| Factor Information | |
|---|---|
| Data ID | 1653 |
| Factor | Brain metabolic profile--Frontal area--Ino/Cho(inositol/choline) |
| Description | Results of magnetic resonance imaging (MRI) of brain at term in fetuses with CHD and controls |
| Biomarker | NA |
| Classification | A6 (clinical factor - other) |
| Association | |
|---|---|
| Application | prognosis and diagnosis |
| Objective | Our aim was to evaluate whether brain development in late pregnancy can be predicted by fetal brain Doppler, head biometry and the clinical form of CHD at the time of diagnosis. |
| p Value | <0.01 |
| Conclusion | We found increased Ino/Cho ratios in the frontal lobe and basal ganglia and decreased NAA/Cho and Cho/Cr ratios in both areas compared to controls. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 547 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | AVSD/TOF/TGV/TA/HLHS/AOS/HAA/TA/EA/PS, PA/NA |
| Reference | |
|---|---|
| PMID | 26053596 |
| Year | 2016 |
| Title | Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth. |
| Sample | ||
|---|---|---|
| Population | Fetuses | |
| Source | CHD fetus | |
| Region | Barcelona, Spain | |
| Method | a prospective cohort study | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD fetuses(Treatment) | control fetuses(Control) |
| Number | 58 | 58 |
| Age | 37.2±0.4 weeks (GA at MRI) | 37.3±0.4 weeks (GA at MRI) |
| Gender (Male: Female) | 37:21 | 29:29 |
| Marker Level | 4.64±0.79 | 3.63±0.49 |
