| Factor Information | |
|---|---|
| Data ID | 17 |
| Factor | total brain volumes |
| Description | Differences between pre- and postoperative brain volumes in CHD infants were significant. |
| Biomarker | NA |
| Classification | E11 (physiological factor - physical sign) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the relationship between perioperative brain volumes and neurodevelopmental outcome in neonates with severe CHD. |
| p Value | <0.0001 |
| Conclusion | CHD infants had lower pre- and postoperative total and regional brain volumes compared to controls |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 397 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | BVP/D-TGA/AAA/DORV/TGA/HLHS/AVSD/VSD/PA/VSD/TOF/TA/other |
| Reference | |
|---|---|
| PMID | 31350426 |
| Year | 2019 |
| Title | Postoperative brain volumes are associated with one-year neurodevelopmental outcome in children with severe congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | term born neonates (>36 weeks of gestation) with CHD | |
| Source | N/A | |
| Region | Zurich, Switzerland | |
| Method | Pre- and postoperative cerebral magnetic resonance imaging (MRI), Brain volumes were measured using an atlas prior-based automated method. One-year neurodevelopmental outcome was assessed with the Bayley-III. | |
| Race | Europe | |
| Disease History | CHD | |
| Treatment History | undergoing neonatal cardiopulmonary bypass (CPB) surgery | |
| Group | CHD infants preo-peratively(Treatment) | CHD infants post operatively(Control) |
| Number | 62 | 43 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 395.2±40.8 | 434.7±51.6 |
