CHDRFKB

Factor Information
Data ID	2164
Factor	preoperative ADAMTS-13 activity of <64.6%
Description	The preoperative ADAMTS-13 activity of <64.6% (mean level for the group), preoperative activated partial thromboplastin time, and the need for cardiopulmonary bypass were characterized as independent risk factors for postoperative bleeding, with respective hazard ratios of 22.35 (95% CI 1.69 to 294.79), 1.096 (95% CI 1.016 to 1.183), and 37.43 (95% CI 1.79 to 782.73).
Biomarker	NA
Classification	E2 (physiological factor - biochemical index)

Association
Application	risk assessment
Objective	To analyze the preoperative plasma antigenic concentration and activity of VWF and its main cleaving protease ADAMTS-13 in pediatric patients with cyanotic congenital heart disease undergoing surgical treatment and investigate possible correlations with postoperative bleeding.
HR	22.35
Conclusion	The preoperative ADAMTS-13 activity of <64.6% (mean level for the group), preoperative activated partial thromboplastin time, and the need for cardiopulmonary bypass were characterized as independent risk factors for postoperative bleeding, with respective hazard ratios of 22.35 (95% CI 1.69 to 294.79), 1.096 (95% CI 1.016 to 1.183), and 37.43 (95% CI 1.79 to 782.73).
Risk Factor	risk factor

Reference
PMID	23778350
Year	2013
Title	Decreased plasma ADAMTS-13 activity as a predictor of postoperative bleeding in cyanotic congenital heart disease.

Sample
Population	pediatric patients
Source	blood
Region	Sa˜o Paulo/SP, Brazil
Method	multivariate analysis
Race	South America
Disease History	N/A
Treatment History	Cardiopulmonary bypass
Group	Patients(Treatment)	N/A(Control)
Number	48	N/A
Age	2.5 years (range from 9 months to 7.6 years)	N/A
Gender (Male: Female)	24:24	N/A
Marker Level	N/A	N/A