| Factor Information | |
|---|---|
| Data ID | 2835 |
| Factor | angiotensin converting enzyme inhibitor (ACEI) |
| Description | We report three cases of angiotensin converting enzyme inhibitor (ACEI) induced nephrotoxicity in preterm infants with congenital heart disease. Patients developed acute renal failure after starting captopril or enalapril at doses commonly prescribed for term neonates. |
| Biomarker | NA |
| Classification | A12 (clinical factor - treatment) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | We report 3 unfortunate cases of acute renal failure in preterm infants with congenital heart disease likely precipitated by ACEI initiation at doses commonly recommended for full term infants. |
| Conclusion | There was no underlying renal disease found in these infants and the acute renal failure was reversible upon discontinuation of the ACEI. Conservative starting doses of ACEI should be used in patients with multiple risk factors for nephrotoxicity. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 148 |
| CHD Type | NA |
| CHD Subtype | NA |
| Reference | |
|---|---|
| PMID | 22477817 |
| Year | 2010 |
| Title | Angiotensin Converting Enzyme Inhibitor (ACEI)-Induced Acute Renal Failure in Premature Newborns with Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | Premature Newborns | |
| Source | cases | |
| Region | California, USA | |
| Method | We report 3 unfortunate cases of acute renal failure in preterm infants with congenital heart disease | |
| Race | North America | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Premature Newborns with CHD(Treatment) | N/A(Control) |
| Number | 3 | N/A |
| Age | gestational age: 36/30/27 week | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
