| Factor Information | |
|---|---|
| Data ID | 2342 |
| Factor | PVR (pulmonary vascular resistance) (WU m2) |
| Description | Comparison between these two groups, the aPH/CHD with high PVR group has significantly higher mPAP and PVR (mPAP 52.1 ± 16.7 mmHg vs. 31.8 ± 2.8 mmHg and PVR 7.8 ± 3.9 WU m2 vs. 2.1 ± 0.6 WU m2, p < 0.05) |
| Biomarker | NA |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | investigated the occurrence of BMPR2 mutation and genetic polymorphisms in children with pulmonary hypertension associated with congenital heart disease (aPH/CHD) and correlated with the pulmonary haemodynamic and vasoreactivity. |
| p Value | 0.001 |
| Conclusion | Comparison between these two groups, the aPH/CHD with high PVR group has significantly higher mPAP and PVR (mPAP 52.1 ± 16.7 mmHg vs. 31.8 ± 2.8 mmHg and PVR 7.8 ± 3.9 WU m2 vs. 2.1 ± 0.6 WU m2, p < 0.05) |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 452 |
| CHD Type | NA |
| CHD Subtype | CHD with PAH |
| Reference | |
|---|---|
| PMID | 23098893 |
| Year | 2012 |
| Title | 5'UTR repeat polymorphisms of the BMPR2 gene in children with pulmonary hypertension associated with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | baseline haemodynamic data | |
| Region | Bangkok, Thailand | |
| Method | cardiac catheterisation, Haemodynamics, Acute Vasoreactivity Testing, Genetic Analysis | |
| Race | Asia | |
| Disease History | N/A | |
| Treatment History | cardiac catheterisation | |
| Group | children with aPH/CHD with high PVR(Treatment) | children with aPH/CHD with normal PVR(Control) |
| Number | 24 | 6 |
| Age | 94.2 ± 73.2 months | 55.6 ± 77.7 months |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 7.8 ± 3.9 WU m2 | 2.1 ± 0.6 WU m2 |
