| Factor Information | |
|---|---|
| Data ID | 1251 |
| Factor | brainstem volume |
| Description | Compared with controls, infants with CHD had reductions of 54 mL in total brain (P = .009), 40 mL in cerebral white matter (P < .001), and 1.2 mL in brainstem (P = .003) volumes. |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine whether brain volume is reduced at 1 year of age and whether these volumes are associated with neurodevelopment in biventricular congenital heart disease (CHD) repaired in infancy. |
| p Value | 0.003 |
| Conclusion | Infants with biventricular CHD show total brain volume reductions at 1 year of age, driven by differences in cerebral white matter. White matter volume correlates with language development, but not broader developmental indices. These findings suggest that abnormalities in white matter development detected months after corrective heart surgery may contribute to language impairment |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 507 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TGA/TOF/TOF, PA/TOF, TA/VSD/AVC |
| Reference | |
|---|---|
| PMID | 27837950 |
| Year | 2016 |
| Title | White Matter Volume Predicts Language Development in Congenital Heart Disease. |
| Sample | ||
|---|---|---|
| Population | infancy | |
| Source | neurodevelopmental outcomes | |
| Region | Boston, USA | |
| Method | brain magnetic resonance imaging (MRI) neurodevelopmental testing with the Bayley Scales of Infant Development-II and the MacArthur-Bates Communicative Development Inventories. A multitemplate based probabilistic segmentation algorithm was applied to volumetric MRI data | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | biventricular CHD(Treatment) | control(Control) |
| Number | 48 | 13 |
| Age | Gestational age: 39.2 ± 1.3 weeks | Gestational age: 39.4 ± 0.8 weeks |
| Gender (Male: Female) | 28:20 | 7:6 |
| Marker Level | 11.2 ± 1.5 mL | 12.5 ± 2.0 |
