| Factor Information | |
|---|---|
| Data ID | 1897 |
| Factor | correlation between early changes in plasma concentrations of intestinal FABP 2 and CPB duration |
| Description | Cytokine response to CPB (cardiopulmonary bypass) was associated with early, but not late, changes in plasma concentrations of intestinal fatty acid–binding protein 2 and citrulline. Peak postoperative plasma FABP2 was associated with CPB duration (p = 0.01). |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | prognosis and risk assessment |
| Objective | Cytokine response to cardiopulmonary bypass |
| p Value | 0.01 |
| Conclusion | Children undergoing cardiopulmonary bypass for repair or palliation of congenital heart disease are at risk for intestinal injury and often present with evidence for loss of intestinal epithelial integrity preoperatively. Greater severity of illness requiring increased cardiopulmonary support rather than the inflammatory response to cardiopulmonary bypass seems to mediate late postoperative intestinal epithelial barrier function |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 563 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TOF/SD/AVC/AS/SS/CoA, HAA/MV/TAPVR/PS/PA/PI/DORV/EA |
| Reference | |
|---|---|
| PMID | 25162512 |
| Year | 2015 |
| Title | Clinical characteristics associated with postoperative intestinal epithelial barrier dysfunction in children with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | blood, urine | |
| Region | Tucson, USA | |
| Method | ELISA, triple-quadrupole mass spectrometer, Cytokine concentrations were evaluated using an xMAP assay and Luminex 100 platform, HPLC | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | repair or palliation of congenital heart disease with cardiopulmonary bypass. | |
| Group | N/A(Treatment) | N/A(Control) |
| Number | 20 | N/A |
| Age | 17 (3.1–76.9) months | N/A |
| Gender (Male: Female) | 14:20 | N/A |
| Marker Level | N/A | N/A |
