DRPMKB knowledgebase

The search result for the key word "NA"

A total of 613 results found based on your keywords

Recommendation		ID	Data Information			Model Information				Application Information						Reference
Rank	Total_Score	Model_ID	Dataset_Name	Element_type	Data_features	Model_name	Algorithm_name	Prediction_type	Code_source	Study_types	Disease_name	Target_name	Drug_name	Interaction_type	Recommended_Number	PMID	Journal	Publication_Year
1	90.6	1539	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Alzheimer's disease (AD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Ldataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Alzheimer's disease (AD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Ldataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Alzheimer's disease (AD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
1	90.6	1539	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/TheWall9/DRHGCN	Case studies	Alzheimer's disease (AD)	NA	NA	NA	Top 10 drugs	34378011	Brief Bioinform	2021
2	87.8	2207	Dataset 3	Drug, Disease	Drug: SMILES, Disease: Mesh semantic	DRDSA (Drug Repositioning Deep Sparse Autoencoder)	Deep sparse autoencoder,Deep feedforward neural network	Drug Disease Association (DDA)	https://github.com/luckymengmeng/HDVD	Case studies	COVID-19	NA	NA	NA	Top 10 drugs	38103130	Interdiscip Sci	2024
2	87.8	2207	Dataset 4	Drug, Disease	Drug: SMILES, Disease: Mesh semantic	DRDSA (Drug Repositioning Deep Sparse Autoencoder)	Deep sparse autoencoder,Deep feedforward neural network	Drug Disease Association (DDA)	https://github.com/luckymengmeng/HDVD	Case studies	COVID-19	NA	NA	NA	Top 10 drugs	38103130	Interdiscip Sci	2024
2	87.8	2207	Dataset 1	Drug, Disease	Drug: SMILES, Disease: Mesh semantic	DRDSA (Drug Repositioning Deep Sparse Autoencoder)	Deep sparse autoencoder,Deep feedforward neural network	Drug Disease Association (DDA)	https://github.com/luckymengmeng/HDVD	Case studies	COVID-19	NA	NA	NA	Top 10 drugs	38103130	Interdiscip Sci	2024
2	87.8	2207	Dataset 2	Drug, Disease	Drug: SMILES, Disease: Mesh semantic	DRDSA (Drug Repositioning Deep Sparse Autoencoder)	Deep sparse autoencoder,Deep feedforward neural network	Drug Disease Association (DDA)	https://github.com/luckymengmeng/HDVD	Case studies	COVID-19	NA	NA	NA	Top 10 drugs	38103130	Interdiscip Sci	2024
3	86.5	1868	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	GLGMPNN	Message Passing Neural Network (MPNN), Gated Fusion Mechanism	Drug Disease Association (DDA)	https://github.com/bdtree/GLGMPNN	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36305457	Brief Bioinform	2022
3	86.5	1868	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	GLGMPNN	Message Passing Neural Network (MPNN), Gated Fusion Mechanism	Drug Disease Association (DDA)	https://github.com/bdtree/GLGMPNN	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36305457	Brief Bioinform	2022
4	85.4	815	Cdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	PREDICT (Fdataset)	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	NA	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	PREDICT (Fdataset)	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	NA	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	Cdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	PREDICT (Fdataset)	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	NA	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
4	85.4	815	Cdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	OMC	Overlap Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/OMC	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31869322	PLoS Comput Biol	2019
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Dexamethasone	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Amantadine	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Gabapentin	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Doxorubicin	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Flecainide	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Frovatriptan	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Dexamethasone	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Amantadine	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Gabapentin	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Doxorubicin	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Flecainide	NA	Top 20 diseases	34610633	Mol Omics	2021
5	85	1566	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	BGMSDDA	K nearest known neighbors (WKNKN)	Drug Disease Association (DDA)	https://github.com/kk-2010000/BGMSDDA	Case studies	NA	NA	Frovatriptan	NA	Top 20 diseases	34610633	Mol Omics	2021
6	84.3	1807	NA	Drug, Disease	Drug: SMILES, Disease: Mesh semantic	GCMM (Graph convolution network based on a multimodal attention mechanism)	Convolutional Neural Network (CNN)	Drug Disease Association (DDA)	https://github.com/FanZhang0820/GCMM	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 5 drugs	36100897	BMC Bioinformatics	2022
7	84.04	289	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Cabergoline	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Cabergoline	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Cabergoline	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	27153662	Bioinformatics	2016
7	84.04	289	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	MBiRW	Random Walk	Drug Disease Association (DDA)	http://github.com//bioinfomaticsCSU/MBiRW	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	27153662	Bioinformatics	2016
8	83.8	893	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	HNet-DNN	Deep Neural Network (DNN)	Drug Disease Association (DDA)	https://github.com/hliu2016/HNet-DNN	Case studies	Breast neoplasms	NA	NA	NA	Top 15 drugs	32118415	J Chem Inf Model	2020
8	83.8	893	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	HNet-DNN	Deep Neural Network (DNN)	Drug Disease Association (DDA)	https://github.com/hliu2016/HNet-DNN	Case studies	NA	NA	Enalapril	NA	Top 15 diseases	32118415	J Chem Inf Model	2020
8	83.8	893	PREDICT (Fdataset)	Drug, Disease	Drug: SMILES, Disease: MeSH	HNet-DNN	Deep Neural Network (DNN)	Drug Disease Association (DDA)	https://github.com/hliu2016/HNet-DNN	Case studies	Breast neoplasms	NA	NA	NA	Top 15 drugs	32118415	J Chem Inf Model	2020
8	83.8	893	PREDICT (Fdataset)	Drug, Disease	Drug: SMILES, Disease: MeSH	HNet-DNN	Deep Neural Network (DNN)	Drug Disease Association (DDA)	https://github.com/hliu2016/HNet-DNN	Case studies	NA	NA	Enalapril	NA	Top 15 diseases	32118415	J Chem Inf Model	2020
9	83	1613	NA	Drug, Disease	Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH	CTST	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Metoprolol	NA	Top 10 diseases	34850815	Brief Bioinform	2022
9	83	1613	NA	Drug, Disease	Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH	CTST	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Propranolol	NA	Top 10 diseases	34850815	Brief Bioinform	2022
9	83	1613	NA	Drug, Disease	Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH	CTST	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Aripiprazole	NA	Top 10 diseases	34850815	Brief Bioinform	2022
9	83	1613	NA	Drug, Disease	Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH	CTST	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Chloroquine	NA	Top 10 diseases	34850815	Brief Bioinform	2022
9	83	1613	NA	Drug, Disease	Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH	CTST	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Flurbiprofen	NA	Top 10 diseases	34850815	Brief Bioinform	2022
10	82.7	1848	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	NA	NA	Dexamethasone	NA	Top 10 diseases	36182762	Comput Biol Med	2022
10	82.7	1848	NA	Drug, Disease, Target, Gene, Pathway	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	NA	NA	Dexamethasone	NA	Top 10 diseases	36182762	Comput Biol Med	2022
10	82.7	1848	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	NA	NA	Ifosfamide	NA	Top 10 diseases	36182762	Comput Biol Med	2022
10	82.7	1848	NA	Drug, Disease, Target, Gene, Pathway	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	NA	NA	Ifosfamide	NA	Top 10 diseases	36182762	Comput Biol Med	2022
10	82.7	1848	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	Breast neoplasms	NA	NA	NA	Top 10 drugs	36182762	Comput Biol Med	2022
10	82.7	1848	NA	Drug, Disease, Target, Gene, Pathway	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	Breast neoplasms	NA	NA	NA	Top 10 drugs	36182762	Comput Biol Med	2022
10	82.7	1848	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	Brain neoplasms	NA	NA	NA	Top 10 drugs	36182762	Comput Biol Med	2022
10	82.7	1848	NA	Drug, Disease, Target, Gene, Pathway	Drug: SMILES, Disease: MeSH	REDDA (Relations-Enhanced Drug-Disease Association prediction)	Heterogeneous Graph Convolutional Network (HGCN)	Drug Disease Association (DDA)	https://github.com/gu-yaowen/REDDA	Case studies	Brain neoplasms	NA	NA	NA	Top 10 drugs	36182762	Comput Biol Med	2022
11	82.1	1842	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
11	82.1	1842	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Breast Cancer	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
11	82.1	1842	Gdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
11	82.1	1842	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
11	82.1	1842	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Breast Cancer	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
11	82.1	1842	Gdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	PSGCN (Partner-specific drug repositioning approach based on graph convolutional network）	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/xinliangSun/PSGCN	Case studies	Breast Cancer	NA	NA	NA	Top 10 drugs	35921345	IEEE J Biomed Health Inform	2022
12	81.9	2175	LRSSL	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Breast carcinoma	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	DNdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Fenoldopam	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Gdataset (Fdataset)	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Breast carcinoma	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	Fdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Indomethacin	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Ldataset	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	DNdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Diltiazem	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Cdataset	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	Cdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Fenoldopam	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Ldataset	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Breast carcinoma	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	DNdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Indomethacin	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Cdataset	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Breast carcinoma	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	Cdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Diltiazem	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	1643	Fdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Fenoldopam	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	Gdataset (Fdataset)	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	Fdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Diltiazem	NA	Top 10 diseases	34864881	Bioinformatics	2022
12	81.9	2175	LRSSL	Drug, Disease	Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes	AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning)	Adaptive Graph Convolutional Network (AGCN)	Drug Disease Association (DDA)	https://github.com/xinliangSun/AdaDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 5 drugs	38070161	Bioinformatics	2024
12	81.9	1643	Cdataset	Drug, Disease	Drug: Hashed fingerprints, Disease: MeSH	springD²A	Encoder,Neural networks	Drug Disease Association (DDA)	https://github.com/wangyuanhao/springD2A	Case studies	NA	NA	Indomethacin	NA	Top 10 diseases	34864881	Bioinformatics	2022
13	81.88	1407	Fdataset	Drug, Disease	Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO.	MSBMF	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MSBMF	Case studies	NA	NA	Vincristine	NA	Top 10 diseases	33147616	Brief Bioinform	2021
13	81.88	1407	Fdataset	Drug, Disease	Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO.	MSBMF	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MSBMF	Case studies	NA	NA	Methotrexate	NA	Top 10 diseases	33147616	Brief Bioinform	2021
13	81.88	1407	Fdataset	Drug, Disease	Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO.	MSBMF	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MSBMF	Case studies	NA	NA	Risperidone	NA	Top 10 diseases	33147616	Brief Bioinform	2021
13	81.88	1407	Fdataset	Drug, Disease	Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO.	MSBMF	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MSBMF	Case studies	NA	NA	Doxorubicin	NA	Top 10 diseases	33147616	Brief Bioinform	2021
13	81.88	1407	Fdataset	Drug, Disease	Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO.	MSBMF	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MSBMF	Case studies	NA	NA	Gemcitabine	NA	Top 10 diseases	33147616	Brief Bioinform	2021
14	81.8	795	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	SKCNN	Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/SKCNN	Case studies	Asthma	NA	NA	NA	Top 20 drugs	31747915	J Transl Med	2019
14	81.8	795	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	SKCNN	Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/SKCNN	Case studies	Obesity	NA	NA	NA	Top 20 drugs	31747915	J Transl Med	2019
14	81.8	795	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	SKCNN	Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/SKCNN	Case studies	Asthma	NA	NA	NA	Top 20 drugs	31747915	J Transl Med	2019
14	81.8	795	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	SKCNN	Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/SKCNN	Case studies	Obesity	NA	NA	NA	Top 20 drugs	31747915	J Transl Med	2019
15	81.7	2036	DTPKS	Drug, Target	Drug: 2D molecular graphs Target: amino acid sequences (AAS)	MDTips	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/XiaoqiongXia/MDTips	Case studies	NA	NA	Melphalan	NA	Top 30 diseases	37379157	Bioinformatics	2023
16	81.4	1860	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Breast carcinoma	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	T2	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	NA	NA	Felodipine	NA	Top 5 diseases	36359016	Biomolecules	2022
16	81.4	1860	T1	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1718	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	MLMC	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MLMC	Case studies	NA	NA	Gemcitabine	NA	Top 5 diseases	35289352	Brief Bioinform	2022
16	81.4	1718	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	MLMC	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MLMC	Case studies	NA	NA	Methotrexate	NA	Top 5 diseases	35289352	Brief Bioinform	2022
16	81.4	1860	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Breast carcinoma	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	T1	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	NA	NA	Felodipine	NA	Top 5 diseases	36359016	Biomolecules	2022
16	81.4	1718	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	MLMC	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MLMC	Case studies	NA	NA	Leucovorin	NA	Top 5 diseases	35289352	Brief Bioinform	2022
16	81.4	1860	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	NA	NA	Felodipine	NA	Top 5 diseases	36359016	Biomolecules	2022
16	81.4	1860	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	T2	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Breast carcinoma	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	T2	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1860	T1	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	Breast carcinoma	NA	NA	NA	Top 10 drugs	36359016	Biomolecules	2022
16	81.4	1718	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	MLMC	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/MLMC	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	35289352	Brief Bioinform	2022
16	81.4	1860	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/hwh7301/EMPHCN	Case studies	NA	NA	Felodipine	NA	Top 5 diseases	36359016	Biomolecules	2022
17	81	2099	NA	Drug, Disease, Target, Side-effect	Drug: SMILES, Target: the amino acid sequences	MOVE	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/scu-kdde/Bioinfo-MOVE2.0	Case studies	COVID-19	Peroxisome proliferator-activated receptor gamma(P37231), Peroxisome proliferator-activated receptor alpha(Q07869), Apoptosis regulator Bcl-2(P10415), Angiotensin-converting enzyme 2(Q9BYF1), Cystic fibrosis transmembrane conductance regulator(P13569), Nuclear receptor subfamily 1 group I member 2(O75469), Annexin A1(P04083)	NA	NA	Top 7 drugs	37586602	Methods	2023
18	80.7	1994	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MSGNN-DTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/songxuanmo/MSGNN-DTA	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 11 drugs	37176031	Int J Mol Sci	2023
18	80.7	1994	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MSGNN-DTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/songxuanmo/MSGNN-DTA	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 11 drugs	37176031	Int J Mol Sci	2023
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Ziprasidone	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Ziprasidone	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Fluconazole	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Citalopram	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Imatinib	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	2071	DTINet	Drug, Disease, Target, Side-effect	Drug: SMILES, Target: the amino acid sequences	SHGCL-DTI	Heterogeneous Graph Convolutional Network (HGCN)	Drug Target Interaction (DTI)	https://github.com/TOJSSE-iData/SHGCL-DTI	Case studies	NA	ADRA1B, CHRM1, CHRM2, CHRM3, HTR1A, HTR2B, HTR2C, GABRA4, OPRD1, SLC6A4	NA	NA	Top 20 drugs	37421738	Comput Biol Med	2023
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Warfarin	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Chloroquine	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Warfarin	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Chloroquine	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Ziprasidone	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Fluconazole	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Citalopram	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Fluconazole	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Citalopram	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Imatinib	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Warfarin	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	Cdataset	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Chloroquine	NA	Top 5 diseases	31999326	Bioinformatics	2020
19	80.6	895	PREDICT (Fdataset)	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion)	Bayesian inductive matrix	Drug Disease Association (DDA)	https://github.com/linwang1982/DRIMC	Case studies	NA	NA	Imatinib	NA	Top 5 diseases	31999326	Bioinformatics	2020
20	80.5	393	NA	Drug, Disease, Target , Side-effect	Drug: chmical structure, Target: genome sequences	DTINet	Random Walk with Restart (RWR)	Drug Target Interaction (DTI)	https://github.com/luoyunan/DTINet	Case studies	NA	COX proteins	NA	NA	3 drugs	28924171	Nat Commun	2017
21	80.4	1670	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
21	80.4	1670	Cdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
21	80.4	1670	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
21	80.4	1670	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
21	80.4	1670	LRSSL	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
21	80.4	1670	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	DRWBNCF	Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP)	Drug Disease Association (DDA)	https://github.com/luckymengmeng/DRWBNCF	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	35039838	Brief Bioinform	2022
22	80.3	1892	DrugBank	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_NR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_GPCR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_E	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	HGBI	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	DrugBank	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_NR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_IC	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_E	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_GPCR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	HGBI	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_NR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_IC	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_IC	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:779 (calcium voltage-gated channel subunit alpha1 S)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_GPCR	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	Yamanishi_E	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	HGBI	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	hsa:775 (calcium voltage-gated channel subunit alpha1 C)	NA	NA	Top 20 drugs	36301791	IEEE J Biomed Health Inform	2023
22	80.3	1892	DrugBank	Drug, Target	Drug: chemical structure information, Target: target sequence	PPAEDTI	Deep Autoencoder	Drug Target Interaction (DTI)	https://github.com/LiYuechao1998/PPAEDTI	Case studies	NA	NA	Nisoldipine	NA	Top 20 targets	36301791	IEEE J Biomed Health Inform	2023
23	79.8	486	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Paclitaxel	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Paclitaxel	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Paclitaxel	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Zoledronic acid	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Zoledronic acid	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Zoledronic acid	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	DNdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Prednisolone	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Prednisolone	NA	Top 5 diseases	29365057	Bioinformatics	2018
23	79.8	486	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	DRRS (Drug Repositioning Recommendation System)	Singular Value Thresholding (SVT)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Prednisolone	NA	Top 5 diseases	29365057	Bioinformatics	2018
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Irinotecan	NA	Top 1 drug	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Cortisol	NA	Top 2 drugs	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Salicylic acid	NA	Top 1 drug	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Ephedrine	NA	Top 2 drugs	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Podophyllotoxin	NA	Top 1 drug	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Testosterone	NA	Top 3 drugs	31138103	BMC Bioinformatics	2019
24	79.71428571	687	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	NA	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	(-)-Prostaglandin E1	NA	Top 1 drug	31138103	BMC Bioinformatics	2019
25	79.3	2179	Cdataset	Drug, Disease, Target	Drug: SMILES, Target: Sequence, Disease: MesH	SiSGC (Simplifying Graph Convolution)	CatBoost	Drug Disease Association (DDA)	https://github.com/MrPhil/SiSGC	Case studies	Breast neoplasms	NA	NA	NA	Top 20 drugs	38103039	J Chem Inf Model	2024
25	79.3	2179	Fdataset	Drug, Disease, Target	Drug: SMILES, Target: Sequence, Disease: MesH	SiSGC (Simplifying Graph Convolution)	CatBoost	Drug Disease Association (DDA)	https://github.com/MrPhil/SiSGC	Case studies	Breast neoplasms	NA	NA	NA	Top 20 drugs	38103039	J Chem Inf Model	2024
25	79.3	2179	Bdataset	Drug, Disease, Target	Drug: SMILES, Target: Sequence, Disease: MesH	SiSGC (Simplifying Graph Convolution)	CatBoost	Drug Disease Association (DDA)	https://github.com/MrPhil/SiSGC	Case studies	Breast neoplasms	NA	NA	NA	Top 20 drugs	38103039	J Chem Inf Model	2024
26	78.3	1615	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	HINGRL	Random Forest (RF)	Drug Disease Association (DDA)	https://github.com/stevejobws/HINGRL	Case studies	Breast neoplasms	NA	NA	NA	Top 10 drugs	34891172	Brief Bioinform	2022
26	78.3	1615	NA	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	HINGRL	Random Forest (RF)	Drug Disease Association (DDA)	https://github.com/stevejobws/HINGRL	Case studies	NA	Clozapine	NA	NA	Top 10 diseases	34891172	Brief Bioinform	2022
26	78.3	1615	NA	Drug, Disease, Target	Drug: SMILES, Disease: MeSH	HINGRL	Random Forest (RF)	Drug Disease Association (DDA)	https://github.com/stevejobws/HINGRL	Case studies	Breast neoplasms	NA	NA	NA	Top 10 drugs	34891172	Brief Bioinform	2022
26	78.3	1615	Fdataset	Drug, Disease	Drug: SMILES, Disease: MeSH	HINGRL	Random Forest (RF)	Drug Disease Association (DDA)	https://github.com/stevejobws/HINGRL	Case studies	NA	Clozapine	NA	NA	Top 10 diseases	34891172	Brief Bioinform	2022
27	78.1	2203	Cdataset	Drug, Disease	Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties	WMAGT	Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron	Drug Disease Association (DDA)	https://github.com/ShiHHe/WMAGT	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38378479	BMC Bioinformatics	2024
27	78.1	2203	LRSSL	Drug, Disease	Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties	WMAGT	Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron	Drug Disease Association (DDA)	https://github.com/ShiHHe/WMAGT	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38378479	BMC Bioinformatics	2024
27	78.1	2203	Fdataset	Drug, Disease	Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties	WMAGT	Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron	Drug Disease Association (DDA)	https://github.com/ShiHHe/WMAGT	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38378479	BMC Bioinformatics	2024
28	78	1644	TL-HBGI	Drug, Disease	Drug: Chemical structure, Disease: MeSH	NMF-DR (Non-negative Matrix Factorization Drug Repurposing)	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/sshaghayeghs/NMF-DR	Case studies	Breast cancer	NA	NA	NA	Top 5 drugs	34875000	Bioinformatics	2022
28	78	1644	DrugNet	Drug, Disease	Drug: Chemical structure, Disease: MeSH	NMF-DR (Non-negative Matrix Factorization Drug Repurposing)	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/sshaghayeghs/NMF-DR	Case studies	Breast cancer	NA	NA	NA	Top 5 drugs	34875000	Bioinformatics	2022
28	78	1644	Cdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	NMF-DR (Non-negative Matrix Factorization Drug Repurposing)	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/sshaghayeghs/NMF-DR	Case studies	Breast cancer	NA	NA	NA	Top 5 drugs	34875000	Bioinformatics	2022
28	78	1644	Fdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	NMF-DR (Non-negative Matrix Factorization Drug Repurposing)	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/sshaghayeghs/NMF-DR	Case studies	Breast cancer	NA	NA	NA	Top 5 drugs	34875000	Bioinformatics	2022
29	77.875	509	LRSSL	Drug, Disease	Drug: substructures, Disease: MeSH	NTSIM (Network Topological Similarity-based Inference Method)	Label Propagation	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 10 diseases	29879508	Methods	2018
29	77.875	2079	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MULGA (Multi-view Learning and Graph Autoencoder framework)	Multi-view Learning and Graph Autoencoder (GAE)	Drug Target Interaction (DTI)	https://github.com/jianiM/MULGA	Case studies	COVID-19	Spike glycoprotein	NA	NA	Top 20 drugs	37610353	Bioinformatics	2023
29	77.875	509	NA	Drug, Disease	Drug: substructures, Disease: MeSH	NTSIM (Network Topological Similarity-based Inference Method)	Label Propagation	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 10 diseases	29879508	Methods	2018
29	77.875	2079	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MULGA (Multi-view Learning and Graph Autoencoder framework)	Multi-view Learning and Graph Autoencoder (GAE)	Drug Target Interaction (DTI)	https://github.com/jianiM/MULGA	Case studies	COVID-19	Spike glycoprotein	NA	NA	Top 20 drugs	37610353	Bioinformatics	2023
29	77.875	2079	DrugBank (version 5.1.9)	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MULGA (Multi-view Learning and Graph Autoencoder framework)	Multi-view Learning and Graph Autoencoder (GAE)	Drug Target Interaction (DTI)	https://github.com/jianiM/MULGA	Case studies	COVID-19	Spike glycoprotein	NA	NA	Top 20 drugs	37610353	Bioinformatics	2023
29	77.875	509	Fdataset	Drug, Disease	Drug: substructures, Disease: MeSH	NTSIM (Network Topological Similarity-based Inference Method)	Label Propagation	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 10 diseases	29879508	Methods	2018
29	77.875	2079	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MULGA (Multi-view Learning and Graph Autoencoder framework)	Multi-view Learning and Graph Autoencoder (GAE)	Drug Target Interaction (DTI)	https://github.com/jianiM/MULGA	Case studies	COVID-19	Spike glycoprotein	NA	NA	Top 20 drugs	37610353	Bioinformatics	2023
29	77.875	509	TL-HGBI	Drug, Target	Drug: substructures, Disease: MeSH	NTSIM (Network Topological Similarity-based Inference Method)	Label Propagation	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 10 diseases	29879508	Methods	2018
30	77.76	766	LRSSL	Drug, Disease, Side-effect	Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology	DisDrugPred	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/pingxuan-hlju/DisDrugPred	Case studies	NA	NA	Etoposide	NA	Top 10 diseases	30865257	Bioinformatics	2019
30	77.76	766	LRSSL	Drug, Disease, Side-effect	Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology	DisDrugPred	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/pingxuan-hlju/DisDrugPred	Case studies	NA	NA	Cefotaxime	NA	Top 10 diseases	30865257	Bioinformatics	2019
30	77.76	766	LRSSL	Drug, Disease, Side-effect	Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology	DisDrugPred	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/pingxuan-hlju/DisDrugPred	Case studies	NA	NA	Ciprofloxacin	NA	Top 10 diseases	30865257	Bioinformatics	2019
30	77.76	766	LRSSL	Drug, Disease, Side-effect	Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology	DisDrugPred	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/pingxuan-hlju/DisDrugPred	Case studies	NA	NA	Clonidine	NA	Top 10 diseases	30865257	Bioinformatics	2019
30	77.76	766	LRSSL	Drug, Disease, Side-effect	Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology	DisDrugPred	Non-negative Matrix Factorization (NMF)	Drug Disease Association (DDA)	https://github.com/pingxuan-hlju/DisDrugPred	Case studies	NA	NA	Ampicillin	NA	Top 10 diseases	30865257	Bioinformatics	2019
31	77.7	2133	Cdataset	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
31	77.7	2133	LRSSL	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
31	77.7	2133	Fdataset	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
31	77.7	2133	LRSSL	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
31	77.7	2133	Fdataset	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
31	77.7	2133	Cdataset	Drug, Disease	NA	DRAGNN	Multi Layer Perception (MLP)	Drug Disease Association (DDA)	https://github.com/1yiw/DRAGNN	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	38019732	Brief Bioinform	2023
32	77.35	1367	Fdataset	Drug, Disease	Drug: SMILES, Disease: Phenotype	DDIPred	Deep gated recurrent units model	Drug Disease Association (DDA)	https://github.com/haichengyi/DDIPre	Case studies	NA	NA	Dexamethasone	NA	Top 15 diseases	34074242	BMC Bioinformatics	2021
32	77.35	1367	Cdataset	Drug, Disease	Drug: SMILES, Disease: Phenotype	DDIPred	Deep gated recurrent units model	Drug Disease Association (DDA)	https://github.com/haichengyi/DDIPre	Case studies	NA	NA	Zoledronic acid	NA	Top 10 diseases	34074242	BMC Bioinformatics	2021
32	77.35	1367	Cdataset	Drug, Disease	Drug: SMILES, Disease: Phenotype	DDIPred	Deep gated recurrent units model	Drug Disease Association (DDA)	https://github.com/haichengyi/DDIPre	Case studies	NA	NA	Dexamethasone	NA	Top 15 diseases	34074242	BMC Bioinformatics	2021
32	77.35	1367	Fdataset	Drug, Disease	Drug: SMILES, Disease: Phenotype	DDIPred	Deep gated recurrent units model	Drug Disease Association (DDA)	https://github.com/haichengyi/DDIPre	Case studies	NA	NA	Zoledronic acid	NA	Top 10 diseases	34074242	BMC Bioinformatics	2021
33	77.3	957	NA	Drug, Disease, Target	NA	BiFusion (Bipartite graph convolution network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/zcwang0702/BiFusion	Case studies	Breast carcinoma	NA	NA	NA	Top 5 drugs	32657387	Bioinformatics	2020
33	77.3	957	NA	Drug, Disease, Target	NA	BiFusion (Bipartite graph convolution network)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	https://github.com/zcwang0702/BiFusion	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 10 drugs	32657387	Bioinformatics	2020
34	77.25	739	Fdataset	Drug, Disease	Drug: Fingerprint, Diseases: MeSH terms	GIPAE (Gaussian interaction profile kernel and autoencoder)	Deep Autoencoder,Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/GIPAE	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drug	31534955	Biomed Res Int	2019
34	77.25	739	Cdataset	Drug, Disease	Drug: Fingerprint, Diseases: MeSH terms	GIPAE (Gaussian interaction profile kernel and autoencoder)	Deep Autoencoder,Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/GIPAE	Case studies	Obesity	NA	NA	NA	Top 20 drug	31534955	Biomed Res Int	2019
34	77.25	739	Cdataset	Drug, Disease	Drug: Fingerprint, Diseases: MeSH terms	GIPAE (Gaussian interaction profile kernel and autoencoder)	Deep Autoencoder,Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/GIPAE	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drug	31534955	Biomed Res Int	2019
34	77.25	739	Fdataset	Drug, Disease	Drug: Fingerprint, Diseases: MeSH terms	GIPAE (Gaussian interaction profile kernel and autoencoder)	Deep Autoencoder,Support Vector Machine (SVM)	Drug Disease Association (DDA)	https://github.com/HanJingJiang/GIPAE	Case studies	Obesity	NA	NA	NA	Top 20 drug	31534955	Biomed Res Int	2019
35	77.2	949	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence data in FASTA format Disease: MeSH	TS-SVD	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	Non-Small Cell Lung Cancer (NSCLC)	NA	NA	NA	Top 10 drugs	32340956	IEEE Trans Nanobioscience	2020
36	76.8	1532	Fdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	LMFDA	Inductive matrix	Drug Disease Association (DDA)	https://github.com/hupengwei/LMFDA_Dataset	Case studies	Ischemic stroke	NA	NA	NA	Top 10 drugs	34736437	BMC Med Inform Decis Mak	2021
36	76.8	720	DNdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Cdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Cdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	1532	Cdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	LMFDA	Inductive matrix	Drug Disease Association (DDA)	https://github.com/hupengwei/LMFDA_Dataset	Case studies	Type 2 Diabetes Mellitus (T2DM)	NA	NA	NA	Top 10 drugs	34736437	BMC Med Inform Decis Mak	2021
36	76.8	720	Cdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	DNdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Levodopa	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	1532	Cdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	LMFDA	Inductive matrix	Drug Disease Association (DDA)	https://github.com/hupengwei/LMFDA_Dataset	Case studies	Ischemic stroke	NA	NA	NA	Top 10 drugs	34736437	BMC Med Inform Decis Mak	2021
36	76.8	720	Cdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	DNdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Doxorubicin	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	DNdataset	Drug, Disease	NA	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Amantadine	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	720	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	BNNR (Bounded Nuclear Norm Regularization)	Matrix Completion	Drug Disease Association (DDA)	https://github.com/BioinformaticsCSU/BNNR	Case studies	NA	NA	Flecainide	NA	Top 5 diseases	31510658	Bioinformatics	2019
36	76.8	1532	Fdataset	Drug, Disease	Drug: Chemical structure, Disease: MeSH	LMFDA	Inductive matrix	Drug Disease Association (DDA)	https://github.com/hupengwei/LMFDA_Dataset	Case studies	Type 2 Diabetes Mellitus (T2DM)	NA	NA	NA	Top 10 drugs	34736437	BMC Med Inform Decis Mak	2021
37	76.54	1197	SND	Drug, Disease	NA	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Dexamethasone	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Loteprednol	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	Fdataset	Drug, Disease	Drug: SMILES; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Sparfloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	SND	Drug, Disease	NA	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Triamcinolone	NA	Top 6 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	Fdataset	Drug, Disease	Drug: SMILES; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Dexamethasone	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	SND	Drug, Disease	NA	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Levofloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Sparfloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	Fdataset	Drug, Disease	Drug: SMILES; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Triamcinolone	NA	Top 6 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	Fdataset	Drug, Disease	Drug: SMILES; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Levofloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	SND	Drug, Disease	NA	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Loteprednol	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Triamcinolone	NA	Top 6 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Dexamethasone	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	LRSSL	Drug, Disease	Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Levofloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	Fdataset	Drug, Disease	Drug: SMILES; Disease: Phenotye	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Loteprednol	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
37	76.54	1197	SND	Drug, Disease	NA	SNF-NN (Similarity network fusion and neural networks)	Similarity Network Fusion (SNF),Neural Network	Drug Disease Association (DDA)	http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php	Case studies	NA	NA	Sparfloxacin	NA	Top 7 diseases	33482713	BMC Bioinformatics	2021
38	76.425	2070	RepoDB	Drug, Disease	Drug: RDKit fingerprints, Disease: MeSH	TNA-DR (Tail-Node Augmentation for Drug Repositioning)	Graph Neural Network (GNN)	Drug Disease Association (DDA)	NA	Case studies	Lung neoplasms	NA	NA	NA	Top 10 drugs	37418410	IEEE/ACM Trans Comput Biol Bioinform	2023
38	76.425	2070	Fdataset	Drug, Disease	Drug: RDKit fingerprints, Disease: MeSH	TNA-DR (Tail-Node Augmentation for Drug Repositioning)	Graph Neural Network (GNN)	Drug Disease Association (DDA)	NA	Case studies	Lung neoplasms	NA	NA	NA	Top 10 drugs	37418410	IEEE/ACM Trans Comput Biol Bioinform	2023
38	76.425	2070	Cdataset	Drug, Disease	Drug: RDKit fingerprints, Disease: MeSH	TNA-DR (Tail-Node Augmentation for Drug Repositioning)	Graph Neural Network (GNN)	Drug Disease Association (DDA)	NA	Case studies	Lung neoplasms	NA	NA	NA	Top 10 drugs	37418410	IEEE/ACM Trans Comput Biol Bioinform	2023
38	76.425	2070	LRSSL	Drug, Disease	Drug: RDKit fingerprints, Disease: MeSH	TNA-DR (Tail-Node Augmentation for Drug Repositioning)	Graph Neural Network (GNN)	Drug Disease Association (DDA)	NA	Case studies	Lung neoplasms	NA	NA	NA	Top 10 drugs	37418410	IEEE/ACM Trans Comput Biol Bioinform	2023
39	76.4	1394	DTINet	Drug, Disease, Target, Side-effect	Drug: structure, Target: sequence	LUNAR	Graph Convolutional Network (GCN)	Drug Target Interaction (DTI)	NA	Case studies	COVID-19	ACE2	NA	NA	Top 8 drugs	34081583	IEEE/ACM Trans Comput Biol Bioinform	2021
39	76.4	1394	DTINet	Drug, Disease, Target, Side-effect	Drug: structure, Target: sequence	LUNAR	Graph Convolutional Network (GCN)	Drug Target Interaction (DTI)	NA	Case studies	COVID-19	Tumor necrosis factor	NA	NA	Top 10 drugs	34081583	IEEE/ACM Trans Comput Biol Bioinform	2021
39	76.4	1394	DTINet	Drug, Disease, Target, Side-effect	Drug: structure, Target: sequence	LUNAR	Graph Convolutional Network (GCN)	Drug Target Interaction (DTI)	NA	Case studies	COVID-19	Nterleukin-l beta	NA	NA	Top 5 drugs	34081583	IEEE/ACM Trans Comput Biol Bioinform	2021
40	76.3	2145	Davis	Drug, Target	Drug: SMILES, Target: The amino acid Sequence.	MdDTI	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/lhhu1999/MdDTI	Case studies	COVID-19	SARS-CoV-2 3C-like protease	NA	NA	Top 5 drugs	37844375	Comput Biol Chem	2023
40	76.3	2145	KIBA	Drug, Target	Drug: SMILES, Target: The amino acid Sequence.	MdDTI	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/lhhu1999/MdDTI	Case studies	COVID-19	SARS-CoV-2 3C-like protease	NA	NA	Top 5 drugs	37844375	Comput Biol Chem	2023
41	76.1	298	NA	Compound, Target	Compound: SMILES, Target: Sequence	REMAP	Dual Regularized One-Class Collaborative Filtering	Compound Protein Interaction (CPI)	https://github.com/hansaimlim/REMAP	Case studies	Many types of cancer	NA	NA	NA	Top 7 drugs	27716836	PLoS Comput Biol	2016
41	76.1	1487	NA	Drug, Gene	NA	GraphRepur	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://github.com/cckamy/GraphRepur	Case studies	Breast cancer	NA	NA	NA	Top 30 drugs	33739367	Bioinformatics	2021
42	76	320	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	TP-NRWRH	Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/td1799/TP-NRWRH	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	28155639	BMC Bioinformatics	2016
42	76	1578	NA	Drug, Target	Drug: chemical structures, Target: primary sequence	GANDTI	Generative Adversarial Network (GAN),Graph convolutional autoencoder	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Ziprasidone	NA	Top 10 targets	32750854	IEEE/ACM Trans Comput Biol Bioinform	2022
42	76	1578	NA	Drug, Target	Drug: chemical structures, Target: primary sequence	GANDTI	Generative Adversarial Network (GAN),Graph convolutional autoencoder	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Quetiapine	NA	Top 10 targets	32750854	IEEE/ACM Trans Comput Biol Bioinform	2022
42	76	1578	NA	Drug, Target	Drug: chemical structures, Target: primary sequence	GANDTI	Generative Adversarial Network (GAN),Graph convolutional autoencoder	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Clozapine	NA	Top 10 targets	32750854	IEEE/ACM Trans Comput Biol Bioinform	2022
42	76	2093	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DGDTA	Graph Attention Network (GAT),Graph Convolutional Network (GCN),Bidirectional Long Short-Term Memory (Bi-LSTM),Multilayer Convolutional Network	Drug Target binding Affinity (DTA)	https://github.com/luojunwei/DGDTA	Case studies	NA	Receptor Tyrosine Kinases (RTKs)	NA	NA	Top 1 drug	37777712	BMC Bioinformatics	2023
42	76	1578	NA	Drug, Target	Drug: chemical structures, Target: primary sequence	GANDTI	Generative Adversarial Network (GAN),Graph convolutional autoencoder	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Olanzapine	NA	Top 10 targets	32750854	IEEE/ACM Trans Comput Biol Bioinform	2022
42	76	2093	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DGDTA	Graph Attention Network (GAT),Graph Convolutional Network (GCN),Bidirectional Long Short-Term Memory (Bi-LSTM),Multilayer Convolutional Network	Drug Target binding Affinity (DTA)	https://github.com/luojunwei/DGDTA	Case studies	NA	Receptor Tyrosine Kinases (RTKs)	NA	NA	Top 1 drug	37777712	BMC Bioinformatics	2023
42	76	1578	NA	Drug, Target	Drug: chemical structures, Target: primary sequence	GANDTI	Generative Adversarial Network (GAN),Graph convolutional autoencoder	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Aripiprnazole	NA	Top 10 targets	32750854	IEEE/ACM Trans Comput Biol Bioinform	2022
42	76	320	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	TP-NRWRH	Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/td1799/TP-NRWRH	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	28155639	BMC Bioinformatics	2016
43	75.8	308	Positive dataset	Drug, Target	Drug: SMILES, Target: The primary sequence	dtipred	Random Forest (RF)	Drug Target Interaction (DTI)	http://bioinformatics.ua.pt/software/dtipred/	Case studies	Methicillin-resistant Staphylococcus aureus	(DNA-directed RNA polymerase subunit alpha_Q5HDY4, 30S ribosomal protein S12_Q5HID0, DNA-directed RNA polymerase subunit beta_Q5HID3, Accessory Sec system protein translocase subunit SecY2_Q5HCP4, 30S ribosomal protein S15_Q5HGF8, Elongation factor G_Q5HIC8, 50S ribosomal protein L22_Q5HDW3, 30S ribosomal protein S3_Q5HDW4, 50S ribosomal protein L13_Q5HDZ0, 50S ribosomal protein L25_Q5HIH4)	NA	NA	Top 5 drugs	27893735	PLoS Comput Biol	2016
43	75.8	308	Negative dataset	Drug, Target	Drug: SMILES, Target: The primary sequence	dtipred	Random Forest (RF)	Drug Target Interaction (DTI)	http://bioinformatics.ua.pt/software/dtipred/	Case studies	Methicillin-resistant Staphylococcus aureus	(DNA-directed RNA polymerase subunit alpha_Q5HDY4, 30S ribosomal protein S12_Q5HID0, DNA-directed RNA polymerase subunit beta_Q5HID3, Accessory Sec system protein translocase subunit SecY2_Q5HCP4, 30S ribosomal protein S15_Q5HGF8, Elongation factor G_Q5HIC8, 50S ribosomal protein L22_Q5HDW3, 30S ribosomal protein S3_Q5HDW4, 50S ribosomal protein L13_Q5HDZ0, 50S ribosomal protein L25_Q5HIH4)	NA	NA	Top 5 drugs	27893735	PLoS Comput Biol	2016
44	75.6	894	Validations-ChEMBL	Drug, Target	Drug: SMILES, targets: Uniprot ID	AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest)	Deep Forest Classifier	Drug Target Interaction (DTI)	https://github.com/ChengF-Lab/AOPEDF	Case studies	Substance abuse disorder	G-protein-coupled receptors (GPCRs)	NA	NA	Top 20 drugs	31971579	Bioinformatics	2020
44	75.6	894	Training Data-(DrugBank (v4.3), TTD, PharmGKB)	Drug, Disease, Target , Side-effect	Drug: SMILES, targets: Uniprot ID	AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest)	Deep Forest Classifier	Drug Target Interaction (DTI)	https://github.com/ChengF-Lab/AOPEDF	Case studies	Substance abuse disorder	G-protein-coupled receptors (GPCRs)	NA	NA	Top 20 drugs	31971579	Bioinformatics	2020
44	75.6	894	Validations-DrugCentral	Drug, Target	Drug: SMILES, targets: Uniprot ID	AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest)	Deep Forest Classifier	Drug Target Interaction (DTI)	https://github.com/ChengF-Lab/AOPEDF	Case studies	Substance abuse disorder	G-protein-coupled receptors (GPCRs)	NA	NA	Top 20 drugs	31971579	Bioinformatics	2020
45	75	2066	Fdataset	Drug, Disease	Drug: SMILES, Disease: the medical description information	SSLDR	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Doxorubicin, Gemcitabine, Vincristine	NA	Top 5 diseases	37028367	IEEE/ACM Trans Comput Biol Bioinform	2023
45	75	2066	Cdataset	Drug, Disease	Drug: SMILES, Disease: the medical description information	SSLDR	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Doxorubicin, Gemcitabine, Vincristine	NA	Top 5 diseases	37028367	IEEE/ACM Trans Comput Biol Bioinform	2023
45	75	2066	DNdataset	Drug, Disease	Drug: SMILES, Disease: the medical description information	SSLDR	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Doxorubicin, Gemcitabine, Vincristine	NA	Top 5 diseases	37028367	IEEE/ACM Trans Comput Biol Bioinform	2023
46	74.9	1623	NA	Drug	Drug: chemical structures, Target: protein sequence	DOTA (Drug repositioning approach using Optimal Transport for Alzheimer's disease)	Deep Autoencoder (Multi-modal,Wasserstein variational)	Drug Disease Association (DDA)	https://github.com/fawer/DOTA	Special studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drugs	35204697	Biomolecules	2022
47	74.3	694	NA	Drug, Target	Drug: Chemical structure, Target: target sequence	LASSO	Deep Neural Network (DNN)	Drug Target Interaction (DTI)	NA	Case studies	Breast Cancer	NA	NA	NA	Top 5 drugs	30939415	Comput Biol Chem	2019
48	73.9	2102	DDKG-V1	Drug, Disease, Target, Gene	NA	DrugRep-HeSiaGraph	Siamese Neural Network (SNN)	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-HeSiaGraph	Case studies	COVID-19	Dipeptidyl Peptidase 4 (DPP-4)	NA	NA	Top 10 drugs	37789314	BMC Bioinformatics	2023
49	73.7	1366	NA	Drug, Target	Molecular descriptors	NA	Random Forest (RF)	Drug Disease Association (DDA)	https://github.com/sblab/DTN	Special studies	Hyperlipidemia	NA	NA	NA	Top 9 drugs	34030115	Comput Biol Chem	2021
50	73.5	1683	RPD-Net	Drug, Disease, Target	Drug: chemical substructures, Target: the primary sequences	DNDTI	Non-negative Matrix Factorization (NMF)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Asenapine	NA	Top 10 targets	34673498	IEEE J Biomed Health Inform	2022
50	73.5	1683	RPD-Net	Drug, Disease, Target	Drug: chemical substructures, Target: the primary sequences	DNDTI	Non-negative Matrix Factorization (NMF)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Amitriptyline	NA	Top 10 targets	34673498	IEEE J Biomed Health Inform	2022
50	73.5	717	LRSSL	Drug, Disease	Drug: chemical substructure, chemical fingerprints, Disease: MeSH	CBPred	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Ceftriaxone	NA	Top 10 diseases	31336774	Cells	2019
50	73.5	717	LRSSL	Drug, Disease	Drug: chemical substructure, chemical fingerprints, Disease: MeSH	CBPred	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Ofloxacin	NA	Top 10 diseases	31336774	Cells	2019
50	73.5	1683	RPD-Net	Drug, Disease, Target	Drug: chemical substructures, Target: the primary sequences	DNDTI	Non-negative Matrix Factorization (NMF)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Clozapine	NA	Top 10 targets	34673498	IEEE J Biomed Health Inform	2022
50	73.5	717	LRSSL	Drug, Disease	Drug: chemical substructure, chemical fingerprints, Disease: MeSH	CBPred	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Ampicillin	NA	Top 10 diseases	31336774	Cells	2019
50	73.5	1683	RPD-Net	Drug, Disease, Target	Drug: chemical substructures, Target: the primary sequences	DNDTI	Non-negative Matrix Factorization (NMF)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Olanzapine	NA	Top 10 targets	34673498	IEEE J Biomed Health Inform	2022
50	73.5	1683	RPD-Net	Drug, Disease, Target	Drug: chemical substructures, Target: the primary sequences	DNDTI	Non-negative Matrix Factorization (NMF)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Aripiprazole	NA	Top 10 targets	34673498	IEEE J Biomed Health Inform	2022
50	73.5	717	LRSSL	Drug, Disease	Drug: chemical substructure, chemical fingerprints, Disease: MeSH	CBPred	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Levofloxacin	NA	Top 10 diseases	31336774	Cells	2019
50	73.5	717	LRSSL	Drug, Disease	Drug: chemical substructure, chemical fingerprints, Disease: MeSH	CBPred	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Ciprofloxacin	NA	Top 10 diseases	31336774	Cells	2019
51	73.2	1981	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	NA	Fludiazepam	NA	Top 20 targets	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	NA	Fludiazepam	NA	Top 20 targets	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 20 drugs	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 20 drugs	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	NA	Fludiazepam	NA	Top 20 targets	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	DrugBank	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	NA	Fludiazepam	NA	Top 20 targets	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 20 drugs	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
51	73.2	1981	DrugBank	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GIFDTI	Convolutional Neural Network (CNN),Transformer	Drug Target Interaction (DTI)	https://github.com/zhaoqichang/GIFDTI	Case studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 20 drugs	36445997	IEEE/ACM Trans Comput Biol Bioinform	2023
52	72.95	2134	External Set-1	Drug	Drug: SMILES	NA	Graph Attention Network (GAT),Graph Isomorphism Network (GIN)	Drug Target binding Affinity (DTA)	NA	Special studies	COVID-19	SARS-CoV-2 main protease (Mpro)	NA	NA	Top 10 drugs	37960886	J Chem Inf Model	2023
52	72.95	2134	External Set-2	Drug	Drug: SMILES	NA	Graph Attention Network (GAT),Graph Isomorphism Network (GIN)	Drug Target binding Affinity (DTA)	NA	Special studies	COVID-19	SARS-CoV-2 main protease (Mpro)	NA	NA	Top 10 drugs	37960886	J Chem Inf Model	2023
52	72.95	2134	DRH	Drug	Drug: SMILES	NA	Graph Attention Network (GAT),Graph Isomorphism Network (GIN)	Drug Target binding Affinity (DTA)	NA	Special studies	COVID-19	SARS-CoV-2 main protease (Mpro)	NA	NA	Top 10 drugs	37960886	J Chem Inf Model	2023
52	72.95	2134	NA	Drug	Drug: SMILES	NA	Graph Attention Network (GAT),Graph Isomorphism Network (GIN)	Drug Target binding Affinity (DTA)	NA	Special studies	COVID-19	SARS-CoV-2 main protease (Mpro)	NA	NA	Top 10 drugs	37960886	J Chem Inf Model	2023
53	72.6	1614	DrugBank	Drug	Drug: enzymes, side effects, substructures and targets	GCNMK	Graph Convolutional Network with multi-kernel (GCNMK)	Drug Drug Interaction (DDI)	NA	Case studies	Lung neoplasms	NA	NA	NA	Top 10 drugs	34864856	Brief Bioinform	2022
53	72.6	1614	DrugBank	Drug	Drug: enzymes, side effects, substructures and targets	GCNMK	Graph Convolutional Network with multi-kernel (GCNMK)	Drug Drug Interaction (DDI)	NA	Case studies	Breast neoplasms	NA	NA	NA	Top 10 drugs	34864856	Brief Bioinform	2022
53	72.6	1614	DrugBank	Drug	Drug: enzymes, side effects, substructures and targets	GCNMK	Graph Convolutional Network with multi-kernel (GCNMK)	Drug Drug Interaction (DDI)	NA	Case studies	Colorectal neoplasms	NA	NA	NA	Top 10 drugs	34864856	Brief Bioinform	2022
54	72.35	812	NA	Drug, Disease, Target , Side-effect	NA	deepDR	Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/ChengF-Lab/deepDR	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 20 drugs	31116390	Bioinformatics	2019
54	72.35	812	External validation set	NA	NA	deepDR	Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/ChengF-Lab/deepDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drugs	31116390	Bioinformatics	2019
54	72.35	812	External validation set	NA	NA	deepDR	Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/ChengF-Lab/deepDR	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 20 drugs	31116390	Bioinformatics	2019
54	72.35	812	NA	Drug, Disease, Target , Side-effect	NA	deepDR	Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/ChengF-Lab/deepDR	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drugs	31116390	Bioinformatics	2019
55	72.3	1765	Human	Drug, Target	Drug: SMILES, Target: binding site	AttentionSiteDTI	Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP)	Drug Target Interaction (DTI)	https://github.com/yazdanimehdi/AttentionSiteDTI	Case studies	COVID-19	SARS-CoV-2	NA	NA	Top 7 drugs	35817396	Brief Bioinform	2022
55	72.3	125	NA	Drug, Disease	Drug: structure chemical, target, side-effect; Diseases: disease phenotypes, disease ontology, disease genes	DDR	Block Coordinate Descent (BCD)	Drug Disease Association (DDA)	NA	Case studies	Systemic Lupus Erythematosus (SLE)	NA	NA	NA	Top 10 drugs	25954437	AMIA Annu Symp Proc	2014
55	72.3	1765	BindingDB	Drug, Target	Drug: SMILES, Target: binding site	AttentionSiteDTI	Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP)	Drug Target Interaction (DTI)	https://github.com/yazdanimehdi/AttentionSiteDTI	Case studies	COVID-19	SARS-CoV-2	NA	NA	Top 7 drugs	35817396	Brief Bioinform	2022
55	72.3	125	NA	Drug, Disease	Drug: structure chemical, target, side-effect; Diseases: disease phenotypes, disease ontology, disease genes	DDR	Block Coordinate Descent (BCD)	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	25954437	AMIA Annu Symp Proc	2014
55	72.3	1765	DUD-E	Drug, Target	Drug: SMILES, Target: binding site	AttentionSiteDTI	Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP)	Drug Target Interaction (DTI)	https://github.com/yazdanimehdi/AttentionSiteDTI	Case studies	COVID-19	SARS-CoV-2	NA	NA	Top 7 drugs	35817396	Brief Bioinform	2022
56	72.15	2125	RepoDB	Drug, Disease	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Congestive heart failure	NA	NA	NA	Top 2 drugs	37925215	Artif Intell Med	2023
56	72.15	2125	NA	Drug, Target, Pathway, Phenotype	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Congestive heart failure	NA	NA	NA	Top 2 drugs	37925215	Artif Intell Med	2023
56	72.15	2125	RepoDB	Drug, Disease	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Rheumatoid arthritis	NA	NA	NA	Top 2 drugs	37925215	Artif Intell Med	2023
56	72.15	2125	RepoDB	Drug, Disease	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Left ventricular hypertrophy	NA	NA	NA	Top 1 drug	37925215	Artif Intell Med	2023
56	72.15	2125	NA	Drug, Target, Pathway, Phenotype	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Rheumatoid arthritis	NA	NA	NA	Top 2 drugs	37925215	Artif Intell Med	2023
56	72.15	2125	NA	Drug, Target, Pathway, Phenotype	NA	BEHOR	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://zenodo.org/record/8402843	Case studies	Left ventricular hypertrophy	NA	NA	NA	Top 1 drug	37925215	Artif Intell Med	2023
57	72.1	2022	HetioNet	Drug, Disease, Gene, Pathway	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
57	72.1	2022	KEGG	Drug, Disease, Gene, Pathway	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
57	72.1	1244	NA	Drug, Disease	Drug: chemical structural,	CMLDR	Collaborative metric learning algorithm	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Risperidone	NA	Top 20 diseases	31283509	IEEE/ACM Trans Comput Biol Bioinform	2021
57	72.1	2022	Multi-scale interactome (MSI) network	Drug, Disease, Gene	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
57	72.1	2022	KEGG	Drug, Disease, Gene, Pathway	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
57	72.1	1244	NA	Drug, Disease	Drug: chemical structural,	CMLDR	Collaborative metric learning algorithm	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Cyclophosphamide	NA	Top 20 diseases	31283509	IEEE/ACM Trans Comput Biol Bioinform	2021
57	72.1	2022	Multi-scale interactome (MSI) network	Drug, Disease, Gene	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
57	72.1	2022	HetioNet	Drug, Disease, Gene, Pathway	Drug: ATC, Disease: MeSH	DREAMwalk	Multi-layer random walk	Drug Disease Association (DDA)	https://github.com/eugenebang/DREAMwalk	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	37322032	Nat Commun	2023
58	71.75	424	NA	Drug, Disease, Gene	Drug: SMILES, Disease: MeSH	SSGC (Semi-Supervised Graph Cut)	Semi-supervised graph cut	Drug Disease Association (DDA)	NA	Case studies	Non-Small Cell Lung Cancer (NSCLC)	NA	NA	NA	Top 20 drugs	29297383	BMC Med Genomics	2017
58	71.75	424	NA	Drug, Disease, Gene	Drug: SMILES, Disease: MeSH	SSGC (Semi-Supervised Graph Cut)	Semi-supervised graph cut	Drug Disease Association (DDA)	NA	Case studies	Alcohol dependence	NA	NA	NA	Top 20 drugs	29297383	BMC Med Genomics	2017
58	71.75	424	NA	Drug, Disease, Gene	Drug: SMILES, Disease: MeSH	SSGC (Semi-Supervised Graph Cut)	Semi-supervised graph cut	Drug Disease Association (DDA)	NA	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 20 drugs	29297383	BMC Med Genomics	2017
58	71.75	424	NA	Drug, Disease, Gene	Drug: SMILES, Disease: MeSH	SSGC (Semi-Supervised Graph Cut)	Semi-supervised graph cut	Drug Disease Association (DDA)	NA	Case studies	Huntington Disease (HD)	NA	NA	NA	Top 20 drugs	29297383	BMC Med Genomics	2017
59	71.7	771	Fdataset	Drug, Disease	Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms	RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning)	Random Walk	Drug Disease Association (DDA)	NA	Case studies	Breast cancer	NA	NA	NA	Top 5 drugs	29994051	IEEE/ACM Trans Comput Biol Bioinform	2019
59	71.7	771	Fdataset	Drug, Disease	Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms	RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning)	Random Walk	Drug Disease Association (DDA)	NA	Case studies	Lung cancer	NA	NA	NA	Top 5 drugs	29994051	IEEE/ACM Trans Comput Biol Bioinform	2019
59	71.7	771	Fdataset	Drug, Disease	Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms	RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning)	Random Walk	Drug Disease Association (DDA)	NA	Case studies	Huntington Disease (HD)	NA	NA	NA	Top 5 drugs	29994051	IEEE/ACM Trans Comput Biol Bioinform	2019
59	71.7	771	Fdataset	Drug, Disease	Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms	RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning)	Random Walk	Drug Disease Association (DDA)	NA	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	Top 5 drugs	29994051	IEEE/ACM Trans Comput Biol Bioinform	2019
60	71.64285714	343	External _Kinases	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	IC	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	NR	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	Global	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	GPCR	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	External_GPCR	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
60	71.64285714	343	Kinases	Drug, Target	Drug: SMILES, Target: The primary sequence	SDTNBI (Substructure–drug–target network-based inference)	NetInfer package	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	NSAIDs	NA	3 targets	26944082	Brief Bioinform	2017
61	71.2	997	NA	Drug	Drug: structure, distance, target	CATNIP	XGBoost	Drug Drug Interaction (DDI)	https://github.com/coryandar/CATNIP	Case studies	Parkinson’s Disease (PD)	NA	NA	NA	2 drugs	32764756	PLoS Comput Biol	2020
61	71.2	997	NA	Drug	Drug: structure, distance, target	CATNIP	XGBoost	Drug Drug Interaction (DDI)	https://github.com/coryandar/CATNIP	Case studies	Type 2 Diabetes Mellitus (T2DM)	NA	NA	NA	1 drug	32764756	PLoS Comput Biol	2020
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Yohimbine	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Thiopental	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Tacrolimus	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Tolmetin	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Ziprasidone	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Fenoprofen	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Nimodipine	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Citalopram	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Progesterone	NA	Top 5 diseases	28096083	Bioinformatics	2017
62	71.04	361	LRSSL	Drug, Disease	Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH	LRSSL (Laplacian regularized sparse subspace learning)	Laplacian regularized sparse subspace learning	Drug Disease Association (DDA)	https://github.com/LiangXujun/LRSSL	Case studies	NA	NA	Dextromethorphan	NA	Top 5 diseases	28096083	Bioinformatics	2017
63	70.85	1798	dataset 1	Drug, Disease, Gene	NA	NEDNBI	Network-Based Inference	Drug Disease Association (DDA)	https://github.com/Qli97/NEDNBI	Case studies	COVID-19	NA	NA	NA	Top 20 drugs	35338586	Mol Inform	2022
63	70.85	1798	dataset 2	Drug, Disease, Gene	NA	NEDNBI	Network-Based Inference	Drug Disease Association (DDA)	https://github.com/Qli97/NEDNBI	Case studies	COVID-19	NA	NA	NA	Top 20 drugs	35338586	Mol Inform	2022
64	70.8	1516	Zhang's book	Side-effect	Drug: chemical structure, side-effect; Disease: UMLS	DRDA	Deep Autoencoder,Adaptive Fusion	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	34717542	BMC Bioinformatics	2021
64	70.8	1516	Zhang's book	Drug, Disease	Drug: chemical structure, side-effect; Disease: UMLS	DRDA	Deep Autoencoder,Adaptive Fusion	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	34717542	BMC Bioinformatics	2021
64	70.8	1516	Zhang's book	Drug, Target	Drug: chemical structure, side-effect; Disease: UMLS	DRDA	Deep Autoencoder,Adaptive Fusion	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	34717542	BMC Bioinformatics	2021
65	70.4	1866	Fdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
65	70.4	2046	aBiofilm	Drug	Drug: SMILES,	Anti-Biofilm	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	https://bioinfo.imtech.res.in/manojk/antibiofilm/	Case studies	Antimicrobial resistance	biofilm	NA	NA	Top 25 drugs	37356913	J Mol Biol	2023
65	70.4	1866	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
65	70.4	1866	Cdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
65	70.4	1866	Cdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Breast cancer	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
65	70.4	1866	Fdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
65	70.4	1866	Bdataset	Drug, Disease, Target	Drug: SMILES, Disease: MeSH, Target: sequence	DDAGDL	Geometric Deep Learning (GDL),XGBoost	Drug Disease Association (DDA)	https://github.com/stevejobws/DDAGDL	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36125202	Brief Bioinform	2022
66	70	14	Fdataset	Drug, Disease	Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic	PREDICT (PREdicting Drug IndiCaTions)	Logistic Regression	Drug Disease Association (DDA)	NA	Case studies	Migrane	NA	NA	NA	1 drug	21654673	Mol Syst Biol	2011
66	70	14	Fdataset	Drug, Disease	Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic	PREDICT (PREdicting Drug IndiCaTions)	Logistic Regression	Drug Disease Association (DDA)	NA	Case studies	Non-papillary renal cell cancer	NA	NA	NA	1 drug	21654673	Mol Syst Biol	2011
67	69.8	2160	DrugRepV	Drug	Drug: SMILES,	Anti-Dengue	Support Vector Machine (SVM),Artificial Neural Network (ANN),k-Nearest Neighbor (kNN),Random Forest (RF)	Drug Disease Association (DDA)	NA	Special studies	Dengue	NA	NA	NA	Top 25 drugs	38257744	Viruses	2023
68	69.4	1769	NA	Drug, Target, Pathway	NA	MSDF-CNN	Graph Convolutional Network (GCN)	Drug Target Interaction (DTI)	https://github.com/lemonfino/MSDF-CNN	Special studies	Parkinson’s Disease (PD)	HTR2A	NA	NA	Top 10 drugs	35897954	Molecules	2022
69	69.38	122	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence, Disease: MeSH terms	TL_HGBI (Triple Layer Heterogeneous Graph Based Inference)	Heterogeneous Graph Based Inference (HGBI)	Drug Disease Association (DDA)	NA	Case studies	Alcohol dependence	NA	NA	NA	Top 10 drugs	24974205	Bioinformatics	2014
69	69.38	122	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence, Disease: MeSH terms	TL_HGBI (Triple Layer Heterogeneous Graph Based Inference)	Heterogeneous Graph Based Inference (HGBI)	Drug Disease Association (DDA)	NA	Case studies	Small Cell Lung Cancer (SCLC)	NA	NA	NA	Top 10 drugs	24974205	Bioinformatics	2014
69	69.38	122	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence, Disease: MeSH terms	TL_HGBI (Triple Layer Heterogeneous Graph Based Inference)	Heterogeneous Graph Based Inference (HGBI)	Drug Disease Association (DDA)	NA	Case studies	Polysubstance abuse	NA	NA	NA	Top 10 drugs	24974205	Bioinformatics	2014
69	69.38	122	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence, Disease: MeSH terms	TL_HGBI (Triple Layer Heterogeneous Graph Based Inference)	Heterogeneous Graph Based Inference (HGBI)	Drug Disease Association (DDA)	NA	Case studies	Huntington Disease (HD)	NA	NA	NA	Top 10 drugs	24974205	Bioinformatics	2014
69	69.38	122	NA	Drug, Disease, Target	Drug: SMILES, Target: target sequence, Disease: MeSH terms	TL_HGBI (Triple Layer Heterogeneous Graph Based Inference)	Heterogeneous Graph Based Inference (HGBI)	Drug Disease Association (DDA)	NA	Case studies	Non-Small Cell Lung Cancer (NSCLC)	NA	NA	NA	Top 10 drugs	24974205	Bioinformatics	2014
70	69.1	1913	drug ECR	Drug, Disease	NA	DRONet	Network embedding (NE)	Drug Disease Association (DDA)	https://github.com/yangkuoone/DRONet	Case studies	Diabetes	NA	NA	NA	Top 10 drugs	36562715	Brief Bioinform	2023
71	68.9	2098	NA	Drug, Disease, Target, miRNA	NA	MTLDR (Multi-task learning framework for drug repurposing)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	37516260	Methods	2023
71	68.9	2098	NA	Drug, Disease, Target, miRNA	NA	MTLDR (Multi-task learning framework for drug repurposing)	Graph Convolutional Network (GCN)	Drug Disease Association (DDA)	NA	Case studies	Tourette's Syndrome	NA	NA	NA	Top 10 drugs	37516260	Methods	2023
72	68.8	2167	GP-KG	Drug, Disease, Gene	NA	MPTN	CompGCN,Transformer,InteractE	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	38043469	Comput Biol Med	2024
72	68.8	2167	OpenBioLink	Drug, Disease, Target	NA	MPTN	CompGCN,Transformer,InteractE	Drug Disease Association (DDA)	NA	Case studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	38043469	Comput Biol Med	2024
73	68.7	2091	DGIdb	Drug, Gene	NA	DGCL (Dynamic hyperGraph Contrastive Learning)	Graph Neural Network (GNN),Multi Layer Perception (MLP)	Drug Gene Interaction (DGI)	https://github.com/wentao228/DGCL	Case studies	NA	HMOX1	NA	NA	Top 10 drugs	37864294	Brief Bioinform	2023
73	68.7	2091	LINCS L1000	Drug, Gene	NA	DGCL (Dynamic hyperGraph Contrastive Learning)	Graph Neural Network (GNN),Multi Layer Perception (MLP)	Drug Gene Interaction (DGI)	https://github.com/wentao228/DGCL	Case studies	NA	HMOX1	NA	NA	Top 10 drugs	37864294	Brief Bioinform	2023
73	68.7	2091	DrugBank	Drug, Gene	NA	DGCL (Dynamic hyperGraph Contrastive Learning)	Graph Neural Network (GNN),Multi Layer Perception (MLP)	Drug Gene Interaction (DGI)	https://github.com/wentao228/DGCL	Case studies	NA	HMOX1	NA	NA	Top 10 drugs	37864294	Brief Bioinform	2023
74	68.5	672	NA	Gene, Celllines	NA	NA	Deep neural Network (DNN),Support Vector Machine (SVM),Random Forest (RF),Gradient Boosted Machine with trees (GBM),logistic regression with elastic net regularization (EN)	Drug Disease Association (DDA)	NA	Special studies	Depressive Disorder	NA	NA	NA	Top 8 drugs	30010603	IEEE J Biomed Health Inform	2019
74	68.5	1768	NA	Drug, Disease, Target	NA	NTD-DR	Nonnegative tensor decomposition	Drug Disease Association (DDA)	https://github.com/AliJam82/NTD-DR	Case studies	Breast ductal carcinoma, Prostate cancer, Pancreatic neoplasms, Colorectal neoplasms, Small cell lung carcinoma	NA	NA	NA	Top 50 drugs	35862409	PLoS One	2022
74	68.5	672	NA	Gene, Celllines	NA	NA	Deep neural Network (DNN),Support Vector Machine (SVM),Random Forest (RF),Gradient Boosted Machine with trees (GBM),logistic regression with elastic net regularization (EN)	Drug Disease Association (DDA)	NA	Special studies	Schizophrenia	NA	NA	NA	Top 8 drugs	30010603	IEEE J Biomed Health Inform	2019
75	68.2	192	NA	Drug, Disease	Disease: Phenotypic terms	PhenoPredict	The iterative network-based ranking algorithm	Drug Disease Association (DDA)	NA	Special studies	Schizophrenia	NA	NA	NA	Top 20 drugs	26151312	J Biomed Inform	2015
76	67.8	2015	NA	Drug, Gene	NA	DTSEA (Drug Target Set Enrichment Analysis)	Random Walk with Restart (RWR)	Drug Disease Association (DDA)	https://github.com/hanjunwei-lab/DTSEAData	Special studies	COVID-19	NA	NA	NA	Top 10 drugs	37105108	Comput Biol Med	2023
77	67	1937	DNdataset	Drug, Disease	Drug: SMILES, Disease: the medical description	PUON	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone	NA	NA	Top 5 diseases	36197871	IEEE/ACM Trans Comput Biol Bioinform	2023
77	67	1937	Ldataset	Drug, Disease	Drug: SMILES, Disease: the medical description	PUON	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone	NA	NA	Top 5 diseases	36197871	IEEE/ACM Trans Comput Biol Bioinform	2023
77	67	1021	NA	Drug, Disease, miRNA	Drug: chemical structure, side-effect, functional consistency; miRNA: target genes, disease targets; Disease: MeSH	BIMC	Bilateral-inductive matrix completion (BIMC)	Drug Disease Association (DDA)	https://github.com/Deepthi-K523/BIMC	Case studies	NA	NA	Almitrine	NA	Top 10 diseases	32583015	Mol Genet Genomics	2020
77	67	1937	Gottlieb dataset (Fdataset)	Drug, Disease	Drug: SMILES, Disease: the medical description	PUON	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone	NA	NA	Top 5 diseases	36197871	IEEE/ACM Trans Comput Biol Bioinform	2023
77	67	1021	NA	Drug, Disease, miRNA	Drug: chemical structure, side-effect, functional consistency; miRNA: target genes, disease targets; Disease: MeSH	BIMC	Bilateral-inductive matrix completion (BIMC)	Drug Disease Association (DDA)	https://github.com/Deepthi-K523/BIMC	Case studies	NA	NA	Aminolevulinic acid	NA	Top 10 diseases	32583015	Mol Genet Genomics	2020
77	67	1937	Cdataset	Drug, Disease	Drug: SMILES, Disease: the medical description	PUON	Matrix Factorization	Drug Disease Association (DDA)	NA	Case studies	NA	Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone	NA	NA	Top 5 diseases	36197871	IEEE/ACM Trans Comput Biol Bioinform	2023
78	66.8	2181	BindingDB	Drug, Target	Drug: SMILES	NA	Extra tree classifier (ETC)	Drug Target Interaction (DTI)	NA	Special studies	NA	Epidermal Growth Factor Receptor (EGFR)	NA	NA	Top 9 drugs	38000720	Eur J Pharmacol	2024
79	66.65	1973	RepoDB	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	Contact Dermatitis	NA	NA	NA	Top 2 drugs	37023229	J Chem Inf Model	2023
79	66.65	1973	Negative set	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	COVID-19	NA	NA	NA	Top 6 drugs	37023229	J Chem Inf Model	2023
79	66.65	1973	RepoDB	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	COVID-19	NA	NA	NA	Top 6 drugs	37023229	J Chem Inf Model	2023
79	66.65	1973	Negative set	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	Atopic Eczema	NA	NA	NA	Top 4 drugs	37023229	J Chem Inf Model	2023
79	66.65	1973	Negative set	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	Contact Dermatitis	NA	NA	NA	Top 2 drugs	37023229	J Chem Inf Model	2023
79	66.65	1973	RepoDB	Drug, Disease	NA	DrugRep-KG	Logistic Regression	Drug Disease Association (DDA)	https://github.com/CBRC-lab/DrugRep-KG	Case studies	Atopic Eczema	NA	NA	NA	Top 4 drugs	37023229	J Chem Inf Model	2023
80	66.4	1990	LRSSL	Drug, Disease	NA	NetPro	Label Propagation	Drug Disease Association (DDA)	https://github.com/hyr0771/NetPro	Case studies	NA	NA	Levodopa, Flecainide, Doxorubicin	NA	Top 5 diseases	37018341	IEEE/ACM Trans Comput Biol Bioinform	2023
80	66.4	1990	PREDICT (Fdataset)	Drug, Disease	NA	NetPro	Label Propagation	Drug Disease Association (DDA)	https://github.com/hyr0771/NetPro	Case studies	NA	NA	Levodopa, Flecainide, Doxorubicin	NA	Top 5 diseases	37018341	IEEE/ACM Trans Comput Biol Bioinform	2023
80	66.4	1990	Cdataset	Drug, Disease	NA	NetPro	Label Propagation	Drug Disease Association (DDA)	https://github.com/hyr0771/NetPro	Case studies	NA	NA	Levodopa, Flecainide, Doxorubicin	NA	Top 5 diseases	37018341	IEEE/ACM Trans Comput Biol Bioinform	2023
81	66.2	386	Yamanishi_GPCR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	DNA topoisomerase 2-alpha (P11388)	NA	NA	31 drugs	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_IC	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Astemizole	NA	14 targets	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_NR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	Alzheimer's Disease (AD)	(D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809)	NA	NA	NA	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_GPCR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	Alzheimer's Disease (AD)	(D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809)	NA	NA	NA	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_IC	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	DNA topoisomerase 2-alpha (P11388)	NA	NA	31 drugs	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_E	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Astemizole	NA	14 targets	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_NR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Astemizole	NA	14 targets	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_IC	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	Alzheimer's Disease (AD)	(D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809)	NA	NA	NA	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_E	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	DNA topoisomerase 2-alpha (P11388)	NA	NA	31 drugs	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_E	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	Alzheimer's Disease (AD)	(D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809)	NA	NA	NA	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_NR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	DNA topoisomerase 2-alpha (P11388)	NA	NA	31 drugs	28808275	Sci Rep	2017
81	66.2	386	Yamanishi_GPCR	Drug, Target	Drug: molecule, Target: target sequence	PUDTI	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	NA	Case studies	NA	NA	Astemizole	NA	14 targets	28808275	Sci Rep	2017
82	65.5	2087	NA	Drug, Disease, Target, Side-effect	Drug: SMILES, Target: the amino acid sequences	BG-DTI	Convolutional Neural Network (CNN),Graph Neural Network (GNN),Graph Attention Network (GAT),Support Vector Machine (SVM)	Drug Target Interaction (DTI)	https://github.com/wyx2012/BG-DTI	NA	NA	NA	NA	NA	NA	37764321	Molecules	2023
83	64.9	1306	NA	Drug, Virus	Drug: chemical structure, Virus: d2* dissimilarity/distance (at k=6) between the viral genome sequences	DVA (Drug Virus Association)	Matrix Completion	Drug Virus Association (DVA)	www.github.com/AanchalMongia/DVA	Case studies	COVID-19	SARS-CoV-2	NA	NA	Top 6 drugs	33907209	Sci Rep	2021
84	64.8	1814	NA	Drug, chemical	NA	NA	Knowledge Graph Embedding	Drug Disease Association (DDA)	NA	Special studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 10 drugs	36180861	BMC Bioinformatics	2022
85	64.6	2116	NA	Drug	Drug: SMILES	NA	Graph Convolutional Network (GCN),XGBoost	Drug Target Interaction (DTI)	NA	Special studies	Parkinson’s Disease (PD)	PINK1 (Phosphatase and Tensin homologue-induced kinase 1)	NA	NA	Top 22 drugs	37544165	Comput Methods Programs Biomed	2023
86	64.5	968	Dataset 1	Drug, Disease, Target	Drug: SMILES, Target: target sequence Disease: MeSH	iDrug	Matrix Completion	Drug Target Interaction (DTI)	https://github.com/Case-esaC/iDrug	NA	NA	NA	NA	NA	NA	32667925	PLoS Comput Biol	2020
86	64.5	968	Fdataset (Dataset 2)	Drug, Disease, Target	Drug: SMILES, Target: target sequence Disease: MeSH	iDrug	Matrix Completion	Drug Target Interaction (DTI)	https://github.com/Case-esaC/iDrug	NA	NA	NA	NA	NA	NA	32667925	PLoS Comput Biol	2020
87	63.7	1856	NA	Drug, Disease, Target, Side-effect	NA	DTI-GTN	Graph Transformer Network	Drug Target Interaction (DTI)	https://github.com/q498756498/DTI-GTN	Case studies	NA	HTR1A	NA	NA	Top 4 drugs	36329406	BMC Bioinformatics	2022
87	63.7	1856	NA	Drug, Disease, Target, Side-effect	NA	DTI-GTN	Graph Transformer Network	Drug Target Interaction (DTI)	https://github.com/q498756498/DTI-GTN	Case studies	NA	CHRM3	NA	NA	Top 2 drugs	36329406	BMC Bioinformatics	2022
88	63.2	356	Yamanishi_NR	Drug, Target	Drug: chemical sturcture, Target: target sequence	Heter-LP	Heterogeneous label propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis with mild chondrodysplasia	NA	NA	NA	2 drugs	28300647	J Biomed Inform	2017
88	63.2	356	NA	Drug, Disease, Target	NA	Heter-LP	Heterogeneous label propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis with mild chondrodysplasia	NA	NA	NA	2 drugs	28300647	J Biomed Inform	2017
88	63.2	356	Yamanishi_E	Drug, Target	Drug: chemical sturcture, Target: target sequence	Heter-LP	Heterogeneous label propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis with mild chondrodysplasia	NA	NA	NA	2 drugs	28300647	J Biomed Inform	2017
88	63.2	356	Yamanishi_IC	Drug, Target	Drug: chemical sturcture, Target: target sequence	Heter-LP	Heterogeneous label propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis with mild chondrodysplasia	NA	NA	NA	2 drugs	28300647	J Biomed Inform	2017
88	63.2	356	Yamanishi_GPCR	Drug, Target	Drug: chemical sturcture, Target: target sequence	Heter-LP	Heterogeneous label propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis with mild chondrodysplasia	NA	NA	NA	2 drugs	28300647	J Biomed Inform	2017
89	62.9	36	NA	Drug, Disease, Target, Gene, Pathway	NA	CauseNet	Computing transition weights	Drug Disease Association (DDA)	NA	Case studies	Crohn's disease (CD)	NA	NA	NA	Top 5 drugs	24564553	BMC Bioinformatics	2013
90	62.5	736	Cdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	ANMF	Additional Neural Matrix Factorization	Drug Disease Association (DDA)	https://github.com/MortySn/ANMF	NA	NA	NA	NA	NA	NA	31412762	BMC Bioinformatics	2019
90	62.5	736	Fdataset	Drug, Disease	Drug: SMILES, Diseases: MeSH terms	ANMF	Additional Neural Matrix Factorization	Drug Disease Association (DDA)	https://github.com/MortySn/ANMF	NA	NA	NA	NA	NA	NA	31412762	BMC Bioinformatics	2019
91	61.8	1096	NA	Drug, Target	Drug: SMILES, Target: sequence	DLDTI	Representation learning,Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/CUMTzackGit/DLDTI	Case studies	Atherosclerosis	NA	Tetramethylpyrazine	NA	288 targets	33187537	J Transl Med	2020
92	60.9	1340	IC	Drug, Target	Drug: SMILES, Target: Sequence	DTI-MLCD	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/a96123155/DTI-MLCD	NA	NA	NA	NA	NA	NA	32964234	Brief Bioinform	2021
92	60.9	1340	GPCR	Drug, Target	Drug: SMILES, Target: Sequence	DTI-MLCD	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/a96123155/DTI-MLCD	NA	NA	NA	NA	NA	NA	32964234	Brief Bioinform	2021
92	60.9	1340	NR	Drug, Target	Drug: SMILES, Target: Sequence	DTI-MLCD	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/a96123155/DTI-MLCD	NA	NA	NA	NA	NA	NA	32964234	Brief Bioinform	2021
92	60.9	1340	E	Drug, Target	Drug: SMILES, Target: Sequence	DTI-MLCD	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/a96123155/DTI-MLCD	NA	NA	NA	NA	NA	NA	32964234	Brief Bioinform	2021
93	60.6	2208	NELL-One	NA	NA	MLAN (Multi-Level Attention Network)	Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL)	Drug Disease Association (DDA)	NA	Case studies	COVID-19	NA	NA	NA	Top 5 drugs	38244473	Comput Biol Med	2024
93	60.6	2208	BIOKG-One	Drug, Disease, Target, Side-effect,	NA	MLAN (Multi-Level Attention Network)	Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL)	Drug Disease Association (DDA)	NA	Case studies	COVID-19	NA	NA	NA	Top 5 drugs	38244473	Comput Biol Med	2024
93	60.6	2208	COVID19-One	NA	NA	MLAN (Multi-Level Attention Network)	Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL)	Drug Disease Association (DDA)	NA	Case studies	COVID-19	NA	NA	NA	Top 5 drugs	38244473	Comput Biol Med	2024
94	60.5	1980	Ovarian Cancer Dataset	Drug, Gene	NA	SPLNMTF (Self-Paced Non-negative Matrix Tri-Factorization)	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/qi0906/SPLNMTF	NA	NA	NA	NA	NA	NA	36445996	IEEE/ACM Trans Comput Biol Bioinform	2023
94	60.5	1980	Acute myeloid leukemia (AML) dataset	Drug, Gene	NA	SPLNMTF (Self-Paced Non-negative Matrix Tri-Factorization)	Matrix Factorization	Drug Disease Association (DDA)	https://github.com/qi0906/SPLNMTF	NA	NA	NA	NA	NA	NA	36445996	IEEE/ACM Trans Comput Biol Bioinform	2023
95	60.1	1867	Yamanishi	NA	NA	MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction)	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/pxystudy/MHADTI	Case studies	NA	NA	Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib	NA	NA	36242566	Brief Bioinform	2022
95	60.1	1867	NEDTP	NA	NA	MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction)	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/pxystudy/MHADTI	Case studies	NA	NA	Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib	NA	NA	36242566	Brief Bioinform	2022
95	60.1	1867	NA	Drug, Target	Drug: SMILES, Disease: MeSH, Target: sequence	MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction)	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/pxystudy/MHADTI	Case studies	NA	NA	Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib	NA	NA	36242566	Brief Bioinform	2022
95	60.1	1867	DTINet	NA	NA	MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction)	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/pxystudy/MHADTI	Case studies	NA	NA	Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib	NA	NA	36242566	Brief Bioinform	2022
95	60.1	1867	AGHEL	NA	NA	MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction)	Multi Layer Perception (MLP)	Drug Target Interaction (DTI)	https://github.com/pxystudy/MHADTI	Case studies	NA	NA	Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib	NA	NA	36242566	Brief Bioinform	2022
96	60.0875	2176	Yamanishi_GPCR	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	BIOSNAP	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	Yamanishi_IC	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	BindingDB	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	Davis	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	Yamanishi_NR	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	Yamanishi_E	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
96	60.0875	2176	DrugBank (version 5.1.9)	Drug, Target	Target: 20D Vector, Drug: SMILES	geNnius (Graph Embedding Neural Network Interaction Uncovering System)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/ubioinformat/GeNNius	NA	NA	NA	NA	NA	NA	38134424	Bioinformatics	2024
97	60	2001	Davis	Drug, Target	NA	BindingSite-AugmentedDTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/yazdanimehdi/BindingSite-AugmentedDTA	Case studies	COVID-19	SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex）	NA	NA	Top 10 drugs	37096593	Brief Bioinform	2023
97	60	2001	KIBA	Drug, Target	NA	BindingSite-AugmentedDTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/yazdanimehdi/BindingSite-AugmentedDTA	Case studies	COVID-19	SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex）	NA	NA	Top 10 drugs	37096593	Brief Bioinform	2023
98	59.9	1060	NA	Drug, Disease, Target, Gene	NA	RepCOOL	Random Forest (RF)	Drug Disease Association (DDA)	NA	Case studies	Breast cancer stage II	NA	NA	NA	Top 4 drugs	33008415	J Transl Med	2020
99	59.7	1140	NA	Chemical molecules, Gene, Gene expression profiles	NA	MNBDR (Module Network Based Drug Repositioning）LINC1000,Cmap	Random Walk	Drug Disease Association (DDA)	https://github.com/nbnbhwyy/MNBDR	Case studies	Breast cancer	NA	NA	NA	NA	33375395	Genes (Basel)	2020
99	59.7	1140	Golden standard	Drug, Disease	NA	MNBDR (Module Network Based Drug Repositioning）LINC1000,Cmap	Random Walk	Drug Disease Association (DDA)	https://github.com/nbnbhwyy/MNBDR	Case studies	Breast cancer	NA	NA	NA	NA	33375395	Genes (Basel)	2020
100	59.6	415	Kinase (K) dataset	Drug, Target	Drug: chemical sturcture, Target: target sequence	BRDTI	Bayesian	Drug Target Interaction (DTI)	https://github.com/lpeska/BRDTI	NA	NA	NA	NA	NA	NA	29054256	Comput Methods Programs Biomed	2017
100	59.6	415	Yamanishi_GPCR	Drug, Target	Drug: chemical sturcture, Target: target sequence	BRDTI	Bayesian	Drug Target Interaction (DTI)	https://github.com/lpeska/BRDTI	NA	NA	NA	NA	NA	NA	29054256	Comput Methods Programs Biomed	2017
100	59.6	415	Yamanishi_E	Drug, Target	Drug: chemical sturcture, Target: target sequence	BRDTI	Bayesian	Drug Target Interaction (DTI)	https://github.com/lpeska/BRDTI	NA	NA	NA	NA	NA	NA	29054256	Comput Methods Programs Biomed	2017
100	59.6	415	Yamanishi_NR	Drug, Target	Drug: chemical sturcture, Target: target sequence	BRDTI	Bayesian	Drug Target Interaction (DTI)	https://github.com/lpeska/BRDTI	NA	NA	NA	NA	NA	NA	29054256	Comput Methods Programs Biomed	2017
100	59.6	415	Yamanishi_IC	Drug, Target	Drug: chemical sturcture, Target: target sequence	BRDTI	Bayesian	Drug Target Interaction (DTI)	https://github.com/lpeska/BRDTI	NA	NA	NA	NA	NA	NA	29054256	Comput Methods Programs Biomed	2017
101	59.2	140	Fdataset	Drug, Disease	NA	NA	ProbS and HeatS	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Felodipine	NA	Top 10 diseases	25969690	Comput Math Methods Med	2015
101	59.2	140	Fdataset	Drug, Disease	NA	NA	ProbS and HeatS	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Aspirin	NA	Top 10 diseases	25969690	Comput Math Methods Med	2015
101	59.2	140	Fdataset	Drug, Disease	NA	NA	ProbS and HeatS	Drug Disease Association (DDA)	NA	Case studies	NA	NA	Tamoxifen	NA	Top 10 diseases	25969690	Comput Math Methods Med	2015
102	58.9	1260	NA	Subject, object, predicate	NA	LBD	Knowledge Graph Completion	Drug Disease Association (DDA)	https://github.com/kilicogluh/lbd-covid	Special studies	COVID-19	NA	NA	NA	5 drugs	33571675	J Biomed Inform	2021
103	58.7	725	NA	Drug, Disease, Target	Drug: drug-target target	NA	CLASH (Complementary Linkage with Anchoring and Scoring),Graph-based Semi-Supervised Learning (SSL)	Drug Drug Interaction (DDI)	NA	Case studies	Vascular dementia	NA	NA	NA	Top 11 drug	31337333	BMC Bioinformatics	2019
104	58.5	1132	Fdataset	Drug, Disease	Drug: SMILES, Disease: medical description data	HAMN (Hybrid Attentional Memory Network)	Collaborative Filtering,Autoencoder	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	33297947	BMC Bioinformatics	2020
104	58.5	1132	Cdataset	Drug, Disease	Drug: SMILES, Disease: medical description data	HAMN (Hybrid Attentional Memory Network)	Collaborative Filtering,Autoencoder	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	33297947	BMC Bioinformatics	2020
104	58.5	1322	NA	Drug, Gene	NA	NA	Deep Autoencoder,XGBoost	Drug Target Interaction (DTI)	https://github.com/tsjshg/ai-drug-dev	Special studies	Alzheimer's Disease (AD)	NA	NA	NA	Top 20 drugs	33941241	Alzheimers Res Ther	2021
105	57	1719	Own dataset	Drug, Target	Drug: side-effects, drug chemical structure, drug physicochemical properties and therapeutic properties, Target: co-pathway, PPI network, Gene Ontology and gene-encoded target sequence	DTI-HETA	Graph Neural Network (GNN),Graph Attention Network (GAT)	Drug Target Interaction (DTI)	https://github.com/ZhangyuXM/DTI-HETA	NA	NA	NA	NA	NA	NA	35380622	Brief Bioinform	2022
105	57	2144	KIBA	Drug, Target	Drug: SMILES, Target: The amino acid Sequence.	TeM-DTBA (Time-efficient Multimodal Drug Target Binding Affinity)	Multi Layer Perception (MLP)	Drug Target binding Affinity (DTA)	https://github.com/hkmztrk/DeepDTA/tree/master/data.	NA	NA	NA	NA	NA	NA	37777631	J Comput Aided Mol Des	2023
105	57	1719	Yamanishi_E	Drug, Target	Drug: side-effects, drug chemical structure, drug physicochemical properties and therapeutic properties, Target: co-pathway, PPI network, Gene Ontology and gene-encoded target sequence	DTI-HETA	Graph Neural Network (GNN),Graph Attention Network (GAT)	Drug Target Interaction (DTI)	https://github.com/ZhangyuXM/DTI-HETA	NA	NA	NA	NA	NA	NA	35380622	Brief Bioinform	2022
105	57	1719	Yamanishi_IC	Drug, Target	Drug: side-effects, drug chemical structure, drug physicochemical properties and therapeutic properties, Target: co-pathway, PPI network, Gene Ontology and gene-encoded target sequence	DTI-HETA	Graph Neural Network (GNN),Graph Attention Network (GAT)	Drug Target Interaction (DTI)	https://github.com/ZhangyuXM/DTI-HETA	NA	NA	NA	NA	NA	NA	35380622	Brief Bioinform	2022
105	57	2144	Davis	Drug, Target	Drug: SMILES, Target: The amino acid Sequence.	TeM-DTBA (Time-efficient Multimodal Drug Target Binding Affinity)	Multi Layer Perception (MLP)	Drug Target binding Affinity (DTA)	https://github.com/hkmztrk/DeepDTA/tree/master/data.	NA	NA	NA	NA	NA	NA	37777631	J Comput Aided Mol Des	2023
106	56.76	1695	Yamanishi_NR	Drug, Target	Drug: chemical substructures, Target: the primary sequences	DT2Vec	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2Vec	NA	NA	NA	NA	NA	NA	35379165	BMC Bioinformatics	2022
106	56.76	1695	CheMBL	Drug, Target	Drug: chemical substructures, Target: the primary sequences	DT2Vec	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2Vec	NA	NA	NA	NA	NA	NA	35379165	BMC Bioinformatics	2022
106	56.76	1695	Yamanishi_E	Drug, Target	Drug: chemical substructures, Target: the primary sequences	DT2Vec	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2Vec	NA	NA	NA	NA	NA	NA	35379165	BMC Bioinformatics	2022
106	56.76	1695	Yamanishi_IC	Drug, Target	Drug: chemical substructures, Target: the primary sequences	DT2Vec	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2Vec	NA	NA	NA	NA	NA	NA	35379165	BMC Bioinformatics	2022
106	56.76	1695	Yamanishi_GPCR	Drug, Target	Drug: chemical substructures, Target: the primary sequences	DT2Vec	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2Vec	NA	NA	NA	NA	NA	NA	35379165	BMC Bioinformatics	2022
107	56.6	380	NA	Drug, Gene	Drug: UniProt ID,	PD-MRW	Random Walk	Drug Gene Association (DGA)	NA	Case studies	Hepatocellular Carcinoma	NA	NA	NA	Top 20 drugs	27076463	IEEE/ACM Trans Comput Biol Bioinform	2017
108	56.5	1546	NA	Drug, Disease, Gene	NA	GCAN (GRU-Cooperation-Attention-Network)	GRU-Cooperation-Attention-Network (GCAN),RNN,Biased random walk	Drug Disease Association (DDA)	NA	Case studies	type I Gaucher disease	NA	NA	NA	Top 2 drugs	34789254	BMC Med Inform Decis Mak	2021
109	55.5	816	NA	Drug, Target	Drug: chemical structure, Target: GO terms	OCSVM (One-class Support Vector Machine)	Support Vector Machine (SVM)	Drug Target Interaction (DTI)	Additional file 4	NA	NA	NA	NA	NA	NA	31881829	BMC Bioinformatics	2019
110	55.4	1915	NA	Drug, Gene	NA	NA	Random Walk with Restart (RWR)	Drug Disease Association (DDA)	NA	Special studies	Non-Small Cell Lung Cancer (NSCLC)	NA	NA	NA	Top 11 drugs	36768566	Int J Mol Sci	2023
110	55.4	1915	NA	Drug, Gene	NA	NA	Random Walk with Restart (RWR)	Drug Disease Association (DDA)	NA	Special studies	Colorectal Cancer	NA	NA	NA	Top 9 drugs	36768566	Int J Mol Sci	2023
111	55	1674	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	Affinity2Vec	XGBoost	Drug Target binding Affinity (DTA)	https://github.com/MahaThafar/Affinity2Vec	NA	NA	NA	NA	NA	NA	35306525	Sci Rep	2022
111	55	1674	KIBA	Drug, Target	Drug: SMILES, Target: the amino acid sequences	Affinity2Vec	XGBoost	Drug Target binding Affinity (DTA)	https://github.com/MahaThafar/Affinity2Vec	NA	NA	NA	NA	NA	NA	35306525	Sci Rep	2022
112	54.5	1567	NeoDTI	Drug, Disease, Target, Side-effect	Drug: SMILES, Target: target sequence	MultiDTI (Multi-modal DTI)	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/Deshan-Zhou/MultiDTI/	NA	NA	NA	NA	NA	NA	34180970	Bioinformatics	2021
113	53.5	475	Dataset 1	Drug, Disease	Drug: drug substructures, target target functional domain and GO annotations, Diseases: MeSH terms	DR2DI	Regularized Kernel Classifier	Drug Disease Association (DDA)	https://github.com/huayu1111/DR2DI	NA	NA	NA	NA	NA	NA	29687309	J Comput Aided Mol Des	2018
113	53.5	2169	DRKG	Drug, Disease, Gene, Pathway, Side-effect, Compound, Anatomy, Tax, Molecular Function, Symptom, Biological Process, Cellular Component, Atc, PharmacologicClass	NA	TransRGNN	Graph Neural Network (GNN)	Drug Disease Association (DDA)	NA	Case studies	COVID-19	NA	NA	NA	Top 30 drugs	38104883	Methods	2024
113	53.5	586	NA	Drug, Disease	Drug: PubChem fingerprints, Disease: MeSH	DrPOCS (projection onto convex sets)	Matrix Completion	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	29993698	IEEE/ACM Trans Comput Biol Bioinform	2019
114	53	1748	C.elegans	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MHSADTI	Graph Attention Network (GAT),Multi-head self-attention mechanism	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33956632	IEEE/ACM Trans Comput Biol Bioinform	2022
114	53	1748	DUD-E	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MHSADTI	Graph Attention Network (GAT),Multi-head self-attention mechanism	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33956632	IEEE/ACM Trans Comput Biol Bioinform	2022
114	53	856	LRSSL	Drug, Disease	Drug: chemical structure, drug target domain, drug target gene ontology (GO); Disease: semantic	DDAPRED	Logistic Matrix Factorization	Drug Disease Association (DDA)	https://github.com/nongdaxiaofeng/DDAPRED	NA	NA	NA	NA	NA	NA	32062701	J Mol Model	2020
114	53	1748	DrugBank	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MHSADTI	Graph Attention Network (GAT),Multi-head self-attention mechanism	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33956632	IEEE/ACM Trans Comput Biol Bioinform	2022
114	53	1748	Human	Drug, Target	Drug: SMILES, Target: the amino acid sequences	MHSADTI	Graph Attention Network (GAT),Multi-head self-attention mechanism	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33956632	IEEE/ACM Trans Comput Biol Bioinform	2022
115	52.98571429	973	dataset1_PK	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_GPCR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	Yamanishi_GPCR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_TR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_NR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	Yamanishi_NR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	Yamanishi_E	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset2_David	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_CR	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_E	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_IC	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	Yamanishi_IC	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset2_Ketz	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
115	52.98571429	973	dataset1_CSM	Drug, Target	Drug: chemical sturcture, Target: target sequence	DTIP_MDHN	Index kernel matrix	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	32703151	BMC Bioinformatics	2020
116	52.75	1659	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GEFA (Graph Early Fusion Affinity)	Graph Convolutional Network (GCN)	Drug Target binding Affinity (DTA)	https://github.com/ngminhtri0394/GEFA	NA	NA	NA	NA	NA	NA	34197324	IEEE/ACM Trans Comput Biol Bioinform	2022
116	52.75	1659	PDBBind	Drug, Target	Drug: SMILES, Target: the amino acid sequences	GEFA (Graph Early Fusion Affinity)	Graph Convolutional Network (GCN)	Drug Target binding Affinity (DTA)	https://github.com/ngminhtri0394/GEFA	NA	NA	NA	NA	NA	NA	34197324	IEEE/ACM Trans Comput Biol Bioinform	2022
117	52.4	1717	D1	Drug, Target	NA	MccDTI	Deep Autoencoder,Matrix Completion	Drug Target Interaction (DTI)	https://github.com/ShangCS/MccDTI	NA	NA	NA	NA	NA	NA	35262678	Brief Bioinform	2022
117	52.4	1717	D2	Drug, Target	NA	MccDTI	Deep Autoencoder,Matrix Completion	Drug Target Interaction (DTI)	https://github.com/ShangCS/MccDTI	NA	NA	NA	NA	NA	NA	35262678	Brief Bioinform	2022
118	51.85	1518	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DTI-End-to-End-DL	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/larngroup/DTI-End-to-End-DL	NA	NA	NA	NA	NA	NA	32142454	IEEE/ACM Trans Comput Biol Bioinform	2021
118	51.85	1518	DrugBank	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DTI-End-to-End-DL	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/larngroup/DTI-End-to-End-DL	NA	NA	NA	NA	NA	NA	32142454	IEEE/ACM Trans Comput Biol Bioinform	2021
118	51.85	1518	Yamanishi	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DTI-End-to-End-DL	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/larngroup/DTI-End-to-End-DL	NA	NA	NA	NA	NA	NA	32142454	IEEE/ACM Trans Comput Biol Bioinform	2021
118	51.85	1518	BioLip	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DTI-End-to-End-DL	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/larngroup/DTI-End-to-End-DL	NA	NA	NA	NA	NA	NA	32142454	IEEE/ACM Trans Comput Biol Bioinform	2021
119	51.5	1838	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DeepLPI	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Target Interaction (DTI)	https://github.com/David-BominWei/DeepLPI	NA	NA	NA	NA	NA	NA	36307509	Sci Rep	2022
119	51.5	1838	COVID19-One	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DeepLPI	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Target Interaction (DTI)	https://github.com/David-BominWei/DeepLPI	NA	NA	NA	NA	NA	NA	36307509	Sci Rep	2022
119	51.5	1838	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	DeepLPI	Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM)	Drug Target Interaction (DTI)	https://github.com/David-BominWei/DeepLPI	NA	NA	NA	NA	NA	NA	36307509	Sci Rep	2022
120	51.4	1056	NA	Drug, Target	Drug: chemical structure	PIMD	Similarity Network Fusion (SNF)	Drug Drug Interaction (DDI)	https://github.com/Sepstar/PIMD/	Case studies	NA	NA	NA	NA	NA	33075523	Genomics Proteomics Bioinformatics	2020
121	51	1678	Davis	Drug, Target	Drug: 2D chemical structure, Target: sequence	NerLTR-DTA	Learning To Rank (LTR)	Drug Target binding Affinity (DTA)	https://github.com/RUXIAOQING964914140/NerLTR-DTA	NA	NA	NA	NA	NA	NA	35134828	Bioinformatics	2022
121	51	1678	KIBA	Drug, Target	Drug: 2D chemical structure, Target: sequence	NerLTR-DTA	Learning To Rank (LTR)	Drug Target binding Affinity (DTA)	https://github.com/RUXIAOQING964914140/NerLTR-DTA	NA	NA	NA	NA	NA	NA	35134828	Bioinformatics	2022
122	50.75	2018	Yamanishi	Drug, Target	NA	DEDTI-IEDTI	Deep Neural Network (DNN)	Drug Target Interaction (DTI)	https://github.com/BioinformaticsIASBS/IEDTI-DEDTI	Case studies	NA	NA	NA	NA	Top 126 drugs	37286613	Sci Rep	2023
122	50.75	2018	DTINet	Drug, Target	NA	DEDTI-IEDTI	Deep Neural Network (DNN)	Drug Target Interaction (DTI)	https://github.com/BioinformaticsIASBS/IEDTI-DEDTI	Case studies	NA	NA	NA	NA	Top 126 drugs	37286613	Sci Rep	2023
123	50.5	569	NA	Drug, Disease, Target	NA	NA	Random Forest (RF),Neural network	Drug Disease Association (DDA)	NA	Case studies	Dysmenorrhea	NA	NA	NA	Candidate drugs with the mean AUC>0.9	30463505	BMC Bioinformatics	2018
123	50.5	569	NA	Drug, Disease, Target	NA	NA	Random Forest (RF),Neural network	Drug Disease Association (DDA)	NA	Case studies	Psoriasis	NA	NA	NA	Candidate drugs with the mean AUC>0.9	30463505	BMC Bioinformatics	2018
123	50.5	569	NA	Drug, Disease, Target	NA	NA	Random Forest (RF),Neural network	Drug Disease Association (DDA)	NA	Case studies	Urticaria	NA	NA	NA	Candidate drugs with the mean AUC>0.9	30463505	BMC Bioinformatics	2018
123	50.5	794	NA	Drug, Target	Drug: SMILES, Proten: the amino acid sequence	BANDIT	Bayesian	Drug Target Interaction (DTI)	Select pieces of custom code can be made available upon request.	NA	NA	NA	NA	NA	NA	31745082	Nat Commun	2019
123	50.5	569	NA	Drug, Disease, Target	NA	NA	Random Forest (RF),Neural network	Drug Disease Association (DDA)	NA	Case studies	Osteoarthritis	NA	NA	NA	Candidate drugs with the mean AUC>0.9	30463505	BMC Bioinformatics	2018
123	50.5	2000	NA	Drug, Disease, Target	Drug: SMILES, Target: the amino acid sequences	DT2Vec+	XGBoost	Drug Target Interaction (DTI)	https://github.com/elmira-amiri/DT2VecPlus	NA	NA	NA	NA	NA	NA	37193964	BMC Bioinformatics	2023
123	50.5	569	NA	Drug, Disease, Target	NA	NA	Random Forest (RF),Neural network	Drug Disease Association (DDA)	NA	Case studies	Chronic lymphocytic leukemia	NA	NA	NA	Candidate drugs with the mean AUC>0.9	30463505	BMC Bioinformatics	2018
124	50.3	1787	Yamanishi_NR	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
124	50.3	1787	Yamanishi_E	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
124	50.3	1787	Yamanishi_IC	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
124	50.3	1787	KEGG	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
124	50.3	1787	Yamanishi_GPCR	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
124	50.3	1787	DrugBank	Drug, Target	Drug: chemical structure, target: protein sequence	Ro-DNILMF	Integrated logistic matrix factorization	Drug Target Interaction (DTI)	https://github.com/LJX0326/Ro-DNILMF.git	NA	NA	NA	NA	NA	NA	36014371	Molecules	2022
125	50.05	187	BindingDB	Drug, Target	Target: Fingerprint	WES	Bayesian network and multi-variate kernel approach	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	26155766	Sci Rep	2015
125	50.05	187	External data	Drug, Target	Target: Fingerprint	WES	Bayesian network and multi-variate kernel approach	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	26155766	Sci Rep	2015
126	50	1343	Davis	Drug, Target	Drug: (the atom symbol, the number of adjacent atoms, the number of adjacent hydrogens, the implicit value of the atom, and whether the atom is in an aromatic structure), Target: (ASCII character string)	GraphDTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/thinng/GraphDTA	NA	NA	NA	NA	NA	NA	33119053	Bioinformatics	2021
126	50	1343	KIBA	Drug, Target	Drug: (the atom symbol, the number of adjacent atoms, the number of adjacent hydrogens, the implicit value of the atom, and whether the atom is in an aromatic structure), Target: (ASCII character string)	GraphDTA	Graph Neural Network (GNN)	Drug Target binding Affinity (DTA)	https://github.com/thinng/GraphDTA	NA	NA	NA	NA	NA	NA	33119053	Bioinformatics	2021
127	49.5	1203	NA	Drug, Virus	NA	IRNMF (Indicator Regularized non-negative Matrix Factorization)	Non-negative Matrix Factorization (NMF)	Drug Virus Association (DVA)	https://github.com/dukebai/IRNMF	NA	NA	NA	NA	NA	NA	33584672	Front Immunol	2021
128	49	1834	Davis	Drug, Target	Drug: SMILES, Target: the amino acid sequences	ICAN (Interpretable Cross-Attention Network)	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/kuratahiroyuki/ICAN	NA	NA	NA	NA	NA	NA	36279284	PLoS One	2022
128	49	1834	BindingDB	Drug, Target	Drug: SMILES, Target: the amino acid sequences	ICAN (Interpretable Cross-Attention Network)	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/kuratahiroyuki/ICAN	NA	NA	NA	NA	NA	NA	36279284	PLoS One	2022
128	49	559	MULAN	Drug, Disease, Gene	Chemical: Extended Connectivity Fingerprint (ECFP), Gene: amino acid sequence	ANTENNA	Dual-regularized weighted,Imputed One Class Collaborative Filtering (OCCF) algorithm,Random Walk Restart	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	29993812	IEEE/ACM Trans Comput Biol Bioinform	2018
128	49	64	Fdataset	Drug, Disease	Drug: structure chemical, target, side-effect, Diseases: MeSH terms	PreDR (Predict Drug Repositioning)	Support Vector Machine (SVM)	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	24244318	PLoS One	2013
128	49	1834	BIOSNAP	Drug, Target	Drug: SMILES, Target: the amino acid sequences	ICAN (Interpretable Cross-Attention Network)	Convolutional Neural Network (CNN)	Drug Target Interaction (DTI)	https://github.com/kuratahiroyuki/ICAN	NA	NA	NA	NA	NA	NA	36279284	PLoS One	2022
129	48.8	1914	Hetero-C	Drug, Target, Gene, Side-effect	NA	MHGNN (Metapath-aggregated Heterogeneous Graph Neural Network)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/Zora-LM/MHGNN-DTI	NA	NA	NA	NA	NA	NA	36592060	Brief Bioinform	2023
129	48.8	1914	Hetero-A	Drug, Disease, Target, Side-effect	NA	MHGNN (Metapath-aggregated Heterogeneous Graph Neural Network)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/Zora-LM/MHGNN-DTI	NA	NA	NA	NA	NA	NA	36592060	Brief Bioinform	2023
129	48.8	1914	Hetero-B	Drug, Disease, Target, Side-effect	NA	MHGNN (Metapath-aggregated Heterogeneous Graph Neural Network)	Graph Neural Network (GNN)	Drug Target Interaction (DTI)	https://github.com/Zora-LM/MHGNN-DTI	NA	NA	NA	NA	NA	NA	36592060	Brief Bioinform	2023
130	48.35	1235	dataset 2	Drug, Target	Drug: constitutional, topological, and geometrical descriptors; Target: amino acid, pseudo-amino acid, and CTD (composition, transition, distribution) descriptors	DTI-SNNFRA	Shared nearest neighbors and fuzzy-rough approximation	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33606741	PLoS One	2021
130	48.35	1235	dataset 1	Drug, Target	Drug: constitutional, topological, and geometrical descriptors; Target: amino acid, pseudo-amino acid, and CTD (composition, transition, distribution) descriptors	DTI-SNNFRA	Shared nearest neighbors and fuzzy-rough approximation	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33606741	PLoS One	2021
131	47.5	1795	NA	Drug, Disease, Target, Side-effect, Substructure	NA	MGATRx	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://github.com/yellajaswanth/MGATRx	NA	NA	NA	NA	NA	NA	34014830	IEEE/ACM Trans Comput Biol Bioinform	2022
132	47	723	Yamanishi_NR	Drug, Target	NA	SPLCMF (Self-paced learning with collaborative matrix factorization)	Matrix Factorization	Drug Target Interaction (DTI)	https://github.com/Macau-LYXia/SPLCMF-DTI	NA	NA	NA	NA	NA	NA	31260620	J Chem Inf Model	2019
132	47	723	Kuang's dataset	Drug, Target	NA	SPLCMF (Self-paced learning with collaborative matrix factorization)	Matrix Factorization	Drug Target Interaction (DTI)	https://github.com/Macau-LYXia/SPLCMF-DTI	NA	NA	NA	NA	NA	NA	31260620	J Chem Inf Model	2019
132	47	723	Yamanishi_E	Drug, Target	NA	SPLCMF (Self-paced learning with collaborative matrix factorization)	Matrix Factorization	Drug Target Interaction (DTI)	https://github.com/Macau-LYXia/SPLCMF-DTI	NA	NA	NA	NA	NA	NA	31260620	J Chem Inf Model	2019
132	47	723	Yamanishi_IC	Drug, Target	NA	SPLCMF (Self-paced learning with collaborative matrix factorization)	Matrix Factorization	Drug Target Interaction (DTI)	https://github.com/Macau-LYXia/SPLCMF-DTI	NA	NA	NA	NA	NA	NA	31260620	J Chem Inf Model	2019
132	47	723	Yamanishi_GPCR	Drug, Target	NA	SPLCMF (Self-paced learning with collaborative matrix factorization)	Matrix Factorization	Drug Target Interaction (DTI)	https://github.com/Macau-LYXia/SPLCMF-DTI	NA	NA	NA	NA	NA	NA	31260620	J Chem Inf Model	2019
133	46.75	2132	DNdataset	Drug, Disease	NA	IDDI-DNN	Convolutional Neural Network (CNN)	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	37993777	BMC Bioinformatics	2023
133	46.75	2132	Fdataset	Drug, Disease	NA	IDDI-DNN	Convolutional Neural Network (CNN)	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	37993777	BMC Bioinformatics	2023
134	46.7	1221	PMID: 24551427	Drug, Target, Side-effect	Drug(structure, target, side-effect)	IntegratedSim	Similarity-fusion methods	Drug Drug Interaction (DDI)	NA	NA	NA	NA	NA	NA	NA	33557749	BMC Bioinformatics	2021
134	46.7	1221	NDF-RT	Drug, Disease	NA	IntegratedSim	Similarity-fusion methods	Drug Drug Interaction (DDI)	NA	NA	NA	NA	NA	NA	NA	33557749	BMC Bioinformatics	2021
135	46.56	1658	Yamanishi_E	Drug, Target	NA	IMCHGAN (Inductive Matrix Completion with Heterogeneous Graph Attention Network)	Graph Attention Network (GAT),Inductive Matrix Completion (IMC)	Drug Target Interaction (DTI)	https://github.com/ljatynu/IMCHGAN/	NA	NA	NA	NA	NA	NA	34115592	IEEE/ACM Trans Comput Biol Bioinform	2022
135	46.56	1658	Yamanishi_IC	Drug, Target	NA	IMCHGAN (Inductive Matrix Completion with Heterogeneous Graph Attention Network)	Graph Attention Network (GAT),Inductive Matrix Completion (IMC)	Drug Target Interaction (DTI)	https://github.com/ljatynu/IMCHGAN/	NA	NA	NA	NA	NA	NA	34115592	IEEE/ACM Trans Comput Biol Bioinform	2022
135	46.56	1658	Yamanishi_GPCR	Drug, Target	NA	IMCHGAN (Inductive Matrix Completion with Heterogeneous Graph Attention Network)	Graph Attention Network (GAT),Inductive Matrix Completion (IMC)	Drug Target Interaction (DTI)	https://github.com/ljatynu/IMCHGAN/	NA	NA	NA	NA	NA	NA	34115592	IEEE/ACM Trans Comput Biol Bioinform	2022
135	46.56	1658	Yamanishi_NR	Drug, Target	NA	IMCHGAN (Inductive Matrix Completion with Heterogeneous Graph Attention Network)	Graph Attention Network (GAT),Inductive Matrix Completion (IMC)	Drug Target Interaction (DTI)	https://github.com/ljatynu/IMCHGAN/	NA	NA	NA	NA	NA	NA	34115592	IEEE/ACM Trans Comput Biol Bioinform	2022
135	46.56	1658	DTI-HN	Drug, Disease, Target, Side-effect	NA	IMCHGAN (Inductive Matrix Completion with Heterogeneous Graph Attention Network)	Graph Attention Network (GAT),Inductive Matrix Completion (IMC)	Drug Target Interaction (DTI)	https://github.com/ljatynu/IMCHGAN/	NA	NA	NA	NA	NA	NA	34115592	IEEE/ACM Trans Comput Biol Bioinform	2022
136	45	1220	NA	Drug, Disease, Gene	NA	SAveRUNNER (Searching off-lAbel dRUg aNd NEtwoRk)	Bi-Random walk-based algorithm	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	33544720	PLoS Comput Biol	2021
137	44.5	1851	DRKG	Drug, Disease, Gene, Anatomies	NA	GDRnet	Graph Neural Network (GNN)	Drug Disease Association (DDA)	https://github.com/siddhant-doshi/GDRnet	Case studies	NA	NA	NA	NA	NA	36228466	Comput Biol Med	2022
138	44	1886	Fdataset	Drug, Disease	NA	NMFDR (Neural Metric Factorization model for computational Drug Repositioning)	Matrix Factorization	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	35061591	IEEE/ACM Trans Comput Biol Bioinform	2023
138	44	1886	Cdataset	Drug, Disease	NA	NMFDR (Neural Metric Factorization model for computational Drug Repositioning)	Matrix Factorization	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	35061591	IEEE/ACM Trans Comput Biol Bioinform	2023
138	44	1886	DNdataset	Drug, Disease	NA	NMFDR (Neural Metric Factorization model for computational Drug Repositioning)	Matrix Factorization	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	35061591	IEEE/ACM Trans Comput Biol Bioinform	2023
138	44	1550	Luo's dataset	Drug, Disease, Target, Side-effect	NA	KGE_NFM	Neural Factorization Machine (NFM)	Drug Target Interaction (DTI)	https://zenodo.org/record/5500305	NA	NA	NA	NA	NA	NA	34811351	Nat Commun	2021
139	42.5	1935	LL	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	DisGeNET (DGN)	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	SLAMS	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	MalaCards (MC)	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	RepoDB (RDB)	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	DrugBank	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
139	42.5	1935	iDrug (ID)	Drug, Disease, Gene	NA	NA	Biased random walks	Drug Disease Association (DDA)	NA	Case studies	Rheumatoid Arthritis	NA	NA	NA	1 drug	35839194	IEEE/ACM Trans Comput Biol Bioinform	2023
140	42.4	465	NA	Drug, Target, Gene, Side-effect	Drug: Chemical structure, target, Gene, side-effect	NA	Growing Self Organizing Map (GSOM)	Drug Drug Interaction (DDI)	https://github.com/fathimanush786/two_tiered_clustrering_data	NA	NA	NA	NA	NA	NA	29642848	BMC Bioinformatics	2018
141	41.66	1473	Yamanishi_E	Drug, Target	NA	DTI-HeNE (DTI based on Heterogeneous Network Embedding)	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/arantir123/DTI-hene/	NA	NA	NA	NA	NA	NA	34479477	BMC Bioinformatics	2021
141	41.66	1473	Olayan RS	Drug, Target	NA	DTI-HeNE (DTI based on Heterogeneous Network Embedding)	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/arantir123/DTI-hene/	NA	NA	NA	NA	NA	NA	34479477	BMC Bioinformatics	2021
141	41.66	1473	Yamanishi_IC	Drug, Target	NA	DTI-HeNE (DTI based on Heterogeneous Network Embedding)	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/arantir123/DTI-hene/	NA	NA	NA	NA	NA	NA	34479477	BMC Bioinformatics	2021
141	41.66	1473	Yamanishi_GPCR	Drug, Target	NA	DTI-HeNE (DTI based on Heterogeneous Network Embedding)	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/arantir123/DTI-hene/	NA	NA	NA	NA	NA	NA	34479477	BMC Bioinformatics	2021
141	41.66	1473	Yamanishi_NR	Drug, Target	NA	DTI-HeNE (DTI based on Heterogeneous Network Embedding)	Random Forest (RF)	Drug Target Interaction (DTI)	https://github.com/arantir123/DTI-hene/	NA	NA	NA	NA	NA	NA	34479477	BMC Bioinformatics	2021
142	40.7	1307	NA	Drug, Target	Drug: 2-D structural representations,	CSConv2d	Convolutional Block Attention Module (CBAM)	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	33925310	Biomolecules	2021
143	40.5	142	NA	Drug, Disease, Gene	NA	NA	Matrix Factorization	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	26078775	Comput Math Methods Med	2015
144	39.2	154	NA	Drug	Drug: chemical structure	NA	Markov Clustering	Drug Drug Interaction (DDI)	NA	NA	NA	NA	NA	NA	NA	24934184	Chem Biol Drug Des	2015
145	38.4	1444	CAS Biomedical Knowledge Graph(COVID-19)	Disease, Gene, Pathway, Virus, Side-effect, Clinical Trial, Small molecule, Molecular Function	NA	NA	A computer algorithm-driven drug-ranking method	Drug Disease Association (DDA)	NA	Special studies	COVID-19	NA	NA	NA	Top 50 drugs	34297570	J Chem Inf Model	2021
146	38	50	STITCH	Drug, Target	NA	RBM model	Restricted Boltzmann Machine	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	23812976	Bioinformatics	2013
146	38	50	MATADOR	Drug, Target	NA	RBM model	Restricted Boltzmann Machine	Drug Target Interaction (DTI)	NA	NA	NA	NA	NA	NA	NA	23812976	Bioinformatics	2013
147	37.8	328	MATADOR	Drug, Target	Drug: pubchem ID, Target: target ID(MeSH, STRING 7)	NA	Common Neighbours,Jaccard Index,Preferential Attachment,Katz Index	Drug Target Interaction (DTI)	http://www.cl.cam.ac.uk/~yg244/16bioinfo	NA	NA	NA	NA	NA	NA	28095781	BMC Bioinformatics	2017
148	37.65	896	SMDC	Drug	Drug: drug perturbation gene expression level, structural fingerprint and physicochemical property	DAMT-Model	Convolutional Neural Network (CNN),Domain-adversarial learning,Bidirectional LSTM (Bi-LSTM)	Drug Disease Association (DDA)	https://github.com/JohnnyY8/DAMT-Model	NA	NA	NA	NA	NA	NA	31999334	Bioinformatics	2020
148	37.65	896	FD dataset	Drug	Drug: drug perturbation gene expression level, structural fingerprint and physicochemical property	DAMT-Model	Convolutional Neural Network (CNN),Domain-adversarial learning,Bidirectional LSTM (Bi-LSTM)	Drug Disease Association (DDA)	https://github.com/JohnnyY8/DAMT-Model	NA	NA	NA	NA	NA	NA	31999334	Bioinformatics	2020
149	30.5	604	Yamanishi	Drug, Disease, Target	NA	Heter-LP	Label Propagation	Drug Target Interaction (DTI),Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	30547450	Methods Mol Biol	2019
150	27.6	1110	NA	Drug, Disease, Gene, Pathway, Side-effect	NA	NA	Support Vector Machine (SVM),Decision Tree (DT),Random Forest (RF)	Drug Disease Association (DDA)	NA	NA	NA	NA	NA	NA	NA	32674665	Health Informatics J	2020