| Factor Information | |
|---|---|
| Data ID | 1883 |
| Factor | HLHS |
| Description | The largest differences from controls occurred in hypoplastic left heart syndrome (HLHS), followed by aortic hypoplasia, transposition of the great arteries (TGA) and tetralogy of Fallot (TOF)(P<0.001). |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | diagnosis |
| Objective | To investigate the volume of intracranial structures in fetuses with congenital heart disease (CHD). |
| p Value | <0.001 |
| Conclusion | The volume of intracranial structures is smaller in fetuses with CHD, particularly in those with HLHS, aortic hypoplasia or TGA. This study highlights the need for routine brain screening and early intervention to improve neurodevelopmental outcomes in fetuses with CHD. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 561 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | HLHS/AH/AS/TOF/VPS/PA, IVS/TA/TGA/TA/AVSD |
| Reference | |
|---|---|
| PMID | 25270670 |
| Year | 2015 |
| Title | Volume of intracranial structures on three-dimensional ultrasound in fetuses with congenital heart disease |
| Sample | ||
|---|---|---|
| Population | fetuses | |
| Source | Total intracranial volume, frontal lobes volume, thalamus volume and cerebellar volume | |
| Region | Changsha, China | |
| Method | three-dimensional ultrasound combined with post-processing software | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD fetuses(Treatment) | normal fetuses(Control) |
| Number | 73 | 168 |
| Age | Maternal age: 27.4±3.8 (21–44) years | Maternal age: 27.2±4.3 (19–39) years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
