| Factor Information | |
|---|---|
| Data ID | 1102 |
| Factor | cTn-I 2 h PO > 14 ng/mL (cardiac troponin I) |
| Description | cTn-I levels (> 14 ng/mL) at 2 hours following heart corrective surgery under CPB were independent predictors of LCOS. |
| Biomarker | YES |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis and risk assessment |
| Objective | To assess the predictive value of atrial natriuretic peptide, b-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome in children with congenital heart disease undergoing cardiopulmonary bypass (CPB). |
| p Value | <0.001 |
| OR | 4.045 |
| Conclusion | Our results suggest that cTn-I at 2 hours post-CPB is, by itself, an evident independent early predictor of low cardiac output syndrome. This predictive capacity is, moreover, reinforced when cTn-I is combined with MR-proADM levels at 24 hours following CPB. These 2 cardiac biomarkers would aid in therapeutic decision-making in clinical practice and would also enable clinicians to modify the type of support to be used in the pediatric intensive care unit. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 500 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TOF/AVC/CoA/IAA/PA/TGA/VSD, ASD/CAT/HLHS/TAPVC/AR/other |
| Reference | |
|---|---|
| PMID | 28137395 |
| Year | 2017 |
| Title | Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | blood | |
| Region | Co´rdoba,Spain | |
| Method | a prospective observational pilot study | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | corrective surgery | |
| Group | group 1: with LCOS(Treatment) | group 2: without LCOS(Control) |
| Number | 33 | 84 |
| Age | 8.5 ± 4 years | 9.5 ± 4 years |
| Gender (Male: Female) | 20:13 (total) | 40:44 (total) |
| Marker Level | 12.3 (4.6-36.1) ng/mL | 0.02 (0-0.04) ng/mL |
