| Factor Information | |
|---|---|
| Data ID | 1824 |
| Factor | serum Cys C levels |
| Description | On postoperative day 2, infants with AKI (Acute kidney injury) showed significant change from baseline in serum Cys C levels compared with non-AKI infants (28% vs. −9%, P = .03). The area under the receiver operating characteristic curve for day 2 Cys C was 0.87 (95% CI 0.67–1.00) in recognizing NGAL(neutrophil gelatinase-associated lipocalin)-positive AKI. |
| Biomarker | YES |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | specific and sensitive biomarker |
| p Value | 0.03 |
| OR | 0.87 |
| Conclusion | Postoperative serum Cys C appears to be a more specific and sensitive biomarker for NGAL-positive AKI resulting from cardiopulmonary bypass surgery in infants undergoing cardiac surgery. |
| Risk Factor | protective factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 25727405 |
| Year | 2015 |
| Title | Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | Infants | |
| Source | Serum | |
| Region | Dallas, USA | |
| Method | latex particle enhanced immunonephelometry using BN II System | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | cardiac surgery under cardiopulmonary bypass | |
| Group | infants with AKI(Treatment) | non-AKI infants(Control) |
| Number | 5 | 12 |
| Age | 5(4,16) days | 99 (5, 272) days |
| Gender (Male: Female) | Male 75% | Male 60% |
| Marker Level | 0.28 | −9% |
