| Factor Information | |
|---|---|
| Data ID | 1685 |
| Factor | SNPs in mothers: MTHFR gene rs1801131:CC |
| Description | Logistic regression analyses adjusted for gender of children, occupation of mothers, family history with CHD, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | The aim of this study is to evaluate the relevant risk-factors of children with CHD and their mothers. |
| p Value | <0.05 |
| OR | >3.0 |
| Conclusion | After adjustment for gender of children, occupation of mothers, family history with CHD, history of abortion, history of ad- verse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure, only rs1801131 (A vs. C) variant genotypes significantly increased their offspring CHD risk, when compared with control group of mothers (OR = 3.67, 95% CI = 1.12–12.05). |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 26035828 |
| Year | 2015 |
| Title | Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | mothers | |
| Source | questionnaire | |
| Region | Nanjing, China | |
| Method | Logistic regression analyses adjusted for gender of children, occupation of mothers, family history with CHD, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure | |
| Race | Asian | |
| Disease History | History of CHD/abortion/adverse pregnancy | |
| Treatment History | N/A | |
| Group | mother of CHD children(Treatment) | mother of control children(Control) |
| Number | 19 | 6 |
| Age | 26.16±4.69 years | 25.39±3.28 years |
| Gender (Male: Female) | 0:19 | 0:6 |
| Marker Level | 19(12.42%) | 6(2.78%) |
