| Factor Information | |
|---|---|
| Data ID | 3081 |
| Factor | brain mineralization/hemosiderin |
| Description | N/A |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | Perioperative stroke and periventricular leukomalacia have been reported to occur commonly in infants with congenital heart disease. We aimed to determine the incidence and type of brain injury in infants undergoing 2-ventricle repair in infancy and to determine risk factors associated with such injury. |
| p Value | 0.003 |
| Conclusion | Qualitative analysis of the image data showed no evidence of severe brain injury or major brain malformations. We found more acquired or developmental abnormalities in subjects with VSD (7 abnormal vs 2 normal), compared with the TOF (11 vs 9) or TGA (5 vs 14) groups. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 648 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | TGA, VSD/TOF, PA, TA/VSD |
| Reference | |
|---|---|
| PMID | 19619781 |
| Year | 2009 |
| Title | Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease |
| Sample | ||
|---|---|---|
| Population | neonates | |
| Source | patients' data | |
| Region | Boston,America | |
| Method | Kruskal-Wallis tests | |
| Race | American | |
| Disease History | N/A | |
| Treatment History | surgery | |
| Group | TGA surgery group(Treatment) | VSD surgery group(Control) |
| Number | 19 | 9 |
| Age | 6 days (range:2-13) | 156 days (range: 39-264) |
| Gender (Male: Female) | 12:7 | 6:3 |
| Marker Level | 3(16%) | 6(67%) |
