| Factor Information | |
|---|---|
| Data ID | 3508 |
| Factor | correlation between FVIII (C level, % normal plasma) and aPC ratio |
| Description | aPC=activated protein C, linear regression model |
| Biomarker | NA |
| Classification | Z (combined factor - combined factor) |
| Association | |
|---|---|
| Application | risk assessment and prognosis |
| Objective | In this report the authors test the hypothesis that hypoxemia is associated with altered sensitivity to activated protein C (aPC) in pediatric patients with congenital heart lesions. |
| p Value | 0.012 |
| Conclusion | The aPC ratio in this population is associated with hypoxemia, independent of factors previously observed in adults. Further studies are under way to determine how aPC resistance or sensitivity may independently affect perioperative hemostasis in this population. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 680 |
| CHD Type | isolated CHD/non-isolated CHD |
| CHD Subtype | ASD/PDA/TGA/AS/HLHS/TOF/AVC/DORV/PA, VSD/PS/TA/TAS/DILV/SAS/EA/other/PA, IVS/CoA/MAS/MVP/AVSD/CACA |
| Reference | |
|---|---|
| PMID | 16458211 |
| Year | 2006 |
| Title | Low Arterial Saturation Is Associated With Increased Sensitivity to Activated Protein C in Children With Congenital Heart Disease |
| Sample | ||
|---|---|---|
| Population | children | |
| Source | patients' data | |
| Region | Tennessee, America | |
| Method | mulitvariate linear regression model | |
| Race | American | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | N/A(Treatment) | N/A(Control) |
| Number | N/A | N/A |
| Age | N/A | N/A |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | N/A | N/A |
