| Factor Information | |
|---|---|
| Data ID | 1820 |
| Factor | ADMA (umol/L) |
| Description | The level of ADMA was significantly higher in CHD patients with PAH than in CHD patients without PAH and healthy controls (P<0.01, P<0.001). The mean ADMA level was higher in CHD patients with severe PAH than in CHD patients with mild-to-moderate PAH (P<0.001) |
| Biomarker | YES |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | diagnosis |
| Objective | we investigated whether ADMA could help specifically identify the disease in a relatively large sample size of CHD patients. |
| p Value | <0.01 |
| Conclusion | The level of ADMA was significantly higher in CHD patients with PAH than in CHD patients without PAH and healthy controls (P<0.01, P<0.001). The mean ADMA level was higher in CHD patients with severe PAH than in CHD patients with mild-to-moderate PAH (P<0.001) |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 390 |
| CHD Type | isolated CHD |
| CHD Subtype | VSD/ASD/PDA |
| Reference | |
|---|---|
| PMID | 25737007 |
| Year | 2015 |
| Title | Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease. |
| Sample | ||
|---|---|---|
| Population | PAH-CHD patients | |
| Source | a single-center prospective observational study | |
| Region | Changsha, China | |
| Method | Plasma ADMA levels were measured by enzyme-linked immunosorbent assay. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Group A:CHD without PAH(Treatment) | Group B:CHD with mild-to-moderate PAH)(Control) |
| Number | 20 | 20 |
| Age | 34.0 ± 12.7 years | 31.36 ± 10.5 years |
| Gender (Male: Female) | 4:16 | 3:17 |
| Marker Level | 0.36 ± 0.13 umol/L | 0.49 ± 0.17 umol/L |
