| Factor Information | |
|---|---|
| Data ID | 1673 |
| Factor | HC Z-score |
| Description | Stepwise logistic regression results showed that fetal MCA-PI (OR, 12.7; P=0.01), CPR (OR, 8.7; P=0.02) and fetalHC(OR, 6.2; P=0.02) at mid-gestation were independent predictors of abnormal brain development. |
| Biomarker | YES |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | prognosis and diagnosis |
| Objective | Our aim was to evaluate whether brain development in late pregnancy can be predicted by fetal brain Doppler, head biometry and the clinical form of CHD at the time of diagnosis. |
| p Value | 0.02 |
| OR | 6.2 |
| Conclusion | Stepwise logistic regression results showed that fetal MCA-PI (OR, 12.7; P=0.01), CPR (OR, 8.7; P=0.02) and fetal HC(OR, 6.2; P=0.02) at mid-gestation were independent predictors of abnormal brain development. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 547 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | AVSD/TOF/TGV/TA/HLHS/AOS/HAA/TA/EA/PS, PA/NA |
| Reference | |
|---|---|
| PMID | 26053596 |
| Year | 2016 |
| Title | Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth. |
| Sample | ||
|---|---|---|
| Population | Fetuses | |
| Source | CHD fetus | |
| Region | Barcelona, Spain | |
| Method | a prospective cohort study | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD fetuses(Treatment) | control fetuses(Control) |
| Number | 58 | 58 |
| Age | 33±5 years | 32±4 years |
| Gender (Male: Female) | 37:21 | 29:29 |
| Marker Level | N/A | N/A |
