The search result for the key word "Case studies"

A total of 487 results found based on your keywords
Recommendation ID Data Information Model Information Application Information Reference
Rank Total_Score Model_ID Dataset_Name Element_type Data_features Model_name Algorithm_name Prediction_type Code_source Study_types Disease_name Target_name Drug_name Interaction_type Recommended_Number PMID Journal Publication_Year
1 91.9 2042 NA Drug, Disease, Target Drug: SMILES, Target: the amino acid sequences VGAEDTI Random Forest (RF),Variational Graph AutoEncoder (VGAE),Graph AutoEncoder (GAE) Drug Target Interaction (DTI) https://github.com/FengYinFei/VGAEDTI Case studies NA NA NA Drug target interaction Top 15 drugs 37415176 BMC Bioinformatics 2023
2 90.6 1539 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Alzheimer's disease (AD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Alzheimer's disease (AD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Ldataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Alzheimer's disease (AD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Alzheimer's disease (AD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
2 90.6 1539 Ldataset Drug, Disease Drug: SMILES, Disease: MeSH DRHGCN (Drug Repositioning based on the Heterogeneous information fusion Graph Convolutional Network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/TheWall9/DRHGCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 34378011 Brief Bioinform 2021
3 87.8 2207 Dataset 2 Drug, Disease Drug: SMILES, Disease: Mesh semantic DRDSA (Drug Repositioning Deep Sparse Autoencoder) Deep sparse autoencoder,Deep feedforward neural network Drug Disease Association (DDA) https://github.com/luckymengmeng/HDVD Case studies COVID-19 NA NA NA Top 10 drugs 38103130 Interdiscip Sci 2024
3 87.8 2207 Dataset 3 Drug, Disease Drug: SMILES, Disease: Mesh semantic DRDSA (Drug Repositioning Deep Sparse Autoencoder) Deep sparse autoencoder,Deep feedforward neural network Drug Disease Association (DDA) https://github.com/luckymengmeng/HDVD Case studies COVID-19 NA NA NA Top 10 drugs 38103130 Interdiscip Sci 2024
3 87.8 2207 Dataset 4 Drug, Disease Drug: SMILES, Disease: Mesh semantic DRDSA (Drug Repositioning Deep Sparse Autoencoder) Deep sparse autoencoder,Deep feedforward neural network Drug Disease Association (DDA) https://github.com/luckymengmeng/HDVD Case studies COVID-19 NA NA NA Top 10 drugs 38103130 Interdiscip Sci 2024
3 87.8 2207 Dataset 1 Drug, Disease Drug: SMILES, Disease: Mesh semantic DRDSA (Drug Repositioning Deep Sparse Autoencoder) Deep sparse autoencoder,Deep feedforward neural network Drug Disease Association (DDA) https://github.com/luckymengmeng/HDVD Case studies COVID-19 NA NA NA Top 10 drugs 38103130 Interdiscip Sci 2024
4 86.5 1868 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH GLGMPNN Message Passing Neural Network (MPNN), Gated Fusion Mechanism Drug Disease Association (DDA) https://github.com/bdtree/GLGMPNN Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 36305457 Brief Bioinform 2022
4 86.5 1868 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH GLGMPNN Message Passing Neural Network (MPNN), Gated Fusion Mechanism Drug Disease Association (DDA) https://github.com/bdtree/GLGMPNN Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 36305457 Brief Bioinform 2022
5 86.05 2168 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MesH, Target: Sequence HMLKGAT Graph Attention Network (The principle of three degrees influence),Multi-Kernel Learning Method (Gaussian kernel function,Cosine similarity function),Neural network Drug Disease Association (DDA) https://github.com/LDD-0914/HMLKGAT.git Case studies NA NA NA Drug disease interaction Top 5 diseases 38051617 IEEE/ACM Trans Comput Biol Bioinform 2024
5 86.05 2168 Hetero-A Drug, Disease, Target NA HMLKGAT Graph Attention Network (The principle of three degrees influence),Multi-Kernel Learning Method (Gaussian kernel function,Cosine similarity function),Neural network Drug Disease Association (DDA) https://github.com/LDD-0914/HMLKGAT.git Case studies NA NA NA Drug disease interaction Top 5 diseases 38051617 IEEE/ACM Trans Comput Biol Bioinform 2024
6 85.6 2118 DTINet Drug, Disease, Target Drug: SMILES(Drugbank), Target: amino acid sequences(HPRD) SATS Graph Neural Network (GNN) Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 30 drugs 37672364 IEEE J Biomed Health Inform 2023
7 85.4 815 Cdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Levodopa NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 PREDICT (Fdataset) Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Flecainide NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 NA Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Doxorubicin NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 PREDICT (Fdataset) Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Levodopa NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 Cdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Doxorubicin NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 NA Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Flecainide NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 NA Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Levodopa NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 Cdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Flecainide NA Top 5 diseases 31869322 PLoS Comput Biol 2019
7 85.4 815 PREDICT (Fdataset) Drug, Disease, Target Drug: SMILES, Disease: MeSH OMC Overlap Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/OMC Case studies NA NA Doxorubicin NA Top 5 diseases 31869322 PLoS Comput Biol 2019
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Gabapentin NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Dexamethasone NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Amantadine NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Flecainide NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Frovatriptan NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Doxorubicin NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Amantadine NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Gabapentin NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Dexamethasone NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Flecainide NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Frovatriptan NA Top 20 diseases 34610633 Mol Omics 2021
8 85 1566 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH BGMSDDA K nearest known neighbors (WKNKN) Drug Disease Association (DDA) https://github.com/kk-2010000/BGMSDDA Case studies NA NA Doxorubicin NA Top 20 diseases 34610633 Mol Omics 2021
9 84.3 1807 NA Drug, Disease Drug: SMILES, Disease: Mesh semantic GCMM (Graph convolution network based on a multimodal attention mechanism) Convolutional Neural Network (CNN) Drug Disease Association (DDA) https://github.com/FanZhang0820/GCMM Case studies Alzheimer's Disease (AD) NA NA NA Top 5 drugs 36100897 BMC Bioinformatics 2022
10 84.04 289 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Doxorubicin NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Amantadine NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Flecainide NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Amantadine NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Cabergoline NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Levodopa NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Doxorubicin NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Amantadine NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Cabergoline NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Levodopa NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Flecainide NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Doxorubicin NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Cabergoline NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Levodopa NA Top 5 diseases 27153662 Bioinformatics 2016
10 84.04 289 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms MBiRW Random Walk Drug Disease Association (DDA) http://github.com//bioinfomaticsCSU/MBiRW Case studies NA NA Flecainide NA Top 5 diseases 27153662 Bioinformatics 2016
11 83.8 893 PREDICT (Fdataset) Drug, Disease Drug: SMILES, Disease: MeSH HNet-DNN Deep Neural Network (DNN) Drug Disease Association (DDA) https://github.com/hliu2016/HNet-DNN Case studies Breast neoplasms NA NA NA Top 15 drugs 32118415 J Chem Inf Model 2020
11 83.8 893 PREDICT (Fdataset) Drug, Disease Drug: SMILES, Disease: MeSH HNet-DNN Deep Neural Network (DNN) Drug Disease Association (DDA) https://github.com/hliu2016/HNet-DNN Case studies NA NA Enalapril NA Top 15 diseases 32118415 J Chem Inf Model 2020
11 83.8 893 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH HNet-DNN Deep Neural Network (DNN) Drug Disease Association (DDA) https://github.com/hliu2016/HNet-DNN Case studies Breast neoplasms NA NA NA Top 15 drugs 32118415 J Chem Inf Model 2020
11 83.8 893 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH HNet-DNN Deep Neural Network (DNN) Drug Disease Association (DDA) https://github.com/hliu2016/HNet-DNN Case studies NA NA Enalapril NA Top 15 diseases 32118415 J Chem Inf Model 2020
12 83 1613 NA Drug, Disease Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH CTST Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies NA NA Metoprolol NA Top 10 diseases 34850815 Brief Bioinform 2022
12 83 1613 NA Drug, Disease Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH CTST Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies NA NA Aripiprazole NA Top 10 diseases 34850815 Brief Bioinform 2022
12 83 1613 NA Drug, Disease Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH CTST Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies NA NA Chloroquine NA Top 10 diseases 34850815 Brief Bioinform 2022
12 83 1613 NA Drug, Disease Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH CTST Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies NA NA Propranolol NA Top 10 diseases 34850815 Brief Bioinform 2022
12 83 1613 NA Drug, Disease Drug: Chemical substructures, the target domains and the gene ontology annotations of target target, Disease: MeSH CTST Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies NA NA Flurbiprofen NA Top 10 diseases 34850815 Brief Bioinform 2022
13 82.7 1848 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies Brain neoplasms NA NA NA Top 10 drugs 36182762 Comput Biol Med 2022
13 82.7 1848 NA Drug, Disease, Target, Gene, Pathway Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies Brain neoplasms NA NA NA Top 10 drugs 36182762 Comput Biol Med 2022
13 82.7 1848 NA Drug, Disease, Target, Gene, Pathway Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies NA NA Dexamethasone NA Top 10 diseases 36182762 Comput Biol Med 2022
13 82.7 1848 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies NA NA Dexamethasone NA Top 10 diseases 36182762 Comput Biol Med 2022
13 82.7 1848 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies NA NA Ifosfamide NA Top 10 diseases 36182762 Comput Biol Med 2022
13 82.7 1848 NA Drug, Disease, Target, Gene, Pathway Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies NA NA Ifosfamide NA Top 10 diseases 36182762 Comput Biol Med 2022
13 82.7 1848 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies Breast neoplasms NA NA NA Top 10 drugs 36182762 Comput Biol Med 2022
13 82.7 1848 NA Drug, Disease, Target, Gene, Pathway Drug: SMILES, Disease: MeSH REDDA (Relations-Enhanced Drug-Disease Association prediction) Heterogeneous Graph Convolutional Network (HGCN) Drug Disease Association (DDA) https://github.com/gu-yaowen/REDDA Case studies Breast neoplasms NA NA NA Top 10 drugs 36182762 Comput Biol Med 2022
14 82.1 1842 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Breast Cancer NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
14 82.1 1842 Gdataset Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Breast Cancer NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
14 82.1 1842 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
14 82.1 1842 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Breast Cancer NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
14 82.1 1842 Gdataset Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
14 82.1 1842 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH PSGCN (Partner-specific drug repositioning approach based on graph convolutional network） Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/xinliangSun/PSGCN Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35921345 IEEE J Biomed Health Inform 2022
15 81.9 2175 Cdataset Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Breast carcinoma NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 1643 DNdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Diltiazem NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 1643 Cdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Fenoldopam NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 2175 Ldataset Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Breast carcinoma NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 1643 Fdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Fenoldopam NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 2175 LRSSL Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Alzheimer's Disease (AD) NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 2175 Gdataset (Fdataset) Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Alzheimer's Disease (AD) NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 1643 DNdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Indomethacin NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 1643 Cdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Diltiazem NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 1643 Cdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Indomethacin NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 1643 Fdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Diltiazem NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 2175 LRSSL Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Breast carcinoma NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 2175 Gdataset (Fdataset) Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Breast carcinoma NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 1643 DNdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Fenoldopam NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 1643 Fdataset Drug, Disease Drug: Hashed fingerprints, Disease: MeSH springD²A Encoder,Neural networks Drug Disease Association (DDA) https://github.com/wangyuanhao/springD2A Case studies NA NA Indomethacin NA Top 10 diseases 34864881 Bioinformatics 2022
15 81.9 2175 Ldataset Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Alzheimer's Disease (AD) NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
15 81.9 2175 Cdataset Drug, Disease Drug: 2D chemical fingerprints, Diseases: The semantic similarity of disease phenotypes AdaDR (Adaptive Graph Convolutional Networks for Drug Repositioning) Adaptive Graph Convolutional Network (AGCN) Drug Disease Association (DDA) https://github.com/xinliangSun/AdaDR Case studies Alzheimer's Disease (AD) NA NA NA Top 5 drugs 38070161 Bioinformatics 2024
16 81.88 1407 Fdataset Drug, Disease Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. MSBMF Matrix Factorization Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MSBMF Case studies NA NA Methotrexate NA Top 10 diseases 33147616 Brief Bioinform 2021
16 81.88 1407 Fdataset Drug, Disease Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. MSBMF Matrix Factorization Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MSBMF Case studies NA NA Risperidone NA Top 10 diseases 33147616 Brief Bioinform 2021
16 81.88 1407 Fdataset Drug, Disease Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. MSBMF Matrix Factorization Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MSBMF Case studies NA NA Doxorubicin NA Top 10 diseases 33147616 Brief Bioinform 2021
16 81.88 1407 Fdataset Drug, Disease Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. MSBMF Matrix Factorization Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MSBMF Case studies NA NA Gemcitabine NA Top 10 diseases 33147616 Brief Bioinform 2021
16 81.88 1407 Fdataset Drug, Disease Drug: SMILES, ATC, side-effect; Disease: the medical subject headings vocabulary, DO. MSBMF Matrix Factorization Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MSBMF Case studies NA NA Vincristine NA Top 10 diseases 33147616 Brief Bioinform 2021
17 81.8 795 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms SKCNN Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/SKCNN Case studies Asthma NA NA NA Top 20 drugs 31747915 J Transl Med 2019
17 81.8 795 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms SKCNN Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/SKCNN Case studies Obesity NA NA NA Top 20 drugs 31747915 J Transl Med 2019
17 81.8 795 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms SKCNN Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/SKCNN Case studies Asthma NA NA NA Top 20 drugs 31747915 J Transl Med 2019
17 81.8 795 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms SKCNN Sigmoid Kernel and Convolutional Neural Network (SKCNN),Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/SKCNN Case studies Obesity NA NA NA Top 20 drugs 31747915 J Transl Med 2019
18 81.7 2036 DTPKS Drug, Target Drug: 2D molecular graphs Target: amino acid sequences (AAS) MDTips Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/XiaoqiongXia/MDTips Case studies NA NA Melphalan NA Top 30 diseases 37379157 Bioinformatics 2023
19 81.4 1860 T2 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1718 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH MLMC Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MLMC Case studies NA NA Leucovorin NA Top 5 diseases 35289352 Brief Bioinform 2022
19 81.4 1860 T1 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Breast carcinoma NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies NA NA Felodipine NA Top 5 diseases 36359016 Biomolecules 2022
19 81.4 1860 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Breast carcinoma NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 T2 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies NA NA Felodipine NA Top 5 diseases 36359016 Biomolecules 2022
19 81.4 1718 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH MLMC Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MLMC Case studies NA NA Doxorubicin NA Top 5 diseases 35289352 Brief Bioinform 2022
19 81.4 1860 T1 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Breast carcinoma NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 T1 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies NA NA Felodipine NA Top 5 diseases 36359016 Biomolecules 2022
19 81.4 1718 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH MLMC Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MLMC Case studies NA NA Gemcitabine NA Top 5 diseases 35289352 Brief Bioinform 2022
19 81.4 1718 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH MLMC Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/MLMC Case studies NA NA Methotrexate NA Top 5 diseases 35289352 Brief Bioinform 2022
19 81.4 1860 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies NA NA Felodipine NA Top 5 diseases 36359016 Biomolecules 2022
19 81.4 1860 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 36359016 Biomolecules 2022
19 81.4 1860 T2 Drug, Disease, Target Drug: SMILES, Disease: MeSH EMPHCN (Enhanced Message Passing and Hypergraph Convolutional Networks) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/hwh7301/EMPHCN Case studies Breast carcinoma NA NA NA Top 10 drugs 36359016 Biomolecules 2022
20 81 2099 NA Drug, Disease, Target, Side-effect Drug: SMILES, Target: the amino acid sequences MOVE Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/scu-kdde/Bioinfo-MOVE2.0 Case studies COVID-19 Peroxisome proliferator-activated receptor gamma(P37231), Peroxisome proliferator-activated receptor alpha(Q07869), Apoptosis regulator Bcl-2(P10415), Angiotensin-converting enzyme 2(Q9BYF1), Cystic fibrosis transmembrane conductance regulator(P13569), Nuclear receptor subfamily 1 group I member 2(O75469), Annexin A1(P04083) NA NA Top 7 drugs 37586602 Methods 2023
21 80.7 1994 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences MSGNN-DTA Graph Neural Network (GNN) Drug Target binding Affinity (DTA) https://github.com/songxuanmo/MSGNN-DTA Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 11 drugs 37176031 Int J Mol Sci 2023
21 80.7 1994 KIBA Drug, Target Drug: SMILES, Target: the amino acid sequences MSGNN-DTA Graph Neural Network (GNN) Drug Target binding Affinity (DTA) https://github.com/songxuanmo/MSGNN-DTA Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 11 drugs 37176031 Int J Mol Sci 2023
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Citalopram NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Ziprasidone NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Fluconazole NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Citalopram NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Fluconazole NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Imatinib NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Warfarin NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Chloroquine NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Imatinib NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Ziprasidone NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Ziprasidone NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Fluconazole NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Citalopram NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 2071 DTINet Drug, Disease, Target, Side-effect Drug: SMILES, Target: the amino acid sequences SHGCL-DTI Heterogeneous Graph Convolutional Network (HGCN) Drug Target Interaction (DTI) https://github.com/TOJSSE-iData/SHGCL-DTI Case studies NA ADRA1B, CHRM1, CHRM2, CHRM3, HTR1A, HTR2B, HTR2C, GABRA4, OPRD1, SLC6A4 NA NA Top 20 drugs 37421738 Comput Biol Med 2023
22 80.6 895 Cdataset Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Imatinib NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Warfarin NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 PREDICT (Fdataset) Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Chloroquine NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Warfarin NA Top 5 diseases 31999326 Bioinformatics 2020
22 80.6 895 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye DRIMC (Drug repositioning approach by using Bayesian inductive matrix completion) Bayesian inductive matrix Drug Disease Association (DDA) https://github.com/linwang1982/DRIMC Case studies NA NA Chloroquine NA Top 5 diseases 31999326 Bioinformatics 2020
23 80.5 393 NA Drug, Disease, Target , Side-effect Drug: chmical structure, Target: genome sequences DTINet Random Walk with Restart (RWR) Drug Target Interaction (DTI) https://github.com/luoyunan/DTINet Case studies NA COX proteins NA NA 3 drugs 28924171 Nat Commun 2017
24 80.4 1670 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Breast cancer NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
24 80.4 1670 Cdataset Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
24 80.4 1670 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Breast cancer NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
24 80.4 1670 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Breast cancer NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
24 80.4 1670 LRSSL Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
24 80.4 1670 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH DRWBNCF Graph Convolutional Network (GCN),Multi Layer Perceptron (MLP) Drug Disease Association (DDA) https://github.com/luckymengmeng/DRWBNCF Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 35039838 Brief Bioinform 2022
25 80.3 1892 Yamanishi_NR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_IC Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_GPCR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 HGBI Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_E Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 HGBI Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 DrugBank Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_IC Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_GPCR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_E Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 HGBI Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 DrugBank Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_NR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_GPCR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_IC Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA NA Nisoldipine NA Top 20 targets 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_E Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 DrugBank Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:779 (calcium voltage-gated channel subunit alpha1 S) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
25 80.3 1892 Yamanishi_NR Drug, Target Drug: chemical structure information, Target: target sequence PPAEDTI Deep Autoencoder Drug Target Interaction (DTI) https://github.com/LiYuechao1998/PPAEDTI Case studies NA hsa:775 (calcium voltage-gated channel subunit alpha1 C) NA NA Top 20 drugs 36301791 IEEE J Biomed Health Inform 2023
26 79.8 486 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Paclitaxel NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Paclitaxel NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Paclitaxel NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Zoledronic acid NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Zoledronic acid NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Zoledronic acid NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Prednisolone NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Prednisolone NA Top 5 diseases 29365057 Bioinformatics 2018
26 79.8 486 DNdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms DRRS (Drug Repositioning Recommendation System) Singular Value Thresholding (SVT) Drug Disease Association (DDA) NA Case studies NA NA Prednisolone NA Top 5 diseases 29365057 Bioinformatics 2018
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Ephedrine NA Top 2 drugs 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Salicylic acid NA Top 1 drug 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Podophyllotoxin NA Top 1 drug 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA (-)-Prostaglandin E1 NA Top 1 drug 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Testosterone NA Top 3 drugs 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Irinotecan NA Top 1 drug 31138103 BMC Bioinformatics 2019
27 79.71428571 687 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Random Forest (RF) Drug Disease Association (DDA) NA Case studies NA NA Cortisol NA Top 2 drugs 31138103 BMC Bioinformatics 2019
28 79.3 2179 Bdataset Drug, Disease, Target Drug: SMILES, Target: Sequence, Disease: MesH SiSGC (Simplifying Graph Convolution) CatBoost Drug Disease Association (DDA) https://github.com/MrPhil/SiSGC Case studies Breast neoplasms NA NA NA Top 20 drugs 38103039 J Chem Inf Model 2024
28 79.3 2179 Cdataset Drug, Disease, Target Drug: SMILES, Target: Sequence, Disease: MesH SiSGC (Simplifying Graph Convolution) CatBoost Drug Disease Association (DDA) https://github.com/MrPhil/SiSGC Case studies Breast neoplasms NA NA NA Top 20 drugs 38103039 J Chem Inf Model 2024
28 79.3 2179 Fdataset Drug, Disease, Target Drug: SMILES, Target: Sequence, Disease: MesH SiSGC (Simplifying Graph Convolution) CatBoost Drug Disease Association (DDA) https://github.com/MrPhil/SiSGC Case studies Breast neoplasms NA NA NA Top 20 drugs 38103039 J Chem Inf Model 2024
29 78.3 1615 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH HINGRL Random Forest (RF) Drug Disease Association (DDA) https://github.com/stevejobws/HINGRL Case studies Breast neoplasms NA NA NA Top 10 drugs 34891172 Brief Bioinform 2022
29 78.3 1615 NA Drug, Disease, Target Drug: SMILES, Disease: MeSH HINGRL Random Forest (RF) Drug Disease Association (DDA) https://github.com/stevejobws/HINGRL Case studies NA Clozapine NA NA Top 10 diseases 34891172 Brief Bioinform 2022
29 78.3 1615 NA Drug, Disease, Target Drug: SMILES, Disease: MeSH HINGRL Random Forest (RF) Drug Disease Association (DDA) https://github.com/stevejobws/HINGRL Case studies Breast neoplasms NA NA NA Top 10 drugs 34891172 Brief Bioinform 2022
29 78.3 1615 Fdataset Drug, Disease Drug: SMILES, Disease: MeSH HINGRL Random Forest (RF) Drug Disease Association (DDA) https://github.com/stevejobws/HINGRL Case studies NA Clozapine NA NA Top 10 diseases 34891172 Brief Bioinform 2022
30 78.1 2203 Fdataset Drug, Disease Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties WMAGT Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron Drug Disease Association (DDA) https://github.com/ShiHHe/WMAGT Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38378479 BMC Bioinformatics 2024
30 78.1 2203 Cdataset Drug, Disease Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties WMAGT Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron Drug Disease Association (DDA) https://github.com/ShiHHe/WMAGT Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38378479 BMC Bioinformatics 2024
30 78.1 2203 LRSSL Drug, Disease Chemical, Pharmacological, Therapeutic, Phenotypic, Genetic, Environment properties WMAGT Graph Convolutional Network,Graph Transformer,Neural Collaborative Filtering,Multilayer Perceptron Drug Disease Association (DDA) https://github.com/ShiHHe/WMAGT Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38378479 BMC Bioinformatics 2024
31 78 1644 DrugNet Drug, Disease Drug: Chemical structure, Disease: MeSH NMF-DR (Non-negative Matrix Factorization Drug Repurposing) Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/sshaghayeghs/NMF-DR Case studies Breast cancer NA NA NA Top 5 drugs 34875000 Bioinformatics 2022
31 78 1644 Cdataset Drug, Disease Drug: Chemical structure, Disease: MeSH NMF-DR (Non-negative Matrix Factorization Drug Repurposing) Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/sshaghayeghs/NMF-DR Case studies Breast cancer NA NA NA Top 5 drugs 34875000 Bioinformatics 2022
31 78 1644 Fdataset Drug, Disease Drug: Chemical structure, Disease: MeSH NMF-DR (Non-negative Matrix Factorization Drug Repurposing) Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/sshaghayeghs/NMF-DR Case studies Breast cancer NA NA NA Top 5 drugs 34875000 Bioinformatics 2022
31 78 1644 TL-HBGI Drug, Disease Drug: Chemical structure, Disease: MeSH NMF-DR (Non-negative Matrix Factorization Drug Repurposing) Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/sshaghayeghs/NMF-DR Case studies Breast cancer NA NA NA Top 5 drugs 34875000 Bioinformatics 2022
32 77.875 2079 DrugBank (version 5.1.9) Drug, Target Drug: SMILES, Target: the amino acid sequences MULGA (Multi-view Learning and Graph Autoencoder framework) Multi-view Learning and Graph Autoencoder (GAE) Drug Target Interaction (DTI) https://github.com/jianiM/MULGA Case studies COVID-19 Spike glycoprotein NA NA Top 20 drugs 37610353 Bioinformatics 2023
32 77.875 509 LRSSL Drug, Disease Drug: substructures, Disease: MeSH NTSIM (Network Topological Similarity-based Inference Method) Label Propagation Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 10 diseases 29879508 Methods 2018
32 77.875 509 NA Drug, Disease Drug: substructures, Disease: MeSH NTSIM (Network Topological Similarity-based Inference Method) Label Propagation Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 10 diseases 29879508 Methods 2018
32 77.875 2079 KIBA Drug, Target Drug: SMILES, Target: the amino acid sequences MULGA (Multi-view Learning and Graph Autoencoder framework) Multi-view Learning and Graph Autoencoder (GAE) Drug Target Interaction (DTI) https://github.com/jianiM/MULGA Case studies COVID-19 Spike glycoprotein NA NA Top 20 drugs 37610353 Bioinformatics 2023
32 77.875 509 Fdataset Drug, Disease Drug: substructures, Disease: MeSH NTSIM (Network Topological Similarity-based Inference Method) Label Propagation Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 10 diseases 29879508 Methods 2018
32 77.875 2079 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences MULGA (Multi-view Learning and Graph Autoencoder framework) Multi-view Learning and Graph Autoencoder (GAE) Drug Target Interaction (DTI) https://github.com/jianiM/MULGA Case studies COVID-19 Spike glycoprotein NA NA Top 20 drugs 37610353 Bioinformatics 2023
32 77.875 509 TL-HGBI Drug, Target Drug: substructures, Disease: MeSH NTSIM (Network Topological Similarity-based Inference Method) Label Propagation Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 10 diseases 29879508 Methods 2018
32 77.875 2079 BindingDB Drug, Target Drug: SMILES, Target: the amino acid sequences MULGA (Multi-view Learning and Graph Autoencoder framework) Multi-view Learning and Graph Autoencoder (GAE) Drug Target Interaction (DTI) https://github.com/jianiM/MULGA Case studies COVID-19 Spike glycoprotein NA NA Top 20 drugs 37610353 Bioinformatics 2023
33 77.76 766 LRSSL Drug, Disease, Side-effect Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology DisDrugPred Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/pingxuan-hlju/DisDrugPred Case studies NA NA Clonidine NA Top 10 diseases 30865257 Bioinformatics 2019
33 77.76 766 LRSSL Drug, Disease, Side-effect Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology DisDrugPred Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/pingxuan-hlju/DisDrugPred Case studies NA NA Ampicillin NA Top 10 diseases 30865257 Bioinformatics 2019
33 77.76 766 LRSSL Drug, Disease, Side-effect Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology DisDrugPred Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/pingxuan-hlju/DisDrugPred Case studies NA NA Etoposide NA Top 10 diseases 30865257 Bioinformatics 2019
33 77.76 766 LRSSL Drug, Disease, Side-effect Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology DisDrugPred Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/pingxuan-hlju/DisDrugPred Case studies NA NA Ciprofloxacin NA Top 10 diseases 30865257 Bioinformatics 2019
33 77.76 766 LRSSL Drug, Disease, Side-effect Drug: chemical substructure, domains of target target, GO terms of drug target, Disease associated with the interested Drug, Drug side-effect; Disease: MeSH, Disease ontology DisDrugPred Non-negative Matrix Factorization (NMF) Drug Disease Association (DDA) https://github.com/pingxuan-hlju/DisDrugPred Case studies NA NA Cefotaxime NA Top 10 diseases 30865257 Bioinformatics 2019
34 77.7 2133 Fdataset Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
34 77.7 2133 LRSSL Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
34 77.7 2133 Fdataset Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Breast cancer NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
34 77.7 2133 LRSSL Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Breast cancer NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
34 77.7 2133 Cdataset Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
34 77.7 2133 Cdataset Drug, Disease NA DRAGNN Multi Layer Perception (MLP) Drug Disease Association (DDA) https://github.com/1yiw/DRAGNN Case studies Breast cancer NA NA NA Top 10 drugs 38019732 Brief Bioinform 2023
35 77.4 607 DTINet Drug, Disease, Target , Side-effect Drug: Morgan fingerprints, Target: target sequence NeoDTI (NEural integration of neighbOr information for DTI prediction) Matrix Factorization Drug Target Interaction (DTI) https://github.com/FangpingWan/NeoDTI Case studies NA NA NA Drug disease interaction Top 20 predictions 30561548 Bioinformatics 2019
36 77.35 1367 Cdataset Drug, Disease Drug: SMILES, Disease: Phenotype DDIPred Deep gated recurrent units model Drug Disease Association (DDA) https://github.com/haichengyi/DDIPre Case studies NA NA Dexamethasone NA Top 15 diseases 34074242 BMC Bioinformatics 2021
36 77.35 1367 Fdataset Drug, Disease Drug: SMILES, Disease: Phenotype DDIPred Deep gated recurrent units model Drug Disease Association (DDA) https://github.com/haichengyi/DDIPre Case studies NA NA Zoledronic acid NA Top 10 diseases 34074242 BMC Bioinformatics 2021
36 77.35 1367 Fdataset Drug, Disease Drug: SMILES, Disease: Phenotype DDIPred Deep gated recurrent units model Drug Disease Association (DDA) https://github.com/haichengyi/DDIPre Case studies NA NA Dexamethasone NA Top 15 diseases 34074242 BMC Bioinformatics 2021
36 77.35 1367 Cdataset Drug, Disease Drug: SMILES, Disease: Phenotype DDIPred Deep gated recurrent units model Drug Disease Association (DDA) https://github.com/haichengyi/DDIPre Case studies NA NA Zoledronic acid NA Top 10 diseases 34074242 BMC Bioinformatics 2021
37 77.3 957 NA Drug, Disease, Target NA BiFusion (Bipartite graph convolution network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/zcwang0702/BiFusion Case studies Breast carcinoma NA NA NA Top 5 drugs 32657387 Bioinformatics 2020
37 77.3 957 NA Drug, Disease, Target NA BiFusion (Bipartite graph convolution network) Graph Convolutional Network (GCN) Drug Disease Association (DDA) https://github.com/zcwang0702/BiFusion Case studies Parkinson’s Disease (PD) NA NA NA Top 10 drugs 32657387 Bioinformatics 2020
38 77.25 739 Cdataset Drug, Disease Drug: Fingerprint, Diseases: MeSH terms GIPAE (Gaussian interaction profile kernel and autoencoder) Deep Autoencoder,Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/GIPAE Case studies Obesity NA NA NA Top 20 drug 31534955 Biomed Res Int 2019
38 77.25 739 Cdataset Drug, Disease Drug: Fingerprint, Diseases: MeSH terms GIPAE (Gaussian interaction profile kernel and autoencoder) Deep Autoencoder,Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/GIPAE Case studies Alzheimer's Disease (AD) NA NA NA Top 20 drug 31534955 Biomed Res Int 2019
38 77.25 739 Fdataset Drug, Disease Drug: Fingerprint, Diseases: MeSH terms GIPAE (Gaussian interaction profile kernel and autoencoder) Deep Autoencoder,Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/GIPAE Case studies Obesity NA NA NA Top 20 drug 31534955 Biomed Res Int 2019
38 77.25 739 Fdataset Drug, Disease Drug: Fingerprint, Diseases: MeSH terms GIPAE (Gaussian interaction profile kernel and autoencoder) Deep Autoencoder,Support Vector Machine (SVM) Drug Disease Association (DDA) https://github.com/HanJingJiang/GIPAE Case studies Alzheimer's Disease (AD) NA NA NA Top 20 drug 31534955 Biomed Res Int 2019
39 77.2 949 NA Drug, Disease, Target Drug: SMILES, Target: target sequence data in FASTA format Disease: MeSH TS-SVD Random Forest (RF) Drug Disease Association (DDA) NA Case studies Non-Small Cell Lung Cancer (NSCLC) NA NA NA Top 10 drugs 32340956 IEEE Trans Nanobioscience 2020
40 76.8 720 Cdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Doxorubicin NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Doxorubicin NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 1532 Fdataset Drug, Disease Drug: Chemical structure, Disease: MeSH LMFDA Inductive matrix Drug Disease Association (DDA) https://github.com/hupengwei/LMFDA_Dataset Case studies Type 2 Diabetes Mellitus (T2DM) NA NA NA Top 10 drugs 34736437 BMC Med Inform Decis Mak 2021
40 76.8 720 DNdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Doxorubicin NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 DNdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Amantadine NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Cdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Amantadine NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Amantadine NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 1532 Fdataset Drug, Disease Drug: Chemical structure, Disease: MeSH LMFDA Inductive matrix Drug Disease Association (DDA) https://github.com/hupengwei/LMFDA_Dataset Case studies Ischemic stroke NA NA NA Top 10 drugs 34736437 BMC Med Inform Decis Mak 2021
40 76.8 1532 Cdataset Drug, Disease Drug: Chemical structure, Disease: MeSH LMFDA Inductive matrix Drug Disease Association (DDA) https://github.com/hupengwei/LMFDA_Dataset Case studies Type 2 Diabetes Mellitus (T2DM) NA NA NA Top 10 drugs 34736437 BMC Med Inform Decis Mak 2021
40 76.8 720 DNdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Flecainide NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Cdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Flecainide NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Flecainide NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Levodopa NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 1532 Cdataset Drug, Disease Drug: Chemical structure, Disease: MeSH LMFDA Inductive matrix Drug Disease Association (DDA) https://github.com/hupengwei/LMFDA_Dataset Case studies Ischemic stroke NA NA NA Top 10 drugs 34736437 BMC Med Inform Decis Mak 2021
40 76.8 720 DNdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Levodopa NA Top 5 diseases 31510658 Bioinformatics 2019
40 76.8 720 Cdataset Drug, Disease NA BNNR (Bounded Nuclear Norm Regularization) Matrix Completion Drug Disease Association (DDA) https://github.com/BioinformaticsCSU/BNNR Case studies NA NA Levodopa NA Top 5 diseases 31510658 Bioinformatics 2019
41 76.6 1691 NA Drug, Target Drug: SMILES, Target: amino-acid sequences NA Convolutional Neural Network (CNN),Deep Neural Network (DNN),Random Forest (RF) Drug Target Interaction (DTI) https://github.com/Shkev/Sars-CoV-2-NSP-Predictions Case studies NA NA NA Drug target interaction 13 predictions 35468672 Front Biosci (Landmark Ed) 2022
42 76.54 1197 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Sparfloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 Fdataset Drug, Disease Drug: SMILES; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Triamcinolone NA Top 6 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 Fdataset Drug, Disease Drug: SMILES; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Dexamethasone NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 SND Drug, Disease NA SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Levofloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 SND Drug, Disease NA SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Loteprednol NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Triamcinolone NA Top 6 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Dexamethasone NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 Fdataset Drug, Disease Drug: SMILES; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Levofloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 SND Drug, Disease NA SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Sparfloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Levofloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 Fdataset Drug, Disease Drug: SMILES; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Loteprednol NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 Fdataset Drug, Disease Drug: SMILES; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Sparfloxacin NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 SND Drug, Disease NA SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Triamcinolone NA Top 6 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 SND Drug, Disease NA SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Dexamethasone NA Top 7 diseases 33482713 BMC Bioinformatics 2021
42 76.54 1197 LRSSL Drug, Disease Drug: drug chemical structure, Pfam domain annotation of drug targets, gene ontology term of targets; Disease: Phenotye SNF-NN (Similarity network fusion and neural networks) Similarity Network Fusion (SNF),Neural Network Drug Disease Association (DDA) http://pages.cpsc.ucalgary.ca/ tnjarada/snf-nn.php Case studies NA NA Loteprednol NA Top 7 diseases 33482713 BMC Bioinformatics 2021
43 76.5 1776 BIOSNAP Drug, Target Drug: SMILES, Target: the amino acid sequences DeepFusion Graph Convolutional Network (GCN),Transformer Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 14 predictions 35219861 Methods 2022
43 76.5 1776 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences DeepFusion Graph Convolutional Network (GCN),Transformer Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 14 predictions 35219861 Methods 2022
44 76.425 2070 Cdataset Drug, Disease Drug: RDKit fingerprints, Disease: MeSH TNA-DR (Tail-Node Augmentation for Drug Repositioning) Graph Neural Network (GNN) Drug Disease Association (DDA) NA Case studies Lung neoplasms NA NA NA Top 10 drugs 37418410 IEEE/ACM Trans Comput Biol Bioinform 2023
44 76.425 2070 LRSSL Drug, Disease Drug: RDKit fingerprints, Disease: MeSH TNA-DR (Tail-Node Augmentation for Drug Repositioning) Graph Neural Network (GNN) Drug Disease Association (DDA) NA Case studies Lung neoplasms NA NA NA Top 10 drugs 37418410 IEEE/ACM Trans Comput Biol Bioinform 2023
44 76.425 2070 RepoDB Drug, Disease Drug: RDKit fingerprints, Disease: MeSH TNA-DR (Tail-Node Augmentation for Drug Repositioning) Graph Neural Network (GNN) Drug Disease Association (DDA) NA Case studies Lung neoplasms NA NA NA Top 10 drugs 37418410 IEEE/ACM Trans Comput Biol Bioinform 2023
44 76.425 2070 Fdataset Drug, Disease Drug: RDKit fingerprints, Disease: MeSH TNA-DR (Tail-Node Augmentation for Drug Repositioning) Graph Neural Network (GNN) Drug Disease Association (DDA) NA Case studies Lung neoplasms NA NA NA Top 10 drugs 37418410 IEEE/ACM Trans Comput Biol Bioinform 2023
45 76.4 1394 DTINet Drug, Disease, Target, Side-effect Drug: structure, Target: sequence LUNAR Graph Convolutional Network (GCN) Drug Target Interaction (DTI) NA Case studies COVID-19 Nterleukin-l beta NA NA Top 5 drugs 34081583 IEEE/ACM Trans Comput Biol Bioinform 2021
45 76.4 1394 DTINet Drug, Disease, Target, Side-effect Drug: structure, Target: sequence LUNAR Graph Convolutional Network (GCN) Drug Target Interaction (DTI) NA Case studies COVID-19 ACE2 NA NA Top 8 drugs 34081583 IEEE/ACM Trans Comput Biol Bioinform 2021
45 76.4 1394 DTINet Drug, Disease, Target, Side-effect Drug: structure, Target: sequence LUNAR Graph Convolutional Network (GCN) Drug Target Interaction (DTI) NA Case studies COVID-19 Tumor necrosis factor NA NA Top 10 drugs 34081583 IEEE/ACM Trans Comput Biol Bioinform 2021
46 76.3 2145 Davis Drug, Target Drug: SMILES, Target: The amino acid Sequence. MdDTI Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/lhhu1999/MdDTI Case studies COVID-19 SARS-CoV-2 3C-like protease NA NA Top 5 drugs 37844375 Comput Biol Chem 2023
46 76.3 2145 KIBA Drug, Target Drug: SMILES, Target: The amino acid Sequence. MdDTI Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/lhhu1999/MdDTI Case studies COVID-19 SARS-CoV-2 3C-like protease NA NA Top 5 drugs 37844375 Comput Biol Chem 2023
47 76.1 298 NA Compound, Target Compound: SMILES, Target: Sequence REMAP Dual Regularized One-Class Collaborative Filtering Compound Protein Interaction (CPI) https://github.com/hansaimlim/REMAP Case studies Many types of cancer NA NA NA Top 7 drugs 27716836 PLoS Comput Biol 2016
47 76.1 1487 NA Drug, Gene NA GraphRepur Graph Neural Network (GNN) Drug Disease Association (DDA) https://github.com/cckamy/GraphRepur Case studies Breast cancer NA NA NA Top 30 drugs 33739367 Bioinformatics 2021
48 76 1578 NA Drug, Target Drug: chemical structures, Target: primary sequence GANDTI Generative Adversarial Network (GAN),Graph convolutional autoencoder Drug Target Interaction (DTI) NA Case studies NA NA Clozapine NA Top 10 targets 32750854 IEEE/ACM Trans Comput Biol Bioinform 2022
48 76 320 Cdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms TP-NRWRH Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/td1799/TP-NRWRH Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 28155639 BMC Bioinformatics 2016
48 76 2093 KIBA Drug, Target Drug: SMILES, Target: the amino acid sequences DGDTA Graph Attention Network (GAT),Graph Convolutional Network (GCN),Bidirectional Long Short-Term Memory (Bi-LSTM),Multilayer Convolutional Network Drug Target binding Affinity (DTA) https://github.com/luojunwei/DGDTA Case studies NA Receptor Tyrosine Kinases (RTKs) NA NA Top 1 drug 37777712 BMC Bioinformatics 2023
48 76 1578 NA Drug, Target Drug: chemical structures, Target: primary sequence GANDTI Generative Adversarial Network (GAN),Graph convolutional autoencoder Drug Target Interaction (DTI) NA Case studies NA NA Olanzapine NA Top 10 targets 32750854 IEEE/ACM Trans Comput Biol Bioinform 2022
48 76 1578 NA Drug, Target Drug: chemical structures, Target: primary sequence GANDTI Generative Adversarial Network (GAN),Graph convolutional autoencoder Drug Target Interaction (DTI) NA Case studies NA NA Aripiprnazole NA Top 10 targets 32750854 IEEE/ACM Trans Comput Biol Bioinform 2022
48 76 320 Fdataset Drug, Disease Drug: SMILES, Diseases: MeSH terms TP-NRWRH Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/td1799/TP-NRWRH Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 28155639 BMC Bioinformatics 2016
48 76 2093 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences DGDTA Graph Attention Network (GAT),Graph Convolutional Network (GCN),Bidirectional Long Short-Term Memory (Bi-LSTM),Multilayer Convolutional Network Drug Target binding Affinity (DTA) https://github.com/luojunwei/DGDTA Case studies NA Receptor Tyrosine Kinases (RTKs) NA NA Top 1 drug 37777712 BMC Bioinformatics 2023
48 76 1578 NA Drug, Target Drug: chemical structures, Target: primary sequence GANDTI Generative Adversarial Network (GAN),Graph convolutional autoencoder Drug Target Interaction (DTI) NA Case studies NA NA Ziprasidone NA Top 10 targets 32750854 IEEE/ACM Trans Comput Biol Bioinform 2022
48 76 1578 NA Drug, Target Drug: chemical structures, Target: primary sequence GANDTI Generative Adversarial Network (GAN),Graph convolutional autoencoder Drug Target Interaction (DTI) NA Case studies NA NA Quetiapine NA Top 10 targets 32750854 IEEE/ACM Trans Comput Biol Bioinform 2022
49 75.8 308 Positive dataset Drug, Target Drug: SMILES, Target: The primary sequence dtipred Random Forest (RF) Drug Target Interaction (DTI) http://bioinformatics.ua.pt/software/dtipred/ Case studies Methicillin-resistant Staphylococcus aureus (DNA-directed RNA polymerase subunit alpha_Q5HDY4, 30S ribosomal protein S12_Q5HID0, DNA-directed RNA polymerase subunit beta_Q5HID3, Accessory Sec system protein translocase subunit SecY2_Q5HCP4, 30S ribosomal protein S15_Q5HGF8, Elongation factor G_Q5HIC8, 50S ribosomal protein L22_Q5HDW3, 30S ribosomal protein S3_Q5HDW4, 50S ribosomal protein L13_Q5HDZ0, 50S ribosomal protein L25_Q5HIH4) NA NA Top 5 drugs 27893735 PLoS Comput Biol 2016
49 75.8 308 Negative dataset Drug, Target Drug: SMILES, Target: The primary sequence dtipred Random Forest (RF) Drug Target Interaction (DTI) http://bioinformatics.ua.pt/software/dtipred/ Case studies Methicillin-resistant Staphylococcus aureus (DNA-directed RNA polymerase subunit alpha_Q5HDY4, 30S ribosomal protein S12_Q5HID0, DNA-directed RNA polymerase subunit beta_Q5HID3, Accessory Sec system protein translocase subunit SecY2_Q5HCP4, 30S ribosomal protein S15_Q5HGF8, Elongation factor G_Q5HIC8, 50S ribosomal protein L22_Q5HDW3, 30S ribosomal protein S3_Q5HDW4, 50S ribosomal protein L13_Q5HDZ0, 50S ribosomal protein L25_Q5HIH4) NA NA Top 5 drugs 27893735 PLoS Comput Biol 2016
50 75.6 894 Training Data-(DrugBank (v4.3), TTD, PharmGKB) Drug, Disease, Target , Side-effect Drug: SMILES, targets: Uniprot ID AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest) Deep Forest Classifier Drug Target Interaction (DTI) https://github.com/ChengF-Lab/AOPEDF Case studies Substance abuse disorder G-protein-coupled receptors (GPCRs) NA NA Top 20 drugs 31971579 Bioinformatics 2020
50 75.6 894 Validations-DrugCentral Drug, Target Drug: SMILES, targets: Uniprot ID AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest) Deep Forest Classifier Drug Target Interaction (DTI) https://github.com/ChengF-Lab/AOPEDF Case studies Substance abuse disorder G-protein-coupled receptors (GPCRs) NA NA Top 20 drugs 31971579 Bioinformatics 2020
50 75.6 894 Validations-ChEMBL Drug, Target Drug: SMILES, targets: Uniprot ID AOPEDF (Arbitrary-Order Proximity Embedded Deep Forest) Deep Forest Classifier Drug Target Interaction (DTI) https://github.com/ChengF-Lab/AOPEDF Case studies Substance abuse disorder G-protein-coupled receptors (GPCRs) NA NA Top 20 drugs 31971579 Bioinformatics 2020
51 75 2066 Fdataset Drug, Disease Drug: SMILES, Disease: the medical description information SSLDR Matrix Factorization Drug Disease Association (DDA) NA Case studies NA NA Doxorubicin, Gemcitabine, Vincristine NA Top 5 diseases 37028367 IEEE/ACM Trans Comput Biol Bioinform 2023
51 75 2066 Cdataset Drug, Disease Drug: SMILES, Disease: the medical description information SSLDR Matrix Factorization Drug Disease Association (DDA) NA Case studies NA NA Doxorubicin, Gemcitabine, Vincristine NA Top 5 diseases 37028367 IEEE/ACM Trans Comput Biol Bioinform 2023
51 75 2066 DNdataset Drug, Disease Drug: SMILES, Disease: the medical description information SSLDR Matrix Factorization Drug Disease Association (DDA) NA Case studies NA NA Doxorubicin, Gemcitabine, Vincristine NA Top 5 diseases 37028367 IEEE/ACM Trans Comput Biol Bioinform 2023
52 74.3 694 NA Drug, Target Drug: Chemical structure, Target: target sequence LASSO Deep Neural Network (DNN) Drug Target Interaction (DTI) NA Case studies Breast Cancer NA NA NA Top 5 drugs 30939415 Comput Biol Chem 2019
53 73.9 2102 DDKG-V1 Drug, Disease, Target, Gene NA DrugRep-HeSiaGraph Siamese Neural Network (SNN) Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-HeSiaGraph Case studies COVID-19 Dipeptidyl Peptidase 4 (DPP-4) NA NA Top 10 drugs 37789314 BMC Bioinformatics 2023
54 73.7 1032 Fdataset Drug, Disease Drug: SMILES, Disease: Phenotye NEDD Random Forest (RF),Random Walk (RW) Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 15 predictions 32938396 BMC Bioinformatics 2020
55 73.5 1683 RPD-Net Drug, Disease, Target Drug: chemical substructures, Target: the primary sequences DNDTI Non-negative Matrix Factorization (NMF) Drug Target Interaction (DTI) NA Case studies NA NA Asenapine NA Top 10 targets 34673498 IEEE J Biomed Health Inform 2022
55 73.5 717 LRSSL Drug, Disease Drug: chemical substructure, chemical fingerprints, Disease: MeSH CBPred Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) Drug Disease Association (DDA) NA Case studies NA NA Ofloxacin NA Top 10 diseases 31336774 Cells 2019
55 73.5 1683 RPD-Net Drug, Disease, Target Drug: chemical substructures, Target: the primary sequences DNDTI Non-negative Matrix Factorization (NMF) Drug Target Interaction (DTI) NA Case studies NA NA Amitriptyline NA Top 10 targets 34673498 IEEE J Biomed Health Inform 2022
55 73.5 717 LRSSL Drug, Disease Drug: chemical substructure, chemical fingerprints, Disease: MeSH CBPred Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) Drug Disease Association (DDA) NA Case studies NA NA Ampicillin NA Top 10 diseases 31336774 Cells 2019
55 73.5 1683 RPD-Net Drug, Disease, Target Drug: chemical substructures, Target: the primary sequences DNDTI Non-negative Matrix Factorization (NMF) Drug Target Interaction (DTI) NA Case studies NA NA Clozapine NA Top 10 targets 34673498 IEEE J Biomed Health Inform 2022
55 73.5 1683 RPD-Net Drug, Disease, Target Drug: chemical substructures, Target: the primary sequences DNDTI Non-negative Matrix Factorization (NMF) Drug Target Interaction (DTI) NA Case studies NA NA Olanzapine NA Top 10 targets 34673498 IEEE J Biomed Health Inform 2022
55 73.5 717 LRSSL Drug, Disease Drug: chemical substructure, chemical fingerprints, Disease: MeSH CBPred Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) Drug Disease Association (DDA) NA Case studies NA NA Ciprofloxacin NA Top 10 diseases 31336774 Cells 2019
55 73.5 717 LRSSL Drug, Disease Drug: chemical substructure, chemical fingerprints, Disease: MeSH CBPred Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) Drug Disease Association (DDA) NA Case studies NA NA Levofloxacin NA Top 10 diseases 31336774 Cells 2019
55 73.5 1683 RPD-Net Drug, Disease, Target Drug: chemical substructures, Target: the primary sequences DNDTI Non-negative Matrix Factorization (NMF) Drug Target Interaction (DTI) NA Case studies NA NA Aripiprazole NA Top 10 targets 34673498 IEEE J Biomed Health Inform 2022
55 73.5 717 LRSSL Drug, Disease Drug: chemical substructure, chemical fingerprints, Disease: MeSH CBPred Convolutional Neural Network (CNN),Bidirectional Long Short-Term Memory (Bi-LSTM) Drug Disease Association (DDA) NA Case studies NA NA Ceftriaxone NA Top 10 diseases 31336774 Cells 2019
56 73.2 1981 BindingDB Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA NA Fludiazepam NA Top 20 targets 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 20 drugs 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 BindingDB Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 20 drugs 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 KIBA Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA NA Fludiazepam NA Top 20 targets 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 DrugBank Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA NA Fludiazepam NA Top 20 targets 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 DrugBank Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 20 drugs 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 KIBA Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA Epidermal Growth Factor Receptor (EGFR) NA NA Top 20 drugs 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
56 73.2 1981 Davis Drug, Target Drug: SMILES, Target: the amino acid sequences GIFDTI Convolutional Neural Network (CNN),Transformer Drug Target Interaction (DTI) https://github.com/zhaoqichang/GIFDTI Case studies NA NA Fludiazepam NA Top 20 targets 36445997 IEEE/ACM Trans Comput Biol Bioinform 2023
57 72.6 1614 DrugBank Drug Drug: enzymes, side effects, substructures and targets GCNMK Graph Convolutional Network with multi-kernel (GCNMK) Drug Drug Interaction (DDI) NA Case studies Lung neoplasms NA NA NA Top 10 drugs 34864856 Brief Bioinform 2022
57 72.6 1614 DrugBank Drug Drug: enzymes, side effects, substructures and targets GCNMK Graph Convolutional Network with multi-kernel (GCNMK) Drug Drug Interaction (DDI) NA Case studies Breast neoplasms NA NA NA Top 10 drugs 34864856 Brief Bioinform 2022
57 72.6 1614 DrugBank Drug Drug: enzymes, side effects, substructures and targets GCNMK Graph Convolutional Network with multi-kernel (GCNMK) Drug Drug Interaction (DDI) NA Case studies Colorectal neoplasms NA NA NA Top 10 drugs 34864856 Brief Bioinform 2022
58 72.5 741 NA Drug, Target Drug: structure, Target: sequence NA Low Rank Embedding (LRE) Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 30 predictions 28541222 IEEE/ACM Trans Comput Biol Bioinform 2019
58 72.5 764 NA Drug, Target Drug: structure, Target: sequence MCM Matrix Completion Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 26 predictions 31538961 IET Syst Biol 2019
59 72.35 812 External validation set NA NA deepDR Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/ChengF-Lab/deepDR Case studies Parkinson’s Disease (PD) NA NA NA Top 20 drugs 31116390 Bioinformatics 2019
59 72.35 812 NA Drug, Disease, Target , Side-effect NA deepDR Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/ChengF-Lab/deepDR Case studies Alzheimer's Disease (AD) NA NA NA Top 20 drugs 31116390 Bioinformatics 2019
59 72.35 812 NA Drug, Disease, Target , Side-effect NA deepDR Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/ChengF-Lab/deepDR Case studies Parkinson’s Disease (PD) NA NA NA Top 20 drugs 31116390 Bioinformatics 2019
59 72.35 812 External validation set NA NA deepDR Multimodal deep autoencoder (MDA),Collective variational autoencoder (cVAE),Random Walk with Restart (RWR) Drug Disease Association (DDA) https://github.com/ChengF-Lab/deepDR Case studies Alzheimer's Disease (AD) NA NA NA Top 20 drugs 31116390 Bioinformatics 2019
60 72.3 125 NA Drug, Disease Drug: structure chemical, target, side-effect; Diseases: disease phenotypes, disease ontology, disease genes DDR Block Coordinate Descent (BCD) Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 25954437 AMIA Annu Symp Proc 2014
60 72.3 1765 BindingDB Drug, Target Drug: SMILES, Target: binding site AttentionSiteDTI Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) Drug Target Interaction (DTI) https://github.com/yazdanimehdi/AttentionSiteDTI Case studies COVID-19 SARS-CoV-2 NA NA Top 7 drugs 35817396 Brief Bioinform 2022
60 72.3 125 NA Drug, Disease Drug: structure chemical, target, side-effect; Diseases: disease phenotypes, disease ontology, disease genes DDR Block Coordinate Descent (BCD) Drug Disease Association (DDA) NA Case studies Systemic Lupus Erythematosus (SLE) NA NA NA Top 10 drugs 25954437 AMIA Annu Symp Proc 2014
60 72.3 1765 DUD-E Drug, Target Drug: SMILES, Target: binding site AttentionSiteDTI Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) Drug Target Interaction (DTI) https://github.com/yazdanimehdi/AttentionSiteDTI Case studies COVID-19 SARS-CoV-2 NA NA Top 7 drugs 35817396 Brief Bioinform 2022
60 72.3 1765 Human Drug, Target Drug: SMILES, Target: binding site AttentionSiteDTI Bidirectional Long Short-Term Memory (Bi-LSTM),Graph Convolutional Network (GCN),Multi-Layer Perceptron (MLP) Drug Target Interaction (DTI) https://github.com/yazdanimehdi/AttentionSiteDTI Case studies COVID-19 SARS-CoV-2 NA NA Top 7 drugs 35817396 Brief Bioinform 2022
61 72.15 2125 NA Drug, Target, Pathway, Phenotype NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Left ventricular hypertrophy NA NA NA Top 1 drug 37925215 Artif Intell Med 2023
61 72.15 2125 RepoDB Drug, Disease NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Congestive heart failure NA NA NA Top 2 drugs 37925215 Artif Intell Med 2023
61 72.15 2125 RepoDB Drug, Disease NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Rheumatoid arthritis NA NA NA Top 2 drugs 37925215 Artif Intell Med 2023
61 72.15 2125 NA Drug, Target, Pathway, Phenotype NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Congestive heart failure NA NA NA Top 2 drugs 37925215 Artif Intell Med 2023
61 72.15 2125 NA Drug, Target, Pathway, Phenotype NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Rheumatoid arthritis NA NA NA Top 2 drugs 37925215 Artif Intell Med 2023
61 72.15 2125 RepoDB Drug, Disease NA BEHOR Graph Neural Network (GNN) Drug Disease Association (DDA) https://zenodo.org/record/8402843 Case studies Left ventricular hypertrophy NA NA NA Top 1 drug 37925215 Artif Intell Med 2023
62 72.1 2022 KEGG Drug, Disease, Gene, Pathway Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 37322032 Nat Commun 2023
62 72.1 2022 Multi-scale interactome (MSI) network Drug, Disease, Gene Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 37322032 Nat Commun 2023
62 72.1 2022 HetioNet Drug, Disease, Gene, Pathway Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Breast cancer NA NA NA Top 10 drugs 37322032 Nat Commun 2023
62 72.1 1244 NA Drug, Disease Drug: chemical structural, CMLDR Collaborative metric learning algorithm Drug Disease Association (DDA) NA Case studies NA NA Risperidone NA Top 20 diseases 31283509 IEEE/ACM Trans Comput Biol Bioinform 2021
62 72.1 2022 HetioNet Drug, Disease, Gene, Pathway Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 37322032 Nat Commun 2023
62 72.1 2022 Multi-scale interactome (MSI) network Drug, Disease, Gene Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Breast cancer NA NA NA Top 10 drugs 37322032 Nat Commun 2023
62 72.1 1244 NA Drug, Disease Drug: chemical structural, CMLDR Collaborative metric learning algorithm Drug Disease Association (DDA) NA Case studies NA NA Cyclophosphamide NA Top 20 diseases 31283509 IEEE/ACM Trans Comput Biol Bioinform 2021
62 72.1 2022 KEGG Drug, Disease, Gene, Pathway Drug: ATC, Disease: MeSH DREAMwalk Multi-layer random walk Drug Disease Association (DDA) https://github.com/eugenebang/DREAMwalk Case studies Breast cancer NA NA NA Top 10 drugs 37322032 Nat Commun 2023
63 71.75 424 NA Drug, Disease, Gene Drug: SMILES, Disease: MeSH SSGC (Semi-Supervised Graph Cut) Semi-supervised graph cut Drug Disease Association (DDA) NA Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 20 drugs 29297383 BMC Med Genomics 2017
63 71.75 424 NA Drug, Disease, Gene Drug: SMILES, Disease: MeSH SSGC (Semi-Supervised Graph Cut) Semi-supervised graph cut Drug Disease Association (DDA) NA Case studies Huntington Disease (HD) NA NA NA Top 20 drugs 29297383 BMC Med Genomics 2017
63 71.75 424 NA Drug, Disease, Gene Drug: SMILES, Disease: MeSH SSGC (Semi-Supervised Graph Cut) Semi-supervised graph cut Drug Disease Association (DDA) NA Case studies Non-Small Cell Lung Cancer (NSCLC) NA NA NA Top 20 drugs 29297383 BMC Med Genomics 2017
63 71.75 424 NA Drug, Disease, Gene Drug: SMILES, Disease: MeSH SSGC (Semi-Supervised Graph Cut) Semi-supervised graph cut Drug Disease Association (DDA) NA Case studies Alcohol dependence NA NA NA Top 20 drugs 29297383 BMC Med Genomics 2017
64 71.7 771 Fdataset Drug, Disease Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) Random Walk Drug Disease Association (DDA) NA Case studies Huntington Disease (HD) NA NA NA Top 5 drugs 29994051 IEEE/ACM Trans Comput Biol Bioinform 2019
64 71.7 771 Fdataset Drug, Disease Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) Random Walk Drug Disease Association (DDA) NA Case studies Parkinson’s Disease (PD) NA NA NA Top 5 drugs 29994051 IEEE/ACM Trans Comput Biol Bioinform 2019
64 71.7 771 Fdataset Drug, Disease Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) Random Walk Drug Disease Association (DDA) NA Case studies Breast cancer NA NA NA Top 5 drugs 29994051 IEEE/ACM Trans Comput Biol Bioinform 2019
64 71.7 771 Fdataset Drug, Disease Drug: SMILES, Proten: the amino acid sequence, Diseases: MeSH terms RWHNDR (Random Walk on a Heterogeneous Network for Drug Repositioning) Random Walk Drug Disease Association (DDA) NA Case studies Lung cancer NA NA NA Top 5 drugs 29994051 IEEE/ACM Trans Comput Biol Bioinform 2019
65 71.64285714 343 NR Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 Global Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 GPCR Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 External_GPCR Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 Kinases Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 External _Kinases Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
65 71.64285714 343 IC Drug, Target Drug: SMILES, Target: The primary sequence SDTNBI (Substructure–drug–target network-based inference) NetInfer package Drug Target Interaction (DTI) NA Case studies NA NA NSAIDs NA 3 targets 26944082 Brief Bioinform 2017
66 71.2 997 NA Drug Drug: structure, distance, target CATNIP XGBoost Drug Drug Interaction (DDI) https://github.com/coryandar/CATNIP Case studies Parkinson’s Disease (PD) NA NA NA 2 drugs 32764756 PLoS Comput Biol 2020
66 71.2 997 NA Drug Drug: structure, distance, target CATNIP XGBoost Drug Drug Interaction (DDI) https://github.com/coryandar/CATNIP Case studies Type 2 Diabetes Mellitus (T2DM) NA NA NA 1 drug 32764756 PLoS Comput Biol 2020
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Tolmetin NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Tacrolimus NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Ziprasidone NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Fenoprofen NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Nimodipine NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Citalopram NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Progesterone NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Dextromethorphan NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Yohimbine NA Top 5 diseases 28096083 Bioinformatics 2017
67 71.04 361 LRSSL Drug, Disease Drug: chemical fingerprints, target target domain, target gene ontology annotation; Disease: MeSH LRSSL (Laplacian regularized sparse subspace learning) Laplacian regularized sparse subspace learning Drug Disease Association (DDA) https://github.com/LiangXujun/LRSSL Case studies NA NA Thiopental NA Top 5 diseases 28096083 Bioinformatics 2017
68 70.9 1796 Zhang's dataset Drug, Disease Drug: SMILES, Disease: Mesh semantic GraphPK (Graph-based Prior Knowledge) Multimodal neural network Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 10 predictions 34375284 IEEE/ACM Trans Comput Biol Bioinform 2022
68 70.9 1796 Zhang's dataset Drug, Disease Drug: SMILES, Disease: Mesh semantic GraphPK (Graph-based Prior Knowledge) Multimodal neural network Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 10 predictions 34375284 IEEE/ACM Trans Comput Biol Bioinform 2022
68 70.9 1796 Amazon's dataset Drug, Disease Drug: SMILES, Disease: Mesh semantic GraphPK (Graph-based Prior Knowledge) Multimodal neural network Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 10 predictions 34375284 IEEE/ACM Trans Comput Biol Bioinform 2022
69 70.85 1798 dataset 2 Drug, Disease, Gene NA NEDNBI Network-Based Inference Drug Disease Association (DDA) https://github.com/Qli97/NEDNBI Case studies COVID-19 NA NA NA Top 20 drugs 35338586 Mol Inform 2022
69 70.85 1798 dataset 1 Drug, Disease, Gene NA NEDNBI Network-Based Inference Drug Disease Association (DDA) https://github.com/Qli97/NEDNBI Case studies COVID-19 NA NA NA Top 20 drugs 35338586 Mol Inform 2022
70 70.8 1516 Zhang's book Drug, Target Drug: chemical structure, side-effect; Disease: UMLS DRDA Deep Autoencoder,Adaptive Fusion Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 34717542 BMC Bioinformatics 2021
70 70.8 1516 Zhang's book Side-effect Drug: chemical structure, side-effect; Disease: UMLS DRDA Deep Autoencoder,Adaptive Fusion Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 34717542 BMC Bioinformatics 2021
70 70.8 1516 Zhang's book Drug, Disease Drug: chemical structure, side-effect; Disease: UMLS DRDA Deep Autoencoder,Adaptive Fusion Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 34717542 BMC Bioinformatics 2021
71 70.4 1866 Fdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 150 Yamanishi_NR Drug, Target Drug: chemical sturcture, Target: target sequence NA Adaptive combination Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 5 predictions 26543857 Biomed Res Int 2015
71 70.4 1866 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 1866 Fdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Breast cancer NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 1866 Bdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Breast cancer NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 150 Yamanishi_E Drug, Target Drug: chemical sturcture, Target: target sequence NA Adaptive combination Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 5 predictions 26543857 Biomed Res Int 2015
71 70.4 150 Yamanishi_IC Drug, Target Drug: chemical sturcture, Target: target sequence NA Adaptive combination Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 5 predictions 26543857 Biomed Res Int 2015
71 70.4 1866 Cdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 1866 Cdataset Drug, Disease, Target Drug: SMILES, Disease: MeSH, Target: sequence DDAGDL Geometric Deep Learning (GDL),XGBoost Drug Disease Association (DDA) https://github.com/stevejobws/DDAGDL Case studies Breast cancer NA NA NA Top 10 drugs 36125202 Brief Bioinform 2022
71 70.4 150 Yamanishi_GPCR Drug, Target Drug: chemical sturcture, Target: target sequence NA Adaptive combination Drug Target Interaction (DTI) NA Case studies NA NA NA Drug target interaction Top 5 predictions 26543857 Biomed Res Int 2015
71 70.4 2046 aBiofilm Drug Drug: SMILES, Anti-Biofilm Support Vector Machine (SVM) Drug Target Interaction (DTI) https://bioinfo.imtech.res.in/manojk/antibiofilm/ Case studies Antimicrobial resistance biofilm NA NA Top 25 drugs 37356913 J Mol Biol 2023
72 70.1 789 NA Drug, Disease Drug: SMILES, Diseases: MeSH terms NA Non-linear computational approach Drug Disease Association (DDA) http://bioinformatics.aut.ac.ir/drug-disc/ (Data) Case studies NA NA NA Drug disease interaction Top 16 predictions 31726977 BMC Bioinformatics 2019
73 70 14 Fdataset Drug, Disease Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic PREDICT (PREdicting Drug IndiCaTions) Logistic Regression Drug Disease Association (DDA) NA Case studies Migrane NA NA NA 1 drug 21654673 Mol Syst Biol 2011
73 70 14 Fdataset Drug, Disease Drug: SMILES, Gene sequence , GO, side-effect, PPI network; Diseases: MeSH, Genetic PREDICT (PREdicting Drug IndiCaTions) Logistic Regression Drug Disease Association (DDA) NA Case studies Non-papillary renal cell cancer NA NA NA 1 drug 21654673 Mol Syst Biol 2011
74 69.38 122 NA Drug, Disease, Target Drug: SMILES, Target: target sequence, Disease: MeSH terms TL_HGBI (Triple Layer Heterogeneous Graph Based Inference) Heterogeneous Graph Based Inference (HGBI) Drug Disease Association (DDA) NA Case studies Non-Small Cell Lung Cancer (NSCLC) NA NA NA Top 10 drugs 24974205 Bioinformatics 2014
74 69.38 122 NA Drug, Disease, Target Drug: SMILES, Target: target sequence, Disease: MeSH terms TL_HGBI (Triple Layer Heterogeneous Graph Based Inference) Heterogeneous Graph Based Inference (HGBI) Drug Disease Association (DDA) NA Case studies Alcohol dependence NA NA NA Top 10 drugs 24974205 Bioinformatics 2014
74 69.38 122 NA Drug, Disease, Target Drug: SMILES, Target: target sequence, Disease: MeSH terms TL_HGBI (Triple Layer Heterogeneous Graph Based Inference) Heterogeneous Graph Based Inference (HGBI) Drug Disease Association (DDA) NA Case studies Small Cell Lung Cancer (SCLC) NA NA NA Top 10 drugs 24974205 Bioinformatics 2014
74 69.38 122 NA Drug, Disease, Target Drug: SMILES, Target: target sequence, Disease: MeSH terms TL_HGBI (Triple Layer Heterogeneous Graph Based Inference) Heterogeneous Graph Based Inference (HGBI) Drug Disease Association (DDA) NA Case studies Huntington Disease (HD) NA NA NA Top 10 drugs 24974205 Bioinformatics 2014
74 69.38 122 NA Drug, Disease, Target Drug: SMILES, Target: target sequence, Disease: MeSH terms TL_HGBI (Triple Layer Heterogeneous Graph Based Inference) Heterogeneous Graph Based Inference (HGBI) Drug Disease Association (DDA) NA Case studies Polysubstance abuse NA NA NA Top 10 drugs 24974205 Bioinformatics 2014
75 69.1 1913 drug ECR Drug, Disease NA DRONet Network embedding (NE) Drug Disease Association (DDA) https://github.com/yangkuoone/DRONet Case studies Diabetes NA NA NA Top 10 drugs 36562715 Brief Bioinform 2023
76 68.9 813 DTD Drug, Disease, Target Drug: chemical structure, Target: the amino acid sequences NA Tensor decomposition Drug Disease Target associations NA Case studies NA NA NA Drug target interaction Top 10 predictions 31839008 BMC Bioinformatics 2019
76 68.9 2098 NA Drug, Disease, Target, miRNA NA MTLDR (Multi-task learning framework for drug repurposing) Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 37516260 Methods 2023
76 68.9 2098 NA Drug, Disease, Target, miRNA NA MTLDR (Multi-task learning framework for drug repurposing) Graph Convolutional Network (GCN) Drug Disease Association (DDA) NA Case studies Tourette's Syndrome NA NA NA Top 10 drugs 37516260 Methods 2023
76 68.9 813 Cancer subset Drug, Disease, Target Drug: chemical structure, Target: the amino acid sequences NA Tensor decomposition Drug Disease Target associations NA Case studies NA NA NA Drug target interaction Top 10 predictions 31839008 BMC Bioinformatics 2019
77 68.8 2167 GP-KG Drug, Disease, Gene NA MPTN CompGCN,Transformer,InteractE Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 38043469 Comput Biol Med 2024
77 68.8 2167 OpenBioLink Drug, Disease, Target NA MPTN CompGCN,Transformer,InteractE Drug Disease Association (DDA) NA Case studies Alzheimer's Disease (AD) NA NA NA Top 10 drugs 38043469 Comput Biol Med 2024
78 68.7 2091 DrugBank Drug, Gene NA DGCL (Dynamic hyperGraph Contrastive Learning) Graph Neural Network (GNN),Multi Layer Perception (MLP) Drug Gene Interaction (DGI) https://github.com/wentao228/DGCL Case studies NA HMOX1 NA NA Top 10 drugs 37864294 Brief Bioinform 2023
78 68.7 2091 DGIdb Drug, Gene NA DGCL (Dynamic hyperGraph Contrastive Learning) Graph Neural Network (GNN),Multi Layer Perception (MLP) Drug Gene Interaction (DGI) https://github.com/wentao228/DGCL Case studies NA HMOX1 NA NA Top 10 drugs 37864294 Brief Bioinform 2023
78 68.7 2091 LINCS L1000 Drug, Gene NA DGCL (Dynamic hyperGraph Contrastive Learning) Graph Neural Network (GNN),Multi Layer Perception (MLP) Drug Gene Interaction (DGI) https://github.com/wentao228/DGCL Case studies NA HMOX1 NA NA Top 10 drugs 37864294 Brief Bioinform 2023
79 68.5 1768 NA Drug, Disease, Target NA NTD-DR Nonnegative tensor decomposition Drug Disease Association (DDA) https://github.com/AliJam82/NTD-DR Case studies Breast ductal carcinoma, Prostate cancer, Pancreatic neoplasms, Colorectal neoplasms, Small cell lung carcinoma NA NA NA Top 50 drugs 35862409 PLoS One 2022
80 67.3 1836 NA Drug, Target Drug: Fingerprint, KUALA (Kinase drUgs mAchine Learning frAmework) Naïve Bayes (NB),Logistic regression (LR),Support Vector Machine (SVM),Decision Tree (DT),Random Forest (RF),Neural Network (NNet),eXtreme Gradient Boosting (XGBoost),K-Nearest Neighbour (K-NN),Classification and Regression Tree (CART),Least Absolute Shrinkage and Selection Operator (LASSO),Ridge Regression (RIDGE),Elastic net regression (ELNET) Drug Target Interaction (DTI) https://github.com/molinfrimed/multi-kinases Case studies NA Kinases NA Drug target interaction 5 pedictions 36284125 Sci Rep 2022
81 67 1937 Cdataset Drug, Disease Drug: SMILES, Disease: the medical description PUON Matrix Factorization Drug Disease Association (DDA) NA Case studies NA Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone NA NA Top 5 diseases 36197871 IEEE/ACM Trans Comput Biol Bioinform 2023
81 67 1937 DNdataset Drug, Disease Drug: SMILES, Disease: the medical description PUON Matrix Factorization Drug Disease Association (DDA) NA Case studies NA Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone NA NA Top 5 diseases 36197871 IEEE/ACM Trans Comput Biol Bioinform 2023
81 67 1937 Ldataset Drug, Disease Drug: SMILES, Disease: the medical description PUON Matrix Factorization Drug Disease Association (DDA) NA Case studies NA Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone NA NA Top 5 diseases 36197871 IEEE/ACM Trans Comput Biol Bioinform 2023
81 67 1021 NA Drug, Disease, miRNA Drug: chemical structure, side-effect, functional consistency; miRNA: target genes, disease targets; Disease: MeSH BIMC Bilateral-inductive matrix completion (BIMC) Drug Disease Association (DDA) https://github.com/Deepthi-K523/BIMC Case studies NA NA Almitrine NA Top 10 diseases 32583015 Mol Genet Genomics 2020
81 67 1021 NA Drug, Disease, miRNA Drug: chemical structure, side-effect, functional consistency; miRNA: target genes, disease targets; Disease: MeSH BIMC Bilateral-inductive matrix completion (BIMC) Drug Disease Association (DDA) https://github.com/Deepthi-K523/BIMC Case studies NA NA Aminolevulinic acid NA Top 10 diseases 32583015 Mol Genet Genomics 2020
81 67 1937 Gottlieb dataset (Fdataset) Drug, Disease Drug: SMILES, Disease: the medical description PUON Matrix Factorization Drug Disease Association (DDA) NA Case studies NA Doxorubicin, Gemcitabine, Vincristine, Methotrexate, Risperidone NA NA Top 5 diseases 36197871 IEEE/ACM Trans Comput Biol Bioinform 2023
82 66.65 1973 Negative set Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies Contact Dermatitis NA NA NA Top 2 drugs 37023229 J Chem Inf Model 2023
82 66.65 1973 RepoDB Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies Atopic Eczema NA NA NA Top 4 drugs 37023229 J Chem Inf Model 2023
82 66.65 1973 RepoDB Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies Contact Dermatitis NA NA NA Top 2 drugs 37023229 J Chem Inf Model 2023
82 66.65 1973 Negative set Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies COVID-19 NA NA NA Top 6 drugs 37023229 J Chem Inf Model 2023
82 66.65 1973 Negative set Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies Atopic Eczema NA NA NA Top 4 drugs 37023229 J Chem Inf Model 2023
82 66.65 1973 RepoDB Drug, Disease NA DrugRep-KG Logistic Regression Drug Disease Association (DDA) https://github.com/CBRC-lab/DrugRep-KG Case studies COVID-19 NA NA NA Top 6 drugs 37023229 J Chem Inf Model 2023
83 66.4 1990 LRSSL Drug, Disease NA NetPro Label Propagation Drug Disease Association (DDA) https://github.com/hyr0771/NetPro Case studies NA NA Levodopa, Flecainide, Doxorubicin NA Top 5 diseases 37018341 IEEE/ACM Trans Comput Biol Bioinform 2023
83 66.4 1990 PREDICT (Fdataset) Drug, Disease NA NetPro Label Propagation Drug Disease Association (DDA) https://github.com/hyr0771/NetPro Case studies NA NA Levodopa, Flecainide, Doxorubicin NA Top 5 diseases 37018341 IEEE/ACM Trans Comput Biol Bioinform 2023
83 66.4 1990 Cdataset Drug, Disease NA NetPro Label Propagation Drug Disease Association (DDA) https://github.com/hyr0771/NetPro Case studies NA NA Levodopa, Flecainide, Doxorubicin NA Top 5 diseases 37018341 IEEE/ACM Trans Comput Biol Bioinform 2023
84 66.2 386 Yamanishi_GPCR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies Alzheimer's Disease (AD) (D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809) NA NA NA 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_IC Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA DNA topoisomerase 2-alpha (P11388) NA NA 31 drugs 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_E Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA NA Astemizole NA 14 targets 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_NR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA NA Astemizole NA 14 targets 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_IC Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies Alzheimer's Disease (AD) (D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809) NA NA NA 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_E Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA DNA topoisomerase 2-alpha (P11388) NA NA 31 drugs 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_E Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies Alzheimer's Disease (AD) (D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809) NA NA NA 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_NR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA DNA topoisomerase 2-alpha (P11388) NA NA 31 drugs 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_GPCR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA NA Astemizole NA 14 targets 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_GPCR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA DNA topoisomerase 2-alpha (P11388) NA NA 31 drugs 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_IC Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies NA NA Astemizole NA 14 targets 28808275 Sci Rep 2017
84 66.2 386 Yamanishi_NR Drug, Target Drug: molecule, Target: target sequence PUDTI Support Vector Machine (SVM) Drug Target Interaction (DTI) NA Case studies Alzheimer's Disease (AD) (D(1A), D(2) and D3 dopamine receptors (P21728, P14416 and P35462), alpha-1A and alpha-1B adrenergic receptor (P35348 and P35368), 5-hydroxytryptamine receptors (P28223) and potassium voltage-gated channel subfamily H member 2(Q12809) NA NA NA 28808275 Sci Rep 2017
85 65.6 573 DNdataset Drug, Disease NA RLSDR (Regularized Least Square for Drug Repositioning) Regularized Least Square Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 19 predictions 29700660 Acta Biotheor 2018
85 65.6 573 Fdataset Drug, Disease Drug: chemical substructures, Disease: MeSH RLSDR (Regularized Least Square for Drug Repositioning) Regularized Least Square Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 19 predictions 29700660 Acta Biotheor 2018
85 65.6 573 Fdataset Drug, Disease Drug: chemical substructures, Disease: MeSH RLSDR (Regularized Least Square for Drug Repositioning) Regularized Least Square Drug Disease Association (DDA) NA Case studies NA NA NA Drug disease interaction Top 19 predictions 29700660 Acta Biotheor 2018
86 65 1396 DTINet Drug, Disease, Target NA DDTE Graph Embedding Algorithm Drug Target Interaction (DTI) NA Case studies NA NA NA Drug disease interaction 3 predictions 34119691 J Biomed Inform 2021
87 64.9 1306 NA Drug, Virus Drug: chemical structure, Virus: d2* dissimilarity/distance (at k=6) between the viral genome sequences DVA (Drug Virus Association) Matrix Completion Drug Virus Association (DVA) www.github.com/AanchalMongia/DVA Case studies COVID-19 SARS-CoV-2 NA NA Top 6 drugs 33907209 Sci Rep 2021
88 63.7 1856 NA Drug, Disease, Target, Side-effect NA DTI-GTN Graph Transformer Network Drug Target Interaction (DTI) https://github.com/q498756498/DTI-GTN Case studies NA HTR1A NA NA Top 4 drugs 36329406 BMC Bioinformatics 2022
88 63.7 1856 NA Drug, Disease, Target, Side-effect NA DTI-GTN Graph Transformer Network Drug Target Interaction (DTI) https://github.com/q498756498/DTI-GTN Case studies NA CHRM3 NA NA Top 2 drugs 36329406 BMC Bioinformatics 2022
89 63.2 356 NA Drug, Disease, Target NA Heter-LP Heterogeneous label propagation Drug Target Interaction (DTI),Drug Disease Association (DDA) NA Case studies Osteoarthritis with mild chondrodysplasia NA NA NA 2 drugs 28300647 J Biomed Inform 2017
89 63.2 356 Yamanishi_E Drug, Target Drug: chemical sturcture, Target: target sequence Heter-LP Heterogeneous label propagation Drug Target Interaction (DTI),Drug Disease Association (DDA) NA Case studies Osteoarthritis with mild chondrodysplasia NA NA NA 2 drugs 28300647 J Biomed Inform 2017
89 63.2 356 Yamanishi_IC Drug, Target Drug: chemical sturcture, Target: target sequence Heter-LP Heterogeneous label propagation Drug Target Interaction (DTI),Drug Disease Association (DDA) NA Case studies Osteoarthritis with mild chondrodysplasia NA NA NA 2 drugs 28300647 J Biomed Inform 2017
89 63.2 356 Yamanishi_GPCR Drug, Target Drug: chemical sturcture, Target: target sequence Heter-LP Heterogeneous label propagation Drug Target Interaction (DTI),Drug Disease Association (DDA) NA Case studies Osteoarthritis with mild chondrodysplasia NA NA NA 2 drugs 28300647 J Biomed Inform 2017
89 63.2 356 Yamanishi_NR Drug, Target Drug: chemical sturcture, Target: target sequence Heter-LP Heterogeneous label propagation Drug Target Interaction (DTI),Drug Disease Association (DDA) NA Case studies Osteoarthritis with mild chondrodysplasia NA NA NA 2 drugs 28300647 J Biomed Inform 2017
90 62.9 36 NA Drug, Disease, Target, Gene, Pathway NA CauseNet Computing transition weights Drug Disease Association (DDA) NA Case studies Crohn's disease (CD) NA NA NA Top 5 drugs 24564553 BMC Bioinformatics 2013
91 62.5 1072 NA Drug, Disease, Target, Pathway, Therapeutic classes NA NMTF (Non-negative Matrix Tri-Factorization) Matrix Factorization Drug Target Interaction (DTI) https://github.com/DEIB-GECO/NMTF-DrugRepositioning Case studies NA NA NA Drug disease interaction Top 5 predictions 32365039 IEEE J Biomed Health Inform 2020
92 61.8 1096 NA Drug, Target Drug: SMILES, Target: sequence DLDTI Representation learning,Convolutional Neural Network (CNN) Drug Target Interaction (DTI) https://github.com/CUMTzackGit/DLDTI Case studies Atherosclerosis NA Tetramethylpyrazine NA 288 targets 33187537 J Transl Med 2020
93 60.6 2208 COVID19-One NA NA MLAN (Multi-Level Attention Network) Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) Drug Disease Association (DDA) NA Case studies COVID-19 NA NA NA Top 5 drugs 38244473 Comput Biol Med 2024
93 60.6 2208 NELL-One NA NA MLAN (Multi-Level Attention Network) Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) Drug Disease Association (DDA) NA Case studies COVID-19 NA NA NA Top 5 drugs 38244473 Comput Biol Med 2024
93 60.6 2208 BIOKG-One Drug, Disease, Target, Side-effect, NA MLAN (Multi-Level Attention Network) Gated Mechanism,Attention Mechanism,MTransD,Commonality Relation Learner (CRL) Drug Disease Association (DDA) NA Case studies COVID-19 NA NA NA Top 5 drugs 38244473 Comput Biol Med 2024
94 60.1 1867 AGHEL NA NA MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction) Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/pxystudy/MHADTI Case studies NA NA Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib NA NA 36242566 Brief Bioinform 2022
94 60.1 1867 Yamanishi NA NA MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction) Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/pxystudy/MHADTI Case studies NA NA Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib NA NA 36242566 Brief Bioinform 2022
94 60.1 1867 NEDTP NA NA MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction) Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/pxystudy/MHADTI Case studies NA NA Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib NA NA 36242566 Brief Bioinform 2022
94 60.1 1867 NA Drug, Target Drug: SMILES, Disease: MeSH, Target: sequence MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction) Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/pxystudy/MHADTI Case studies NA NA Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib NA NA 36242566 Brief Bioinform 2022
94 60.1 1867 DTINet NA NA MHADTI (Multiview heterogeneous information network embedding with Hierarchical Attention mechanisms to discover potential Drug–Target Interaction) Multi Layer Perception (MLP) Drug Target Interaction (DTI) https://github.com/pxystudy/MHADTI Case studies NA NA Pregabalin,Oxycodone,Sunitinib,Acetaminophen,Gefitinib NA NA 36242566 Brief Bioinform 2022
95 60 2001 KIBA Drug, Target NA BindingSite-AugmentedDTA Graph Neural Network (GNN) Drug Target binding Affinity (DTA) https://github.com/yazdanimehdi/BindingSite-AugmentedDTA Case studies COVID-19 SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex） NA NA Top 10 drugs 37096593 Brief Bioinform 2023
95 60 2001 Davis Drug, Target NA BindingSite-AugmentedDTA Graph Neural Network (GNN) Drug Target binding Affinity (DTA) https://github.com/yazdanimehdi/BindingSite-AugmentedDTA Case studies COVID-19 SARS-CoV-2 (3C-like protease, RNA-dependent RNA polymerase(RdRp), helicase, Spike/ACE2 complex） NA NA Top 10 drugs 37096593 Brief Bioinform 2023
96 59.9 1060 NA Drug, Disease, Target, Gene NA RepCOOL Random Forest (RF) Drug Disease Association (DDA) NA Case studies Breast cancer stage II NA NA NA Top 4 drugs 33008415 J Transl Med 2020
97 59.7 1140 NA Chemical molecules, Gene, Gene expression profiles NA MNBDR (Module Network Ba​​sed Drug Repositioning）LINC1000,Cmap Random Walk Drug Disease Association (DDA) https://github.com/nbnbhwyy/MNBDR Case studies Breast cancer NA NA NA NA 33375395 Genes (Basel) 2020
97 59.7 1140 Golden standard Drug, Disease NA MNBDR (Module Network Ba​​sed Drug Repositioning）LINC1000,Cmap Random Walk Drug Disease Association (DDA) https://github.com/nbnbhwyy/MNBDR Case studies Breast cancer NA NA NA NA 33375395 Genes (Basel) 2020
98 59.2 140 Fdataset Drug, Disease NA NA ProbS and HeatS Drug Disease Association (DDA) NA Case studies NA NA Tamoxifen NA Top 10 diseases 25969690 Comput Math Methods Med 2015
98 59.2 140 Fdataset Drug, Disease NA NA ProbS and HeatS Drug Disease Association (DDA) NA Case studies NA NA Felodipine NA Top 10 diseases 25969690 Comput Math Methods Med 2015
98 59.2 140 Fdataset Drug, Disease NA NA ProbS and HeatS Drug Disease Association (DDA) NA Case studies NA NA Aspirin NA Top 10 diseases 25969690 Comput Math Methods Med 2015
99 58.7 725 NA Drug, Disease, Target Drug: drug-target target NA CLASH (Complementary Linkage with Anchoring and Scoring),Graph-based Semi-Supervised Learning (SSL) Drug Drug Interaction (DDI) NA Case studies Vascular dementia NA NA NA Top 11 drug 31337333 BMC Bioinformatics 2019
100 56.6 380 NA Drug, Gene Drug: UniProt ID, PD-MRW Random Walk Drug Gene Association (DGA) NA Case studies Hepatocellular Carcinoma NA NA NA Top 20 drugs 27076463 IEEE/ACM Trans Comput Biol Bioinform 2017
101 56.5 1546 NA Drug, Disease, Gene NA GCAN (GRU-Cooperation-Attention-Network) GRU-Cooperation-Attention-Network (GCAN),RNN,Biased random walk Drug Disease Association (DDA) NA Case studies type I Gaucher disease NA NA NA Top 2 drugs 34789254 BMC Med Inform Decis Mak 2021
102 53.5 2169 DRKG Drug, Disease, Gene, Pathway, Side-effect, Compound, Anatomy, Tax, Molecular Function, Symptom, Biological Process, Cellular Component, Atc, PharmacologicClass NA TransRGNN Graph Neural Network (GNN) Drug Disease Association (DDA) NA Case studies COVID-19 NA NA NA Top 30 drugs 38104883 Methods 2024
103 51.4 1056 NA Drug, Target Drug: chemical structure PIMD Similarity Network Fusion (SNF) Drug Drug Interaction (DDI) https://github.com/Sepstar/PIMD/ Case studies NA NA NA NA NA 33075523 Genomics Proteomics Bioinformatics 2020
104 50.75 2018 DTINet Drug, Target NA DEDTI-IEDTI Deep Neural Network (DNN) Drug Target Interaction (DTI) https://github.com/BioinformaticsIASBS/IEDTI-DEDTI Case studies NA NA NA NA Top 126 drugs 37286613 Sci Rep 2023
104 50.75 2018 Yamanishi Drug, Target NA DEDTI-IEDTI Deep Neural Network (DNN) Drug Target Interaction (DTI) https://github.com/BioinformaticsIASBS/IEDTI-DEDTI Case studies NA NA NA NA Top 126 drugs 37286613 Sci Rep 2023
105 50.5 569 NA Drug, Disease, Target NA NA Random Forest (RF),Neural network Drug Disease Association (DDA) NA Case studies Psoriasis NA NA NA Candidate drugs with the mean AUC>0.9 30463505 BMC Bioinformatics 2018
105 50.5 569 NA Drug, Disease, Target NA NA Random Forest (RF),Neural network Drug Disease Association (DDA) NA Case studies Osteoarthritis NA NA NA Candidate drugs with the mean AUC>0.9 30463505 BMC Bioinformatics 2018
105 50.5 569 NA Drug, Disease, Target NA NA Random Forest (RF),Neural network Drug Disease Association (DDA) NA Case studies Urticaria NA NA NA Candidate drugs with the mean AUC>0.9 30463505 BMC Bioinformatics 2018
105 50.5 569 NA Drug, Disease, Target NA NA Random Forest (RF),Neural network Drug Disease Association (DDA) NA Case studies Chronic lymphocytic leukemia NA NA NA Candidate drugs with the mean AUC>0.9 30463505 BMC Bioinformatics 2018
105 50.5 569 NA Drug, Disease, Target NA NA Random Forest (RF),Neural network Drug Disease Association (DDA) NA Case studies Dysmenorrhea NA NA NA Candidate drugs with the mean AUC>0.9 30463505 BMC Bioinformatics 2018
106 44.5 1851 DRKG Drug, Disease, Gene, Anatomies NA GDRnet Graph Neural Network (GNN) Drug Disease Association (DDA) https://github.com/siddhant-doshi/GDRnet Case studies NA NA NA NA NA 36228466 Comput Biol Med 2022
107 42.5 1935 iDrug (ID) Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 DrugBank Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 LL Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 DisGeNET (DGN) Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 SLAMS Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 MalaCards (MC) Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
107 42.5 1935 RepoDB (RDB) Drug, Disease, Gene NA NA Biased random walks Drug Disease Association (DDA) NA Case studies Rheumatoid Arthritis NA NA NA 1 drug 35839194 IEEE/ACM Trans Comput Biol Bioinform 2023
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