| Factor Information | |
|---|---|
| Data ID | 3352 |
| Factor | serum folate concentration |
| Description | N/A |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | To investigate the inter-relation between mother and infant homocysteine, folate and vitamin B12 status and the risk of a child with congenital heart disease (CHD). |
| p Value | <0.01 |
| Conclusion | Maternal hyperhomocysteinaemia is associated with an increased risk of CHD, partially due to low folate and vitamin B12 status. The folate status of children warrants further investigation. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 673 |
| CHD Type | isolated CHD |
| CHD Subtype | TOF/TGA/AVSD/VSD/CoA/AVS/PVS/HLHS |
| Reference | |
|---|---|
| PMID | 17081182 |
| Year | 2006 |
| Title | Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients' data | |
| Region | Rotterdam, Netherlands | |
| Method | Mann-Whitney U test | |
| Race | Dutch | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | hyperhomocysteinaemic case-mothers (Treatment) | normohomocysteinaemic case-mothers(Control) |
| Number | N/A | N/A |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 11.1 (6.2-24.1) nmol/L | 15.1 (8.0-27.8) nmol/L |
