Welcome to dbGVOSCC
Oral squamous cell carcinoma is a malignant tumor idiopathic in the oral cavity, which is the most malignant and most harmful tumor of head and neck. At present, more and more researches focus on the subtype analysis and immunotherapy of OSCC. To understand the heterogeneity of OSCC, a database for integrating fragmented data and unifying annotations is desperately needed. This research sorting data and knowledge in PubMed literature through NLP and manual work, and successfully established a genetic variation database for OSCC.
Statistics
dbGVOSCC contains 1,788 entries of somatic genetic variations, including 329 epimutations/methylations, 669 point mutations (comprising 411 single nucleotide polymorphisms [SNPs]), 98 insertion-deletion mutations (indel mutations), 348 copy number variations (CNVs), 28 instances of loss of heterozygosity (LOH), and 333 unspecified gene mutations, all manually extracted from 400 original research articles between January 1991 and December 2024, providing a reliable and accurate open-source dataset for OSCC researchers.
