OVERVIEW OF dbGVOSCC

Breif introduction

dbGVOSCC contains 1,672 entries of somatic genetic variations, including 329 epimutations/methylations, 600 point mutations (comprising 369 single nucleotide polymorphisms [SNPs]), 90 insertion-deletion mutations (indel mutations), 336 copy number variations (CNVs), 28 instances of loss of heterozygosity (LOH), 108 other variants, and 181 unspecified gene mutations, all manually extracted from 384 original research articles between January 1991 and December 2023.

Homepage

The "Home" page has provide:

1) A brief introduction and statistical information about dbGVOSCC.
2) How to citate dbGVOSCC.
3) The latest news and related databases of dbGVOSCC.
4) The address and official website of researcher’s institute.

Browse

There is a navigation bar on the left on "Browse" page (Figure 1):

Variations are divided into 8 categories; Experiment location are classified according to continent and online source. Genes are divided into 3 categories according to whether they encode proteins

Every result in the overview contains the following data: related publication ID(PMID), published date, variation name, pathologic function, related gene symbol, detailed information of each items can be acquired by clicking the "Details" button at the end of the entry.

Figure 1

Search

Users can search by variation name, experimental location (continent or country), and gene symbol involved in the variation, these key words will be automatically combined by the Boolean operator "AND" (Figure 2). Corresponding results will be generated in the right window after you click the “Search” button.

Statistics

dbGVOSCC also provides data statistics result contains The distribution of different variations, top 10 gene and status of gene on the chromosome, geographical distribution of population size and number of experiments, annual increase in the number of publication. In most charts, you can move the mouse over the chart to see the specific values.

Submit

If you think dbGVOSCC has missed any related muations about oral squamous cell carcinoma, please upload it in the "Submit" page. The data you submit will be added to dbGVOSCC once we approved. Please don't forget to write down your email address for further contact.