| Factor Information | |
|---|---|
| Data ID | 202 |
| Factor | Pulmonary vascular resistance index (PVRI) after Acute vasoreactivity test(AVT) |
| Description | The children in the favorable group had lower PVRI, PASP, mPAP, and PVR/SVR values than those in the unfavorable group, and the differences were significant (all P < 0.05) |
| Biomarker | YES |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | evaluated the predictors and prognoses of children with PAH-CHD who underwent surgical correction. |
| p Value | <0.001 |
| Conclusion | Although the criteria for positive AVT currently used are unsuitable for pediatric patients with PAH-CHD, PVR and PVR/SVR during AVT are excellent predictors of outcome in pediatric PAH-CHD. Surgery aided by anti-PAH drugs is an effective strategy and should be recommended for severe pediatric PAH-CHD with PVR ≤ 6.65WU/m2 and PVR/SVR ≤ 0.39 after iloprost aerosol inhalation. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 426 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | VSD/ASD/PDA/APSD/VSD, PDA/ASD, PDA/ASD, VSD/AVSD/PAH |
| Reference | |
|---|---|
| PMID | 30789367 |
| Year | 2019 |
| Title | Predictors of operability in children with severe pulmonary hypertension associated with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | Guangzhou, China | |
| Region | Guangzhou, China | |
| Method | A regression analysis, receiver-operating characteristic (ROC) curves, and Kaplan-Meier curves were used for survival analysis. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | heart catheterization and correction, with or without specific anti- PAH drugs postoperatively, | |
| Group | favorable PAH-CHD(Treatment) | unfavorable PAH-CHD(Control) |
| Number | 42 | 14 |
| Age | 6.5 (3.8–13.2) years | 9 (7.1–14.2) years |
| Gender (Male: Female) | 20:22 | 6:8 |
| Marker Level | 3.5 (2.3–4.7)(WU/m2) | 11.4 (9.6–14.1)(WU/m2) |
