| Factor Information | |
|---|---|
| Data ID | 2330 |
| Factor | FMD (flow-mediated dilatation) |
| Description | Compared to the control group, the mean FMD was significantly reduced in the cyanotic group (5.26 ± 2.42% and 9.48 ± 2.60%, respectively; P-value < 0.001). |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To assess endothelial dysfunction and the risk for coronary atherosclerosis in children with irreversible pulmonary hypertension due to CHD. |
| p Value | <0.001 |
| Conclusion | Systemic endothelial dysfunction in children with irreversible pulmonary hypertension due to CHD was noted but there was no increased risk for atherosclerosis. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 23129906 |
| Year | 2012 |
| Title | Endothelial dysfunction and atherosclerosis in children with irreversible pulmonary hypertension due to congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | Children | |
| Source | Blood, Lipid | |
| Region | Antalya, Turkey | |
| Method | flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), atherosclerotic risk factors, Detection of endothelial dysfunction, Measurement of carotid artery intima media thickness | |
| Race | Asia | |
| Disease History | cyanotic patients | |
| Treatment History | N/A | |
| Group | cyanotic patients (patients with irreversible PAH due to CHD)(Treatment) | control patients (children with no hypertension, diabetes mellitus and obesity)(Control) |
| Number | 18 | 18 |
| Age | 12.28 ± 3.26 years | 11.78 ± 3.00 years |
| Gender (Male: Female) | 8:10 | 8:10 |
| Marker Level | 5.26 ± 2.42% | 9.48 ± 2.60 |
