| Factor Information | |
|---|---|
| Data ID | 3166 |
| Factor | Fluoxetine prescription dose |
| Description | N/A |
| Biomarker | NA |
| Classification | A12 (clinical factor - treatment) |
| Association | |
|---|---|
| Application | prognosis |
| Objective | To determine the risk of congenital cardiac abnormalities associated with use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy. |
| p Value | 0.01 |
| Conclusion | The median doses of several SSRIs (citalopram, venlafaxine, fluoxetine, and sertraline) were significantly lower when prescribed during the second and third trimesters compared with the doses given before conception. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 657 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | VSD/VSD, other |
| Reference | |
|---|---|
| PMID | 19121250 |
| Year | 2009 |
| Title | Congenital Heart Disease Associated With Selective Serotonin Reuptake Inhibitor Use During Pregnancy |
| Sample | ||
|---|---|---|
| Population | adults | |
| Source | patients' data | |
| Region | Rochester, America | |
| Method | Wilcoxon ranks sum test | |
| Race | American | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Fluoxetine dose initiated before conception(Treatment) | Fluoxetine dose initiated during second or third trimester (more than 14 gestational weeks)(Control) |
| Number | 545 | 119 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | median=20mg (interquartile range=20-40mg) | median=20mg (interquartile range=20-20mg) |
