| Factor Information | |
|---|---|
| Data ID | 2383 |
| Factor | Prevalence of first and second-degree relatives |
| Description | The prevalence of congenital heart disease in first-degree relatives was 43.0%, that is 46 out of 107, significantly higher than that in second-degree relatives, that is, 4.4%, 11 out of 252 (x2=83.897, P<0.01). |
| Biomarker | NA |
| Classification | A8 (clinical factor - relationship) |
| Association | |
|---|---|
| Application | prognosis and morbidity assessment |
| Objective | explore genetic mechanisms of congenital heart disease by analysing family data. |
| p Value | <0.01 |
| Conclusion | Morbidity in relatives was related to blood relationship, with a closer relationship increasing the risk of congenital heart disease. Genetic factors appear to play an important role in congenital heart disease. |
| Risk Factor | risk factor(article mentioned) |
| CHD Type | |
|---|---|
| ID | 601 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/VSD/VSD, ASD, PDA/VSD, PDA, PAH/TOF/HLHS/CoA/PA, VSD, PS/PS, RVOTO/ASD, MRMV, PMT/PA, VSD/SA, SV, CAVC, HLHS/PDA/CAF/VSD, RVOTO, CoA/AS |
| Reference | |
|---|---|
| PMID | 23021226 |
| Year | 2012 |
| Title | Familial congenital heart disease: data collection and preliminary analysis. |
| Sample | ||
|---|---|---|
| Population | All | |
| Source | N/A | |
| Region | Shanghai, China | |
| Method | Individuals who were reported as having congenital heart disease had the diagnosis confirmed by clinical evaluation, including detailed medical history, comprehensive physical examination, echocardiography, chest X-ray, electrocardiogram, cardiac catheterisation, or surgery. | |
| Race | Asia | |
| Disease History | ASD/VSD/PDA/PH/TOF/HLHS/COA/PA/PS/RVOTO/MRMV/PMT/SA/SV/CAVC/CAF/AS | |
| Treatment History | N/A | |
| Group | congenital heart disease in first-degree relatives(Treatment) | congenital heart disease in second-degree relatives(Control) |
| Number | 46 (total: 107) | 11 (total: 252) |
| Age | 2.22 ± 2.79 (27 weeks of pregnancy - 14 years) years | 2.22 ± 2.79 (27 weeks of pregnancy - 14 years) years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 43% (46/107) | 4.4% (11/252) |
