| Factor Information | |
|---|---|
| Data ID | 2385 |
| Factor | threatened abortion in early pregnancy |
| Description | There was an increased incidence of threatened abortion in early pregnancy in patients with familial congenital heart disease when compared with sporadic congenital heart disease (x2=8.704, P<0.05). |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | explore genetic mechanisms of congenital heart disease by analysing family data. |
| p Value | <0.05 |
| Conclusion | Morbidity in relatives was related to blood relationship, with a closer relationship increasing the risk of congenital heart disease. Genetic factors appear to play an important role in congenital heart disease. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 601 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/VSD/VSD, ASD, PDA/VSD, PDA, PAH/TOF/HLHS/CoA/PA, VSD, PS/PS, RVOTO/ASD, MRMV, PMT/PA, VSD/SA, SV, CAVC, HLHS/PDA/CAF/VSD, RVOTO, CoA/AS |
| Reference | |
|---|---|
| PMID | 23021226 |
| Year | 2012 |
| Title | Familial congenital heart disease: data collection and preliminary analysis. |
| Sample | ||
|---|---|---|
| Population | All | |
| Source | N/A | |
| Region | Shanghai, China | |
| Method | Individuals who were reported as having congenital heart disease had the diagnosis confirmed by clinical evaluation, including detailed medical history, comprehensive physical examination, echocardiography, chest X-ray, electrocardiogram, cardiac catheterisation, or surgery. | |
| Race | Asia | |
| Disease History | ASD/VSD/PDA/PH/TOF/HLHS/COA/PA/PS/RVOTO/MRMV/PMT/SA/SV/CAVC/CAF/AS | |
| Treatment History | N/A | |
| Group | threatened abortion in early pregnancy with familial congenital heart disease(Treatment) | sporadic congenital heart disease(Control) |
| Number | 11 (total: 42) | 6 (total: 84) |
| Age | 2.22 ± 2.79 (27 weeks of pregnancy - 14 years) years | 2.22 ± 2.79 (27 weeks of pregnancy - 14 years) years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 26.2%(11/42) | 7.1%(6/84) |
