| Factor Information | |
|---|---|
| Data ID | 1547 |
| Factor | P-selectin candidate gene SNPs---825T/C:TT |
| Description | The genotypes frequencies of the -825T/C TT, CT, CC in PAH-CHD patients were 87.93%, 12.07% and 0.00% respectively. The genotypes frequencies of the -825T/C TT, CT, CC in healthy controls were 71.71%, 26.83%, 1.46% respectively. The difference between two groups was statistical significantly (P=0.016). |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | prognosis and risk assessment |
| Objective | Relationship between P-selectin gene polymorphism and PAH-CHD |
| OR | 1 |
| Conclusion | P-selectin probably involves in the development of PAH-CHD. The polymorphism of -825T/C is associated with the risk of PAH-CHD, and may be one of its risk factors. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 539 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/PDA/VSD |
| Reference | |
|---|---|
| PMID | 26261613 |
| Year | 2015 |
| Title | P-selectin gene polymorphism associates with pulmonary hypertension in congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | adolescents and adults | |
| Source | blood | |
| Region | Nantong, China | |
| Method | case-control correlation analysis | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | PAH-CHD patients(P-selectin gene 825TT)(Treatment) | controls(P-selectin gene 825TT)(Control) |
| Number | 51 | 147 |
| Age | 31 (17.66) years | 33 (16.3) years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 51 (87.93%) | 147 (71.71%) |
