| Factor Information | |
|---|---|
| Data ID | 1695 |
| Factor | SNPs in children: MTHFR gene rs1801131:AA:AC:CC |
| Description | Logistic regression analyses adjusted for gender of children, occupation of mothers, family history with CHD, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure |
| Biomarker | NA |
| Classification | D1 (molecular factor - DNA) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | The aim of this study is to evaluate the relevant risk-factors of children with CHD and their mothers. |
| p Value | <0.001 |
| OR | 2.44 |
| Conclusion | After adjustment for gender of children, occupation of mother, family history with CHD, history of abortion, history of adverse pregnancy, early preg- nancy health, fetus during pregnancy, pesticide exposure and drug exposure, only rs1801131 (A vs. C) variant genotypes significantly increased host CHD risk, when compared with chil- dren without CHD (OR = 1.42, 95% CI = 1.00–2.44 in additive model) |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 26035828 |
| Year | 2015 |
| Title | Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | questionnaire | |
| Region | Nanjing, China | |
| Method | logistic regression analyses adjusted for gender of children, occupation of mothers, family history with CHD, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure | |
| Race | Asian | |
| Disease History | History of CHD/abortion/adverse pregnancy | |
| Treatment History | N/A | |
| Group | CHD children(Treatment) | control children(Control) |
| Number | 1900-01-03 02:57:07.000 | 1900-01-06 19:36:08.000 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 74(53.63%):57(41.3%):7(5.07%) | 163(80.20%):36(15.94%):8(3.86%) |
