| Factor Information | |
|---|---|
| Data ID | 2767 |
| Factor | Total/HDL-cholesterol(cut off>3.5 mmol/l)(association between maternal lipids and total homocysteine and CHD risk) |
| Description | After adjustment for potential confounders, a lipid profile with apolipoprotein B > 85.0 mg dl-1, apolipoprotein B/apolipoprotein A-I > 0.6 and cholesterol/HDL-cholesterol > 3.5 is associated with an almost twofold increased risk of CHD, which is independent of homocysteine. |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | risk assessment |
| Objective | We examined whether maternal lipid levels are associated with the risk of CHD offspring. |
| p Value | 0.003 |
| OR | 1.8 |
| Conclusion | After adjustment for potential confounders, a lipid profile with apolipoprotein B > 85.0 mg dl-1, apolipoprotein B/apolipoprotein A-I > 0.6 and cholesterol/HDL-cholesterol > 3.5 is associated with an almost twofold increased risk of CHD, which is independent of homocysteine. |
| Risk Factor | risk factor |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 21186113 |
| Year | 2012 |
| Title | A derangement of the maternal lipid profile is associated with an elevated risk of congenital heart disease in the offspring |
| Sample | ||
|---|---|---|
| Population | mothers of children with and without CHD | |
| Source | a case-control study | |
| Region | Rotterdam, The Netherlands | |
| Method | Demographics/ a:Adjusted for maternal age, parity, BMI, ethnicity, family history of CHD, periconception smoking, folic acid and/or (multi)vitamin use and diabetes/b: Adjusted for all before mentioned covariates and total homocysteine | |
| Race | Europe | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | CHD group(Treatment) | Control group(Control) |
| Number | 104 | 107 |
| Age | 33.1 (25.3-41.5) years | 32.6 (24.5-39.8) years |
| Gender (Male: Female) | 0:104 | 0:107 |
| Marker Level | N/A | N/A |
