| Factor Information | |
|---|---|
| Data ID | 3362 |
| Factor | increasing maternal tHcy concentration |
| Description | N/A |
| Biomarker | NA |
| Classification | E2 (physiological factor - biochemical index) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | To investigate the inter-relation between mother and infant homocysteine, folate and vitamin B12 status and the risk of a child with congenital heart disease (CHD). |
| Conclusion | A high maternal fasting tHcy concentration is associated with an approximately three-fold higher risk of a child with CHD in a concentration-dependent manner. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 673 |
| CHD Type | isolated CHD |
| CHD Subtype | TOF/TGA/AVSD/VSD/CoA/AVS/PVS/HLHS |
| Reference | |
|---|---|
| PMID | 17081182 |
| Year | 2006 |
| Title | Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients' data | |
| Region | Rotterdam, Netherlands | |
| Method | Logistic regression analysis | |
| Race | Dutch | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | case-mothers(Treatment) | control-mothers (Control) |
| Number | 98 | 134 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
