| Factor Information | |
|---|---|
| Data ID | 3569 |
| Factor | cNCR [corrected NCR] |
| Description | The cNCR in simple CHD (post atrial or ventricular septal defect closure), complex biventricular CHD, and Fontan patients were 0.92±0.04, 0.94±0.04 and 0.96±0.04, respectively, and higher than in controls (0.87±0.03, p<0.001). |
| Biomarker | NA |
| Classification | A3 (clinical factor - disease & symptom) |
| Association | |
|---|---|
| Application | treatment and prognosis |
| Objective | To investigate the negative chronotropic response (NCR) to low-dose atropine in postoperative patients with congenital heart disease (CHD). |
| p Value | <0.001 |
| Conclusion | NCR is attenuated in proportion to the impaired cardiac parasympathetic nervous system and hemodynamics in postoperative complex biventricular CHD patients. In addition to PST, β sensitivity of the sinus node significantly influences the NCR in Fontan patients. |
| Risk Factor | unknown |
| CHD Type | |
|---|---|
| ID | 557 |
| CHD Type | isolated CHD |
| CHD Subtype | ASD/VSD/other |
| Reference | |
|---|---|
| PMID | 15771928 |
| Year | 2005 |
| Title | Negative chronotropic response to low-dose atropine is associated with parasympathetic nerve-mediated cardiovascular response in postoperative patients with congenital heart disease. |
| Sample | ||
|---|---|---|
| Population | All (9-36 years) | |
| Source | patients | |
| Region | Osaka, Japan | |
| Method | NCR corrected for basal heart rate (HR) (minimal HR/basal HR=cNCR) was determined after low-dose atropine (3 Ag/kg) administration and was compared with the cardiac autonomic nervous and functional status. | |
| Race | Asian | |
| Disease History | N/A | |
| Treatment History | N/A | |
| Group | Fontan(Treatment) | Control(Control) |
| Number | 27 | 11 |
| Age | 14.4±5.8 years | 15.6±4.6 years |
| Gender (Male: Female) | N/A | N/A |
| Marker Level | 0.96±0.04 | 0.87±0.03 |
