| Factor Information | |
|---|---|
| Data ID | 1900 |
| Factor | correlation between dual sugar permeability test ratio and symptoms of feeding intolerance |
| Description | Variation in biomarker concentrations over time was associated with aspects of ICU care indicating greater severity of illness: claudin 3, intestinal fatty acid–binding protein 2, and dual sugar permeability test ratio were associated with symptoms of feeding intolerance (p< 0.05). Claudin 3 (p = 0.02) concentrations and FABP2 (p = 0.02) were significantly associated with symptoms of feeding intolerance, mixed effects linear regression |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | prognosis and risk assessment |
| Objective | greater severity of illness, symptoms of feeding intolerance, mixed effects linear regression |
| p Value | <0.05 |
| Conclusion | Children undergoing cardiopulmonary bypass for repair or palliation of congenital heart disease are at risk for intestinal injury and often present with evidence for loss of intestinal epithelial integrity preoperatively. Greater severity of illness requiring increased cardiopulmonary support rather than the inflammatory response to cardiopulmonary bypass seems to mediate late postoperative intestinal epithelial barrier function |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 563 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TOF/SD/AVC/AS/SS/CoA, HAA/MV/TAPVR/PS/PA/PI/DORV/EA |
| Reference | |
|---|---|
| PMID | 25162512 |
| Year | 2015 |
| Title | Clinical characteristics associated with postoperative intestinal epithelial barrier dysfunction in children with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | blood, urine | |
| Region | Tucson, USA | |
| Method | ELISA, triple-quadrupole mass spectrometer, Cytokine concentrations were evaluated using an xMAP assay and Luminex 100 platform, HPLC | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | repair or palliation of congenital heart disease with cardiopulmonary bypass. | |
| Group | N/A(Treatment) | N/A(Control) |
| Number | 20 | N/A |
| Age | 17 (3.1–76.9) months | N/A |
| Gender (Male: Female) | 14:20 | N/A |
| Marker Level | N/A | N/A |
