| Factor Information | |
|---|---|
| Data ID | 1882 |
| Factor | diagnostic category |
| Description | Multivariable analysis showed that the diagnostic category (P<0.001) was independently associated with smaller brain volumes in fetuses with CHD. |
| Biomarker | NA |
| Classification | A12 (clinical factor - treatment) |
| Association | |
|---|---|
| Application | diagnosis |
| Objective | smaller brain volumes |
| p Value | <0.001 |
| Conclusion | The volume of intracranial structures is smaller in fetuses with CHD, particularly in those with HLHS, aortic hypoplasia or TGA. This study highlights the need for routine brain screening and early intervention to improve neurodevelopmental outcomes in fetuses with CHD. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 561 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | HLHS/AH/AS/TOF/VPS/PA, IVS/TA/TGA/TA/AVSD |
| Reference | |
|---|---|
| PMID | 25270670 |
| Year | 2015 |
| Title | Volume of intracranial structures on three-dimensional ultrasound in fetuses with congenital heart disease |
| Sample | ||
|---|---|---|
| Population | fetuses | |
| Source | Total intracranial volume, frontal lobes volume, thalamus volume and cerebellar volume | |
| Region | Changsha, China | |
| Method | three-dimensional ultrasound combined with post-processing software | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD fetuses(Treatment) | normal fetuses(Control) |
| Number | 73 | 168 |
| Age | Maternal age: 27.4±3.8 (21–44) years | Maternal age: 27.2±4.3 (19–39) years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
