| Recommendation |
ID |
Data Information |
Model Information |
Application Information |
Reference |
| Rank |
Total_Score |
Model_ID |
Dataset_Name |
Element_type |
Data_features |
Model_name |
Algorithm_name |
Prediction_type |
Code_source |
Study_types |
Disease_name |
Target_name |
Drug_name |
Interaction_type |
Recommended_Number |
PMID |
Journal |
Publication_Year |
| 1 |
74.9 |
1623 |
NA |
Drug |
Drug: chemical structures, Target: protein sequence |
DOTA (Drug repositioning approach using Optimal Transport for Alzheimer's disease) |
Deep Autoencoder (Multi-modal,Wasserstein variational) |
Drug Disease Association (DDA) |
https://github.com/fawer/DOTA |
Special studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 20 drugs |
35204697 |
Biomolecules |
2022 |
| 2 |
73.7 |
1366 |
NA |
Drug, Target |
Molecular descriptors |
NA |
Random Forest (RF) |
Drug Disease Association (DDA) |
https://github.com/sblab/DTN |
Special studies |
Hyperlipidemia |
NA |
NA |
NA |
Top 9 drugs |
34030115 |
Comput Biol Chem |
2021 |
| 3 |
72.95 |
2134 |
External Set-2 |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 3 |
72.95 |
2134 |
DRH |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 3 |
72.95 |
2134 |
NA |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 3 |
72.95 |
2134 |
External Set-1 |
Drug |
Drug: SMILES |
NA |
Graph Attention Network (GAT),Graph Isomorphism Network (GIN) |
Drug Target binding Affinity (DTA) |
NA |
Special studies |
COVID-19 |
SARS-CoV-2 main protease (Mpro) |
NA |
NA |
Top 10 drugs |
37960886 |
J Chem Inf Model |
2023 |
| 4 |
69.8 |
2160 |
DrugRepV |
Drug |
Drug: SMILES, |
Anti-Dengue |
Support Vector Machine (SVM),Artificial Neural Network (ANN),k-Nearest Neighbor (kNN),Random Forest (RF) |
Drug Disease Association (DDA) |
NA |
Special studies |
Dengue |
NA |
NA |
NA |
Top 25 drugs |
38257744 |
Viruses |
2023 |
| 5 |
69.4 |
1769 |
NA |
Drug, Target, Pathway |
NA |
MSDF-CNN |
Graph Convolutional Network (GCN) |
Drug Target Interaction (DTI) |
https://github.com/lemonfino/MSDF-CNN |
Special studies |
Parkinson’s Disease (PD) |
HTR2A |
NA |
NA |
Top 10 drugs |
35897954 |
Molecules |
2022 |
| 6 |
68.5 |
672 |
NA |
Gene, Celllines |
NA |
NA |
Deep neural Network (DNN),Support Vector Machine (SVM),Random Forest (RF),Gradient Boosted Machine with trees (GBM),logistic regression with elastic net regularization (EN) |
Drug Disease Association (DDA) |
NA |
Special studies |
Depressive Disorder |
NA |
NA |
NA |
Top 8 drugs |
30010603 |
IEEE J Biomed Health Inform |
2019 |
| 6 |
68.5 |
672 |
NA |
Gene, Celllines |
NA |
NA |
Deep neural Network (DNN),Support Vector Machine (SVM),Random Forest (RF),Gradient Boosted Machine with trees (GBM),logistic regression with elastic net regularization (EN) |
Drug Disease Association (DDA) |
NA |
Special studies |
Schizophrenia |
NA |
NA |
NA |
Top 8 drugs |
30010603 |
IEEE J Biomed Health Inform |
2019 |
| 7 |
68.2 |
192 |
NA |
Drug, Disease |
Disease: Phenotypic terms |
PhenoPredict |
The iterative network-based ranking algorithm |
Drug Disease Association (DDA) |
NA |
Special studies |
Schizophrenia |
NA |
NA |
NA |
Top 20 drugs |
26151312 |
J Biomed Inform |
2015 |
| 8 |
67.8 |
2015 |
NA |
Drug, Gene |
NA |
DTSEA (Drug Target Set Enrichment Analysis) |
Random Walk with Restart (RWR) |
Drug Disease Association (DDA) |
https://github.com/hanjunwei-lab/DTSEAData |
Special studies |
COVID-19 |
NA |
NA |
NA |
Top 10 drugs |
37105108 |
Comput Biol Med |
2023 |
| 9 |
66.8 |
2181 |
BindingDB |
Drug, Target |
Drug: SMILES |
NA |
Extra tree classifier (ETC) |
Drug Target Interaction (DTI) |
NA |
Special studies |
NA |
Epidermal Growth Factor Receptor (EGFR) |
NA |
NA |
Top 9 drugs |
38000720 |
Eur J Pharmacol |
2024 |
| 10 |
64.8 |
1814 |
NA |
Drug, chemical |
NA |
NA |
Knowledge Graph Embedding |
Drug Disease Association (DDA) |
NA |
Special studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 10 drugs |
36180861 |
BMC Bioinformatics |
2022 |
| 11 |
64.6 |
2116 |
NA |
Drug |
Drug: SMILES |
NA |
Graph Convolutional Network (GCN),XGBoost |
Drug Target Interaction (DTI) |
NA |
Special studies |
Parkinson’s Disease (PD) |
PINK1 (Phosphatase and Tensin homologue-induced kinase 1) |
NA |
NA |
Top 22 drugs |
37544165 |
Comput Methods Programs Biomed |
2023 |
| 12 |
58.9 |
1260 |
NA |
Subject, object, predicate |
NA |
LBD |
Knowledge Graph Completion |
Drug Disease Association (DDA) |
https://github.com/kilicogluh/lbd-covid |
Special studies |
COVID-19 |
NA |
NA |
NA |
5 drugs |
33571675 |
J Biomed Inform |
2021 |
| 13 |
58.5 |
1322 |
NA |
Drug, Gene |
NA |
NA |
Deep Autoencoder,XGBoost |
Drug Target Interaction (DTI) |
https://github.com/tsjshg/ai-drug-dev |
Special studies |
Alzheimer's Disease (AD) |
NA |
NA |
NA |
Top 20 drugs |
33941241 |
Alzheimers Res Ther |
2021 |
| 14 |
55.4 |
1915 |
NA |
Drug, Gene |
NA |
NA |
Random Walk with Restart (RWR) |
Drug Disease Association (DDA) |
NA |
Special studies |
Non-Small Cell Lung Cancer (NSCLC) |
NA |
NA |
NA |
Top 11 drugs |
36768566 |
Int J Mol Sci |
2023 |
| 14 |
55.4 |
1915 |
NA |
Drug, Gene |
NA |
NA |
Random Walk with Restart (RWR) |
Drug Disease Association (DDA) |
NA |
Special studies |
Colorectal Cancer |
NA |
NA |
NA |
Top 9 drugs |
36768566 |
Int J Mol Sci |
2023 |
| 15 |
38.4 |
1444 |
CAS Biomedical Knowledge Graph(COVID-19) |
Disease, Gene, Pathway, Virus, Side-effect, Clinical Trial, Small molecule, Molecular Function |
NA |
NA |
A computer algorithm-driven drug-ranking method |
Drug Disease Association (DDA) |
NA |
Special studies |
COVID-19 |
NA |
NA |
NA |
Top 50 drugs |
34297570 |
J Chem Inf Model |
2021 |