| Factor Information | |
|---|---|
| Data ID | 1252 |
| Factor | MacArthur-Bates Communicative Development Inventory (CDI) language development |
| Description | Within the group with CHD, brain volumes were not correlated with Bayley Scales of Infant Development-II scores but did correlate positively with MacArthur-Bates Communicative Development Inventory language development. CDI was completed for 38 subjects with CHD; scores were significantly below age and sex norms for understanding of vocabulary and development of gestures. subjects with CHD who underwent MRI had both significantly lower phrases and total gestures CDI percentiles (mean ± SD, phrases: 43 ± 28 vs 59 ± 29, P = .02; total gestures: 32 ± 27 vs 52 ± 29, P = .002). |
| Biomarker | NA |
| Classification | F6 (psychosocial factor - other) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine whether brain volume is reduced at 1 year of age and whether these volumes are associated with neurodevelopment in biventricular congenital heart disease (CHD) repaired in infancy. |
| p Value | <0.05 |
| Conclusion | Subjects with CHD who underwent MRI had both significantly lower phrases and total gestures CDI percentiles |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 507 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TGA/TOF/TOF, PA/TOF, TA/VSD/AVC |
| Reference | |
|---|---|
| PMID | 27837950 |
| Year | 2016 |
| Title | White Matter Volume Predicts Language Development in Congenital Heart Disease. |
| Sample | ||
|---|---|---|
| Population | infancy | |
| Source | neurodevelopmental outcomes | |
| Region | Boston, USA | |
| Method | brain magnetic resonance imaging (MRI) neurodevelopmental testing with the Bayley Scales of Infant Development-II and the MacArthur-Bates Communicative Development Inventories. A multitemplate based probabilistic segmentation algorithm was applied to volumetric MRI data | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | biventricular CHD(Treatment) | control(Control) |
| Number | 48 | 13 |
| Age | Gestational age: 39.2 ± 1.3 weeks | Gestational age: 39.4 ± 0.8 weeks |
| Gender (Male: Female) | 28:20 | 7:6 |
| Marker Level | phrases (mean ± SD): 43 ± 28; total gestures (mean ± SD): 32 ± 27. | phrases(mean ± SD): 59 ± 29; total gestures (mean ± SD): 52 ± 29. |
