096593 |
Brief Bioinform |
2023 |
| 14 |
60 |
2001 |
KIBA |
Drug, Target |
NA |
BindingSite-AugmentedDTA |
Graph Neural Network (GNN) |
Drug Target binding Affinity (DTA) |
https://github.com/yazdanimehdi/BindingSite-AugmentedDTA |
Case studies |
COVID-19 |
SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex) |
NA |
NA |
Top 10 drugs |
37096593 |
Brief Bioinform |
2023 |
| 15 |
58.9 |
1260 |
NA |
Subject, object, predicate |
NA |
LBD |
Knowledge Graph Completion |
Drug Disease Association (DDA) |
https://github.com/kilicogluh/lbd-covid |
Special studies |
COVID-19 |
NA |
NA |
NA |
5 drugs |
33571675 |
J Biomed Inform |
2021 |
| 16 |
53.5 |
2169 |
DRKG |
Drug, Disease, Gene, Pathway, Side-effect, Compound, Anatomy, Tax, Molecular Function, Symptom, Biological Process, Cellular Component, Atc, PharmacologicClass |
NA |
TransRGNN |
Graph Neural Network (GNN) |
Drug Disease Association (DDA) |
NA |
Case studies |
COVID-19 |
NA |
NA |
NA |
Top 30 drugs |
38104883 |
Methods |
2024 |
| 17 |
38.4 |
1444 |
CAS Biomedical Knowledge Graph(COVID-19) |
Disease, Gene, Pathway, Virus, Side-effect, Clinical Trial, Small molecule, Molecular Function |
NA |
NA |
A computer algorithm-driven drug-ranking method |
Drug Disease Association (DDA) |
NA |
Special studies |
COVID-19 |
NA |
NA |
NA |
Top 50 drugs |
34297570 |
J Chem Inf Model |
2021 |