| Factor Information | |
|---|---|
| Data ID | 3562 |
| Factor | NCR (negative chronotropic response) (bpm) |
| Description | In Fontan patients, the lower β sensitivity of the sinus node and the PST mainly determined the higher cNCR ( p<0.01) and the cNCR did not correlate with either hemodynamics or exercise capacity. |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | treatment and prognosis |
| Objective | To investigate the negative chronotropic response (NCR) to low-dose atropine in postoperative patients with congenital heart disease (CHD). |
| p Value | <0.001 |
| Conclusion | NCR is attenuated in proportion to the impaired cardiac parasympathetic nervous system and hemodynamics in postoperative complex biventricular CHD patients. In addition to PST, β sensitivity of the sinus node significantly influences the NCR in Fontan patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 557 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/other |
| Reference | |
|---|---|
| PMID | 15771928 |
| Year | 2005 |
| Title | Negative chronotropic response to low-dose atropine is associated with parasympathetic nerve-mediated cardiovascular response in postoperative patients with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | All (9-36 years) | |
| Source | patients | |
| Region | Osaka, Japan | |
| Method | NCR corrected for basal heart rate (HR) (minimal HR/basal HR=cNCR) was determined after low-dose atropine (3 Ag/kg) administration and was compared with the cardiac autonomic nervous and functional status. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Complex CHD(Treatment) | Control(Control) |
| Number | 80 | 11 |
| Age | 15.5±5 years | 15.6±4.6 years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | -3.9±2.7 bpm | -8.8±1.7 bpm |
