| Factor Information | |
|---|---|
| Data ID | 3440 |
| Factor | correlation between VE/VCO2 slope and cumulative survival rate |
| Description | 1st, 2nd, 3rd quartiles, VE/VCO2 slope<38 vs. 4th quartile, VE/VCO2 >=38 |
| Biomarker | YES |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | We sought to establish the distribution, relation to cyanosis, and prognostic value of the V˙ E/V˙ CO2 slope across a wide spectrum of ACHD patients. |
| p Value | <0.0001 |
| Conclusion | Ventilatory response to exercise is abnormal across the spectrum of ACHD. Cyanosis is a powerful stimulus for such exaggerated ventilatory patterns irrespective of the presence of pulmonary arterial hypertension. Increased V˙ E/V˙ CO2 slope is the strongest exercise predictor of death in noncyanotic ACHD patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 676 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/AVSD/ccTGA/CoA/other/EA/ES/TOF/CHD with PAH/VSD |
| Reference | |
|---|---|
| PMID | 16769913 |
| Year | 2006 |
| Title | Abnormal Ventilatory Response to Exercise in Adults With Congenital Heart Disease Relates to Cyanosis and Predicts Survival |
| Sample | ||
|---|---|---|
| Population | adults | |
| Source | patients' data | |
| Region | London, United Kindom | |
| Method | onestep multivariate Cox proportional risks analyses and Kaplan-Meier survival chart | |
| Race | British | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | N/A(Treatment) | N/A(Control) |
| Number | 357 | 121 |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
