| Factor Information | |
|---|---|
| Data ID | 1543 |
| Factor | Complex disease |
| Description | Uni- and multivariate predictors of the need for anti-depressant drugs on logistic regression analysis |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To examine the number of ACHD patients treated with antidepressant drugs (ADDs) at a tertiary centre, identify predictors of ADD use and test the hypothesis that severe depression requiring ADD therapy is directly or indirectly related to a worse outcome in this growing population. |
| p Value | <0.001 |
| OR | >1.50 |
| Conclusion | On univariate logistic regression analysis, older age, female gender, a higher NYHA class, more complex underlying cardiac disease as well as signs and symptoms of heart failure or arrhythmia requiring therapy were significantly related to ADD use. On multivariate analysis, the association of age, female gender, and complex disease with ADD therapy remained statistically significant. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 538 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/VSD/AVSD/CoA/TOF/TGA/ccTGA/EA/ES/other |
| Reference | |
|---|---|
| PMID | 26314687 |
| Year | 2016 |
| Title | Depression requiring anti-depressant drug therapy in adult congenital heart disease: prevalence, risk factors, and prognostic value. |
| Sample | ||
|---|---|---|
| Population | Adults | |
| Source | a retrospective study | |
| Region | London, UK | |
| Method | univariate analysis; multivariate analysis | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | ADD therapy | |
| Group | Group A: patients on antidepressant drugs, ADDs(Treatment) | Group B: patients not on antidepressant drugs, ADDs(Control) |
| Number | 204 | 5958 |
| Age | 36.1±15.5 years | 30.2±16.4 years |
| Gender (Male: Female) | 136:68 | 2943:3015 |
| Marker Level | N/A | N/A |
