| Factor Information | |
|---|---|
| Data ID | 3431 |
| Factor | Mean VE/VCO2 slope |
| Description | N/A |
| Biomarker | YES |
| Classification | E10 (physiological factor - other) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | We sought to establish the distribution, relation to cyanosis, and prognostic value of the V˙ E/V˙ CO2 slope across a wide spectrum of ACHD patients. |
| p Value | <0.0001 |
| Conclusion | Ventilatory response to exercise is abnormal across the spectrum of ACHD. Cyanosis is a powerful stimulus for such exaggerated ventilatory patterns irrespective of the presence of pulmonary arterial hypertension. Increased V˙ E/V˙ CO2 slope is the strongest exercise predictor of death in noncyanotic ACHD patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 676 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/AVSD/ccTGA/CoA/other/EA/ES/TOF/CHD with PAH/VSD |
| Reference | |
|---|---|
| PMID | 16769913 |
| Year | 2006 |
| Title | Abnormal Ventilatory Response to Exercise in Adults With Congenital Heart Disease Relates to Cyanosis and Predicts Survival |
| Sample | ||
|---|---|---|
| Population | adults | |
| Source | patients' data | |
| Region | London, United Kindom | |
| Method | upaired student t test | |
| Race | British | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | cyanotic patients(Treatment) | noncyanotic patients(Control) |
| Number | 560 | 478 |
| Age | N/A | 33.0±12.9 yrs |
| Gender (Male: Female) | 298:262 | 263:215 |
| Marker Level | 36.3±15.3 | 25.6±3.1 |
