| Factor Information | |
|---|---|
| Data ID | 2513 |
| Factor | goiter |
| Description | N/A |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | Amiodarone therapy in adults with congenital heart disease (CHD) is associated with a significant risk of amiodarone-induced thyrotoxicosis (AIT). We developed a risk index to identify those patients being considered for amiodarone treatment who are at high risk for AIT. |
| p Value | 0.003 |
| HR | 4.08 |
| Conclusion | We derived the first model to quantify the risk for developing AIT among adults with CHD. Before using it clinically to help selecting among alternative antiarrhythmic options, it needs validation in an independent population |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 22518347 |
| Year | 2012 |
| Title | A Risk Prediction Index for Amiodarone-Induced Thyrotoxicosis in Adults with Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | adults | |
| Source | patients' data | |
| Region | Rochester, America | |
| Method | bivariate cox proportional hazard model | |
| Race | American | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | group with AIT (amiodarone-induced thyrotoxicosis)(Treatment) | group without AIT(Control) |
| Number | 23 | 146 |
| Age | 3.51(2.7-5.2) | 2.96(3.05-4.12) |
| Gender (Male: Female) | 13:10:00.000 | 76:93 |
| Marker Level | N/A | N/A |
