| Factor Information | |
|---|---|
| Data ID | 1279 |
| Factor | number of offspring with CHD(mother with diabetes mellitus, type 2) |
| Description | For mothers with the following chronic disease, the overall prevalence of congenital heart disease in their children was significantly higher than for mothers without these disease: diabetes mellitus type 2 (adjusted OR 2.85, 95% CI 2.60–3.12), |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | the overall prevalence of congenital heart disease in their children |
| OR | 2.85 |
| Conclusion | The children of women with several kinds of chronic disease appear to be at risk for congenital heart disease. Preconception counselling and optimum treatment of pregnant women with chronic disease would seem prudent. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 512 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/PDA/VSD/PS/CoA/ECD/AS/EA/other/TOF/TGA/DORV/TAPVR/Common ventricle/HLHS/Common truncus/TA/ccTGA |
| Reference | |
|---|---|
| PMID | 27729382 |
| Year | 2016 |
| Title | Association of maternal chronic disease with risk of congenital heart disease in offspring |
| Sample | ||
|---|---|---|
| Population | Mothers | |
| Source | Taiwan Maternal and Child Health Database | |
| Region | Taiwan, China | |
| Method | multivariable logistic regression analysis | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | mothers with diabetes mellitus type 2(Treatment) | mothers without diabetes mellitus type 2(Control) |
| Number | No. of offspring with CHD: 638 | No. of offspring with CHD: 22845 |
| Age | N/A | N/A |
| Gender (Male: Female) | Femal | Femal |
| Marker Level | 638; Prevalence per 1000 live births (95% CI) =57.9 (53.5–62.6) | 22845; Prevalence per 1000 live births (95% CI) =16.6 (16.4–16.8) |
