| Factor Information | |
|---|---|
| Data ID | 1639 |
| Factor | Frontal FMBV Z-score |
| Description | Mid-gestation ultrasound biometry and Doppler parameters in fetuses with CHD and controls |
| Biomarker | YES |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | prognosis and diagnosis |
| Objective | Our aim was to evaluate whether brain development in late pregnancy can be predicted by fetal brain Doppler, head biometry and the clinical form of CHD at the time of diagnosis. |
| p Value | <0.01 |
| Conclusion | Fetuses with CHD showed significantly lower mean Z-scores for MCA-PI and CPR and significantly higher mean Z-score for FMBV compared with controls. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 547 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | AVSD/TOF/TGV/TA/HLHS/AOS/HAA/TA/EA/PS, PA/NA |
| Reference | |
|---|---|
| PMID | 26053596 |
| Year | 2016 |
| Title | Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth. |
| Sample | ||
|---|---|---|
| Population | Fetuses | |
| Source | CHD fetus | |
| Region | Barcelona, Spain | |
| Method | a prospective cohort study | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD fetuses(Treatment) | control fetuses(Control) |
| Number | 58 | 58 |
| Age | 22.3±0.9 weeks (GA at ultrasound) | 22.1±0.8 weeks (GA at ultrasound) |
| Gender (Male: Female) | 37:21 | 29:29 |
| Marker Level | 2.09±0.83 | 0.09±1.43 |
