MiRNA-BD is an evidence-based bioinformatics model and software tool for microRNA (miRNA) biomarker discovery. It identifies miRNA biomarkers on the basis of two measures and two evidences as follows:
Measure 1: Number of single-line regulation (NSR) represents the number of genes that independently or uniquely regulated by single miRNAs.
Measure 2: Transcription factor (TF) percentage (TFP) is the percentage of TF genes targeted by a single miRNA.
Evidence 1: Biomarker miRNAs tended to have high NSR values.
Evidence 2: Biomarker miRNAs tended to have high TFP values.
The schematic pipeline shows in Figure 1. Please refer to the published article and the User Guide for details.
Figure 1. The schematic pipeline of the MiRNA-BD model.
How to cite: Yuxin Lin, Wentao Wu, Zhandong Sun, Li Shen & Bairong Shen (2018) MiRNA-BD: an evidence-based bioinformatics model and software tool for microRNA biomarker discovery, RNA Biology, 15:8, 1093-1105.